• Title/Summary/Keyword: biological stability

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Spectral Analysis of the ECG Using the Improved ARMA FTF Algorithm (개선된 ARMA FTF 알고리즘을 이용한 ECG 신호의 스펙트럼 해석)

  • Nam, Hyeon-Do;An, Dong-Jun;Lee, Cheol-Hui
    • Journal of Biomedical Engineering Research
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    • v.15 no.4
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    • pp.395-400
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    • 1994
  • High resolution spectral analysis is essential for ECG anaysis. The fast Fourier transform has been widely used for frequency analysis of ECG signals but this procedure provides poor resolution when the data record is short and shows Gibb's phenomena. The ARMA FTF (Fast Transversal Filter) algorithm is used for high resolution spectral analysis. The reason of unsalability of this algorithm is investigated and the method for improving the numerical stability is proposed. The proposed algorithm is applied to spectral analysis of the ECG. Since this result has less variations than the FFT based results, it can be used for the computerized diagonosis of the ECG.

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Development of an Auto Dilution Unit of Substrate Solutionfor a Flow Injection Type Biosensor (흐름주입식 바이오센서용 기질용액 자동희석 장치 개발)

  • Song, D.B.;Jung, H.S.;Jung, D.H.;Kim, S.T.
    • Journal of Biosystems Engineering
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    • v.31 no.5 s.118
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    • pp.443-448
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    • 2006
  • For development of an on-line monitoring unit of fermentation process, an auto dilution unit based on traditional chemical and biological analytical method was developed and the performance was evaluated. The dilution unit was constructed with two syringe pumps and flow direction change valves and fully automated. Total delivery volume of two pumps using distilled water was measured to confirm the operating stability And diluted concentrations of three substrate solutions (glucose, lactic acid, ethanol) were compared with a standard method with a high performance liquid chromatograph (glucose, lactic acid) and gas chromatograph (ethanol). Relative error values of total delivery volume of the pumps were below 3% and standard deviation values were 0.003 (n=5). Relative error values of diluted concentration of the dilution unit measurements were below 2% with 1/10 of dilution ratio and 70, $80{\mu}{\ell}$ of sample volume conditions for glucose and lactic acid, 1/30 of dilution ratio and $70{\mu}{\ell}$ of sample volume conditions for ethanol, respectively. In case of the ethanol, cause of the evaporative characteristics, the relative error values showed over 5% whole experimental conditions.

The Development of Microwave Tissue Coagulator (마이크로파를 이용한 수술기의 개발)

  • Park, B.W.;Jeong, B.S.;Park, Mi-Gnon;Lee, S.B.;Son, W.J.;Jeong, D.G.;Yang, S.H.
    • Proceedings of the KOSOMBE Conference
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    • v.1989 no.05
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    • pp.81-83
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    • 1989
  • In surgery the hemostatic control is very important for the parenchymatous organs. These organs consist of the fragile and the blood content tissues such as liver, spleen and kidney, etc.. One of the control methods to solve this problem is to insert the mono polar typed needle electrode, which gathers the thermal effect of microwave, directly into tissues so as to coagulate and stop the hemorrhage. This method has same advantages: First, the range of the heat energy is limited. Second, the coagulation, the hemostatic characteristic, and stability are excellent. Third, more convenient operation is possible. This paper is aimed to manufacture the microwave tissue coagulation system and to suggest the new direction for development, hereafter.

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Synthesis and Physical Properties of Hydrophilic Biomedical Polymers -Poly (N-substituted Acrylamide) and its Copolymer- (친수성 생의용 고분자의 합성 및 물성에 관한 연구)

  • 성용길;고대유
    • Journal of Biomedical Engineering Research
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    • v.9 no.1
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    • pp.47-60
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    • 1988
  • N-n-Propylacrylamide has been synthesized from acrylamide and n-propyl bromide. N -n Propylacrylamide was copolymerized with acrylamide at $60^{\circ}C$ in tetrahydrofuran using ${\alpha},{\alpha}'$-azobisisbutyronitrile as initiator. The synthesized monomer and copolymers have been identified by NMR and FT-lR spectrophotometer. The swelling properties of the crosslinked homopolymers were investigated at different temperatures. Three types of hydration layer around the back-bone structure of gels were determined. The thermal properties of copolymers were also measured by differential scanning calorimeter and thermogravimetry. As the amounts of N-n-propylacrylamide are increased, the enthalpic changes associated with endothermic transition and glass transition of the copolymers are decreased. As the amount of N-n-propylacrylamide is increased, the thermal stability is increased. The activation energies of thermal decomposition and dehydration for the poly (acrylamide-co-N -n-propylacrylamide) have been evaluated by Freeman and Carroll's method. As the amounts of N-n- propylacrylamide are increased, the activation energies of thermal decomposition and dehydration are increased.

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Development of P-5 Transducer or Detection of the Pulse Wave (맥파검출용 트랜스듀서의 개발)

  • Han, S.H.;Kwon, O.S.;Park, S.H.;Hong, S.H.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.11
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    • pp.395-398
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    • 1997
  • Human pulse represents the physical characteristics of heart and cardiovascular system. Therefore, malfunctions and errors of heart and cardiovascular system can be determined by using an automatic diagnosis system that can detect the pulse signal. Not only will the computerised system preclude the possibilities of observational errors by giving an accurate measurement with great stability, but minimize the possibilities of misinterpretation by using an automated diagnostic logic. A new combinational fiber-optic sensor, which has a detecting part and a transmitting part was used to acquire radial pulse signal noninvasively. The development of P-5 transducer makes it possible to obtain more effective detection and obvious display of pulse signals in the aspect of reliability. Using P-5 transducer in the field of plethysomography and MAC- JIN, one of our diagnoses in Korean traditional medicine, it is expected that we can ontain quantitative and valuable information or the diagnosis of human pulses.

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Change and Development of the Orthopaedic Manual Therapy (정형물리치료의 변화와 발전)

  • Ju Mu-Yeol;Kim Seung-Joon;Park Seung-Kyu;Jung Yeon-Woo;Bae Sung-Soo
    • The Journal of Korean Physical Therapy
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    • v.14 no.4
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    • pp.475-486
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    • 2002
  • Orthopaedic manual therapy(OMT) includes knowledge in arthokinematic, biological, behavioral, biomechanical, patholology, anatomy, and clinical science. it allows proper approach to patient evaluation and program development and relieves joint and soft tissue lesions. The OMT has sports injurys, traumatic, developmental, and neuromusculoskeletal disorders of acute and chronic states, and prevention of dysfunction as well as the development, improvement, restoration, or maintenance of joint and muscular mobility, stability, relaxation, strenth, endurance, balance, and functional skills. The purpose of this article has to define and clarify the change and development of basic concepts of orthopaedic manual therapy. OMT is ancient in origin. The book of ' Manipulation Past and Present ' contains pictures recording various types of joint mobilization by Hippocrates. Recently, there are many kinds of manual therapeutic maneuvers to assess and relieve joint and soft tissue lesions developed by James Cyriax, John McM Mennell, Brian R Mullign, Robin McKenzie, Freddy Kaltenborn, Geoffrey Maitland, and Ola Grimsby.

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Real-time Water Quality Prediction for Evaluation of Influent Characteristics in a Full-scale Sewerage Treatment Plant (하수처리장 유입수의 특성평가를 위한 실시간 수질예측)

  • Kim, Youn-Kwon;Chae, Soo-Kwon;Han, In-Sun;Kim, Ju-Hwan
    • Journal of Environmental Impact Assessment
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    • v.19 no.6
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    • pp.617-623
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    • 2010
  • It is the most important subject to figure out characteristics of the wastewater inflows of sewerage treatment plant(STP) when situation models are applied to operation of the biological processes and in the automatic control based on ICA(Instrument, Control and Automation). For the purposes, real-time influent monitoring method has been applied by using on-line monitoring equipments for the process optimization in conventional STP. Since, the influent of STP is consist of complex components such as, COD, BOD, TN, $NH_4$-N, $NO_3$-N, TP and $PO_4$-P. MRA2(Microbial Respiration Analyzer 2), which is capable of real-time analyzing of wastewater characteristics is used to overcome the limitations and defects of conventional online monitoring equipments in this study. Rapidity, accuracy and stability of developed MRA2 are evaluated and compared with the results from on-line monitoring equipments for seven months after installation in Full-scale STP.

Metabolic Engineering of Escherichia coli for the Biological Synthesis of 7-O-Xylosyl Naringenin

  • Simkhada, Dinesh;Kim, EuiMin;Lee, Hei Chan;Sohng, Jae Kyung
    • Molecules and Cells
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    • v.28 no.4
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    • pp.397-401
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    • 2009
  • Flavonoids are a group of polyphenolic compounds that have been recognized as important due to their physiological and pharmacological roles and their health benefits. Glycosylation of flavonoids has a wide range of effects on flavonoid solubility, stability, and bioavailability. We previously generated the E. coli BL21 (DE3) ${\Delta}pgi$ host by deleting the glucose-phosphate isomerase (Pgi) gene in E. coli BL21 (DE3). This host was further engineered for whole-cell biotransformation by integration of galU from E. coli K12, and expression of calS8 (UDP-glucose dehydrogenase) and calS9 (UDP-glucuronic acid decarboxylase) from Micromonospora echinospora spp. calichensis and arGt-4 (7-O-glycosyltransferase) from Arabidopsis thaliana to form E. coli (US89Gt-4), which is expected to produce glycosylated flavonoids. To test the designed system, the engineered host was fed with naringenin as a substrate, and naringenin 7-O-xyloside, a glycosylated naringenin product, was detected. Product was verified by HPLC-LC/MS and ESI-MS/MS analyses. The reconstructed host can be applied for the production of various classes of glycosylated flavonoids.

Cavitation Effects on Radiated Sounds and Break Efficiency Induced by Piezoelectric Extracorporeal Shock Wave Lithotripter (ESWL 장치에 의한 방사음 및 파쇄효율에 미치는 캐비테이션의 영향)

  • 장윤석
    • Journal of Biomedical Engineering Research
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    • v.22 no.2
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    • pp.205-210
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    • 2001
  • The effectiveness of extracorporeal shock wave lithotripter for the therapy of calculus has been well known in the field of urology. There are many studies about the performance of that and the influence into human body. Among them, it is an impertant issue that cavitation is always deal with shock wave. A medium of the shock wave is related to the cavitation phenomenon. In this paper, therefore, we analysis the spectra of radiated sounds and the break efficiency on focal region due to the medium of shock wave. The results show that the cavitation bubbles produce a harmful on the break efficiency and the stability of the radiated sounds due to the ESWL.

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Improving Solubility through Carboxymethylation of Different-sized Endosperm, Bran, and Husk Rice Powders

  • Choi, Kyeong-Ok;Yang, Seung-Cheol;Kim, Dong-Eun;Kang, Wie-Soo;Shin, Malshick;Choi, Yoon-Hee;Ko, Sang-Hoon
    • Food Science and Biotechnology
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    • v.18 no.6
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    • pp.1439-1446
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    • 2009
  • The surfaces of different-sized endosperm, bran, and husk rice powders were modified using carboxymethylation. Carboxymethylation was carried out using aqueous alkalization and neutralization. After the carboxymethylation process, the centrifuged products were milled and classified by size: particles passed through sieves of 45, 106, and $300-{\mu}m$ width. The effect of carboxymethylation on physical properties such as solubility and dispersibility of endosperm, bran, and husk particles were studied. Overall, carboxymethylation increased solubility of the particles, while size reduction increased dispersibility. In particular, carboxymethylation created good aqueous suspensions by minimizing interparticle agglomeration. Our results show that the combination of size reduction and carboxymethylation improves solubility and dispersibility, resulting in better stability of the suspension. This study may be helpful for expanding the use of rice and its byproducts as ingredients in a variety of food and beverage applications.