• Molecules and Cells
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• 제27권3호
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• pp.271-277
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• 2009

Proteins interact with each other within a cell, and those interactions give rise to the biological function and dynamical behavior of cellular systems. Generally, the protein interactions are temporal, spatial, or condition dependent in a specific cell, where only a small part of interactions usually take place under certain conditions. Recently, although a large amount of protein interaction data have been collected by high-throughput technologies, the interactions are recorded or summarized under various or different conditions and therefore cannot be directly used to identify signaling pathways or active networks, which are believed to work in specific cells under specific conditions. However, protein interactions activated under specific conditions may give hints to the biological process underlying corresponding phenotypes. In particular, responsive functional modules consist of protein interactions activated under specific conditions can provide insight into the mechanism underlying biological systems, e.g. protein interaction subnetworks found for certain diseases rather than normal conditions may help to discover potential biomarkers. From computational viewpoint, identifying responsive functional modules can be formulated as an optimization problem. Therefore, efficient computational methods for extracting responsive functional modules are strongly demanded due to the NP-hard nature of such a combinatorial problem. In this review, we first report recent advances in development of computational methods for extracting responsive functional modules or active pathways from protein interaction network and microarray data. Then from computational aspect, we discuss remaining obstacles and perspectives for this attractive and challenging topic in the area of systems biology.

• 운동영양학회지
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• 제25권3호
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• pp.28-35
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• 2021

[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.157-166
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• 1995

The Electroencephalogram (EEG) and evoked potential (EP) t;ave widely been used for study of brain functions. The EEG and EP signals acquired from multi-channel electrodes placed on the head surface are often interfered by other relatively large physiological signals such as electromyogram (EMG) or electroculogram (EOG). Since these artifact-affected EEG signals degrade EEG mapping, the removal of the artifact-affected EEGs is one of the key elements in neuro-functional mapping. Conventionally this task has been carried out by human experts spending lots of examination time. In this paper a neural-network based classification is proposed to replace or to reduce human expert's efforts and time. From experiments, the neural-network based classification performs as good as human experts : variation of decisions between the neural network and human expert appears even smaller than that between human experts.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.228-231
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• 1997

In this paper, we designed an ART(Adaptive Resonance Theory) network based on LPC(Linear Prediction Coefficient) for classification of PVB (Premature Ventricular Beat: PVC, LBBB, RBBB). The procedure of proposed system consists of the error calculation, feature generation and processing of the ART network. The error is calculated after processing by linear prediction algorithm and the features of ART network or classification are obtained from the binary ata determined by threshold method. In conclusion, ART network has good performance in classification of PVB.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.205-206
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• 1998

In this paper, we present the detection algorithm of interictal epileptic waveform using LVQ network and wavelet transform. First wavelet coefficients is used to represent the characteristics of a single channel EEG wave, and make a number of neural network input node smaller. Then, three-layer neural network employing LVQ network is trained and tested using parameters obtained from the first stage. This study showed that preprocessed EEG data can be successfully used to train ANNs to detect epileptogenic discharges with a high success.

• 대한전기학회논문지:시스템및제어부문D
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• 제50권11호
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• pp.522-531
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• 2001

Recently conventional artificial intelligence(AI) approaches have been employed to build action selectors for the autonomous mobile robot(AMR). However, in these approaches, the decision making process to choose an action from multiple competence modules is still an open question. Many researches have been focused on the reactive planning systems such as the biological immune system. In this paper, we attempt to construct an action selector for an AMR based on the artificial immune network and internet. The information from vision sensors is used for antibody. We propose a learning method for artificial immune network using evolutionary algorithm to produce antibody automatically. The internet environment for an AMR action selector shows the usefulness of the proposed learning artificial immune network application.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 춘계학술대회 논문집
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• pp.330-335
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• 2003

This paper deals with the network interface of research and observation instruments in the oceanographic research vessel with an establishment of related database for measured information. The system is implemented to integrated communication network system which allows to effective survey by using real time observation and GUI(Graphic User Interface). The system also consists of the LAN systems and serial interface to link chemical, physical, biological and environmental relations. And, other network service and vessel data service for data communication between vessel and earth station such as INMARSAT-B, WWW service, BBS, E-Mail etc., are needed for integrated communication network system.

• 한국항해항만학회지
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• 제31권3호
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• pp.263-269
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• 2007

적조는 1994년 이전에는 남해에서 산발적으로 발생했으나, 1995년 이후로는 주기적으로 발생하고 있으며, 발생지역 또한 남해와 동해 전역으로 넓게 퍼지고 있다. 이에 따라 적조의 연구 분야도 다양한 변화를 격고 있으며, 적조를 모니터링하기 위해 원격지 센싱, GIS, 퍼지 모델 시스템 등의 다양한 기술들이 적용되고 있다. 본 논문의 목적은 무선 센서 네트워크를 이용하여 적조와 해양 생물학적 인자 데이터를 수집하는 적조 모니터링 시스템을 개발하는 것이다. 무선 센서 네트워크는 유비쿼터스 컴퓨팅을 실현시키기 위한 핵심 기술로 알려져 있으며 다른 지역의 센서들로부터 기상관측과 환경 탐색을 위한 데이터를 수집하는데 사용된다. 본 논문은 무선 센서 네트워크를 이용하여 적조 데이터 베이스를 효율적으로 설계함으로써 적조 모니터링 소프트웨어와 웹서비스를 제공하는 것에 관한 것이다.

• Bioinformatics and Biosystems
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• 제1권1호
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• pp.38-45
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• 2006

본 논문은 베이지안 네트워크를 기반으로 대규모 유전자 상호작용 네트워크를 추론하기 위한 클라이언트-서버 시스템 구조를 제시한다. 유전체 수준(genome-wide)의 대규모 유전자 상호작용 네트워크를 베이지안 네트워크 형태로 추론하기 위해서는 병렬 서버를 이용하더라도 통상 수십시간이 소요된다. 따라서, 일반적인 대화형(interactive) 독자(standalone) 시스템 구조보다는 배치형(batch) 분산(distributed) 시스템 구조가 적합하다. 본 논문에서는 그와 같은 상황에 적합한 느슨한 연결의 (loosely-coupled) 클라이언트-서버 시스템을 구현할 결과를 기술한다. 유전자 상호작용 네트워크 추론은 크게 두 단계로 나누어진다. 첫째로, 생물주석정보(biological annotation)과 유전자 발현정보(expression data)를 사용하여, 전체 유전자 집단을 서로 중복이 가능한 모듈들로 나누며, 둘째로, 각각의 모듈들에 대해 독립적인 베이지안 학습을 수행하여 추론결과를 얻고, 각 모듈들이 공통으로 포함하는 유전자를 사용하여 각 모듈의 추론결과들을 하나로 통합한다.

• Genomics & Informatics
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• 제13권3호
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• pp.76-80
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• 2015

Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. The recent advances in gene expression microarray technologies as well as network-based analysis methodologies provide groundbreaking opportunities to study type 2 diabetes mellitus. In the present study, we used previously published gene expression microarray datasets of human skeletal muscle samples collected from 20 insulin sensitive individuals before and after insulin treatment in order to construct insulin-mediated regulatory network. Based on a motif discovery method implemented by iRegulon, a Cytoscape app, we identified 25 candidate regulons, motifs of which were enriched among the promoters of 478 up-regulated genes and 82 down-regulated genes. We then looked for a hierarchical network of the candidate regulators, in such a way that the conditional combination of their expression changes may explain those of their target genes. Using Genomica, a software tool for regulatory network construction, we obtained a hierarchical network of eight regulons that were used to map insulin downstream signaling network. Taken together, the results illustrate the benefits of combining completely different methods such as motif-based regulatory factor discovery and expression level-based construction of regulatory network of their target genes in understanding insulin induced biological processes and signaling pathways.