• Bulletin of the Korean Chemical Society
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• v.31 no.1
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• pp.157-161
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• 2010

A sensory element against carbaryl, as a widely used pesticide was prepared based on adsorbed acetylcholine esterase (AChE) from Torpedo california. Octadecyl was substituted on macro-porous silica, confirmed by infra-red (IR) spectroscopy and quantitatively estimated through thermo-gravimetric analysis (TGA). Immobilization of the enzyme was achieved by adsorption on this support. Activity of the immobilization product was measured as a function of the loaded enzyme concentration, and maximum binding capacity of the support was estimated to be 43.18 nmol.mg-1. The immobilized preparations were stable for more than two months at storage conditions and showed consistency in continuous operations. Possible application of the immobilized AChE for quantitative analysis of carbaryl is proposed in this study.

• Current Optics and Photonics
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• v.5 no.3
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• pp.278-288
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• 2021

We propose a characterization method for the scattering property of microspheres using spectroscopic optical coherence tomography (OCT). To prove the effectiveness of the proposed method, we prepare solutions of different concentrations using microspheres ranging from 28 to 2300 nm in diameter. Time-frequency analysis is performed on the measured interference spectrum of each solution, and the resulting spectroscopic information is converted into histograms for centroid wavelengths. The histograms present a very sensitive response to changes in the concentration and size of microspheres. We classify them into three categories according to their characteristics. When the histogram of each category is replaced with the corresponding calculated value of the scattering coefficient, each category is mapped to a different scattering-coefficient region. It is expected that the proposed method could be used to investigate the optical characteristics of a biological sample from OCT images, which would be helpful for optical diagnostic and therapeutic applications.

• Genomics & Informatics
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• v.18 no.4
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• pp.35.1-35.7
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• 2020

Identifying the patterns of gene expression in breast cancers is essential to understanding their pathophysiology and developing anticancer drugs. Breast cancer is a heterogeneous disease with different subtypes determined by distinct biological features. Luminal breast cancer is characterized by a relatively high expression of estrogen receptor (ER) and progesterone receptor (PR) genes, which are expressed in breast luminal cells. In ~25% of invasive breast cancers, human epidermal growth factor receptor 2 (HER2) is overexpressed; these cancers are categorized as the HER2 type. Triple-negative breast cancer (TNBC), in which the cancer cells do not express ER/PR or HER2, shows highly aggressive clinical outcomes. TNBC can be further classified into specific subtypes according to genomic mutations and cancer immunogenicity. Herein, we discuss the brief history of TNBC classification and its implications for promising treatments.

• Fisheries and Aquatic Sciences
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• v.25 no.10
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• pp.517-524
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• 2022

Over production of methylglyoxal (MGO) a highly reactive dicarbonyl compound, has been associated in progressive diabetes with vascular complication. Therefore, we investigated whether hot water extract of Loliolus beka meat (LBM-HWE) presents a preserve effect against MGO-induced cellular damage in human umbilical vein endothelial cells (HUVECs). The LBM-HWE extract showed to inhibit MGO-induced cytotoxicity. Additionally, the LBM-HWE reduced mRNA expression of pro-inflammatory cytokines, and reduced MGO-induced advanced glycation end product (AGEs) formation. Furthermore, LBM-HWE induced glyoxalase-1 mRNA expression and reduced MGO-induced carbonyl protein formation in HUVECs. The results implicate that LBM-HWE has protective ability against MGO-induced HUVECs toxicity by preventing AGEs formation. In conclusion, LBM-HWE could be used as a potential treatment material for the prevention of vascular complications of diabetes.

• International Journal of Industrial Entomology and Biomaterials
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• v.47 no.2
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• pp.73-78
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• 2023

Currently, Hyphantira cunea Drury, the fall webworms (FWW), is one of the most severe insect pest for various landscaping trees and mulberry trees. In this study, we investigated whether FWW might be managed by Sodium saccharin (SAC) which is a food additive and not toxic to humans and environment. We found that FWW larvae treated with various concentrations of SAC showed dose-dependent delayed development and low survival rates. The lethal-concentration 50% of FWW larvae to SAC was 0.03 M. We also confirmed that SAC can be used to control FWW larvae attacking mulberry trees in the field. Compared to not-treated or tap-water-spraying control groups, SAC-spraying groups showed significantly higher mortality rates of FWW larvae (56.2%). Thus, SAC can be used for control FWW larvae in mulberry trees.

• Journal of Marine Bioscience and Biotechnology
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• v.15 no.2
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• pp.90-95
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• 2023

This study aimed to develop low-salt seasoned Gim (김) with new functionality to meet the diversification of the export market and consumer demand for Gim, which is one of the four major seafood products in Chungcheongnam-do province. Spirulina, a microalgae containing essential amino acids, vitamins, and minerals, is known to have antioxidant components such as phycocyanin. Therefore, to determine the suitability of spirulina as a seasoning material, we conducted seaweed. It can be used as a substitute for seasoning salt in the development of low-salt seasoned laver with enhanced functionality.

• Journal of Korea Artificial Intelligence Association
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• v.1 no.1
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• pp.17-21
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• 2023

The primary objective of this research is to utilize machine learning models to analyze factors tailored to each dataset for predicting mental health conditions. The study aims to develop appropriate models based on specific datasets, with the goal of accurately predicting mental health states through the analysis of distinct factors present in each dataset. This approach seeks to design more effective strategies for the prevention and intervention of depression, enhancing the quality of mental health services by providing personalized services tailored to individual circumstances. Overall, the research endeavors to advance the development of personalized mental health prediction models through data-driven factor analysis, contributing to the improvement of mental health services on an individualized basis.

• Fisheries and Aquatic Sciences
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• v.27 no.2
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• pp.111-121
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• 2024

Particulate matter (PM) is a mixture of microscopic solid inhalable particles including airborne liquid droplets, and it is implicated with several diseases. The eye does not have a protective barrier among the human organs, consequently it get directly exposed to environmental substances such as PM. The scarcity of treatments for damage to the eyesight and the vision and eye structure being closely related to the structure and function of the central nervous system highlights the cruciality of novel therapeutics. In this study was conducted using in vivo zebrafish vertebrate model which is a useful model due to the conserved genes between human. We found that protective effect of Octopus minor extract against particulate matter-induced adverse effects on eye development in zebrafish (Danio rerio) embryos by regulating antioxidant and anti-inflammatory mRNA expression.

• Journal of Acupuncture Research
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• v.26 no.1
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• pp.197-206
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• 2009

Objectives : This is a clinical report about the Conversion Disorder, Wei symptom patient. Methods : The patient was treated by acupuncture, herb medication, moxibustion, physical therapy and bio feedback. The improvement of the patient was judged by lower limb elevation test and gait condition test. Results : During the 1st duration, lower limb elevation angle of the patient had improved. And the patient's gait condition had improved. But he received stress so that same symptom appeared again. Then, after the second treatment, He could walk alone again. Conclusions : Oriental medicine treatment including Acupuncture, Herb medication was very effctive to improve the Conversion disorder patient's symptoms. It is necessary to have more observation and many cases of patients with Conversion disorder.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.11
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• pp.1337-1342
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• 2019

Medical institutions face the challenge of securing competitiveness among medical institutions due to the rapid spread of ICT convergence, and managing data that is growing at an enormous rate due to the emergence of big data and the emergence of the Internet of Things. The big data paradigm of the medical community is not just about large data or tools and processes for processing and analyzing it, but also means a computerized shift in the way people live, think and study. As the medical data is recently released, the demand for the use of medical data is increasing. Therefore, the research on disease detection system based on public data using open source that can help rational and efficient decision making was conducted. As a result of the experiment, unlike a simple disease inquiry or a symptom inquiry about a single disease provided by a public institution, related diseases are searched by a symptom or a cause.