• 한국병원경영학회지
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• 제15권4호
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• pp.63-77
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• 2010

The purposes of this study were to describe the effects of perception of organizational culture type and job satisfaction on university hospital nurses' innovation behavior. A survey was conducted with 418 respondents working in a university hospital in Cheonan City. Organizational culture types (developmental, group, rational, hierarchical), job satisfaction and individual characteristics were surveyed. The relationships between each variable and the innovation behavior were analyzed by univariate analysis and the independent effects of these variables were examined with multiple regression. The mean score of general employees innovation behavior was 3.33 (p=.58) and that of managers was 3.53(p=.64). For general employees, there were statistically significant differences in innovation behavior according to education level. For managers, there were statistically significant differences in innovation behavior for education level, marital status and duration of work. On multiple regression analysis, the factors affecting innovation behavior of general employees were developmental culture( =.297, ${\beta}$ p<.01), group culture (${\beta}$=.184, p<.01) and job satisfaction(${\beta}$=.148, p<.05). And the factors affecting innovation behavior of managers were developmental culture(${\beta}$=.181, p<.01), rational culture(${\beta}$=.171, p<.01) and group culture(${\beta}$=.408, p<.01), In conclusion, the results of this study show that organizational culture and job satisfaction influence hospital nurses'innovation behavior.

• KSBB Journal
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• 제32권1호
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• pp.16-21
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• 2017

The multiple sclerosis caused by multiple inflammatory disease or immune system disorder, is usually treated by interferon ${\beta}$ through adjusting the abnormal immune reactions. For high production of human interferon ${\beta}$ using recombinant E. coli, codon optimized and wild type genes were synthesized. When pET-15b or pET-21a vector was used as an expression vector with each gene, there was no target protein expression. When pQE30 vector was used as an expression vector, human interferon ${\beta}$ was expressed by recombinant E. coli XL1-blue and E. coli JM109. Using the codon optimized gene, the expression of human interferon ${\beta}$ was slightly increased as compared to that from wild type gene. However, most of expressed human interferon ${\beta}$ was insoluble form.

• The Korean Journal of Physiology and Pharmacology
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• 제7권5호
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• pp.261-266
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• 2003

Type 1 diabetes is an organ-specific autoimmune disease caused by the cytotoxic T cells-mediated destruction of the insulin-producing beta cells in the Langerhans pancreatic islets. Hepatocyte growth factor (HGF) is a potent mitogen and a promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF via viral vector in the development of streptozotocin (STZ)-induced diabetes in mice, we have developed an adenoviral vector genetically engineered to carry the gene for human HGF (hHGF) and evaluate the change of blood glucose, insulin level, and insulin-secreting beta cells of pancreatic islets. We demonstrate that the treatment with hHGF gene prevented the development of STZ-induced diabetes and increased serum insulin level to above normal range. Furthermore, it preserved pancreatic beta cells from destruction. These in vivo results may support previous findings that HGF is insulinotropic agent for beta cells and HGF treatment renders the cells to be resistant to the development of diabetes from STZ administration. We suggest that an adenoviral mediated hHGF gene therapy is a good candidate for the prevention and treatment of type 1 diabetes.

• Molecules and Cells
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• 제40권7호
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• pp.457-465
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• 2017

Streptozotocin (STZ)-induced murine models of type 1 diabetes have been used to examine ER stress during pancreatic ${\beta}$-cell apoptosis, as this ER stress plays important roles in the pathogenesis and development of the disease. However, the mechanisms linking type 1 diabetes to the ER stress-modulating anti-diabetic signaling pathway remain to be addressed, though it was recently established that ERK5 (Extracellular-signal-regulated kinase 5) contributes to the pathogeneses of diabetic complications. This study was undertaken to explore the mechanism whereby ERK5 inhibition instigates pancreatic ${\beta}$-cell apoptosis via an ER stress-dependent signaling pathway. STZ-induced diabetic WT and CHOP deficient mice were i.p. injected every 2 days for 6 days under BIX02189 (a specific ERK5 inhibitor) treatment in order to evaluate the role of ERK5. Hyperglycemia was exacerbated by co-treating C57BL/6J mice with STZ and BIX02189 as compared with mice administered with STZ alone. In addition, immunoblotting data revealed that ERK5 inhibition activated the unfolded protein response pathway accompanying apoptotic events, such as, PARP-1 and caspase-3 cleavage. Interestingly, ERK5 inhibition-induced exacerbation of pancreatic ${\beta}$-cell apoptosis was inhibited in CHOP deficient mice. Moreover, transduction of adenovirus encoding an active mutant form of $MEK5{\alpha}$, an upstream kinase of ERK5, inhibited STZ-induced unfolded protein responses and ${\beta}$-cell apoptosis. These results suggest that ERK5 protects against STZ-induced pancreatic ${\beta}$-cell apoptosis and hyperglycemia by interrupting the ER stress-mediated apoptotic pathway.

• 한국직업건강간호학회지
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• 제22권1호
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• pp.47-56
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• 2013

Purpose: This study is to identify the factors that affect middle-aged workers' health promoting behaviors. Methods: 214 middle-aged workers participated in surveys, and the data were collected from August to September 2012 and analyzed by using descriptive statistics, Pearson's correlation coefficient, and multiple regression analysis with PASW 18.0 program. Results: It was found that among the factors, the degree of job stress (t=7.69, p<.001) and depression (t=6.23, p<.001) were significantly high for type D individuals, while non type D showed meaningful degree of self-related health status (t=-3.66, p<.001) and health promoting behaviors (t=-4.71, p<.001). The notable variable that affected the health promoting behaviors of the middle-aged workers was depression for both type D (${\beta}$=-.357, p= .029) and non type D (${\beta}$=-.325, p<.001) individuals, and this variable accounted for 24.1% and 18.2% respectively. Conclusion: The study revealed that the middle-aged workers showed high degree of job stress and depression that influenced on their health promoting behaviors. Thus, they are recommended to receive health management programs that offer treatment through consulting considering their individual personalities.

• 마케팅과학연구
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• 제20권2호
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• pp.208-218
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• 2010

互联网快速增长, 已经成为一个重要的零售渠道, 并出现了各种互联网零售商, 又称电子零售商. 一种网上代购店蓬勃发展起来, 吸引了国内市场的消费者. 这是一种独特的电子零售商, 他们从全球购买国内市场尚未进口的名牌产品, 寄给个人购买者, 并收取服务费. 有些消费者喜欢高端独特但无进口资格的品牌, 却因付款问题或国内的寄送问题很难直接从海外零售商处购买. 在韩国, 网上代购店的数量和销售量快速增长-2008年韩国有超过430个活跃商店和5000亿销售额, 需要这种代购服务的消费者数量也在急剧增加. 这种电子零售的概念源于 "代理中介采购" -种存在已久的形式和内容多样化的代购. 通常市场经营者面对的是购买者的代表人而非本人, 由消费者决定的代理购买者影响越来越大. 很多市场营销和心理学领域的学者都研究过代理对消费者购买决定的影响范围. 然而, 在互联网商务方面却没有深入的研究. 此外, 网上代购店作为代理购买者, 将海外品牌或零售商同国内消费者连接起来. 它有一个特点, 代理购买国, 即代购商品所在国的形象对消费者的态度和购买倾向有重要影响, 还会影响消费者在进行信息处理时所感知的风险维度. 然而, 尽管对原产国不同维度的影响已有很多研究, 对网络内容的相关研究却很少. 已有研究证明, 原产国信息作为产品制造情况的线索对消费者的评价有正面影响, 但对这种形式下网络代理购买国的形象和产品评价之间的关系进行的研究却很少. 因此, 作者们发这种具体的零售渠道很值得研究, 重点结构间的系统关系以及各自不同的路径很值得探索. 已有研究证明代购原产国, 也就是代购店购买商品所在地的形象, 不仅对消费者的产品评价(包括态度和购买意向)有正面影响, 还对感知风险的三个维度有负面影响: 产品相关, 行员相关, 以及购买后的风险. 在所有的感知风险中, 由于对产品性能的高度不确定性, 产品相关的风险受负面形象的影响最大(${\beta}$= -.30), 其次是航运相关风险(${\beta}$= -.18)和购买后的风险(${\beta}$= -.15). 对产品态度(${\beta}$= .10)和购买倾向(${\beta}$= .14)也有一定影响. 此外, 经证明, 感知风险的三个维度通过对产品的态度作为中介, 对购买倾向有负面的的影响(${\beta}$= -.57: 产品相关风险${\rightarrow}$ 对产品的态度; ${\beta}$= -.24: 航运相关风险${\rightarrow}$ 对产品的态度; ${\beta}$= -.44: 购买后风险${\rightarrow}$ 对产品的态度). 从更多的分析可以看出, 消费者处理信息的路径会因其对产品知识的等级不同而改变. 新手购买者知识等级较低, 只会考虑感知风险, 而知识等级较高的专家购买者则会考虑到代理购买国的形象和感知风险两个方面, 对产品形成更准确更系统的态度和决定. 这同之前的研究相一致. 本研究提出一些理论和实际的建议. 代理购买国的形象会影响消费者的风险感知和行为结果, 因此应谨慎选择代购国家, 如果这种新型的零售业务快速发展起来, 应控制好消费者的风险, 无论是新手或专家. 另外, 由于消费者各自知识等级不同, 处理信息的路径也不尽相同, 针对不同消费者应形成成熟的市场营销手段. 新手购买者需要风险消减方面的建议, 以帮助他们形成更好的态度, 而专家购买者应选择更好更发达的国家进行代购. 消费者可以使用担保策略来促使在线购物的顺利进行. 本研究没有拘于概括性等限制. 在今后的研究中, 应进一步测试比较有相关结构的不同电子零售商.

• 미생물학회지
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• 제42권2호
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• pp.125-130
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• 2006

본 연구에서는 도축장과 도축물에서 plasmid 매개성 광범위 ${\beta}$-lactam (extended spectrum ${\beta}$-lactamase) 분해효소를 생성하는 Klebsiella pneumoniae와Escherichia coli가 분리됨으로서 한국에서는 이들 균주가 임상범위를 넘어 자연계까지 확산되었음을 확인하였다. 디스크 확산 시험, 등전점 수치, 접합시험 등을 통하여 돼지의 분변으로부터 최종 10균주의 접합자를 얻었고 이들의 형별결정은 아미노산서열분석과 기준주와 대조등을 BCM Search Laucncher 및 NCBI blast를 통해 이루어졌다. 광범위 ${\beta}$-lactam 유형은 Klebsiella pneumoniae 8균주가 TEM-52형이었고 2균주 Escherichia coli가 SHV-12형이었다. CMY-1형은 본 연구에서 분리되지 않았다.

• Journal of the Korean Data and Information Science Society
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• 제10권1호
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• pp.155-162
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• 1999

This paper is concerned with the empirical Bayes estimation of one of the two shape parameters(${\theta}$) in the Burr(${\beta},\;{\theta}$) type XII failure model based on type-II censored data. We obtain the bootstrap empirical Bayes confidence intervals of ${\theta}$ by the parametric bootstrap introduced by Laird and Louis(1987). The comparisons among the bootstrap and the naive empirical Bayes confidence intervals through Monte Carlo study are also presented.

• 한국조리학회지
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• 제19권3호
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• pp.1-17
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• 2013

본 연구는 호텔 조리사의 다운사이징이 직무태도에 미치는 영향을 고찰하고, 이러한 인과관계에서 DISC행동유형에 따른 개개인의 행동특성별 관계를 검중하고자 하였다. 실증연구를 위해 확보된 200개의 표본을 바탕으로 SPSS 17.0 프로그램을 통해 빈도분석, 요인분석, 신뢰성 분석, 상관관계분석, 다중회귀 분석을 실시하였다. 다운사이징 항목 2개의 요인과 직무태도 관련 항목 2개 요인으로 추출되어졌다. 가설1.는 호텔 내 다운사이징이 직무태도에 유의한 부(-)의 영향을 준다고 설정하였으며, 검증결과 조직몰입 요인은 고용환경변화(${\beta}$=-.256), 고용불안감(${\beta}$=-.258), 직무만족의 요인은 고용환경변화(${\beta}$=-.319), 고용불안감(${\beta}$=-.174)이 다운사이징이 조리직 종사자의 직무태도에 유의한 부(-)의 영향을 주는 것으로 나타났다. 가설2.는 DISC행동유형에 따른 다운사이징이 직무효율성에 부(-)의 영향을 준다고 설정하였으며, 검증결과 조직몰입요인에서 주도형(D)이 타 유형에 비하여 고용불안감(${\beta}$=-.435)에 가장 큰 영향을 받으며, 신중형(C)은 조직몰입에 영향을 받지 않는 것으로 나타났다. 직무만족요인에서는 안정형(S)이 타 유형에 비하여 고용환경변화(${\beta}$=-.414)에 영향을 받으며, 주도형(D)은 영향을 받지 않는 것으로 나타났다. 본 연구는 호텔 조리사의 다운사이징 전략이 종사원의 조직몰입과 직무만족 등의 직무태도에 영향을 미치게 되며, 종사원 개개인의 행동유형에 따라 그 관계정도가 다름을 시사한 것으로 볼 수 있다.

• 한국전산유체공학회지
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• 제16권2호
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• pp.56-61
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• 2011

Numerical study is conducted to design the high temperature heat exchanger of Stirling engine by using the commercial CFD solver, FLUENT. The Fin-tube type of heat exchanger is designed as a reference model by considering the type of engine which is ${\beta}$-configuration. To find the optimal design of heat exchanger in heat transfer capacity numerical calculation is conducted by changing the shape, the number, and material of reference model in three-dimensional combustion field. Adjusted one-way constant velocity of working fluid that is helium is considered as the representative velocity of oscillating flow. The optimal design of heat exchanger considering the heat transfer capability is suggested by using the calculation results.