• 한국컴퓨터산업학회논문지
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• 제4권4호
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• pp.533-546
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• 2003

기존의 대금지불 방법들은 개별 정보들과 같은 소액 상품의 결제 수단으로는 부적절하다. 이유는 상품의 가치보다 결제 수단을 운영하는데 들어가는 비용이 더 크기 때문에 경제성이 전혀 없기 때문이다. 그리하여, 인터넷 상에서 활발한 거래가 예견되는 초소액의 정보 상품들을 경제적으로 처리할 수 있는 새로운 대금결제 방식이 요구된다. 최근에 제안된 몇몇 소액지불 시스템들로는 "Millicent", "PayWord", "MicroMint", "iKP" 등이 있다. 이들 각각은 나금대로의 방식으로 안전성과 소비용화를 추구하고 있다. 그러나, 이들 방식들은 핵심 메커니즘의 소비용화와 적절한 보안의 만족 등에는 문제가 없었으나 "계좌(account)의 관리"와 "지불 화폐의 집중,관리" 에는 큰 문제점을 가지고 있다. 소액대금결제 시스템에서는 계좌 관리의 복잡성과 지불 값들의 집중의 효율적인 해결이 가장 먼저 고려되어지고 우선시 되어져야 할 항목이다. 그리하여, 본 논문은 PayWord시스템을 바탕으로 적절한 보안 만족, 운영 비용의 저렴화를 이룰 수 있게 하는 핵심 메커니즘의 사용, 불필요한 계좌의 이중 사용 배제, 지불 화폐 값들의 집중관리 해결 등을 만족시켜줄 수 있는 효율적인 소액대금결제 시스템인 PayHash를 설계, 구현하였다.의 집중관리 해결 등을 만족시켜줄 수 있는 효율적인 소액대금결제 시스템인 PayHash를 설계, 구현하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.265-271
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• 2014

Interleukin-7 (IL-7) is a potent anti-apoptotic cytokine that enhances immune effector cell functions and is essential for lymphocyte survival. While it known to induce differentiation and proliferation in some haematological malignancies, including certain types of leukaemias and lymphomas, little is known about its role in solid tumours, including breast cancer. In the current study, we investigated whether IL-7 could enhance the in vivo antitumor activity of tumor-reactive $CD8^+$ T cells with induction of IFN-${\gamma}$ in a murine breast cancer model. Human IL-7 cDNA was constructed into the eukaryotic expression plasmid pcDNA3.1, and then the recombinational pcDNA3.1-IL-7 was intratumorally injected in the TM40D BALB/C mouse graft model. Serum and intracellular IFN-${\gamma}$ levels were measured by ELISA and flow cytometry, respectively. $CD8^+$ T cell-mediated cytotoxicity was analyzed using the MTT method. Our results showed that IL-7 administration significantly inhibited tumor growth from day 15 after direct intratumoral injection of pcDNA3.1-IL-7. The anti-tumor effect correlated with a marked increase in the level of IFN-${\gamma}$ and breast cancer cells-specific CTL cytotoxicity. In vitro cytotoxicity assays showed that IL-7-treatment could augment cytolytic activity of $CD8^+$ T cells from tumor bearing mice, while anti-IFN-${\gamma}$ blocked the function of $CD8^+$ T cells, suggesting that IFN-${\gamma}$ mediated the cytolytic activity of $CD8^+$ T cells. Furthermore, in vivo neutralization of $CD8^+$ T lymphocytes by CD8 antibodies reversed the antitumor benefit of IL-7. Thus, we demonstrated that IL-7 exerts anti-tumor activity mainly through activating $CD8^+$ T cells and stimulating them to secrete IFN-${\gamma}$ in a murine breast tumor model. Based on these results, our study points to a potential novel way to treat breast cancer and may have important implications for clinical immunotherapy.

• Clinical and Experimental Pediatrics
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• 제59권11호
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• pp.446-450
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• 2016

Purpose: Generally, aspirin is used as a protective agent against thrombogenic phenomenon after pulmonary valve replacement (PVR) using a bioprosthetic valve. However, the appropriate duration of aspirin use is unclear. We analyzed the impact of postoperative duration of aspirin use on the longevity of bioprosthetic pulmonary valves in patients who underwent repair for congenital heart diseases. Methods: We retrospectively reviewed the clinical data of 137 patients who underwent PVR using a bioprosthetic valve between January 2000 and December 2003. Among these patients, 89 were included in our study and divided into groups I (${\leq}12$ months) and II (>12 months) according to duration of aspirin use. We analyzed echocardiographic data from 9 to 11 years after PVR. Pulmonary vale stenosis and regurgitation were classified as mild, moderate, or severe. Results: The 89 patients consisted of 53 males and 36 females. Their mean age was $14.3{\pm}8.9$ years (range, 2.6-48 years) and body weight was $37.6{\pm}14.7kg$ (range, 14-72 kg). The postoperative duration of aspirin use was $7.3{\pm}2.9$ months in group I and $32.8{\pm}28.4$ months in group II. However, no significant difference in sex ratio, age, body weight, type of bioprosthetic valve, and number of early redo-PVRs. In the comparison of echocardiographic data about 10 years later, no significant difference in pulmonary valve function was found. The overall freedom rate from redo-PVR at 10 years showed no significant difference (P=0.498). Conclusion: Our results indicated no benefit from long-term aspirin medication (>6 months) in patients who underwent PVR with a bioprosthetic valve.

• 한국유통학회지:유통연구
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• 제12권2호
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• pp.23-49
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• 2007

본 연구는 혁신적인 서비스전달채널의 수용과정을 설명하는데 있어, 기존의 수용관련 연구에서 논의되어온 수용대상에 대한 지각된 속성을 혜택, 비용 및 위험 차원에서 구성요인을 통합하여 각 요인이 수용의도에 미치는 직 간접적 영향관계를 살펴보고, 또한 기존 연구에서 간과되어왔던 이미 이용 중에 있는 기존채널에 대한 이용경험 요인이 기존채널과의 관계에 대한 장기지향성 즉, 지속적 이용의도의 형성과정 및 신규 서비스전달채널의 수용의도에 미치는 영향과정을 모형화하고 실증적 검증을 시도하고 있다. 연구결과, 기존 연구에서 주로 수행되었던 신규 수용대상의 특성에 대한 지각뿐만 아니라 사회교환이론에 기반한 기존채널에 대한 만족도와 대안적 채널의 매력도 등 과정적 변수로서 태도요인의 고려를 통해 상호작용적인 관점에서 수용행동의 결정과정을 설명하는 것이 타당함을 보여주었다. 통합된 구성개념으로서 수용채널의 특성에 대한 지각은 수용채널에 대한 매력도에 유의한 영향관계를 미치는 것으로 나타났으며, 과정적 태도변수로서 기존채널에 대한 만족도와 신규채널에 대한 매력도는 수용행동에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 실증결과를 바탕으로 다채널 이용 상황에서의 신규 서비스채널의 수용은 기존채널의 이용을 종결시키는 것이 아니기 때문에 신규채널의 수용을 기존 서비스채널의 이용경험과 대안의 매력도 등 다차원적 측면에서 고려하여야 할 것이고, 수용 후 확산에 대한 문제 또한 기존채널의 이용 연속선상에서 기존채널과 신규채널을 모두 고려해야 되는 등 통합적인 마케팅전략에 대한 관리적 시사점을 제시하였다.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.117-122
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• 2018

대용량 3상 시스템 에어컨은 최근 들어 소비 전력 저감을 위해 인버터 회로를 포함하고 있다. 인버터 회로는 교류를 다이오드를 통해 정류하고 DC-link 전원부 콘덴서에 의해 평활된 직류를 사용한다. 이 때 평활에 사용되는 DC-link 전원부 콘덴서는 전압 리플, 전류 리플 조건을 만족하기 위해 전해 콘덴서가 일반적으로 사용된다. 콘덴서의 용량을 줄이게 되면 회로부의 크기 및 무게, 비용을 줄일 수 있게 된다. 본 논문에서는 최소점 추정 PPL(Phase Locked Loop) 위상 제어와 평균 전압 d축 전류제어 기법을 조합하여 입력 리플 전류를 약 90% 저감하는 알고리즘을 제안한다. 입력 리플 전류의 감소로 인해 DC-link 콘덴서의 전류 리플도 감소하므로 콘덴서의 용량을 줄일 수 있지만 전해 콘덴서의 경우 등가 직렬 저항(ESR : Equivalent Series Resistance)이 크기 때문에 발열로 인한 수명이 한계를 가진다. 본 논문에서는 전해 콘덴서 대신 DC-link 단에 전류 리플을 고려한 필름 콘덴서를 선정하는 방법을 제안한다. 필름 콘데서의 정전 용량 선정, 내압 선정, RMS(Root Mean Square) 전류 용량, RMS 전류 주파수 해석을 고려해 콘덴서의 용량을 선정할 경우 1680uF의 전해 콘덴서를 20uF로 용량을 낮추어 설계함으로써 전원부 콘덴서의 크기 및 무게, 비용을 줄였으며 전동기 구동을 통해 동작을 확인하였다.

• 보험의학회지
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• 제24권
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• pp.97-117
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• 2005

Internally Korean insurance market is that whole life products' growth are becoming slowdown that's why new insurance products have appeared on the market in consideration of consumer's needs recently. Externally domestic insurance market competitions has drifted from insurance industry to whole financial industry since bankasurance started. Life insurance companies should open up a new market to survive from severe competitions. Worksite marketing can be an alternative. An insurer make arrangements with an employer about an insurance terms which an insurer offers in Worksite marketing. Then eligible individuals enroll in the plans at their own discretion and pay 100 percent of the premium for coverage through payroll deductions. An employer doesn't need to pay extra money for additional benefit but can raise employee's loyalty and satisfaction of company through worksite marketing. An employee can be covered at discounted premium rate and less strict underwriting guidelines to an insurer compared to individual insurance. In developed countries specially U.S insurance market, Worksite marketing is getting very popular and growing rapidly due to the advantages. Worksite marketing has both individual insurance characters and group insurance characters. Individual insurance characters are that employees enroll in the plans at their own discretion and pay 100 percent of the premium for coverage. Group insurance characters are that actively at work and participation etc. An insurer have to reflect these two characters on Worksite marketing when an insurance company work out a plan for developing products and underwriting guidelines. When an insurer devise worksite products, one should consider participation level which means percentage of eligible employees participating. Participation is related to anti-selection. As we know underwriting is essential for every kind of insurance, especially underwriting plays major role in worksite marketing. We can see that in the below. Firstly, it has a function in calculation of premium rate. When calculate premium rate for worksite products underwriters have to estimate expected participation level and risk factors. So underwriters and acturies keep in close contact with each other. Secondly, underwriting methods are important. When an insurer underwrite worksite products, there are three kinds of underwriting methods. These are Simplified issue underwriting, Full underwriting and Guaranteed issue underwriting. Simplified issue underwriting typically requires no medical examination, but usually requires supplying satisfactory answers to one or several health and/or lifestyle questions. Full underwriting requires a complete medical history questionnaire that may further require an exam. Guaranteed issue underwriting means that coverage is issued without the employee having to provide evidence of insurability. When insurer set the GI limit are usually based on the type of industry, number of eligible employees, the average amount of coverage and participation level. In addition to insurer should have a clear definition of eligible employee on the insurance provision and application form. It will minimize possibility of trouble claims and anti-selection. An insurer also establish preexisting condition exclusion and special guidelines for late entrants. When an insurer introduce Worksite marketing to Korean insurance market, an insurer has to examine market research to analyze potential market and strategy of sales most of all. Also an insurer should review real situation of the U.S, England and Japanese market etc. There are a lot of new technologies about worksite marketing process that an insurer should learn. When an insurer consider many things which we explained it can be a real alternative.

• 한국조경학회지
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• 제42권3호
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• pp.76-89
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• 2014

건강 증진, 기후변화 적응 및 완화 등 도시공원의 역할과 기능은 확장하고 있으나, 확장된 기능을 어떻게 분배할 것인가에 대한 문제는 상대적으로 관심이 미흡한 실정이다. 본 연구에서는 중앙정부 및 지방자치단체의 도시공원 정책개발 및 집행 과정에 도시공원의 다기능성과 분배적 형평성을 반영하기 위해 녹색복지 개념을 제안한다. 녹색복지 관점에서 서울시 생활권 도시공원(NUP)의 분배적 형평성 차이를 분석하기 위해 관련 이론 및 선행연구 고찰을 통해 공원복지 지표를 선정하였다. 분석방법은 SPSS 18.0을 이용하여 상관분석, 군집분석을 실시하였다. 녹색복지는 사회경제적 지위에 관계없이 생애주기별 시민 모두가 건강 증진과 기후변화로 인한 환경위험으로부터 안전할 수 있는 녹색 서비스 전달과정에 참여하고 공정한 혜택을 누리는 것으로 정의했다. 분석결과 서울시는 자치구별 사회 경제 환경적 지위에 따라 1인당 NUP 면적에 차이가 있는 것으로 나타났다. 1인당 NUP 면적과 상관관계가 있는 공원복지 지표는 인구밀도(-), 65세 이상 고령인구 비율(+), 재정자립도(+), 홍수 및 대기오염 취약성(-)인 것으로 분석되었다. 군집분석 결과 공원복지 수준에 차이가 있는 3개의 군집이 도출되었고, 이를 통해 녹색복지 관점에서 서울시 NUP는 불균형적으로 공급되어 있음을 알 수 있다. 서울시의 향후 도시공원 정책은 양적 확충을 넘어 공원이 지닌 기능의 공정한 분배가 요구되며, 이는 공원서비스의 수요자인 지역주민과 지역사회가 우선적으로 고려되어야 하겠다.

• 의료법학
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• 제13권2호
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• pp.79-113
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• 2012

This study focuses on the protection of trial subjects, who participate in clinical trials for new drug. It takes long time to develop new drugs and the clinical trials are required. Usually, pharmaceutical company, which develop new drug, request a research institution(usually, hospital) to investigate the examination of security and side effects of new drug. The institution recruit trial subject to participate in the trials. The contract for clinical research of investigational new drug is concluded between the pharmaceutical company and the institution. This thesis studies the legal regulations for protection of participants of clinical research for new drug. In this respect the first matter of this study is to seek which relation between pharmaceutical firm and participants of clinical trials. Especially, there is a question which the trial subject is entitled to demand the pharmaceutical company which requested clinical trials the institution to supply the investigational new drug, after the contract for clinical trials had terminated or cancelled. This study take into account the liability of the pharmaceutical company to trial subject. Secondly, it is researched the roles and authority of Institutional Review Board(IRB). IRB is Research Ethics Committee of the institution, in which clinical trials for new drug are conducted. According to the rule of Korea good clinical practice(KGCP), IRB is the mandatory organization which is authorized to approve, secure approval or disapprove the clinical trials for investigational new drug in the institution. The important roles are the review of ethical perspective of trial research and the protection of trial subject. Thirdly, this paper focuses if the participants are to be paid for the participation for clinical research. This is ethical aspect of clinical trials. It is resonable that the participant is reimbursed for expenditure such as travels, and other expenses incurred in participation in trials. It is not allowed that the benefit of clinical trials is paid to trial subject. The payment should not function as financial inducements for participations of trials. Finally, the voluntary consent of the trial subject is required. The institution ought to inform the subject, who would like to participate in trials, and it ought to received informed consent in writing for subject. In this regard, it is matter that trial subject has ability of consent. It is principle that the subject as severely psychogeriatric patient has not ability of consent. However, it is required that not only healthy people but also patients are allowed to take part in clinical trials of new drug, in order to confirm which the investigation new drug is secure. Therefore there are cases, in which the legal representative of subject consent the participation of the trials. In addition, it is very important that the regulations concerning clinical trials of new drug is to be systematically well-modified. The approach of legal and political approach is needed to achieve this purpose.

• 한국도로학회논문집
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• 제17권1호
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• pp.129-142
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• 2015

PURPOSES : The purpose of this study is to suggest a basis for setting appropriate safety goals specifically related to the threshold zone luminance in a vehicular traffic tunnel. METHODS : In the test, drivers were divided into two groups. One group consisted of all drivers (average drivers) group with an age ratio of drivers holding domestic driver's license and driver group by age to produce threshold zone luminance in the tunnel. The threshold zone luminance produced as a result was used to analyze how it affects the safety level of each driver group and provide a basis for setting an appropriate safety criterion that can be used to determine threshold zone luminance. We used test equipment, test conditions, and ananalysis of threshold zone luminance identical to that reported by ChoandJung(2014) but the values of adaptation luminance in our analys is were expanded to range from100 to $10,000cd/m^2$. RESULTS : Adaptation luminance and threshold zone luminance are found to be related by a quadratic function. The threshold zone luminance needed by older drivers to ensure a certain safety level is significantly higher than that for drivers of other age brackets when adaptation luminance increases. 56% of older drivers are at an increased risk of an accident at the same luminance for which the safety level of average drivers is 75%. The safety level that can be achieved for older drivers increases to above 60% when threshold zone luminance level is set with the goal of attaining a safety level of more than 85% for average drivers. The safety level that can be attained for average drivers is above 90% when the threshold zone luminance is high enough to ensure over 75% in the safety level of older drivers. Results of this study are applicable to highways and others whose designed speed is 100 km/h. CONCLUSIONS : Threshold zone luminance determined on the basis of drivers having average visual ability is of limited value as a performance standard for ensuring the safety of older drivers. Hence, safety level for older drivers should be considered separately from safety levels for drivers with an average ability to avoid risk. Upward adjustment of older drivers' safety level in the process of determining appropriate threshold zone luminance in a vehicular traffic tunnel may bring both tangible and intangible benefit as a result of reducing accidents. However, there is an associated dollar cost arising from installing and operating lights. As a result, the economic impact of these trade-offs should also be considered.

• 대한의생명과학회지
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• 제6권2호
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• pp.119-129
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• 2000

피부는 인체의 표면을 보호하는 중요한 기관으로 피부가 손상되었을 경우 상처 재생은 염증기, 상피화기, 수복기의 정상적인 재생 단계를 거치며 치유된다 최근 저강도 레이저의 생물학적 효과로서 상처 재생과의 밀접한 관련성이 알려지고 있다. 본 연구는 저강도 레이저가 상처 재생에 미치는 유의한 효과를 세포 형태학적으로 확인하기 위해 실험적으로 유도한 가토 피부 상처 (2$\times$2 cm)에 12일 동안 5 Hz, 830 nm, 1.6 J/$cm^2$의 자극강도 (10 min/day)로 상처면에 레이저를 적용한 결과, 다음과 같은 곁과를 얻었다. 레이저 조사군의 경우 결합조직의 수복과 상피의 재형성이 대조군과 비교했을 매우 빠르게 진행되는 것으로 관찰되었으며, 특히 섬유아세포의 활성과 육아조직 합성율이 유의하게 증가되는 것으로 확인되었다. 이상의 연구 곁과를 종합해 달 때 유효한 치료강도의 저강도 레이저 자극은 피부의 개방성 창상 및 욕창 등의 상처 치유를 촉진할 수 있는 것으로 사료된다.