• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2097-2100
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• 2013

Background: To estimate the numbers and trends in cervix cancer cases visiting the Radiotherapy Department at Manipal Teaching Hospital, Pokhara, Nepal, statistical modelling from retrospective data was applied. Materials and Methods: A retrospective study was carried out on data for a total of 159 patients treated for cervix cancer at Manipal Teaching Hospital, Pokhara, Nepal, between $28^{th}$ September 2000 and $31^{st}$ December 2008. Theoretical statistics were used for statistical modelling and forecasting. Results: Using curve fitting method, Linear, Logarithmic, Inverse, Quadratic, Cubic, Compound, Power and Exponential growth models were validated. Including the constant term, none of the models fit the data well. Excluding the constant term, the cubic model demonstrated the best fit, with $R^2$=0.871 (p=0.004). In 2008, the observed and estimated numbers of cases were same (12). According to our model, 273 patients with cervical cancer are expected to visit the hospital in 2015. Conclusions: Our data predict a significant increase in cervical cancer cases in this region in the near future. This observation suggests the need for more focus and resource allocation on cervical cancer screening and treatment.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권1호
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• pp.123-132
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• 1997

영국에서는 현재 음악치료가 자폐아 치료의 주요 수단으로 자리잡고 있고, 그 치료의 효과 또한 의학계와 교육계에서 널리 인정받고 있다. 이 글은 영국 음악치료의 주 동향이라 할 수 있는 즉흥연주를 바탕으로한 정신역동적 음악치료법(Psychodynamically Informed Improvisational Music Therapy)이 자폐증에 효과적 치료법임을 두 개의 사례연구를 통해 소개하고자 한다. 두 개의 사례연구는 매순간 개개인에 알맞게 응용되는 즉흥연주를 바탕으로한 음악치료의 과정이 어떻게 자폐아와 치료자간의 치료 관계를 형성시키고 발전시키는가를 보여준다. 첫번째 사례 Charlie를 통해서는 음악이 비언어적, 언어적 의사 소통과 초기 놀이발달 과정에 미치는 영향을 살펴보겠다. 두번째 사례에서는, 음악치료라는 환경이 어떻게 Mark에게 안전한 자기표현과 의사 소통의 장을 열어 주고, 자신과 다른 사람들에 대한 인식의 발달에까지 영향을 미치는가를 보겠다. 음악치료의 임상 과정에 대한 이해를 돕기 위하여 위의 사례는 발달적, 음악역동적, 정신역동적인 시점에서 고찰되어진다.

• Advances in Traditional Medicine
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• 제7권4호
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• pp.409-417
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• 2007

We investigated the effect of Arogh, a polyherbal formulation (PHF) on animal models of anxiety based on exploratory behavior. The anxiolytic activity of polyherbal formulation (30, 100, 300 and 500 mg/kg) was studied using various behavioural paradigms such as elevated plus maze (EPM), light/dark apparatus (LDA), open field apparatus (OFA), hole board apparatus (HBA). Diazepam (1 mg/kg) was used as a standard anxiolytic drug. The effect of PHF (100 and 300 mg/kg) on serotonin, dopamine and noradrenaline mediated behaviour was studied by lithium induced head twitches in rats, haloperidol induced catalepsy in mice and clonidine induced hypothermia in rats respectively. In EPM, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries in open arms. In LDA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in lit zone. In OFA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of assisted rearing and the number of squares traversed. In HBA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of head poking. In lithium induced head twitches, PHF (100 and 300 mg/kg) significantly (P < 0.05) decreased the number of head twitches. In haloperidol induced catalepsy, PHF (300 mg/kg) decreased the duration of catalepsy significantly (P < 0.05) at 60 min. In clonidine-induced hypothermia, PHF (300 mg/kg) did not modify the effect. Drugs must be carefully assessed on EPM test and therefore in the present study EPM is supported by other tests. Present study indicates that Arogh, a polyherbal formulation possess anxiolytic activity. It diminished serotonergic transmission and decreased the duration of catalepsy indicating potentiation of dopaminergic transmission. Thus, Arogh a polyherbal formulation contains bioactive principles which possess anxiolytic activity and modified 5-HT and DA mediated behaviour.

• Spatial Information Research
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• 제5권1호
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• pp.11-26
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• 1997

본 논문은 제2의 금융중심지로 부상하고 있는 강남구를 사례로 GIS 기법을 활용하여 은행점포의 입지를 분석하였다. 금융자율화 이후 급격한 증가추세를 보이고 있는 은행점포의 수는 상당한 지역적인 편재현상을 나타내고 있다. 통계기법을 활용하여 은행 입지에 영향을 주는 입지요인을 추출하였고, 은행이용 고객들에 대한 설문조사를 통하여 은행점포의 상권을 조사하였다. 이러한 기초자료를 바탕으로 하여 GIS기법을 활용하여 입지분석을 실시하였다. 먼저 은행이용고객들에게 최적의 서비스를 공급할 수 있는 목적함수를 토대로한 입지-배분 모델을 적용하여 추출된 입지와 현재의 은행점포의 입지를 비교하였다. 또한 그리드 연산 기법을 활용하여 잠재 수요력과 잠재 공급력의 차이를 통해 앞으로 은행점포의 신규 설립이 가능한 지구를 추출하였다. 본 연구를 통해 GIS기법을 활용하여 입지분석을 실시하는 경우 제한점과 앞으로 해결되어야 할 문제점에 대해 논하였다.

• 한국문헌정보학회지
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• 제30권2호
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• pp.51-86
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• 1996

본 연구는 전문데이터베이스의 탐색에 있어서 주제전문가와 탐색전문가는 어떠한 특징적인 차이가 있는지를 밝히려 하였다. 이 연구를 통하여 얻어진 결론을 요약하면, 주제전문가와 탐색전문가는 전문데이터베이스의 탐색에, 있어서 탐색질문의 분석(탐색질문의 이해도. 탐색어 선정의 난이도, 탐색결과에 대한 기대수준), 탐색과정(탐색어수, 연산자 순 브라우징 문헌 순 접속시긴 출력문헌 건당 소요시긴 적합문헌 건당 소요시간), 탐색결과 (적합문헌수 재현율 정확율, 총 탐색비용 출력문헌 건당 소요비용, 적합문헌 건당 소요비용, 탐색결과에 대한 만족도)에 대하여 뚜렷한 차이를 나타내는 것으로 밝혀졌다.

• Nutrition Research and Practice
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• 제8권1호
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• pp.94-102
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• 2014

Diet attrition and failure of long term treatment are very frequent in obese patients. This study aimed to identify pre-treatment variables determining dropout and to customise the characteristics of those most likely to abandon the program before treatment, thus making it possible to modify the therapy to increase compliance. A total of 146 outpatients were consecutively enrolled; 73 patients followed a prescriptive diet while 73 followed a novel brief group Cognitive Behavioural Treatment (CBT) in addition to prescriptive diet. The two interventions lasted for six months. Anthropometric, demographic, psychological parameters and feeding behaviour were assessed, the last two with the Italian instrument VCAO Ansisa; than, a semi-structured interview was performed on motivation to lose weight. To identify the baseline dropout risk factors among these parameters, univariate and multivariate logistic models were used. Comparison of the results in the two different treatments showed a higher attrition rate in CBT group, despite no statistically significant difference between the two treatment arms (P = 0.127). Dropout patients did not differ significantly from those who did not dropout with regards to sex, age, Body Mass Index (BMI), history of cycling, education, work and marriage. Regardless of weight loss, the most important factor that determines the dropout appears to be a high level of stress revealed by General Health Questionnaire-28 items (GHQ-28) score within VCAO test. The identification of hindering factors during the assessment is fundamental to reduce the dropout risk. For subjects at risk, it would be useful to dedicate a stress management program before beginning a dietary restriction.

• Journal of Animal Science and Technology
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• 제60권4호
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• pp.7.1-7.5
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• 2018

Background: Mice are widely accepted research models of great clinical significance. Maintenance of laboratory mice breed is an essential aspect for performing research activities in various fields of science. Infanticide is one of the prominent causes of litter loss during maintenance of laboratory mice stock. The present study is an effort to monitor the effect of change in ambient temperature of female mice below the normal range on cannibalism and infanticide during early postparturition phase. Adult female Swiss albino mice have been divided into two groups of control and treatment. On the day of litter group one was maintained under controlled temperature conditions (minimum $20^{\circ}C$ to maximum $23^{\circ}C$) throughout, while female mice belong to group two have been exposed to variation of room temperature (maximum $15^{\circ}C$ to minimum $10^{\circ}C$ for two nights and one day) until 36 h postparturition. Results: The effects of temperature changes were observed on the infanticide behaviour of dams along with the survival of pups in early postparturition phase till 36 h after delivery. The significant statistical difference (P < 0.05) was reported in infanticide behaviour of dams when control and treatment group was compared. It is observed that decrement in surrounding temperature promotes decrement in the ambient body temperature of dams during early postparturition. It is proposed that alteration of hypothalamic homeostasis due to temperature change induces cannibalism and infanticide behaviour. Lack of thermoregulation during early postparturition creates the sense of insecurity, in-satiety, anxiety and stress. Conclusions: Authors strongly recommend the maintenance of body and surrounding temperature to prevent infanticidal behaviour and cannibalism within Swiss albino mice population. Further investigations are advisable to authenticate the active behavioural and biochemical pathway behind the phenomena.

• 한국지능시스템학회논문지
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• 제27권2호
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• pp.170-178
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• 2017

본 논문은 무인잠수정의 동특성을 고려하지 않아 실제로 항행이 불가능한 급격히 변화하는 경로를 계획하기도 하는 기존 $A^*$ 알고리즘 기반 경로계획의 단점을 개선하기 위하여, 무인잠수정의 동특성을 고려한 항행궤적에 기반한 개선된 경로계획 알고리즘을 제안한다. 기존의 $A^*$ 기반 알고리즘은 무인잠수정이 인접노드로 이동하는 경로를 직선으로 가정하여 이동비용을 계산하는 반면, 개선된 경로계획 알고리즘은 경로점 제어에 의하여 생성된 현실적 항행궤적을 노드 간의 이동경로로 설정하고 이동비용을 계산하여 최적의 경로를 계획한다. 모의실험에서 제안한 기법과 기존의 기법의 경로계획을 비교하여 본 논문의 논의가 타당함을 보인다.

• 디지털융복합연구
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• 제11권11호
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• pp.219-231
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• 2013

기업은 불확실한 환경 하에서 지속적인 성장을 하기 위해 성과측정시스템(performance measurement systems, 이하 'PMS'라 함)을 구축 및 활용하고 있다. 대부분의 PMS에 관한 실증연구들은 조직차원에서 많은 연구가 이루어져 왔다. 성과측정지표의 다양성이 조직구성원들의 행동에 미치는 영향에 관한 연구는 많이 부족하며, 조직수준의 분석이 아닌 개인행동에 대한 세부적인 조사를 수행하는 연구는 의미가 있을 것이다. 따라서 본 연구는 성과측정지표의 다양성과 관리적 성과간의 관계에서 공정성과 조직시민행동의 매개역할을 연구하였다. 연구결과, 성과측정지표의 다양성과 관리적성과 간의 관계에서 공정성의 매개역할과 공정성과 관리적성과 간의 관계에서 조직시민행동의 매개역할을 발견하였다.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.322-326
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• 1995

General pharmacology of LB20304, a quinolone antibiotic, were examined in terms of general behaviour, cardiovascular, and central nervous system. LB20304 at oral dose of 2,000 mg/kg did not induce significant behavioural changes in mice. In contrast with ciprofloxacin, LB20304 at dose of 20 mg/kg, iv. did not show any observable effects on the blood pressure in rats. Displacement of [$^3$H]muscimol binding to the rat brain synaptic membranes was measured. LB20304 was shown to be about five times less potent than ciprofloxacin in specific GABA receptor binding. Drug interaction between LB20304 and 4-biphenyl acetic acid, an active metabolite of fenbufen, was assessed in mice by measuring convulsion and/or subsequent death. A single oral pretreatment with 4-BPA at 400 mg/kg increased the incidence of convulsion and death after oral administration of ciprofloxacin at the doses of 25, 50, and 100 from zero of five to three of five, two of five, and four of five, respectively, whereas LB20304 alone or combination with 4-BPA caused neither convulsions nor death at the doses of 12.5, 25, 50, and 100 mg/kg, respectively. Quinolones-induced epileptogenic activities were assessed by a direct intracerebral injection of test articles. The CD$_{50}$ values (nmole) are as follows; 169.47, 35.36, 105.29, and 88.67 for LB20304, ciprofloxacin, of loxacin, and lomefloxacin, respectively. From these data, LB 20304 at therapeutic doses seems to be much more safe than any other quinolones tested.d.