• 대한약침학회지
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• 제16권4호
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• pp.43-48
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• 2013

Objectives: The current study was performed to compare the bee venom pharmacopuncture skin test reactions among groups with different sexes and Sasang constitutions. Methods: Between July 2012 and June 2013, all 76 patients who underwent bee venom pharmacopuncture skin tests and Sasang constitution diagnoses at Oriental Medicine Hospital of Sangji University were included in this study. The skin test was performed on the patient's forearm intracutaneously with 0.05 ml of sweet bee venom (SBV) on their first visit. If the patients showed a positive response, the test was discontinued. On the other hand, if the patient showed a negative response, the test was performed on the opposite forearm intracutaneously with 0.05 ml of bee venom pharmacopuncture 25% on the next day or the next visit. Three groups were made to compare the differences in the bee venom pharmacopuncture skin tests according to sexual difference and Sasang constitution: group A showed a positive response to SBV, group B showed a positive response to bee venom pharmacopuncture 25%, and group C showed a negative response on all bee venom pharmacopuncture skin tests. Fisher's exact test was performed to evaluate the differences statistically. Results: The results of the bee venom pharmacopuncture skin tests showed no significant differences according to Sasang constitution (P = 0.300) or sexual difference (P = 0.163). Conclusion: No significant differences on the results of bee venom pharmacopuncture skin tests were observed according to two factors, Sasang constitution and the sexual difference.

• 대한한의진단학회지
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• 제23권1호
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• pp.1-8
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• 2019

Objectives The purpose of this study is to determine if there is a difference in acupuncture sensation depending on the bee venom pharmacopunctures. The study was designed to identify the intrinsic acupuncture sensation of the bee venom pharmacopunctures compared to saline. Methods Bee venom,(BV), Sweet bee venom(SBV), and normal saline were injected in order to the left of ST36 (Joksamni), ST37 (Sang-geoheo), right ST36 (Joksamni), ST37 (Sanggeoheo) each. The order of insertion of the BV, SBV, and normal saline was randomly assigned using a computerized random number table. The questionnaire used in this study was based on the Massachusetts General Hospital Acupuncture Sensation Scale (MASS). Results : BV and SBV was statistically significantly higher than saline in soreness, aching, distention, sharp pain and itchiness. Above this, BV was statistically significantly higher than saline in tingling and throbbing. And SBV was statistically significantly higher than saline in warmth. BV was statistically significantly higher than SBV in ichiness. Conclusion. BV and SBV were mainly strong, heavy, and gave a sharp feeling to the subjects. The results of the study can be used as references for future bee venom pharmacopunctures use. In addition, the results of the study can be used as basic data for clinical trials using bee venom pharmacopunctures.

• Journal of Acupuncture Research
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• 제19권4호
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• pp.74-88
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• 2002

Objectives : This study is aimed to investigate the effects of bee venom and melittin on cell death in synovial cell line. Methods : It was evaluated by using MTT assay, morphologic method, DNA fragmenation, NO generation, flow cytometry, immunocytochemistry analysis, RT-PCR, Western blot. Results : The obtained results are summarized as follows: 1. The MTT assay demonstrated that synovial cell viability was significantly inhibitted dose-dependently by treatment with bee venom and melittin in comparison with control. 2. The morphologic study demonstrated that synovial cell showed apoptosis after treatment with bee venom and melittin for 6 hours using microscope. 3. In case of NO generation bee venom group and melittin group showed significant inhibition in comparison with control. 4. The Flow cytometry demonstrated that apoptosis of synovial cell treated with bee venom and melittin was related with stop of cell cycle in stage of $G_0/G_1$. 5. DNA fragmenation demonstrated that synovial cell treated with bee venom and melittin showed DNA ladder below l Kbp. 6. Immunocytochemistry assay demonstrated that COX-II and PLA2 were strongly down-regulated by treatment with bee venom and melittin whereas iNOS was almostly not expressed by bee venom treatment and slightly expressed by melittin treatment. 7. RT-PCR analysis demonstrated that iNOS were strongly down-regulated by treatment with bee venom and melittin whereas COX-II was almostly not expressed by bee venom treatment and slightly expressed by melittin treatment. 8. Western blot demonstrated that iNOS were strongly down-regulated by treatment with $15{\mu}g/ml$ bee venom whereas COX-II was strongly down-regulated from $5{\mu}g/ml$ bee venom. Conclusions : These results suggest that bee venom and melittin have significant effect on cell death in synovial cell line and further study is needed in vivo.

• 융합보안논문지
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• 제22권1호
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• pp.81-92
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• 2022

빠르게 성장하고 있는 IoT 시장은 일반 가정에서뿐만 아니라 스마트홈이나 스마트시티까지 확대되고 있다. IoT에서 사용하는 주요 프로토콜 중 ZigBee는 스마트홈의 도어락 시장에서 90% 이상 차지하고 있고 소형화된 센서 디바이스에서 주로 사용하고 있어 프로토콜의 안전성이 매우 중요하다. 하지만, ZigBee를 사용하는 디바이스가 네트워크에 연결되는 인증과정에서 고정된 키를 사용하고 있어 전방향 안전성을 만족하지 못하고 있고, 최근에 개발한 ZigBee 3.0에서도 해결되지 못하였다. 본 논문에서는 ZigBee 인증 프로토콜에 전방향 안전성을 제공함과 동시에 기존 프로토콜에서도 빠르게 적용할 수 있는 설계방법을 제안한다. 제안하는 개선된 ZigBee 인증 프로토콜은 IoT에서 연산량이 적고 전방향 안전성을 제공하는 ECDH를 적용하기 위해 최근 개발된 OWE 프로토콜을 분석 및 적용하였다. 이를 바탕으로 ZigBee 인증 프로토콜의 안전성을 제공하며, 별도의 인증서나 패스워드 입력이 필요하지 않아 사용자의 편의성 또한 제공할 수 있을 것으로 본다.

• 혜화의학회지
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• 제21권1호
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• pp.117-124
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• 2012

Objective : The purpose of this report is to introduce hypersensitivity reaction of bee venom pharmacopuncture, and remind caution when use bee venom pharmacopuncture. Methods : After skin test, we were treated with bee venom pharmacopuncture to severe lower back pain and facial palsy patients depending on the state of the individual. After the treatment, bee venom hypersensitivity reaction was appeared, and we retreated hypersensitivity reaction depending on progress. Result & Conclusion : Hypersensitivity reaction of bee venom appears as various symptoms depending on the patient's condition, procedure amount and procedure point. We might reinforce skin test, and remind caution when use bee venom pharmacopuncture.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 학술대회 논문집 정보 및 제어부문
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• pp.228-230
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• 2004

ZigBee Alliance is a network designed for low-cost and very low-power short-range wireless communications. The ZigBee Alliance is a consortium formed by several leading semiconductor and industrial manufactures, and end users. One of the tasks of this organization is the definition of the networking support and applications profiles that will use IEEE Std 802.15.4-compliant transceivers. In the case of IEEE Std 802.15.4, the ZigBee Alliance is an organization that has led the development of the upper layers, through the definition of application profiles. We have implemented ZigBee home control system, however we have not fully implemented. Because of the ZigBee is not perfectly standarded. We will have to implement according to ZigBee Specifications.

• 혜화의학회지
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• 제8권2호
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• pp.299-315
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• 2000

Literatual Study on the Effect of Acupuncture and Moxibustion Treatment for Bee Jeung was studies from the viewpoint of therapeutic acpuncture and moxibustion effect. And the results were as follows. 1. Generally speaking, the cause of Bee Jeung was distributed Wind(風), Coldness(寒), Wetness(濕) of meridian. 2. The symptom of Bee Jeung was dysesthesia and dyscinesia. 3. The therapeutic acupuncture and moxibustion of Bee Jeung was expel devil(祛邪) of expel wind(祛風), disperse coldness(散寒), eliminate wetness(除濕) and rectify energy(調氣). 4. The treatment of acupuncture and moxibustion had a rule generally. 5. The most used meridian was The Leg Greater Yang Bladder Meridian(足太陽膀胱經), and acupoint was Yangnungch'on(陽陵泉). 6. In the therapeutic acupuncture and moxibustion of Bee Jeung, Pung Bee was used by Tam-Kyonjong(膽肩井), Han Bee was used by Samumgyo(三陰交), Soup Bee was used by Hyonjong(懸鍾).

• 한국태양에너지학회 논문집
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• 제31권4호
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• pp.122-127
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• 2011

A bee venom is very useful and expensive medical resource. A bee venom collector has some difficulties and inconveniences because of its complex component. This is used normal battery as an electric power. However, using the solar cell of the bee venom collector reduces economic burden and guarantees high efficiency. We have performed comparative experiment between the bee venom collector to use battery and the one to use solar cell(polycrystalline silicon) by collecting the bee venom simultaneously. At the same electricity, the electric frequency(AC),312 Hz is more superior than 450Hz. This paper verified through the experiments that the bee venom collector to adopt solar cell is more effective than normal collector.

• 대한토목학회논문집
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• 제32권3D호
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• pp.247-258
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• 2012

본 논문은 건설 유비쿼터스 실현을 통한 건설생산성 향상 및 무선계측모니터링의 효율성을 향상을 위해 최근 관심을 갖고 연구가 진행되고 있는 ZigBee 무선통신기술의 건설산업 사용성 분석을 수행하였다. 건설산업 적용 대상분야로서 교량, 사면, 도로, 교통 등에 ZigBee기술이 적용된 각종 문헌을 조사하여 그 사례를 분석하였고, 다양한 무선통신기술의 장단점 분석을 통해 각 기술들이 제공할 수 있는 건설산업 적용성을 기술하였으며, 그 중 ZigBee기술의 하드웨어, 네트워크, 보안에 관한 기술적인 사항을 소개하였다. 이와 같은 기초자료를 바탕으로 건설업계, 센서개발자, 학생, 대학 및 연구기관의 4분야 설문대상자를 바탕으로 ZigBee기술의 사용성에 관한 설문조사를 수행하였으며, 그 결과를 바탕으로 ZigBee기술이 제공하는 기능성, 적용분야, 보완사항, 향후 전망 등에 대한 가이드라인을 제시하고 있다. 설문조사를 통한 ZigBee기술의 건설산업 사용성 분석결과는 향후 ZigBee응용기술의 활성화 및 연구개발을 추진할 때 의미있는 기초자료로 활용될 수 있을 것이라고 판단된다.

• 대한한의학회지
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• 제21권3호
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• pp.3-8
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• 2000

1. Definition : Bee-venom therapy does not involve actual bee-stings: it is a treatment method with acquired bee-venom extract through the electric stimulus on the bee, It is injected subcutaneusly on the acupuncture point after refining, according to the diagnosis of constitution and disease. 2. History : Around 2000 B.C., records that Bee-venom was used for therapy were written in the medical book of Babylonia and Papirus of ancient Egypt. Hippocrates, who is called the father of Medicine, said that Bee-venom is Arcanum, which means mysteric medicine. In Oriental medicine, B.C. 200, there was a clinical record that the meat suspended in front of the bee house on the tree in order to get bee-venom, was attached on the lesion. 3. Mechanism of Action : There are two aspects: 1) The effect of stimulating acupunture point It is similar to the chemical moxa. I think that there are several methods of stimulating the acupuncture point： For example, a simple needle is a mechanical stimulus, Moxa is a heating stimulus and electric and Raser acupunture etc. And another stimulus: in the ancient orient, a chemical stimulus called Chungu(Tianjiu), is attached to the lesions by using grinded insects (ex. Mylaris phalerate PALL.) which have toxin. So Bee venom therapy is similar to this. 2) The effect of biochemical ingredients Bee venom consists of 40 kinds of ingredients. For example, me Iii tin, Apamin, Pospholipase A2, MCD peptide, Adolapin and so on. They have effects which have been proven through experimentation l) tonifying mechanism of the body through increasing hormon secretion 2) tonifying immune system through proliferation of WBC, lymphocytes, macrophage 3) anti-inflammatory reaction Therefore Bee venom therapy is the representative 3rd Medicine, which combined East & West medicine. 4. Application of disease : L.B.P and HIVD, O.A, R.A, degenerative arthritis, shoulder pain and other pain diseases. 5. Therapic methods : According to constitution and disease, proper concentration of bee venom is injected on acupunture point, 2 times a week. Generally one term is consisted of 15times. 6. Contraindication : Heart disease, TBc, DM, kidney disease(nephritis), pregnancy, woman in menstruation 3-4 persons per 100,000 persons may have severe allergic reaction.