Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Bee Venom Pharmacopuncture Responses According to Sasang Constitution and Gender

  • Kim, Chaeweon (Department of Acupuncture & Moxibustion Medicine, Sangji University College of Oriental Medicine) ;
  • Lee, Kwangho (Department of Acupuncture & Moxibustion Medicine, Sangji University College of Oriental Medicine)
  • Received : 2013.10.22
  • Accepted : 2013.10.30
  • Published : 2013.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The current study was performed to compare the bee venom pharmacopuncture skin test reactions among groups with different sexes and Sasang constitutions. Methods: Between July 2012 and June 2013, all 76 patients who underwent bee venom pharmacopuncture skin tests and Sasang constitution diagnoses at Oriental Medicine Hospital of Sangji University were included in this study. The skin test was performed on the patient's forearm intracutaneously with 0.05 ml of sweet bee venom (SBV) on their first visit. If the patients showed a positive response, the test was discontinued. On the other hand, if the patient showed a negative response, the test was performed on the opposite forearm intracutaneously with 0.05 ml of bee venom pharmacopuncture 25% on the next day or the next visit. Three groups were made to compare the differences in the bee venom pharmacopuncture skin tests according to sexual difference and Sasang constitution: group A showed a positive response to SBV, group B showed a positive response to bee venom pharmacopuncture 25%, and group C showed a negative response on all bee venom pharmacopuncture skin tests. Fisher's exact test was performed to evaluate the differences statistically. Results: The results of the bee venom pharmacopuncture skin tests showed no significant differences according to Sasang constitution (P = 0.300) or sexual difference (P = 0.163). Conclusion: No significant differences on the results of bee venom pharmacopuncture skin tests were observed according to two factors, Sasang constitution and the sexual difference.

Keywords

References

  1. Korean Pharmacopuncture Institute. Pharmacopuncturology. Seoul: Elsevier Korea LLC; 2012. Chapter 9, Animal Based Pharmacopunctrue; p. 147-77.
  2. Hwang YJ, Lee BC. [Clinical study of anaphylaxis on bee - venom acupuncture]. The Journal of Korean Acupuncture & Moxibustion Medicine Society. 2000;17(4):149-59. Korean.
  3. Youn HM. [The clinical observation of anaphylaxis on bee - venom acupuncture]. The Journal of Korean Acupuncture & Moxibustion Medicine Society. 2005;22(4):179-88. Korean.
  4. Kim CW, Lee YH, Lee KH. [The case report of an anaphylaxis occurred when using sweet bee venom and common bee venom at the same time]. Pharmacopuncture. 2011;14(4):59-61. Korean. https://doi.org/10.3831/KPI.2011.14.4.059
  5. Yoon KS, Cho E, Kang JH, Lee H. [The clinical observation of bee venom hypersensitivity reaction after bee venom pharmacopuncture treatment]. Collection of papers of Oriental Medicine Laboratory in DaeJeon University. 2012;21(1):117-24. Korean.
  6. Kwon KR, Kang JC. [The clinical studies to developing BV Partner]. Pharmacopuncture. 2001;4(3):93-9. Korean. https://doi.org/10.3831/KPI.2001.4.3.093
  7. Kwon KR, Lee KH, Park WP. [Experimental study on anti-body effects of anti-BV on the bee venom herbal acupuncture]. Pharmacopuncture. 2005;8(1):21-30. Korean. https://doi.org/10.3831/KPI.2005.8.1.021
  8. Kim HJ, Kim MS, Park YJ, Lee EY. [The effect of magnetic therapy on the allergic reaction of bee venom]. The Journal of Korean Acupuncture & Moxibustion Medicine Society. 2004;21(6):187-94. Korean.
  9. Choi YG, Kwon KR, Choi SH. [Purification of peptide components including melittin from bee venom using gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis]. Pharmacopuncture. 2006;9(2):105-11. Korean. https://doi.org/10.3831/KPI.2006.9.2.105
  10. Choi SH, Cha BC, Kwon KR. [Component analysis of sweet BV and clinical trial on antibody titer and allergic reactions]. Pharmacopuncture. 2006;9(2):79-86. Korean. https://doi.org/10.3831/KPI.2006.9.2.079
  11. Lee JS, Lee JY, Kwon KR, Lee HC. [A study on allergic responses between bee venom and sweet bee venom pharmacopuncture]. Pharmacopuncture. 2006;9(3):61-77. Korean. https://doi.org/10.3831/KPI.2006.9.3.061
  12. Paull BR, Yunginger JW, Gleich GJ. Melittin: an allergen of honeybee venom. J Allergy Clin Immunol. 1977;59(4):334-8. https://doi.org/10.1016/0091-6749(77)90056-2
  13. Kwon KR, Kang KS, Lee KH, Lim CS, Jeong HS, Kwon HY. [Clinical observation of anaphylaxis after treated with Sweet BV]. Pharmacopuncture. 2009;12(2):85-90. Korean. https://doi.org/10.3831/KPI.2009.12.2.085
  14. Lee JD. [Bee-Venom therapy - Methods of Clinical Approach -]. J Korean Oriental Med. 2000;32(3):3-8. Korean.
  15. Bilo BM, Rueff F, Mosbech H, Bonifazi F, Oude-Elberink JN; EAACI Interest Group on Insect Venom Hypersensitivity. Diagnosis of hymenoptera venom allergy. Allergy. 2005;60(11):1339-49. https://doi.org/10.1111/j.1398-9995.2005.00963.x
  16. Kwon KR, Koh HK. [The clinical observation of immune response by Korean bee venom therapy]. The Journal of Korean Acupuncture & Moxibustion Medicine Society. 2000;17(1):169-74. Korean.
  17. Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT. Molecular mechanisms of anaphylaxis: lessons from studies with murine models. J Allergy Clin Immunol. 2005;115(3):449-59. https://doi.org/10.1016/j.jaci.2004.12.1125
  18. Toro K, Borka K, Kardos M, Kristóf I, Sótonyi P. Expression and function of C5a receptor in a fatal anaphylaxis after honey bee sting. J Forensic Sci. 2011;56(2):526-8. https://doi.org/10.1111/j.1556-4029.2010.01681.x
  19. Gauldie J, Hanson JM, Rumjanek FD, Shipolini RA, Vernon CA. The peptide components of bee venom. Eur J Biochem. 1976;61(2):369-76. https://doi.org/10.1111/j.1432-1033.1976.tb10030.x
  20. Oh SK. [Stimulation Therapy]. Seoul: Koonja; 2011. p. 401, 61-2. Korean.
  21. Lee KH. Correlation between the constitution of Sasang and sexual difference in the hypersensitive reaction of sweet bee venom. Pharmacopuncture. 2012;15(3):45-7. https://doi.org/10.3831/KPI.2012.15.005
  22. Position paper: Allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology. Allergy. 1993;48(14 Suppl):48-82. https://doi.org/10.1111/j.1398-9995.1993.tb04698.x
  23. Lee SM, Kim K, Oh SY, Kym, Joo JC. [Effects of bee venom acupuncture on heart rate variability, pulse wave, and cerebral blood flow for types of Sasang constitution]. Pharmacopuncture. 2009;12(1):35-42. Korean. https://doi.org/10.3831/KPI.2009.12.1.035
  24. Golden DB, Kagey-Sobotka A, Norman PS, Hamilton RG, Lichtenstein LM. Insect sting allergy with negative venom skin test responses. J Allergy Clin Immunol 2001;107(5):897-901. https://doi.org/10.1067/mai.2001.114706