• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.7.1-7.12
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• 2018

Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were collected from four independent HCC cohorts (n = 941). A prediction model was constructed using Bayesian compound covariate prediction, and the robustness of the APOB gene signature was validated in HCC cohorts. The correlation of the APOB signature with previously validated gene signatures was performed, and network analysis was conducted using ingenuity pathway analysis. APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts. Poor prognosis with APOB inactivation was consistently observed through cross-validation with previously reported gene signatures (NCIP A, HS, high-recurrence SNUR, and high RS subtypes). Knowledge-based gene network analysis using genes that differed between low-APOB and high-APOB groups in all four cohorts revealed that low-APOB activity was associated with upregulation of oncogenic and metastatic regulators, such as HGF, MTIF, ERBB2, FOXM1, and CD44, and inhibition of tumor suppressors, such as TP53 and PTEN. In conclusion, APOB inactivation is associated with poor outcome in patients with HCC, and APOB may play a role in regulating multiple genes involved in HCC development.

• The korean journal of orthodontics
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• v.52 no.5
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• pp.313-323
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• 2022

Objective: This study aimed to estimate the clinical effects of different types of bone-anchored maxillary protraction devices by using a network meta-analysis. Methods: We searched seven databases for randomized and controlled clinical trials that compared bone-anchored maxillary protraction with tooth-anchored maxillary protraction interventions or untreated groups up to May 2021. After literature selection, data extraction, and quality assessment, we calculated the mean differences, 95% confidence intervals, and surface under the cumulative ranking scores of eleven indicators. Statistical analysis was performed using R statistical software with the GeMTC package based on the Bayesian framework. Results: Six interventions and 667 patients were involved in 18 studies. In comparison with the tooth-anchored groups, the bone-anchored groups showed significantly more increases in Sella-Nasion-Subspinale (°), Subspinale-Nasion-Supramentale(°) and significantly fewer increases in mandibular plane angle and the labial proclination angle of upper incisors. In comparison with the control group, Sella-Nasion-Supramentale(°) decreased without any statistical significance in all treated groups. IMPA (angle of lower incisors and mandibular plane) decreased in groups with facemasks and increased in other groups. Conclusions: Bone-anchored maxillary protraction can promote greater maxillary forward movement and correct the Class III intermaxillary relationship better, in addition to showing less clockwise rotation of mandible and labial proclination of upper incisors. However, strengthening anchorage could not inhibit mandibular growth better and the lingual inclination of lower incisors caused by the treatment is related to the use of a facemask.

• Atmosphere
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• v.16 no.1
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• pp.19-31
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• 2006

The purpose of this study is to develop the statistical model to predict sea level pressure of typhoon period in south coast of the Korean Peninsula. Seven typhoons, which struck south coast of the Korean Peninsula, are selected for this study, and the data for analysis include the central pressure and location of typhoon, and sea level pressure and location of 19 observing site. Models employed in this study are the first order regression, the second order regression and the neural network. The dependent variable of each model is a 3-hr interval sea level pressure at each station. The cause variables are the central pressure of typhoon, distance between typhoon center and observing site, and sea level pressure of 3 hrs before, whereas the indicative variable reveals whether it is before or after typhoon passing. The data are classified into two groups - one is the full data obtained during typhoon period and the other is the data that sea level pressure is less than 1000 hPa. The stepwise selection method is used in the regression model while the node number is selected in the neural network by the Schwarz's Bayesian Criterion. The performance of each model is compared in terms of the root-mean square error. It turns out that the neural network shows better performance than other models, and the case using the full data produces similar or better results than the case using the other data.

• Journal of Korea Multimedia Society
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• v.10 no.11
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• pp.1483-1495
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• 2007

Thanks to IEEE 802.11 technique, accessing Internet through a wireless LAN(Local Area Network) is possible in the most of the places including university campuses, shopping malls, offices, hospitals, stations, and so on. Most of the APs(access points) for wireless LAN are supporting 2.4 GHz band 802.11b and 802.11g protocols. This paper is introducing a C# library function which can be used to read RSSIs(Received Signal Strength Indicator) from APs. An LBS(Location Based Service) estimates the current location of the user and provides useful user's location-based services such as navigation, points of interest, and so on. Therefore, indoor, LBS is very desirable. However, an indoor LBS cannot be realized unless indoor position ing is possible. For indoor positioning, techniques of using infrared, ultrasound, signal strength of UDP packet have been proposed. One of the disadvantages of these techniques is that they require special equipments dedicated for positioning. On the other hand, wireless LAN-based indoor positioning does not require any special equipments and more economical. A wireless LAN-based positioning cannot be realized without reading RSSIs from APs. Therefore, our C# library function will be widely used in the field of indoor positioning. In addition to providing a C# library function of reading RSSI, this paper introduces implementation of indoor positioning modules making use of the library function. The methods used in the implementation are K-NN(K Nearest Neighbors), Bayesian and trilateration. K-NN and Bayesian are kind of fingerprinting method. A fingerprint method consists of off-line phase and realtime phase. The process time of realtime phase must be fast. This paper proposes a decision tree method in order to improve the process time of realtime phase. Experimental results of comparing performances of these methods are also discussed.

• Journal of Korea Water Resources Association
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• v.55 no.8
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• pp.589-601
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• 2022

Although drought is a natural phenomenon, its damage occurs in combination with regional physical and social factors. Especially, related to the supply and demand of various waters, drought causes great socio-economic damage. Even meteorological droughts occur with similar severity, its impact varies depending on the regional characteristics and water supply system. Therefore, this study assessed regional drought risk considering regional socio-economic factors and water supply system. Drought hazard was assessed by grading the joint drought management index (JDMI) which represents water shortage. Drought vulnerability was assessed by weighted averaging 10 socio-economic factors using Entropy, Principal Component Analysis (PCA), and Gaussian Mixture Model (GMM). Drought response capacity that represents regional water supply factors was assessed by employing Bayesian networks. Drought risk was determined by multiplying a cubic root of the hazard, vulnerability, and response capacity. For the drought hazard meaning the possibility of failure to supply water, Goesan-gun was the highest at 0.81. For the drought vulnerability, Daejeon was most vulnerable at 0.61. Considering the regional water supply system, Sejong had the lowest drought response capacity. Finally, the drought risk was the highest in Cheongju-si. This study identified the regional drought risk and vulnerable causes of drought, which is useful in preparing drought mitigation policy considering the regional characteristics in the future.

• Molecules and Cells
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• v.28 no.5
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• pp.423-430
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• 2009

In order to elucidate the precise phylogenetic relationships of Korean wild boar (Sus scrofa coreanus), a partial mtDNA D-loop region (1,274 bp, NC_000845 nucleotide positions 16576-1236) was sequenced among 56 Korean wild boars. In total, 25 haplotypes were identified and classified into four distinct subgroups (K1 to K4) based on Bayesian phylogenetic analysis using Markov chain Monte Carlo methods. An extended analysis, adding 139 wild boars sampled worldwide, confirmed that Korean wild boars clearly belong to the Asian wild boar cluster. Unexpectedly, the Myanmarese/Thai wild boar population was detected on the same branch as Korean wild boar subgroups K3 and K4. A parsimonious median-joining network analysis including all Asian wild boar haplotypes again revealed four maternal lineages of Korean wild boars, which corresponded to the four Korean wild boar subgroups identified previously. In an additional analysis, we supplemented the Asian wild boar network with 34 Korean and Chinese domestic pig haplotypes. We found only one haplotype, C31, that was shared by Chinese wild, Chinese domestic and Korean domestic pigs. In contrast to our expectation that Korean wild boars contributed to the gene pool of Korean native pigs, these data clearly suggest that Korean native pigs would be introduced from China after domestication from Chinese wild boars.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.678-683
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• 2006

A novel and intuitive way of accessing applications of mobile devices is presented. The key idea is to use grip-pattern, which is naturally produced when a user tries to use the mobile device, as a clue to determine an application to be launched. To this end, a capacitive touch sensor system is carefully designed and installed underneath the housing of the mobile terminal to capture the image of the user's grip-pattern. The captured data is then recognized by a recognizer with dedicated preprocessing and postprocessing algorithms. The recognition test is performed to validate the feasibility of the proposed user interface system.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.43 no.6 s.312
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• pp.1-9
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• 2006

For the indoor positioning, wireless fingerprinting is most favorable because fingerprinting is most accurate among the techniques for wireless network based indoor positioning which does not require any special equipments dedicated for positioning. The deployment of a fingerprinting method consists of off-line phase and on-line phase. Off-line phase is not a time critical procedure, but on-line phase is indeed a time-critical procedure. If it is too slow then the user's location can be changed while it is calculating and the positioning method would never be accurate. Even so there is no research of improving efficiency of on-line phase of wireless fingerprinting. This paper proposes a decision-tree method for wireless fingerprinting and performs comparative analysis of the fingerprinting techniques including K-NN, Bayesian and our decision-tree.

• Journal of Korea Multimedia Society
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• v.11 no.3
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• pp.301-314
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• 2008

The existing event recognition is accomplished with the limited systematic foundation, and thus much longer learning time is needed for emergency scenario interpretation due to large scale of probability data. In this paper, we propose a method for nile-based event recognition of an independent object(human) which extract a feature vectors from the object and analyze the behavior pattern of each object and interpretation of emergency scenarios using a probability and object's events. The event rule of an independent object is composed of the Primary-event, Move-event, Interaction-event, and 'FALL DOWN' event and is defined through feature vectors of the object and the segmented motion orientated vector (SMOV) in which the dynamic Bayesian network is applied. The emergency scenario is analyzed using current state of an event and its post probability. In this paper, we define diversified events compared to that of pre-existing method and thus make it easy to expand by increasing independence of each events. Accordingly, semantics information, which is impossible to be gained through an.

• Journal of KIISE:Software and Applications
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• v.37 no.10
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• pp.779-787
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• 2010

Since robots have been used widely recently, research about human-robot communication is in process actively. Typically, natural language processing or gesture generation have been applied to human-robot interaction. However, existing methods for communication among robot and human have their limits in performing only static communication, thus the method for more natural and realistic interaction is required. In this paper, an emotional gesture based dialogue management system is proposed for sophisticated human-robot communication. The proposed system performs communication by using the Bayesian networks and pattern matching, and generates emotional gestures of robots in real-time while the user communicates with the robot. Through emotional gestures robot can communicate the user more efficiently also realistically. We used behavior networks as the gesture generation method to deal with dialogue situations which change dynamically. Finally, we designed a usability test to confirm the usefulness of the proposed system by comparing with the existing dialogue system.