• International Journal of Control, Automation, and Systems
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• v.4 no.5
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• pp.559-566
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• 2006

In the real system application, the interacting multiple model (IMM) based algorithm requires less computing resources as well as a good performance with respect to the various target maneuverings. And it further requires an easy design procedure in terms of its structures and parameters. To solve these problems, a fuzzy interacting multiple model (FIMM) algorithm, which is based on the basis sub-models defined by considering the maneuvering property and the time-varying mode transition probabilities designed by using the mode probabilities as inputs of a fuzzy decision maker, is proposed. To verify the performance of the proposed algorithm, airborne target tracking is performed. Simulation results show that the FIMM algorithm solves all problems in the real system application of the IMM based algorithm.

• Kyungpook Mathematical Journal
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• v.58 no.4
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• pp.615-625
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• 2018

In this paper, we discuss the connection between the 5-dimensional complex Lie algebra ${\mathcal{K}} _5$ and Special functions. We construct certain two variable models of the irreducible representations of ${\mathcal{K}}_5$. We also use an Euler type integral transformation to obtain the new transformed models, in which the basis function appears as $_2F_1$. Further, we utilize these models to get some generating functions and recurrence relations.

• International Journal of Control, Automation, and Systems
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• v.5 no.3
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• pp.307-316
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• 2007

In real system application, the interacting multiple model (IMM) based algorithm operates with the following problems: it requires less computing resources as well as a good performance with respect to the various target maneuvering, it requires a robust performance with respect to the time-varying measurement noise, and further, it requires an easy design procedure in terms of its structures and parameters. To solve these problems, an adaptive fuzzy interacting multiple model (AFIMM) algorithm, which is based on the basis sub-models defined by considering the maneuvering property and the time-varying mode transition probabilities designed by using the mode probabilities as the inputs of the fuzzy decision maker whose widths are adjusted, is proposed. To verify the performance of the proposed algorithm, a radar target tracking is performed. Simulation results show that the proposed AFIMM algorithm solves all problems in the real system application of the IMM based algorithm.

• Molecules and Cells
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• v.47 no.1
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• pp.100005.1-100005.15
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• 2024

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease with a complex genetic basis, presenting both in familial and sporadic forms. The hexanucleotide (G₄C₂) repeat expansion in the C9orf72 gene, which triggers distinct pathogenic mechanisms, has been identified as a major contributor to familial and sporadic Amyotrophic lateral sclerosis cases. Animal models have proven pivotal in understanding these mechanisms; however, discrepancies between models due to variable transgene sequence, expression levels, and toxicity profiles complicate the translation of findings. Herein, we provide a systematic comparison of 7 publicly available Drosophila transgenes modeling the G₄C₂ expansion under uniform conditions, evaluating variations in their toxicity profiles. Further, we tested 3 previously characterized disease-modifying drugs in selected lines to uncover discrepancies among the tested strains. Our study not only deepens our understanding of the C9orf72 G₄C₂ mutations but also presents a framework for comparing constructs with minute structural differences. This work may be used to inform experimental designs to better model disease mechanisms and help guide the development of targeted interventions for neurodegenerative diseases, thus bridging the gap between model-based research and therapeutic application.

• Molecules and Cells
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• v.27 no.6
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• pp.651-656
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• 2009

The formation of ${\beta}$-amyloid peptide ($A{\beta}$) is initiated from cleavage of amyloid precursor protein (APP) by a family of protease, ${\alpha}$-, ${\beta}$-, and ${\gamma}$-secretase. Sub W, a substrate peptide, consists of 10 amino acids, which are adjacent to the ${\beta}$-cleavage site of wild-type APP, and Sub M is Swedish mutant with double mutations on the left side of the ${\beta}$-cleavage site of APP. Sub W is a normal product of the metabolism of APP in the secretary pathway. Sub M is known to increase the efficiency of ${\beta}$-secretase activity, resulting in a more specific binding model compared to Sub W. Three-dimensional structures of Sub W and Sub M were studied by CD and NMR spectroscopy in water solution. On the basis of these structures, interaction models of ${\beta}$-secretase and substrate peptides were determined by molecular dynamics simulation. Four hydrogen bonds and one water-mediated interaction were formed in the docking models. In particular, the hydrogen bonding network of Sub M-BACE formed spread over the broad region of the active site of ${\beta}$-secretase (P5-P3'), and the side chain of P2- Asn formed a hydrogen bond specifically with the side chain of Arg235. These are more favorable to the cleavage of Sub M by ${\beta}$-secretase than Sub W. The two substrate peptides showed different tendency to bind to ${\beta}$-secretase and this information may useful for drug development to treat and prevent Alzheimer's disease.

• Proceedings of the IEEK Conference
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• summer
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• pp.137-142
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• 2004

In this paper, we propose a new scheme for geometry coding of three-dimensional (3-D) mesh models using a fixed spectral basis. In order to code the mesh geometry information, we generate a fixed spectral basis using the dual graph derived from the 3-D mesh topology. After we partition a 3-D mesh model into several independent sub-meshes to reduce coding complexity, the mesh geometry information is projected onto the generated orthonormal bases which are the eigenvectors of the Laplacian matrix of the 3-D mesh. Finally, spectral coefficients are coded by a quantizer and a variable length coder. The proposed scheme can not only overcome difficulty of generating a fixed spectral basis, but also reduce coding complexity. Moreover, we can provide an efficient multi-resolution representation of 3-D meshes.

• Journal of the Korean Institute of Intelligent Systems
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• v.17 no.7
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• pp.855-861
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• 2007

In real system application, the IMM-based position tracking algorithm requires robust performance, less computing resources and easy design procedure with respect to the uncertain target maneuvering, To solve these problems, an adaptive fuzzy interacting multiple model (AFIMM) algorithm, which is based on the well-defined basis sub-models and well-adjusted mode transition probabilities (MTPs), is proposed. Simulation results show that the proposed algorithm effectively solves the problems in the real system application of the IMM-based position tracking algorithm.

• Journal of the Korean Ceramic Society
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• v.44 no.4 s.299
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• pp.219-223
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• 2007

The ionic conductivity of $Li_2O-ZrO_2-SiO_2$ glasses has been designed and analyzed on the basis of a mixture design experiment with constraints. Fitted models for the activation energy and the ionic conductivity are as follows: $Q(kJ/moi)=54.8565x_1+144.825x_2+133.846x_3-170.908x_1x_3-334.338x_2x_3$ $log{\sigma}(300K)=-5.00245x_1-1.17876x_2-15.5173x_3+17.4522x_1x_3$. The electrical properties are very sensitive to the ratio of $Li_2O/SiO_2$. The effect of $ZrO_2$ is less than that of this ratio but $ZrO_2$ component attributes to the reduction of the activation energy. The optimal composition for best ionic conduction based on these fitted models is $55Li_2O{\cdot}10ZrO_2{\cdot}35SiO_2$. Its activation energy and ionic conductivity at 300 K are 46.98 kJ/mol and $1.08{\times}10^{-5}{\Omega}^{-1}{\cdot}cm^{-1}$, respectively.

• Journal of Biosystems Engineering
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• v.37 no.4
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• pp.215-224
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• 2012

Purpose: This study was conducted to classify the energy efficiency of 131 tractor models tested during from 2006 to 2010 in Korea. Methods: Four sub-indexes were developed using the fuel consumptions at 60% and 90% of rated speed with partial loads and at pull speeds of 3.0 km/h and 7.5 km/h with maximum drawbar pull. Weighting factors of the sub-indexes were also considered to reflect the characteristics of tractor's actual working hours in Korea. Four sub-indexes were integrated into a classification index. Using the developed classification index, a five-classification system was made on the basis of normal distribution of tractors over the classification range. Percentage of $1^{st}$ grade interval was expected to be close to 15%, $2^{nd}$ grade 20%, $3^{rd}$ grade 30%, $4^{th}$ grade 20%, $5^{th}$ grade 15%. Results: Number of $1^{st}$ grade was 21, $2^{nd}$ grade 23, $3^{rd}$ grade 39, $4^{th}$ grade 33, $5^{th}$ grade 15 among 131 models. Conclusions: Classification index was developed by integrating four sub-indexes. By the classification method using developed index, distribution of classified tractors was acceptable for practical application.

• Journal of The Korean Astronomical Society
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• v.48 no.3
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• pp.165-175
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• 2015

We investigate physical properties of the nearby (∼ 7.5 pc) astrometric binary μ Cas in the context of standard evolutionary theory. Based on the spectroscopically determined relative abundances ([α/Fe] ≳ +0.4 dex, [Fe/H] ∼ −0.7 dex), all physical inputs such as opacities and equation of state are consistently generated. By combining recent spectroscopic analyses with the astrometric observations from the HIPPARCOS parallaxes and the CHARA array, the evolutionary model grids have been constructed. Through the statistical evaluation of the χ²-minimization among alternative models, we find a reliable evolutionary solution (M_A, M_B, t_age) = (0.74 M_⊙, 0.19 M_⊙, 11 Gyr) which excellently satisfies observational constraints. In particular, we find that the helium abundance of μ Cas is comparable with the primordial helium contents (Y_p ∼ 0.245). On the basis of the well-defined stellar parameters of the primary star, the internal structure and the p-mode frequencies have been estimated. From our seismic computation, μ Cas is expected to have a first order spacing ∆ν ∼ 169 μHz. The ultimate goal of this study is to describe physical processes inside a low-mass star through a complete modelling from the spectroscopic observation to the evolutionary computation.