• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1800-1805
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• 2018

Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Intestinal epithelial cells (IECs) constitute barrier surfaces and play a critical role in maintaining gut health. Dysregulated immune responses and destruction of IECs disrupt intestinal balance. Dextran sodium sulfate (DSS) is the most widely used chemical for inducing colitis in animals, and its treatment induces colonic inflammation, acute diarrhea, and shortening of the intestine, with clinical and histological similarity to human UC. Current treatments for this inflammatory disorder have poor tolerability and insufficient therapeutic efficacy, and thus, alternative therapeutic approaches are required. Recently, dietary supplements with probiotics have emerged as promising interventions by alleviating disturbances in the indigenous microflora in UC. Thus, we hypothesized that the probiotic Bifidobacterium animalis subsp. lactis strain BB12 could protect against the development of colitis in a DSS-induced mouse model of UC. In the present study, oral administration of BB12 markedly ameliorated DSS-induced colitis, accompanied by reduced tumor necrosis factor-${\alpha}$-mediated IEC apoptosis. These findings indicate that the probiotic strain BB12 can alleviate DSS-induced colitis and suggest a novel mechanism of communication between probiotic microorganisms and intestinal epithelia, which increases intestinal cell survival by modulating pro-apoptotic cytokine expression.

• 한국콘텐츠학회논문지
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• 제8권1호
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• pp.339-347
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• 2008

게임에서 밸런스 조절은 그 게임의 성공 여부에 큰 영향을 미치는 중요한 요인으로 자리 잡고 있다. 실제 게임 밸런싱이 정확하게 무엇을 의미하고 어떻게 해야 하는지 구현하기가 매우 어려운 실정이다. 무엇을 위해 게임 밸런싱이 필요하고 게임 중에 게이머를 위한 것인지 게임 자체의 운영을 위한 것인지, 얼마만큼 레벨을 조절할 때 정확하게 밸런싱이 되었다고 해야 할지, 그리고 실제 밸런싱 때 플레이어의 경험과는 어떻게 연계하여 레벨을 조절해서 밸런스를 유지시켜야 할지 등 매우 어려운 문제가 내제되어 있기 때문이다. 이러한 문제에 대한 답변은 매우 주관적이며 게임의 특성에 따라 다르게 표현된다. 따라서 본 연구에서는 객관적 지표를 제공할 수 있는 로그 함수를 이용한 레벨 조절 방안을 제안하고자 한다. 제안된 알고리즘을 사용한 결과 레벨 조절을 수행한 결과와 그렇지 않은 결과가 통계적으로 유의한 차이가 있음을 확인할 수 있었다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.752-755
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• 2006

Evaportranspiration is an important factor in hydrology cycle. Traditionally, it is measured by using basin or empirical formula with meteorology data, while it does not represent the evaportranspiration over a regional area. With the advent of improved remote sensing technology, it becomes a surface parameter of research interest in the field of remote sensing. Airborne and satellite imagery are utilized in this study. The high resolution airborne images include visible, near infrared, and thermal infrared bands and the satellite images are acquired by MODIS. Surface heat fluxes such as latent heat flux and sensible heat flux are estimate by using airborne and satellite images with surface meteorological measurements. We develop a new method to estimate the evaportranspiration over the rice paddy. The surface heat fluxes are initialized with a surface energy balance concept and iterated for convergent solution with atmospheric correct functions associated with aerodynamic resistance of heat transport. Furthermore, we redistribute the total net energy into sensible heat and latent heat fluxes. The result reveals that radiation and evaporation controlled extremes can be properly decided with both airborne and satellite images. The correlation coefficient of latent heat flux and sensible heat flux with corresponding in situ observations are 0.66 and 0.76, respectively. The relative root mean squared errors (RMSEs) for latent heat flux and sensible heat flux are 97.81 $(W/m^2)$ and 124.33 $(W/m^2)$, respectively. It is also shown that the newly developed retrieval scheme performs well when it is tested by using MODIS date.

• Journal of Chest Surgery
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• 제47권5호
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• pp.451-457
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• 2014

Background: The balance of the risks and the benefits of cardiac surgery in the elderly remains a major concern. We evaluated the early and mid-term clinical results of patients aged over 75 years who underwent major cardiovascular surgery. Methods: Two hundred and fifty-one consecutive patients, who underwent cardiac surgery at Seoul National University Bundang Hospital between July 2003 and June 2011, were included in this study (mean age, $78.7{\pm}3.4$ years; male:female=130:121). Elective surgery was performed in 112 patients, urgent in 90, and emergency in 49. Results: Early mortality was 12.7% (32/251). Follow-up completion was 100%, and the mean follow-up duration was $2.8{\pm}2.2$ years. Late mortality was 24.2% (53/219). There were 283 readmissions in a total of 109 patients after discharge. However, the reason for readmission was related more to non-cardiac factors (71.3%) than to cardiac factors. The overall survival estimates were 79.2% at the 1-year follow-up and 58.4% at the 5-year follow-up. Patients who underwent elective surgery had a lower early mortality rate (elective, 4.5%; urgent, 13.3%; emergency, 30.6%) and better overall survival rate than those that underwent urgent or emergency surgery (p<0.001). Conclusion: The timing of cardiac surgery was found to be an independent risk factor for early and late mortality. Thus, earlier referral and intervention may improve operative results. Further, comprehensive coordinated postoperative care is needed for other comorbid problems in aged patients.

• 디지털융복합연구
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• 제12권7호
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• pp.85-93
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• 2014

본 연구는 최근 급격히 늘어난 국내 원전 보도의 불균형성에 대한 비판을 문제의식으로 하여 원전에 대한 정보를 직접적으로 얻는 유관기관 종사자들과 심층인터뷰를 통해 국내 원전 보도에 대하여 어떻게 인식하고 있는지 파악했다. 원전에 대한 논의에서 당사자적 입장을 갖는 이들은 원전보도가 원자력에 대한 부정적 측면만 편중보도하고 있으며, 위험에 대해서만 과장되고 왜곡된 보도를, 전문지식의 부족으로 원전에 대한 몰이해를 유발하고 있다고 인식하고 있었다. '원전 비리' 사건에 대해서는 더욱 철저히 파헤쳐야 한다고 인식하고 있었다. 이로서 선정적이고 위협적 소구에 편중된 프레임을 초월하는 균형 잡힌 원전보도를 위해 저널리즘적 성찰과 경계에서 나아가 과학적 전문 지식의 점검, 에너지 영역 전문 기자 양성 등 과학보도에 대한 정책적 변화의 필요성을 촉구했다.

• Nuclear Engineering and Technology
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• 제52권3호
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• pp.508-519
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• 2020

During transients or accidents, the reactor core is uncovered, and droplets entrained above the quench front collides with the uncovered fuel rod surface. Droplet impact cooling can reduce the peak cladding temperature. Besides zirconium-based cladding, versatile accidental tolerant fuel (ATF) claddings, including FeCrAl, have been proposed to increase the accident coping time. In order to investigate the effect of surface properties on droplet impact cooling of cladding surfaces, the droplet impact phenomena are photographed on the FeCrAl and zircaloy-4 (Zr-4) surfaces under different conditions. On the oxidized FeCrAl surface, the Leidenfrost phenomenon is not observed even when the surface temperature is as high as 550 ℃ with We > 30. Comparison of the impact behaviors observed on different materials shows that nucleate and transition boiling is more intensive on surfaces with larger thermal conductivity. The Leidenfrost point temperature (LPT) decreases with the solid thermal effusivity (${\sqrt{k{\rho}C_p}}$). However, the CHF temperature is relatively insensitive to the surface oxidation and Weber number. Droplet spreading diameter is analyzed quantitatively in the film boiling stage. Based on the energy balance a correlation is proposed for droplet maximum spreading factor. A mechanistic model is also developed for the LPT based on homogeneous nucleation theory.

• 한국지능시스템학회논문지
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• 제15권1호
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• pp.81-86
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• 2005

본 연구에서는 복잡하고 비선형 시스템을 모델 동정하기 위해 정보 granules에 기반한 퍼지 추론 시스템의 새로운 범주를 소개한다. 비공식적으로 말하면, 정보 granules는 근접성, 유사성 또는 기능성 등에 인하여 서로 결합되는 대상(특히, 수치 데이터)의 연결된 모임으로 간주된다. HCM 클러스터링에 의한 정보 granulation은 퍼지 규칙의 전반부 및 후반부에서 사용되는 멤버쉽 함수의 포기 정점과 다항식함수의 초기 값과 같은 퍼지 모델의 초기 파라미터를 결정하는데 도움을 준다. 그리고 포기 파라미터는 유전자 알고리즘과 최소자승법에 의해 효과적으로 동조된다. 또한, 퍼지 모델의 성능사이의 상호균형을 얻기 위하여 하중값을 가진 합성 목적함수를 사용하여 근사화와 예측성능의 향상을 꾀한다. 제안된 모델은 수치적인 예제를 가지고 평가하고, 문헌에서 나타난 기존의 퍼지 모델의 성능과 대조된다.

• IMMUNE NETWORK
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• 제10권5호
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• pp.164-172
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• 2010

Background: We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a $T_H1$-skewed immune response as opposed to dengue fever (DF). Methods: We estimated intracellular (in T-cells) and serum levels of designate $T_H1/T_H2$ cytokines [interferon-${\gamma}$ (IFN-${\gamma}$), interleukin-4 (IL-4), and tumor necrosis factor-${\alpha}$] and macrophage inflammatory protein-$1{\alpha}$ (MIP-$1{\alpha}$) at admission, 48h, and day 5 in 20 adults with dengue (DF=10, DHF=10) and 10 dengue-naive healthy controls. Results: At admission, intracellular IFN-${\gamma}$/IL-4 ratio in CD4+ T-cells and proportion of MIP-$1{\alpha}$-positive CD8+ T-cells were significantly higher in patients with DHF [7.21 (5.36~10.81) vs. 3.04 (1.75~4.02); p=0.011 and 6.2% (3.2~8.2%) vs. 2.4% (2.0~3.6%); p=0.023]. The latter showed a significant positive correlation with IFN-${\gamma}$/IL-4 ratio in CD4+ T-cells (Spearman's rho=0.64; p=0.003), percentage-change in haematocrit (rho=0.47; p=0.048), and serum alanine amino-transferase level (rho=0.61; p=0.009). Conclusion: We conclude that DHF is associated with a $T_H1$-skewed immune response. Further, MIP-$1{\alpha}$ in CD8+ T-cells is an important immunologic correlate of disease severity in dengue.

• 통상정보연구
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• 제11권2호
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• pp.343-367
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• 2009

This research is about global investment for managing the important position, what Korea is doing in World's main market. Considering there are some differences between developed countries' model and developing countries' model in doing direct overseas investment, they target to get political agreement and develop the new invest plan and strategy by understanding changes of Korean manufacturing companies in direct overseas investment between 2000 and 2007 and analyzing the change of yearly investment motivation factors and determining factors for investment. The result from this result let us know that company should develop their own idea for their competitive advantage by doing direct overseas investment with the existing theory which convinces the need of competitive advantage for investing overseas. I set actual model and analyze results from it with the considering that it is so important to get knowledge and information for globalizing companies to invest overseas and companies, which want to be world leading ones for their field through innovation and changes, need to have more active strategy. And, the overseas investment, which was already done in other countries, 1. Review its realities and tendency in terms of investing countries, investing industries, and its scale. 2. Set up an actual model, based on strategic combination of investing location select and determination of Korean manufacturing companies and yearly investing factor-effect analysis. 3. Analyze how the situational factors have influenced and what factors would be considered for direct overseas investment. From the analyzing result, even though it is fairly true that raising wage and getting resources, avoiding customs, and developing alternating industries for export had influenced at the beginning, overseas investing companies' policy will be influenced by the results from studying marketing-pursuit type, which emphasizes to manage trade income and outgo, keeping the balance in the black, ensuring raw materials, local producing and manufacturing by using low-wage people for local sale, and situation for changing investing tendency as service industry.

• 전기전자학회논문지
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• 제23권4호
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• pp.1140-1149
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• 2019

전압형 컨버터의 다양한 전압 합성 방법을 구현하기 위해서, 옵셋 전압을 주입하는 방법이 널리 사용되고 있다. 즉, 전압 변조 방식(pulse width modulation; PWM)들은 교류 측 전압 지령에 적절한 옵셋 전압을 주입하는 것과 수학적으로 동일하다. 이러한 옵셋 전압을 이용한 AC 단 출력 전압 합성 방법에 따라 DC 단 전압의 전압 이용률이 달라지며, 이는 모듈형 다단 컨버터(modular multilevel converter; MMC) 시스템에서도 동일하다. 따라서, DC 단의 용량이 정해져 있는 고압 직류(high voltage DC; HVDC) 송전 시스템의 경우에도 AC 단에 옵셋 전압을 이용함에 따라 AC 단으로 공급 가능한 최대 무효 전력의 크기를 변화시킬 수 있다. 본 논문에서는 대표적인 전압 변조 방식을 적용한 옵셋 전압 주입 시 합성된 AC 측 출력 전압에 따라 MMC 시스템의 레그 에너지 맥동을 수학적으로 분석하였다. 또한, 이를 실제 스케일의 400MVA급 MMC 시스템 시뮬레이션을 통해 수학적 분석의 경향성을 검증하였다.