• 대한인간공학회지
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• 제33권1호
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• pp.39-48
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• 2014

Objective: This entire study has two parts. Study I aimed to develop a psychological assessment scale and the study II aimed to investigate the effects of LFN (low frequency noise) on the psychological responses in humans, using the scale developed in the study I. Background: LFN is known to have a negative impact on the functioning of humans. The negative impact of LFN can be categorized into two major areas of functioning of humans, physiological and psychological areas of functioning. The physiological impact can cause abnormalities in threshold, balancing and/or vestibular system, cardiovascular system and, hormone changes. Psychological functioning includes cognition, communication, mental health, and annoyance. Method: 182 college students participated in the study I in development of a psychological assessment scale and 42 paid volunteers participated in the study II to measure psychological responses. The LFN stimuli consisted of 12 different pure tones and 12 different 1 octave-band white noises and each stimulus had 4 different frequencies and 3 different sounds pressure levels. Results: We developed the psychological assessment scale consisting of 17 items with 3 dimensions of psychological responses (i.e., perceived physical, perceived physiological, and emotional responses). The main findings of LFN on the responses were as follows: 1. Perceived psychological responses showed a linear relation with SPL (sound pressure level), that is the higher the SPL is, the higher the negative psychological responses were. 2. Psychological responses showed quadric relations with SPL in general. 3. More negative responses at 31.5Hz LFN than those of 63 and 125Hz were reported, which is deemed to be caused by perceived vibration by 31.5Hz. 'Perceived vibration' at 31.5Hz than those of other frequencies of LFN is deemed to have amplified the negative psychological response. Consequently there found different effects of low frequency noise with different frequencies and intensity (SPL) on multiple psychological responses. Conclusion: Three dimensions of psychological responses drawn in regard to this study differed from others in the frequencies and SLP of LFN. Negative psychological responses are deemed to be differently affected by the frequency, SPL of the LFN and 'feel vibration' induced by the LFN. Application: The psychological scale from our study can be applied in quantitative psychological measurement of LFN at home or industrial environment. In addition, it can also help design systems to block LFN to provide optimal conditions if used the study outcome, .i.e., the relations between physical and psychological responses of LFN.

• 대한인간공학회지
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• 제32권3호
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• pp.279-291
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• 2013

Objective: The aim of this study was to compare old standard EN 954-1 and new standard EN ISO 13849-1 through case study and provide necessity of adaptation of EN ISO 13849-1 in Korea. Background: International and EU harmonized standard EN ISO 13849 "safety of machinery - Safety-related parts of control system" is classified into Part 1: General principles for design and Part 2: Validation. EN ISO 13849-1 standard was introduced in Official Journal of the European Union on September 8, 2009 as harmonized standard, and old standard EN 954-1 was withdrawn on December 31, 2011. So, EU decided to use of EN ISO 13849-1 standard forcibly from January 1, 2012 for safety of machinery. New machines need to be CE marked if they are to be placed on the market in the European Economic Area(EEA), Switzerland or Turkey, and Korean machine builder should apply EN ISO 3849-1 standard for safety of machinery accordingly. However, current Korean Safety Certification system(KCs mark) for dangerous machinery is not referred to EN ISO 13849-1 standard as safety standard. There is a need of research for adaptation of EN ISO 13849-1 standard in Korea as safety standards for new design of safety-related control system which use mostly electronic components. Method: Five case studies of representative designs for safety-related control system in accordance with EN 954-1were selected according to safety category from B to 4. And these five representative designs were tried to change new design in accordance with EN ISO 13849-1 standard. The results of comparison were analyzed in aspect of economy and technical complexity. Results: The results showed that EN ISO 13849-1 provided quantitative method of application and it enabled designers to create safety-related control systems that require fewer components and less wiring, with many of the components being to a lower specification and, therefore, less costly. Conclusion: EN ISO 13849-1 standard is good for electronic safety-related control systems compare to EN 954-1. By considering the importance of application of EN ISO 13849-1 and benefits, the application of EN ISO 13849-1 as safety standard for safety of machinery is urgent in Korea. Application: The results of comparing EN 954-1 and EN ISO 13849-1 standard might help to determine the adaptation of EN ISO 13849-1 standard for safety of industrial machinery in Korea.

• 한국환경보건학회지
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• 제36권5호
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• pp.343-350
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• 2010

This study was performed to investigate laboratory workers' exposures to airborne nanoparticles at a university laboratory where acid treatment experiments were conducted on the surfaces of engineered carbon nanotubes (CNTs). The surface area concentrations, number concentrations, and mass concentrations of airborne nanoparticles were measured at personal breathing zones (PBZs) for various tasks using direct reading instruments. For all three metrics, airborne nanoparticle concentrations during the experiments were higher than background levels measured before and after the experiments for all three metrics. Among the various tasks that were performed as part of these experiments, one task that involved filtering a mixture of acid and CNTs showed the highest concentrations in all three metrics, with concentrations of $116.6\;{\mu}m^2$/cc, 24320 pt/cc, and $9.0\;{\mu}g/m^3$, respectively. Nanoparticle surface area concentrations measured at a representative area fluctuated with those at the PBZs in the laboratory. This result indicates that nanoparticles generated during the experiments were not just limited to the PBZs of the workers but were also present throughout the room, potentially exposing co-located workers. CNTs were detected by a transmission electron microscope in an air sample collected while handling the CNTs. All the tasks were performed inside fume hoods, with the sliding sashes open to their required heights. It was noted that the capture velocities of the fume hoods were much lower than the American National Standards Institute (ANSI)'s recommendation level (0.4 to 0.6 m/s). In conclusion, this study showed that, due to inadequate control, laboratory researchers performing acid treatment experiments on surfaces of CNTs were exposed to airborne nanoparticles generated during the tasks.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.731-732
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• 2007

This paper presents the final configuration of test field and test items for the application of IEC 60364-4-44 in Korea. IEC 60364-4-44 provides rules for the protection against the effects of conducted and radiated disturbances on electrical installations. Especially this standard deals with the protection of low voltage facility against the ground fault in the high voltage side of power distribution system. Many countries define the regulations on the use of electrical facilities based on their own power system and technical references which are considered to be suitable for them. The background of circuit of IEC 60364-4-44 is based on the ungrounded system as most of European countries. However, domestic electric power distribution system is based on multi-grounding system different from European system. Therefore, it is necessary to evaluate or prove the effect of the IEC 60364-4-44 for introducing and applying it to the domestic grounding system as a national standard. The authors with KEA(Korea Electric Association) carried out a project on the application of IEC 60364-4-44 to Korean electrical installations of buildings sponsored by Korean ministry of commerce, industry and energy for three years(2004.4.1$\sim$2007.3.31). The test field is established in K.E.R.I.(Korea Electrotechnology Research Institute), which is the purpose of evaluating the formula to calculate touch voltage and stress voltage in the IEC standards. This paper presents some considerations and final configuration of test field to evaluate and introduce the IEC 60364-4-44 applicable to domestic rule for the protection against ground fault.

• 한국항해항만학회지
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• 제37권2호
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• pp.203-210
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• 2013

그 동안 각종 IMO 협약의 채택에도 불구하고 인명 및 해양환경에 관련된 대형 선박사고가 발생하는 것은 기국이 의무를 충실히 이행하고 있지 않고 이로 인하여 IMO 협약들이 효과적으로 이행되지 않기 때문이다. 특히, 기국 중 해당 선박과 기국 간에 진정한 연계가 없는 기국에서는 자국 내 해사안전 및 환경보호를 담당할 인적, 구조적 조직이 잘 정비되어 있지 않기 때문에 협약의 이행이 제대로 이루어 지지 않고 있다. 이와 같은 배경으로 IMO에서는 2003년 11월 제23차 총회에서 자발적 회원국 감사제도에 관한 결의서 A.946(23)이 채택되었고, 동 제도는 2009년 11월 총회 결의서 A.1018(26)의 채택으로 2015년에 강제화 될 예정이다. 따라서 이 연구에서는 IMO 회원국 감사제도의 개요와 동 제도의 감사기준으로 사용하고 있는 강제협약 이행코드를 살펴보았다. 또한 2015년 회원국 감사제도의 강제화에 따른 당사국의 의무와 책임에 대해 검토하였다. 이를 중심으로 우리나라의 해기교육기관이 회원국 감사제도의 강제화에 선제적으로 대응하기 위한 해기 교육 강화방안을 제안하였다.

• 대한유전성대사질환학회지
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• 제3권1호
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• pp.86-93
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• 2003

Background : The SCL began screening of newborns and high risk group blood spots with tandem mass spectrometry (MS/MS) in April 2001. Our goal was to determine approximate prevalence of metabolic disorders, optimization of decision criteria for estimation of preventive effect with early diagnosis. This report describes the ongoing effort to identify more than 30 metabolic disorders by MS/MS in South Korea. Methods : Blood spot was collected from day 2 to 30 (mostly from day 2 to 10) after birth for newborn. Blood spot of high risk group was from the pediatric patients in NICU, developmental delay, mental retardation, strong family history of metabolic disorders. One punch (3.2 mm ID) of dried blood spots was extracted with $150{\mu}L$ of methanol containing isotopically labelled amino acids (AA) and acylcarnitines (AC) internal standards. Butanolic HCl was added and incubated at $65^{\circ}C$ for 15 min. The butylated extract was introduced into the inlet of MS/MS. Neutral loss of m/z 102 and parent ion mode of m/z 85 were set for the analyses of AA and AC, respectively. Diagnosis was confirmed by repeating acylcarnitine profile, urine organic acid and plasma amino acid analysis, direct enzyme assay, or molecular testing. Results : Approximately 31,000 neonates and children were screened and the estimated prevalence (newborn/high risk group), sensitivity, specificity and recall rate amounted to 1:2384/1:2066, 96.55%, 99.98%, and 0.73%, respectively. Confirmed 28 (0.09%) multiple metabolic disorders (newborn/high risk) were as follows; 13 amino acid disorders [classical PKU (3/4), BH4 deficient-hyperphenylalaninemia (0/1), Citrullinemia (1/0), Homocystinuria (0/2), Hypermethioninemia (0/1), Tyrosinemia (1/0)], 8 organic acidurias [Propionic aciduria (2/1), Methylmalonic aciduria (0/1), Isovaleric aciduria (1/1), 3-methylcrotonylglycineuria (1/0), Glutaric aciduria type1 (1/0)], 7 fatty acid oxidation disorders [LCHAD def. (2/2), Mitochondrial TFP def. (0/1), VLCAD def. (1/0), LC3KT def. (0/1). Conclnsion : The relatively normal development of 10 patients with metabolic disorders among newborns (except for the expired) demonstrates the usefulness of newborn screening by MS/MS for early diagnosis and medical intervention. However, close coordination between the MS/MS screening laboratory and the metabolic clinic/biochmical geneticists is needed to determine proper decision of screening parameters, confirmation diagnosis, follow-up scheme and additional tests.

• 한국항만경제학회지
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• 제32권1호
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• pp.151-163
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• 2016

본 연구는 기업의 업무프로세스 상에서의 정보기술 경쟁우위가 공급사슬통합에 어떻게 영향을 미치는지를 분석하고, 업종별 비교분석을 통해 기업들의 효과적인 공급사슬통합을 위한 정보기술 경쟁우위달성방안을 제시하는데 목적이 있다. 연구가설은 이론적 배경을 기초로 하여 크게 두 가지로 구성하였다. 첫 번째 연구가설은 정보기술 경쟁우위가 공급사슬에 미치는 영향에 대한 가설이고, 두 번째 가설은 정보기술 경쟁우위가 공급사슬통합에 미치는 영향이 업종별로 차이가 있다는 가설이다. 기업의 경쟁력 확보를 위한 정보기술 경쟁우위 달성을 위해서는 IT인프라의 확보가 선행되어야 할 것이다. IT인프라에 대한 지속적인 관심과 투자를 바탕으로 정보기술의 도입, 통합, 활용 등 정보기술 경쟁우위 그 자체로 기업성과 향상에 직접적인 영향을 미칠 수 있지만, 정보통합, 조직통합, 전략통합과 같은 공급사슬통합 수준향상에 전략적으로 활용되어야 한다. 정보기술 경쟁우위 확보를 통해 공급사슬 통합이 효과적으로 이루어지면, 기업성과 향상을 도모할 수 있을 것이고 이를 바탕으로 기업의 경쟁우위를 창출하게 될 것이다. 기업의 정보기술 경쟁우위가 공급사슬통합에 미치는 영향을 분석하고, 각 업종 유형별 특징에 따라 어떠한 차이가 있는지를 비교분석하여, 효과적인 공급사슬통합을 위한 정보기술 경쟁우위와 공급사슬통합방안을 제시할 수 있을 것이다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권5호
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• pp.413-429
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• 2021

Background: Migraine headaches are the second leading cause of disability worldwide and are responsible for significant morbidity, reduction in the quality of life, and loss of productivity on a global scale. The purpose of this systematic review and meta-analysis was to evaluate the efficacy of ketamine on migraines and other primary headache disorders compared to placebo and other active interventions, such as midazolam, metoclopramide/diphenhydramine, and prochlorperazine/diphenhydramine. Methods: An electronic search of databases published up to February 2021, including Medline via PubMed, EMBASE, Web of Science, and Cochrane Library, a hand search of the bibliographies of the included studies, as well as literature and systematic reviews found through the search was conducted to identify randomized controlled trials (RCTs) investigating ketamine in the treatment of migraine/headache disorders compared to the placebo. The authors assessed the risk of bias according to the Cochrane Handbook guidelines. Results: The initial search strategy yielded 398 unduplicated references, which were independently assessed by three review authors. After evaluation, this number was reduced to five RCTs (two unclear risk of bias and three high risk of bias). The total number of patients in all the studies was 193. Due to the high risk of bias, small sample size, heterogeneity of the outcomes reported, and heterogeneity of the comparison groups, the quality of the evidence was very low. One RCT reported that intranasal ketamine was superior to intranasal midazolam in improving the aura attack severity, but not duration, while another reported that intranasal ketamine was not superior to metoclopramide and diphenhydramine in reducing the headache severity. In one trial, subcutaneous ketamine was superior to saline in migraine severity reduction; however, intravenous (I.V.) ketamine was inferior to I.V. prochlorperazine and diphenhydramine in another study. Conclusion: Further double-blind controlled studies are needed to assess the efficacy of ketamine in treating acute and chronic refractory migraines and other primary headaches using intranasal and subcutaneous routes. These studies should include a long-term follow-up and different ketamine dosages in diagnosed patients following international standards for diagnosing headache/migraine.

• 한국임상약학회지
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• 제29권1호
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• pp.45-55
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• 2019

Background: Although the importance of pharmaceutical care service has been growing to meet the needs of customers with the improvement of clinical and humanistic outcomes, there was not a systematic strategy to promote research in Korea. The aim of this study was to suggest the core agendas for pharmaceutical care services research and development (R&D) considering priorities. Methods: Based on desk researches, we developed R&D agendas for the needs of improving pharmaceutical care services in the area of institution, community, and public health. To determine the priority of agendas in developing pharmaceutical care service, analytic hierarchy process (AHP) analysis was performed by the 14 experts. Criteria and subcriteria were assessed for significance by pairwise comparisons. Then, agendas were evaluated for importance according to each subcriteria, and rank ordered considering the weight calculated by multiplying the importance scores of the criteria and the subcriteria. Results: We derived 25 agendas including 13 for institutional pharmaceutical care service, 8 for community pharmaceutical care service, and 4 for public-health related pharmaceutical care service. AHP model was constructed based on 4 criteria and 8 subcriteria by a hierarchical structure. From the AHP survey, the 'Development of pharmaceutical care service for metabolic and chronic disease' agenda accounted for the highest priority. Conclusion: We have developed the R&D agendas of the pharmaceutical care service which should be promoted. The results should be utilized by the government to nationally support the development of the standards and relevant regulations related to pharmaceutical care services in Korea.

• 헤리티지:역사와 과학
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• 제47권3호
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• pp.86-107
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• 2014

영성현(寧城縣) 소흑석구(小黑石溝) 8501호 대형 석곽묘는 중국의 시기 구분으로 서주 후기에 조성된 무덤이다. 그런데 이 무덤에는 중국 중원식 청동예기는 물론 토착식 청동예악기와 토착식과 중원식이 혼합되어 있는 혼합식 청동예기가 다량으로 출토되었다. 소흑석구의 청동예기 조합은 같은 시기 중국 중원 지역의 예제와 정궤제(鼎?制)에 대비하여 볼 때 가장 낮은 신분인 사급(士級) 특일정(特一鼎)에 속한다. 그럼에도 불구하고 중국 중원 지역의 사급 고분들과는 달리 정(鼎)과 궤(?)를 제외한 다른 식기와 주기의 조합에서는 천자와 제후국(공국, 후국) 국군의 수준에 필적한다. 이러한 점은 악기가 부장되어 있는 것을 통해서도 드러난다. 소흑석구 8501호 대형 석곽묘의 청동예기 가운데 토착식과 혼합식은 현지의 금속기 제작 기술을 고려할 때 자체 제작한 것으로 판단된다. 그러나 서주식 청동예기는 형태와 문양은 물론 규격까지 중국 중원 지역과 동일하여 서주에서 제작된 것임이 분명하다. 중국 중원 지역의 여러 제후국에서 제작하여 사용되던 해당 제후국의 보기(寶器)가 소흑석구에 부장된 배경은 하가점상층문화와 서주 사이에 양측과 빈번하게 교류하던 별개의 문화권이 형성되어 있었던 점 등을 고려할 때, 소흑석구 집단에 의한 약탈이라기 보다는 소흑석구 집단과 이들 집단 간의 경제적인 교역과 정치문화적인 상호 관계에 따른 것으로 해석된다.