• 산업공학
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• 제10권1호
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• pp.209-222
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• 1997

The paper provides a methodology to obtain the automaticity indicator of a factory and the sequence of enabling technologies of factory automation. The automaticity indicator is the measure of the current automation status of a factory and can be used as a crucial criteria for the future automation schedule and investment. Although most industries have their own computation methods which usually consider the number of workers in the shop floor, this research covers five evaluation items of automation, such as, production facility, material transfer system, inspection and test system, information system, and flexibility. The detailed evaluation models are developed for each item. Automation sequencing prioritizes the enabling technologies of factory automation on the basis of several criteria which consist of two phases. The first phase includes the automation indicator and the second phase includes six sub-criteria such as production rate, quality, number of workers, capital investment, development duration, development difficulty. For this evaluation, AHP(Analytical Hierarchy Process) is introduced to prevent the decision maker's subject intention. As results of the automaticity indicator and automation sequence, the manager can save time and cost in building constructive and transparent automation plans.

• 말소리와 음성과학
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• 제5권4호
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• pp.157-169
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• 2013

Using a target detection task, this study compared the processing automaticity of phonemes and features in spoken syllable stimuli to determine the primitive representation in speech perception, phoneme or distinctive feature. For this, we modified the visual search task(Treisman et al., 1992) developed to investigate the processing of visual features(ex. color, shape or their conjunction) for auditory stimuli. In our task, the distinctive features(ex. aspiration or coronal) corresponded to visual primitive features(ex. color and shape), and the phonemes(ex. /$t^h$/) to visual conjunctive features(ex. colored shapes). The automaticity is measured by the set size effect that was the increasing amount of reaction time when the number of distracters increased. Three experiments were conducted. The laryngeal features(experiment 1), the manner features(experiment 2), and the place features(experiment 3) were compared with phonemes. The results showed that the distinctive features are consistently processed faster and automatically than the phonemes. Additionally there were differences in the processing automaticity among the classes of distinctive features. The laryngeal features are the most automatic, the manner features are moderately automatic and the place features are the least automatic. These results are consistent with the previous studies(Bae et al., 2002; Bae, 2010) that showed the perceptual hierarchy of distinctive features.

• 대한수의학회지
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• 제41권4호
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• pp.497-503
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• 2001

Evidence from the last 10 years have been suggested that melatonin mainly produce a depressant effect on the cardiac system, but we found an activating effect of melatonin on heart rate in this research. To determine the hypothesis that melatonin has dual effects on physiological behaviour of cardiac system, we investigated the effects of melatonin on heart rate in isolated rat atria and anesthetized rats. Regardless of concentration, melatonin produced bradycardia in the 84 cases of 148 experiments (57 %) and tachycardia in the 64 cases of 148 experiments (43 %). And in atrium, melatonin produced a decrease automaticity in 52 cases of 86 experiments (60 %) and increase automaticity in 40 % (34/86 cases). Also, these effects are not significnat relationship with concetration of melatonin. The melatonin-induced bradycardia in vivo was inhibited by pretreatment of atropine or bilateral cervical vagotomy. Also, in isolated atrium the melatonin-induced decrease in automaticity was inhibited by pretreatment of atropine. These melatonin-induced responses were potenitated by pretreatment of propranolol. The melatonin-induced tachycardia in vivo was inhibited by pretreatment of propranolol, nifedipine or bilateral cervical vagotomy, but not by pretreatment of atropine. The melatonin-induced incease in automaticity in isolated atrium was converted to decrease in automaticity by pretreatment of propranolol. In addition, the change in heart rate caused by adrenoceptor agonists was inhibited by pretreatment of melatonin. These results indicate that melatonin-induced bradycardia may be related to a muscarinic receptor activation and melatonin-induced tachycardia may be related to a $\beta$-adrenoceptor stimulation.

• The Korean Journal of Physiology and Pharmacology
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• 제12권5호
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• pp.267-274
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• 2008

Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, $Ca^{2+}$ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated $Na^+$ channel, whereas the later phase was driven by the reverse-mode operation of $Na^+/Ca^{2+}$ exchange current secondary to the accumulation of $Na^+$ and $Ca^{2+}$ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.

• Archives of Pharmacal Research
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• 제28권8호
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• pp.930-935
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• 2005

We have investigated the effects of relatively high concentration of carbachol (CCh), an agonist of muscarinic acetylcholine receptor (mAChR), on cardiac automaticity in mouse heart. Action potentials from automatically beating right atria of mice were measured with conventional microelectrodes. When atria were treated with $100{\mu}M$ CCh, atrial beating was immediately arrested and diastolic membrane potential (DMP) was depolarized. After exposure of the atria to CCh for $\~4 min$, action potentials were regenerated. The regenerated action potentials had lower frequency and shorter duration when compared with the control. When atria were pre-exposed to pirenzepine $(1{\mu}M)$, an $M_1$ mAChR antagonist, there was complete inhibition of CCh-induced depolarization of DMP and regeneration of action potentials. Pre-exposure to AFDX-116 (11 ({2-[(diethylamino)-methyl]-1-piperidyl}acetyl)-5, 11-dihydro-6H-pyridol[2,3-b][1,4] benzodiazepine-6-one base, $1{\mu}M$), an $M_2$ mAChR antagonist, failed to block CCh-induced arrest of the beating. However, prolonged exposure to CCh elicited gradual depolarization of DMP and slight acceleration in beating rate. Our data indicate that high concentration of CCh depolarizes membrane potential and recovers right atrial automaticity via $M_1$ mAChR, providing functional evidence for the role of $M_1$ mAChR in the atrial myocytes.

• 대한수의학회지
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• 제41권3호
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• pp.311-317
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• 2001

In this work we have investigated the physiological effects of $MgCl_2$ in isolated atrium, papillary muscle, perfused heart and anesthesized guinea pig, The addition or infusion of $MgCl_2$ (0~20 mM or mg/kg) to perfused hearts and to anesthesized guinea pigs induced a marked and dose-dependent negative chronotropic effect. The sinoatrial node automaticity could also be reduced by $MgCl_2$. The addition of $MgCl_2$to isolated atria and to papillary muscles induced a marked and dose-dependent negative inotropic effect. The threshold voltage could be increased by $MgCl_2$in papillary muscle. Increasing $MgCl_2$ shortened the action potential duration (APD) in dose-dependent manner at 30% ($APD_{30}$) and 90% repolarization ($APD_{90}$) measured with conventional microelectrode technique in papillary muscle. In anesthesized guinea pig, the magnesium infusion resulted in a dose-dependent drop in blood pressure. These results suggested that magnesium is closely associated with cardiac physiological condition and exerts antiarrhythmic activities.

• 복식
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• 제55권4호
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• pp.29-37
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• 2005

Beauty Art is an act which makes a face beautiful using various methods such as permanent, manicure and make-up. Recently, Beauty Art is recognized as the personal culture expressing the value of beauty and spirit. Therefore, there are growing interests in the comprehensive study of Beauty Art nor only from the beauty industries but also from academia, because Beauty Art is the high value-added field and Is recognized as a style of the dress. The purpose of this study is to open a new view to understand the Nail Art as a fold of experimental plastic art. The arctic expression is added to Beauty Art to develop it from the routine technique of the make-up and hairstyling to creative art. Assemblage is adopted to provide Beauty Art with fine harmonious expression which develop Nail Art into interesting and unique art area. Assemblage meaning compounding or collection is a technique through which three-dimension is added to two-dimension paintings, and which is an expression of an art work by recollection of miscellaneous articles or waste materials. Assemblage is a term which Jean Dubuffet coioned first in order to differentiate collage used by Picaso or Braque. Here, I present Nail Art Designs which applied Jean Dubuffet's works focusing on Automaticity and Happenstantial phenomena of materials, Materialization, and Directness. These features are characteristics of Assemblage which basic frameworks are fantastic collection, accumulation, constructive collection, and object collection.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제1회 추계심포지움 and 제2회 생리분자과학연구센터워크숍
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• pp.25-27
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• 1993

The effect of alpha$_1$-adrenergic stimulation on cardiac automaticity changes during myocardial development. To illustrate, in isolated tissues from the mature canine heart, alpha$_1$-adrenergic stimulation usually induces a decrease in automatic rate. On the other hand, many early neonatal fibers exhibit an increase in automatic rate In response to alpha$_1$-agonists, which is not seen in the adult.

• Journal of Chest Surgery
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• 제27권5호
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• pp.339-344
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• 1994

Sinus node dysfunction is common after orthotopic heart transplantation.Electrophysiologic studies have documented a high incidence [46% to 50%] of impaired sinus node automaticity and sinoatrial conduction in the early posttransplantation period. Sinus node dysfunction persists in over 20 % of patients and leads to prolonged bradyarrythmias, including sinus or nodal bradycardia and sinus arrest.The purpose of this paper was to observe sinus node dysfunction after orthotopic heart transplantation. Ten cardiac recipient dogs were monitored continuously after orthotopic transplantations between unrelated adult mongrel dogs. Crystalloid cardioplegic solution [Choongwoi Cardioplegia

• 한국재난정보학회 논문집
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• 제18권3호
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• pp.495-506
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• 2022

연구목적: 일반적으로, 사람들은 일상생활 속에서 자신이 어떻게, 어디서 걷는지 등에 대해 많은 관심을 기울이지 않는 경향이 있다. 하지만, 심각한 화재나 지진이 일어났을 때, 사람들은 가능한 한 빨리 위험지역에서 벗어나려고 노력한다. 만일 사람들이 비상상황에서 의사결정 이론에 근거하여 탈출하게 된다면, 사상 자는 크게 줄어들게 될 것이다. 본 연구는 심리학적인 관점과 인지과학의 관점으로 인간의 행동을 보다 구체적으로 이해하고자 한다. 연구방법: 본 연구에서는 유튜브, CCTV 등에서 얻은 비상상황에서의 영상자료를 수집하여 상황별 사람들의 보행 특성을 분류하였다. 연구결과: 비상상황에서의 보행자의 속도나 방향 전환이 평상시와 전혀 다른 특징을 가지는 것으로 나타났다. 재난 발생 시 탈출 방향이 주로 한 방향이기 때문에, 방향전환이 적으며, 평균 보행속도가 상대적으로 높은 것으로 나타났다. 분석결과, 평상시에서의 인간의 행동은 살면서 학습한 습관에 기반하지만 비상 상황의 경우, 원초적인 본능에 기반하는 것으로 나타났다. 결론 : 본 연구에서 활용된 방법론과 연구 결과는 비상상황에서 사람들의 보행 행태에 대한 시뮬레이션과 분석에 활용 될 수 있을것으로 판단된다.