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Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes  

Youm, Jae-Boum (National Research Laboratory for Mitochondrial Signaling, Department of Physiology and Biophysics, College of Medicine, Inje University)
Leem, Chae-Hun (Department of Physiology and the Institute for Calcium Research, University of Ulsan College of Medicine)
Zhang, Yin Hua (Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital)
Kim, Na-Ri (National Research Laboratory for Mitochondrial Signaling, Department of Physiology and Biophysics, College of Medicine, Inje University)
Han, Jin (National Research Laboratory for Mitochondrial Signaling, Department of Physiology and Biophysics, College of Medicine, Inje University)
Earm, Yung-E. (Department of Physiology and National Research Laboratory for Cellular Signalling, Seoul National University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.12, no.5, 2008 , pp. 267-274 More about this Journal
Abstract
Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, $Ca^{2+}$ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated $Na^+$ channel, whereas the later phase was driven by the reverse-mode operation of $Na^+/Ca^{2+}$ exchange current secondary to the accumulation of $Na^+$ and $Ca^{2+}$ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.
Keywords
Stretch; Automaticity; Atrial fibrillation; Modeling;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
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