• Toxicological Research
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• 제35권4호
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• pp.343-351
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• 2019

Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made intermittent attempts to introduce in vitro assays as screening tests for developmental toxicity of inhouse candidate products. Two cell-based assays which were developed two decades apart were intensively studied. One was an assay of inhibitory effects on mouse ascites tumor cell attachment to a concanavalin A-coated plastic sheet surface (MOT assay), which we studied in the early days of assay development. The other was an assay of inhibitory effects on the differentiation of mouse embryonic stem cell to beating heart cells (EST assay), which we assessed more recently. We evaluated the suitability of the assays for screening in-house candidates. The concordance rates with in vivo developmental toxicity were at the 60% level. The EST assay classified chemicals that inhibited cell proliferation as embryo-toxic. Both assays had a significant false positive rate. The assays were generally considered unsuitable for screening the developmental toxicity of our candidate compounds. Recent test systems adopt advanced technologies. Despite such evolution of materials and methods, the concordance rates of the EST and MOT systems were similar. This may suggest that the fundamental predictivity of in vitro developmental toxicity assays has remained basically unchanged for decades. To improve their predictivity, in vitro developmental toxicity assays should be strictly based on elucidated pathogenetic mechanisms of developmental toxicity.

• 한국식생활문화학회지
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• 제21권4호
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• pp.396-405
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• 2006

The purpose of this study was to analyze the effect of the consumer-brand relationship quality on revisit intent and recommendation intent in the family restaurant. The questionnaires were distributed to 320 students in the K University located in Masan, who were sampled by convenience-sampling method. The surveys were conducted from November,10 to 24,2005. The 287 questionnaires were responded, and 15 unusable questionnaires were excluded, then 272 were used for the final analysis(response rate: 85.0%). The result of this study showed that 3 constructs(self-connective attachment, satisfaction and intimacy) of consumer-brand relationship quality have significant effects on the revisit intent(p<.01) and 2 constructs(satisfaction and intimacy) of consumer-brand relationship quality had significant positive effects on the recommendation intent in the family restaurant(p<.01) It meant that as consumer-brand relationship quality became stronger, the customer's revisit intent and recommendation intent became greater. As a conclusion, the foodservice manager in the family restaurant should focus on the marketing strategy to strengthen the quality of consumer-brand relationship especially emphasizing on satisfaction and intimacy in order to increase the revisit intent and recommendation intent of customers.

• 한국의류학회지
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• 제48권1호
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• pp.94-107
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• 2024

This study developed compression pants with excellent wearability and signal quality by approaching the design of wireless sEMG monitoring pants from the perspective of technical design, including the evaluation of wearability and the stable wireless transmission of signals through electrode and circuit design, and using e-textiles. An electrode, sewn with silver thread and a circuit stitched in a zigzag pattern using stainless steel wire, were applied. Additionally, polyurethane sealing tape was used to enhance adherence to the skin and reduce electrical resistance. Conductive snaps completed the design, allowing attachment and detachment to the bio-signal acquisition mainboard. Through the subjects' evaluation, it was determined that the final pants were applied with a pattern reduction rate of 25% to provide superior comfort according to different body parts while also minimizing skin irritation around the thigh circuit. The final pants for wireless sEMG monitoring, which demonstrated stable transmission of wireless measurements, was positively evaluated in terms of cognitive acceptability. This study is significant in that it achieved an optimal design by considering both technical aspects and the electrical characteristics of bio-signal monitoring garments, as well as the wearer's perception when designing smart wear.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.179-179
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• 2016

A radio-frequency (RF) Inductively Coupled Plasma (ICP) torch system was used for boron-nitride nano-tube (BNNT) synthesis. Because of electrodeless plasma generation, no electrode pollution and effective heating transfer during nano-material synthesis can be realized. For stable plasma generation, argon and nitrogen gases were injected with 60 kW grid power in the difference pressure from 200 Torr to 630 Torr. Varying hydrogen gas flow rate from 0 to 20 slpm, the electrical and optical plasma properties were investigated. Through the spectroscopic analysis of atomic argon line, hydrogen line and nitrogen molecular band, we investigated the plasma electron excitation temperature, gas temperature and electron density. Based on the plasma characterization, we performed the synthesis of BNNT by inserting 0.5~1 um hexagonal-boron nitride (h-BN) powder into the plasma. We analysis the structure characterization of BNNT by SEM (Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy), also grasp the ingredient of BNNT by EELS (Electron Energy Loss Spectroscopy) and Raman spectroscopy. We treated bundles of BNNT with the atmospheric pressure plasma, so that we grow the surface morphology in the water attachment of BNNT. We reduce the advancing contact angle to purity bundles of BNNT.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권2호
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• pp.163-168
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• 2001

Purpose : This study is conducted to evaluate the clinical success of secondary alveolar bone grafting using autogenous iliac particulate cancellous bone marrow in cleft maxilla. Materials and methods : We evaluated 107 cleft patients who had been admitted to the Dept. of Oral and Maxillofacial Surgery of Pusan National University Hospital from January 1, 1991 to January 31, 1999 and had been performed secondary alveolar bone grafting with autogenous particulated cancellous bone marrow from iliac crest. Results : 1. Men were 70 and women were 37, which shows 65.4% and 34.6% and the proportion of males to females was 1.9:1. Unilateral cases were 89(83.2%) and bilateral cases were 18(16.8%). 2. Age of bone grafting is widely distributed from 7 to 29, and the average was 13.2. 3. Success rate was 97.8% in unilateral cases, 94.4% in bilateral cases. Overall success rate was 96.7%. 4. We evaluated the bone graft contour by the percentage of bone attachment level adjacent to the alveolar cleft and the menial side showed 82.4% and the distal 87.7%. 5. The amount of notching the alveolar ridge at the grafted site through the ratio of notching length up to the most apical base to the length of proximal segment anatomic root was 0.19.

• 한국산업정보학회논문지
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• 제17권7호
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• pp.209-214
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• 2012

본 논문은 항만폐기물 수거에 및 관리에 자동인식 시스템인 RFID를 활용하기 위한 선행연구로써, 최근 급속히 늘고 있는 구리와 아연합금의 양식용 철제 가두리에 대하여 RFID를 부착하는 효율적인 방안을 제시하고자 한다. 이는 재활용률 향상과 환경오염 예방을 위하여 꼭 해결이 필요한 과제인데, 철제 가두리는 사용 환경 특성으로 인하여 수분이 함유된 철제 어구(fishing equipment)인 바, 금속 혹은 고무, 유리 등과 같은 물질에 RFID 태그를 부착할 때 발생하는 RFID 인식률과 관련된 중요한 기술적 난제인 RFID에너지의 반사와 흡수 현상을 극복할 수 있는 실용적 방안이 강구되어야 한다. 최근 스티로폼(Styrofoam)이나 합성수지 등을 이용하여 금속에 부착할 수 있는 900MHz 대역의 금속태그가 개발되어 보급되고 있으나, 이 또한 일반 태그에 비하면 가격이 상대적으로 고가인 현실적인 문제점이 있다. 본 연구에서는 전형적 금속형 어구인 철제 가두리를 대상으로 RFID 인식률 향상을 위한 스치로폼 패드(styrofoam pad) 활용 방안을 제시하고, 아울러 안테나 각도 등의 리더기 활용 최적조건 등을 실험을 통하여 살펴본다. 실험계획 및 분석은 다구찌(Taguchi)기법을 적용하였고, Minitab S/W를 활용하였다. 실험결과로써, 스티로폼 패드의 두께는 두꺼울수록 좋으며, 태그의 부착위치는 모서리(edge)부분, 리더기 각도는 $0^{\circ}$(정면)가 인식률이 가장 좋은 것으로 나타났다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권6호
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• pp.620-627
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• 2000

The purpose of this study is to investigate the clinical and histologic changes in distraction osteogenesis according to different distraction rates in the rat's tibia. Eighteen adult rats underwent open osteotomy and attachment of an external unilateral distraction device in the middle of left tibia. Latency was allowed for 7 days before distracton began. The distraction device was activated with varying distraction rates of 0.5mm, 1mm, 2mm and same rhythm of twice a day until 5mm length gain was achieved. The animals were sacrificed at post-distraction 4, 8 weeks to observe the bony healing states. At each group, clinical, radiographic and histologic studies were done. The results obtained from this study were as follows: 1. The 0.5mm group showed excellent osteogenesis than other groups. The new bone was formed by intramembranous bone formation mostly and endochondral bone formation partly. 2. The 1mm group showed delayed osteogenesis and incomplete bony healing at 8 weeks. 3. The 2mm group showed weak osteogenesis and fibrous union or nonunion at 8 weeks. From these results, it could be stated that distraction rate of 0.5mm per day was most useful in rat's tibia. The rate of 1mm showed delayed bony healing and needed more consolidation period. Distraction osteogenesis is a excellent clinical method for regenerating local bone deficiencies in limbs and craniofacial area. The more studies needed for the higher animals and human about distraction rates and other biomechanical factors on the basis of this study.

• 한국양식학회지
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• 제9권2호
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• pp.109-115
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• 1996

우리나라 연안성에서 가장 중요한 양식대상종의 하나인 참전복의 표식 방류효과에 관한 조사는 보고된 바 없는 실정이다. 따라서 본 연구는 우리 배양장에서 자체 생산된 참전복의 표지 방법별 효과를 검토하고, 방류효과를 구명함으로서 연안 자원의 증강을 도모 하고자 1994년 11월 10일 부터 1995년 3월 30일까지 조사한 결과를 요약하면 다음과 같다. 1. 참전복의 표지 및 표시 방법별 효과는 Al-teco에 의한 표지 부착이 가장 좋았다. 2. 실내 사육에 의한 표지의 탈락 및 폐사율은 각각 $6.7\%$ 및 $8.3\%$였고, 표지에 의한 폐사는 없었다. 3. 실내 사육 및 방류한 표지 개체는 실험 개시시 각구 공히 평균각장 및 전중량이 1.0 cm, 0.092 g 이던 것이 실험종료시에는 각각 1.80cm, 0.74 g, 1.68 cm, 0.68 g으로 성장하였다. 4. 재포된 모든 개체의 분포 중심 수심은 2.6m 였다. 재포된 모든 개체의 평균 이동 거리는 2.6m 였다. 6. 어획사망계수, 자연사망계수 및 전사망계수의 추정치는 각각 0.0195, 0.4652, 0.4847였다.

• 공업화학
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• 제18권2호
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• pp.136-141
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• 2007

본 연구에서는 열플라즈마를 이용하여 클로로메탄 즉 사염화탄소($CCl_4$), 삼염화탄소($CCl_3H$), 이염화탄소($CCl_2H_2$)를 분해하는 실험을 수행하였으며 열플라즈마분해공정의 특성에 대한 연구를 진행하였다. Factsage program을 이용하여 열역학적 평형조성을 알아보았으며, 또한 Gas chromatography를 이용하여 농도, 캐리어 가스의 유량 및 quenching 속도등 세가지 변수의 변화에 따른 분해율을 살펴보았다. 실험 결과 92%이상의 높은 분해율을 얻었다. FT-IR을 이용하여 최종 생성물을 확인한 결과 중성 분위기에서는 주로 카본, 염소, 염화수소가 생성되었고 산화 분위기에서는 카본의 생성이 억제되었으며 주로 이산화탄소, 염화수소, 염소가 생성되었다. FT-IR생성물에 대한 분석과 Factsage program에 의한 온도 분포 별 생성된 라디칼 및 기타 입자의 종류와 결부하여 이에 따른 분해 메커니즘에 대해 알아보았다. 분해 경로는 주로 라디칼에 의한 산화반응과 전자 부착에 의한 분해 반응으로 이루어짐을 확인하였다.

• 한국수산과학회지
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• 제44권3호
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• pp.259-266
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• 2011

To produce cupped oyster sprat consistently, we investigated the efficiency of nine settlement substrates using selective breeding of Pacific oyster Crassostrea gigas, with the goal of popularizing off-bottom culture on the west coast of Korea. We also compared the growth and survival of selectively bred sprat (diploid) with triploid sprat from an off-bottom culture system. Considering, the attachment rate and detachment efficiency, producing cupped oyster in a polypropylene gunny bag proved to be the most effective method. There were no differences in shell growth or total weight between the diploids from selective breeding and triploids from off-bottom culture for 5 months. However, the survival rate was 8 times higher in the diploids than the triploids. Transplanting sprat from selective breeding is one way to restore oyster farms and nurture off-bottom culture along the west coast.