• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.98.1-98
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• 1999

No Abstract, See Full Text

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.481-481
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• 2005

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2001년도 Korean Environmental Mutagen Society
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• pp.183-183
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• 2001

• Biomolecules & Therapeutics
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• 제18권3호
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• pp.286-293
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• 2010

Cytokine production is a sensitive indicator for monitoring perturbations of the immune system by xenobiotics in animals and humans. In the present study, we evaluated the changes in $IFN{\gamma}$, IL-5 and $TNF{\alpha}$ mRNA expression after atrazine (ATZ), perfluorooctanoic acid (PFOA) or zearalenone (ZEA) exposure in Jurkat cells. The IC50 (concentration for a 50% inhibition of cell proliferation) of PFOA and ZEA after 3 days culture were $226.6\;{\mu}M$ and $52.6\;{\mu}M$, respectively. The effects of ATZ on cytokine expression followed in increasing order of $IFN{\gamma}$>IL-5>$TNF{\alpha}$ at $3\;{\mu}M$ and at the lower concentrations the degree of effects on three cytokines were less clear between the cytokines when compared to control level. PFOA had marked increasing effect in order of $IFN{\gamma}$>$TNF{\alpha}$>IL-5 mRNA expression at IC50, and these patterns were continued at the lower concentrations, IC50/2 and IC50/4. ZEA caused the overexpression of cytokine mRNAs in order of IL-5>$IFN{\gamma}$>$TNF{\alpha}$ at both IC50 and IC50/2, and at IC50/4 the overexpression order was IL-5>$TNF{\alpha}$. On other hand, $IFN{\gamma}$ was less distinct compared to the control. These data indicate that ATZ, PFOA and ZEA caused the overtranscription of $IFN{\gamma}$, IL-5 and $TNF{\alpha}$ mRNA, and the overproduction of these cytokines may eventually lead to immune disorders.

• 한국잡초학회지
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• 제10권2호
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• pp.99-102
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• 1990

새로운 양질(良質) 초다수성(超多收性) 화본과(禾本科) 사료작물(飼料作物)인 진주(眞珠)조(Pennisetum americanum(L.) Leeke)의 잡초방제(雜草防除)에 적합(適合)한 제초제(除草劑)를 선발(選拔)하기 위하여 청예(靑刈)조(수원1호(水原1號))를 공시(供試), 선택성(選擇性) 제초제(除草劑)인 triazine 제초제(除草劑) Propazine, Atrazine, Simazine, acid amide 제초제(除草劑) Alachlor, dinitroaniline 제초제(除草劑) Pendimethalin 및 비선택성제초제(非選擇性除草劑) Paraquat를 사용(使用)하여 잡초방제시험(雜草防除試驗)을 수원(水原)에서 1986~'89년(年)까지 실시(實施)하여 얻은 주요연구결과(主要硏究結果)는 다음과 같다. 1. Propazine(Milogard 4L) 250cc/10a 철포구(撤布區)에서 잡초방제효과(雜草防除效果)가 가장 컸고 진주(眞珠)조의 출아(出芽) 및 생육(生育)에 약해(藥害)가 거의 없었으며 생존율(生存率)도 다른 공시제초제(供試除草劑)에 비하여 가장 높았다. 2. Atrazine과 Simazine을 살포(撒布)할 때는 진주(眞珠)조의 생존율(生存率)이 손제초구(除草區)에 비하여 낮았으나 출아후(出芽後) 약해(藥害)는 거의 없었다. 3. 진주(眞珠)조 파종직후(播種直後)에 Alachlor를 살포(撒布)하였을 때는 거의 대부분(大部分)이 출아(出芽)하지 않았으며 Pendimethaline을 살포(撒布)하였을 때는 진주(眞珠)조의 생존율(生存率)이 33~38%에 불과(不過)하였다. 4. 진주(眞珠)조에 약해(藥害)가 비교적(比較的) 없으며 잡초방제효과(雜草防除效果)도 높은 Propazine은 현재(現在) 국내(國內)에서 시판(市販)이 되고 있지 않으므로 진주(眞珠)조 파종적기(播種適期) 1~2주전(週前)에 파종준비(播種準備)(경운(耕耘), 정지(整地), 시비(施肥) 등)를 완료(完了)하여 두었다가 파종직전(播種直前)에 출아(出芽)한 잡초(雜草)를 비선택성(非選擇性) 제초제(除草劑)(Paraquat 등)로 완전(完全)히 방제(防除)한 다음에 진주(眞珠)조를 파종(播種)하면 잡초문제(雜草問題)를 해결(解決)할 수 있었다. 현재(現在) 시판(市販)되고 있는 Simazine은 진주(眞珠)조의 파종(播種)골에은 살포(撒布)하지 말고 휴간(畦間)의 잡초(雜草)만 방제(防除)할 수 있어 진주(眞珠)조의 수량성(收量性)을 높이면서 생산비(生産費)를 절감(節減)할 수 있다.

• Bulletin of the Korean Chemical Society
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• 제10권2호
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• pp.196-200
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• 1989

Some s-triazine herbicides, namely simazine, atrazine, and propazine present as trace components in a complex mixture were analyzed by GC/MS and GC/MS/MS methods. Even though monitoring the molecular ions was the best in terms of sensitivity, adequate analysis could not be done when interfering species were present. When doubly charged ions which appeared at characteristic m/z values were monitored, chromatograms were rather free from interference. More importantly, selected reaction monitoring was found to provide a selective means of detection with general applicability.

• 분석과학
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• 제15권6호
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• pp.489-495
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• 2002

본 연구는 우리나라 수계에 서식하는 어류와 양서류에 대해 trifluralin, atrazine, metribuzink, alachlor, malathion, nitrofen, permethrin, cypermethrin, fenvalerate, parathion 등의 유기 농약의 잔류실태를 조사한 것이다. 전국의 주요 하천 유역 31개 지점에서 양서류와 어류를 채집하였으며, 이들의 근육 부분을 최종 분석시료로 하였다. 전처리 과정에서 아세토니트릴로 추출한 후 n-헥산으로 씻어 지질성분을 제거하고 정제수를 넣고 디클로로메탄으로 재추출하였다. 추출액을 탈수 농축하여 플로리실 컬럼으로 정제한 후 동위원소 표준물질을 첨가하여 GC-MS를 이용하여 분석하였다. 검출된 농도 범위는 양서류에서는 $0.17{\sim}6.8{\mu}g/kg$, 그리고 어류에서는 cypermethrin이 최대 $16{\mu}g/kg$을 비롯해서 $0.26{\sim}16{\mu}g/kg$의 농도로 검출되었다.

• Mass Spectrometry Letters
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• 제9권3호
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• pp.77-80
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• 2018

The focus of this paper is to present techniques to overcome certain difficulties in quantitative analysis with a time-of-flight mass spectrometer (TOF-MS). The method is based on conventional solid-phase extraction, followed by reversed-phase ultra high performance liquid chromatography of the extract, and mass spectrometric analysis. The target compounds included atenolol, atrazine, caffeine, carbamazepine, diclofenac, estrone, ibuprofen, naproxen, simazine, sucralose, sulfamethoxazole, and triclosan. The matrix effects caused by high concentrations of organic compounds in wastewater are especially significant in electrospray ionization mass spectroscopy. Internal-standard calibration with isotopically labeled standards corrects the results for many matrix effects, but some peculiarities were observed. The problems encountered in quantitation of carbamazepine and triclosan, due to nonlinear calibration were solved by changing the internal standard and using a narrower mass window. With simazine, the use of a quadratic calibration curve was the best solution.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.175-175
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• 2001

This experiment tested whether in utero and lactational exposure to 4-nonylphenol (NP) alters mammary gland differentiation in the female offspring rat. Pregnant Sprague Dawley rats were administered NP (l0, 100 mg/kg), atrazine (l00 mg/kg), pesticide demonstrating antiestrogenic activity in mammary gland development, or vehicle (0.5% methyl cellulose) by oral gavage from gestation day 15-19.(omitted)

• The Korean Journal of Ecology
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• 제15권3호
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• pp.257-265
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• 1992

The effects of insecticide dimilin including the technical grade(tg) and wettable power(wp-25), inhibiting the synthesis of chitin in the cuticle of insect larvae, and herbicides alachlor and atrazine on the development of shrimp caridina denticulata denticulata were investigated in various concentrations. This species is abundant in the freshwater such as river and pond. The shrimp larvae were reared at dimilin solutions(tg and wp 2), alachlor solutions, and atrazin solutions. the concentrations of dimiline were 0, 1, 5, 10 and 25 ppb dimilin solutions, and those of alachlor and atrazin were 0, 1, 5, 10 and 25ppm, respectively.mortality was high at 10 ppb when the larvae were exposed to dimilin and at 25ppm in the case of alachlor and atranzine solutions. If lethal concentration is defined as a concentration in which less than 10% of larvae to the post larval stage from hatching it can be concluded that the lethal concentration of dimilin is 5ppb, and that of alachlor and atrazin is 25 ppm.