• Mycobiology
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• v.47 no.3
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• pp.346-349
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• 2019

AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress such as salt stress. Snf1 regulates metabolic enzymes such as acetyl-CoA carboxylase, indicating a possible role for Snf1 in metabolic regulation. In this article, we performed nuclear magnetic resonance (NMR) spectroscopy to profile the metabolic changes induced by Snf1 under environmental stress. According to our NMR data, we suggest that Snf1 plays a role in regulating cellular concentrations of a variety of metabolites during environmental stress responses.

• Archives of Pharmacal Research
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• v.27 no.1
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• pp.1-12
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• 2004

Initial burst is one of the major challenges in protein-encapsulated microparticle systems. Since protein release during the initial stage depends mostly on the diffusional escape of the protein, major approaches to prevent the initial burst have focused on efficient encapsulation of the protein within the microparticles. For this reason, control of encapsulation efficiency and the extent of initial burst are based on common formulation parameters. The present article provides a literature review of the formulation parameters that are known to influence the two properties in the emulsion-solvent evaporation/extraction method. Physical and chemical properties of encapsulating polymers, solvent systems, polymer-drug interactions, and properties of the continuous phase are some of the influential variables. Most parameters affect encapsulation efficiency and initial burst by modifying solidification rate of the dispersed phase. In order to prevent many unfavorable events such as pore formation, drug loss, and drug migration that occur while the dispersed phase is in the semi-solid state, it is important to understand and optimize these variables.

• Advances in nano research
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• v.10 no.5
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• pp.437-448
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• 2021

In this article, an analytically and numerically 3D nanoliquid flow by a porous rotatable disk is presented in the presence of gyrotactic microorganisms. The mathematical model in the form of partial differential system is transmuted into dimensionless form by utilizing the appropriate transformation. The homotopy analysis approach is applied to attain the analytic solution of the problem. The effect of promising parameters on velocity distribution, temperature profile, nanoparticles volume fraction and motile microorganism distribution field are evaluated through graphs and in tabular form. The existence of Brownian motion and thermophoresis impacts are more proficient for heat transfer enhancement. Further the unique features like heat absorption/generation and energy activation are also examined for the present flow problem. The obtained results are compared with the earliear investigation to check the accuracy of present model.

• Archives of Craniofacial Surgery
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• v.22 no.6
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• pp.287-295
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• 2021

Orthognathic surgery has steadily evolved, gradually expanding its scope of application beyond its original purpose of simply correcting malocclusion and the facial profile. For instance, it is now used to treat obstructive sleep apnea and to achieve purely cosmetic outcomes. Recent developments in three-dimensional digital technology are being utilized throughout the entire process of orthognathic surgery, from establishing a surgical plan to printing the surgical splint. These processes have made it possible to perform more sophisticated surgery. The goal of this review article is to introduce current trends in the field of orthognathic surgery and controversies that are under active discussion. The role of a plastic surgeon is not limited to performing orthognathic surgery itself, but also encompasses deep involvement throughout the entire process, including the set-up of surgical occlusion and overall surgical planning. The authors summarize various aspects in the field of orthognathic surgery with the hope of providing helpful information both for plastic surgeons and orthodontists who are interested in orthognathic surgery.

• International Journal of Computer Science & Network Security
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• v.21 no.11
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• pp.11-16
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• 2021

The article proposes that empathy differs in severity and types among students of different specialties. And to test this hypothesis, an experimental study of students from 4 different faculties was carried out. As a result of the study, it was found that empathy is more pronounced among students of "humanitarian" specialties, and students of "exact" specialties have the least pronounced empathic abilities.

• Journal of Korean Society of Forest Science
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• v.83 no.1
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• pp.63-74
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• 1994

One of the essential factors to estimate the stem and stand growth is to correctly portray a stem form (profile). It is also required to numerically approximate a stem form in order to dynamically grasp and represent a stand growth. A whole stem form seems to be a conical form but a stem outline at various positions tapers off differently. Accordingly it is difficult to model a whole stand form with single taper equation. A stem taper equation with different coefficients on each subinterval can be useful tools to accurately portray a stem form. This article presents the derivation method of individual stem taper curve using spline function. It is also in this paper aimed to study how a stand taper curve car, be derived from the population of single stem taper curve in a stand. These taper equations numerically formulated enable to dynamically represent and prognosticate the development process of a stand and prepare the foundation of variety on growth model study and rational forest planning model.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.1
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• pp.37-53
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• 2021

The purpose of this study is to analyze the types of latent profiles depending on the job satisfaction of youth entrepreneurs in South Korea and examine the influence of related variables. Latent profile analysis (LPA) was conducted using data from the 12th year of the Youth Panel Study. Results of the study revealed that there were five latent profiles based on job satisfaction among young entrepreneurs: lowest job satisfaction, mid-low job satisfaction, middle job satisfaction, mid-high job satisfaction, and highest job satisfaction. By applying multinomial logistic analysis, the influencing factors for each latent profiles have been derived. Gender, marital status, subjective health, self-esteem, entrepreneurial motivation, difficulty in start-up, person-job fit, intrinsic or extrinsic job values, business scale, income, work hour, education or training, and labor insurance were significant predictors of youth entrepreneurs' job satisfaction. Based on these results, the article discusses practical implications that can enhance the job satisfaction of young entrepreneurs.

• Earthquakes and Structures
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• v.9 no.4
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• pp.789-830
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• 2015

The recent re-assessment of the seismic hazard in Europe led for many regions of low to moderate seismicity to an increase in the seismic demand. As a consequence, several modern unreinforced masonry (URM) buildings, constructed with reinforced concrete (RC) slabs that provide an efficient rigid diaphragm action, no longer satisfy the seismic design check and have been retrofitted by adding or replacing URM walls with RC walls. Of late, also several new construction projects have been conceived directly as buildings with both RC and URM walls. Despite the widespread use of such construction technique, very little is known about the seismic behaviour of mixed RC-URM wall structures and codes do not provide adequate support to designers. The aim of the paper is therefore to propose a displacement-based design methodology for the design of mixed RC-URM edifices and the retrofit of URM buildings by replacing or adding selected URM walls with RC ones. The article describes also two tools developed for estimating important quantities relevant for the displacement-based design of structures with both RC and URM walls. The tools are (i) a mechanical model based on the shear-flexure interaction between URM and RC walls and (ii) an elastic model for estimating the contribution of the RC slabs to the overturning moment capacity of the system. In the last part of the article the proposed design method is verified through nonlinear dynamic analyses of several case studies. These results show that the proposed design approach has the ability of controlling the displacement profile of the designed structures, avoiding concentration of deformations in one single storey, a typical feature of URM wall structures.

• Safety and Health at Work
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• v.9 no.3
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• pp.265-276
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• 2018

Background: Resilience engineering is a paradigm for safety management that focuses on coping with complexity to achieve success, even considering several conflicting goals. Modern sociotechnical systems have to be resilient to comply with the variability of everyday activities, the tight-coupled and under-specified nature of work, and the nonlinear interactions among agents. At organizational level, resilience can be described as a combination of four cornerstones: monitoring, responding, learning, and anticipating. Methods: Starting from these four categories, this article aims at defining a semiquantitative analytic framework to measure organizational resilience in complex sociotechnical systems, combining the resilience analysis grid and the analytic hierarchy process. Results: This article presents an approach for defining resilience abilities of an organization, creating a structured domain-dependent framework to define a resilience profile at different levels of abstraction, and identifying weaknesses and strengths of the system and potential actions to increase system's adaptive capacity. An illustrative example in an anesthesia department clarifies the outcomes of the approach. Conclusion: The outcome of the resilience analysis grid, i.e., a weighed set of probing questions, can be used in different domains, as a support tool in a wider Safety-II oriented managerial action to bring safety management into the core business of the organization.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.1
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• pp.69-85
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• 2024

Objectives : By analyzing articles on xerostomia and burning mouth syndrome, two representative diseases that cause various symptoms in oral cavity. Methods : We analyzed articles by dividing them into review articles, original articles, case reports. The subjects were 11 articles on xerostomia and 13 articles on burning mouth syndrome published in Korean medical journals. Results : 1. The subjects were 11 articles on xerostomia and 13 articles on burning mouth syndrome published in Korean medical journals. 2. The first article was published in 2007 and the most published articles were three each in 2013, 2018 and 2022. 3. Classification by type of article was as follows: 2 review articles(8.3%), 16 original articles(66.7%) and 6 case reports(25.0%). 4. The journal with the most published articles was journal of internal Korean medicine and the topics were xerostomia(72.7%), burning mouth syndrome(76.9%). 5. For both diseases, the number of female patients was higher than that of male patients. 6. The main symptom of xerostomia is dryness in the mouth and the main symptom of burning mouth syndrome is pain in the oral cavity. 7. Questionnaires, diagnosis based on dialectics and diagnostic devices were used to diagnose xerostomia and burning mouth syndrome. Conclusion : Diagnosis of xerostomia and burning mouth syndrome require overall consideration the entire hum an body along with the oral cavity. Since there are many different diagnostic methods, appropriate methods must be carefully selected and used.