• 한국정보과학회논문지:소프트웨어및응용
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• 제30권9호
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• pp.867-875
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• 2003

본 논문에서는 연속 밀도 HMM 구조의 최적화 문제를 다룬다. HMM 구조의 최적화를 위해 여러 연구가 있었는데, 그 중에서도 잘 알려진 BIC(Bayesian Information Citerion)등과 같이 이미 제안된 모델 선택 기준은 동질의 파라미터를 갖는 데이타에 대해 통계적으로 잘 행동하는 모델을 가정하고 있어서 연속 밀도 HMM 등과 같이 복잡한 파라미터를 갖는 구조에는 적합하지 않고, 파라미터 수를 줄이는데는 어느 정도 효과가 있었으나 인식률 향상에 있어서는 한계를 보였다. 이에 본 논문에서는 HMM의 파라미터 유형에 따라 별도의 확률 밀도를 추정하여 사전 모델 확률(a priori model probability)로 사용하는 모델 선택 기준인 HBIC(HMM-oriented BIC)를 제안했다. 또한 HMM의 변별력을 높이기 위해 변별력 특성을 갖는 안티확률을 BIC와 결합한 새로운 모델 선택 기준인 BIC_Anti를 제안했다. 제안한 모델 선택 기준의 유용성을 검증하기 위해 온라인 필기 데이타를 대상으로 실험하여 기존의 연구와 비교하였다. 그 결과 제안한 HBIC와 BIC_Anti 모델 선택 기준을 사용하는 것이 BIC를 사용하는 것보다 더 적은 파라미터 수로도 향상된 인식률을 얻을 수 있음을 확인했다.

• Journal of Electrical Engineering and Technology
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• 제9권6호
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• pp.1921-1927
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• 2014

A new method for optimizing the magnetic field gradient in the exciting coil of electronic anti-fouling (EAF) system is presented based on changing exciting coil size. In the proposed method, two optimization expressions are deduced based on biot-savart law. The optimization expressions, which can describe the distribution of the magnetic field gradient in the coil, are the function of coil radius and coil length. These optimization expressions can be used to obtain an accurate coil size if the magnetic field gradient on a certain point on the coil's axis of symmetry is needed to be the maximum value. Comparing with the experimental results and the computation results using Finite Element Method simulation to the magnetic field gradient on the coil's axis of symmetry, the computation results obtained by the optimization expression in this article can fit the experimental results and the Finite Element Method results very well. This new method can optimize the EAF system's anti-fouling performance based on improving the magnetic field gradient distribution in the exciting coil.

• International Journal of Industrial Entomology and Biomaterials
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• 제17권1호
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• pp.109-113
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• 2008

Realizing the scope of utilizing by-products of silk cocoons by applying appropriate methods is the immediate crave to optimize returns. The nutritive value of pupae suits for human diet, feed for poultry, carps, fish, rabbits, piggery and dogs. The pupal skin, fat, oil, cocoon palade have applications in oleo chemical, soap, glycerin, cosmetic, artificial fibres, membranes and n-triacontanol isolation. The pupal proteins Chitin, Shinki fibroin, Serrapeptidase, glucosamine are latent precursors of post surgical, anti-carcinogenic, anti-inflammative, anti-bacterial, anti-histaminic, gastric, hepatitis, pancreatitis, leukocytopenia, neurological, ophthalmic, blood pressure, cardiac and diabetic medicines and for preparation of vitamins A, E and K. The silk and its proteins sericin and fibroin are potentially used for wound healing, diabetes, impotence, sinusitis, arthritis, edema, cystitis, epididymitis, tissue regeneration, cancer, post-surgical trauma and used as anti-oxidatives, bio-adhesives, ultra violet screens and bio-active textiles. The waste cocoons can be used in making art crafts like garlands, carpets, overcoats, decoratives and greeting cards. The in-depth research towards utility optimization and make aware this reality to sericulturists, reelers, weavers, traders, entrepreneurs, policy makers etc., is the upright want of the today's Sericulture industry.

• 제어로봇시스템학회논문지
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• 제16권2호
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• pp.134-139
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• 2010

In order to overcome some problems of existing anti-windup methods, this paper defines LQ (Linear Quadratic) observer and proposes a new anti-windup method using the LQ observer. LQ observer is derived by linear quadratic optimization in order to calculate controller states, which make the controller outputs equal to the plant inputs. And we propose an algorithm so that it can be implemented by a digital controller easily. The relationship between the design parameters and the anti-windup performance is shown via some numerical examples, which cover the cases with the anti-windup method using LQ observer designed and the case without it. Finally, the anti-windup performance of the proposed method is exemplified via comparison with the existing model-based conditioning scheme method[4].

• Biomolecules & Therapeutics
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• 제23권6호
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• pp.493-509
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• 2015

Antibody-drug conjugates utilize the antibody as a delivery vehicle for highly potent cytotoxic molecules with specificity for tumor-associated antigens for cancer therapy. Critical parameters that govern successful antibody-drug conjugate development for clinical use include the selection of the tumor target antigen, the antibody against the target, the cytotoxic molecule, the linker bridging the cytotoxic molecule and the antibody, and the conjugation chemistry used for the attachment of the cytotoxic molecule to the antibody. Advancements in these core antibody-drug conjugate technology are reflected by recent approval of Adectris$^{(R)}$(anti-CD30-drug conjugate) and Kadcyla$^{(R)}$(anti-HER2 drug conjugate). The potential approval of an anti-CD22 conjugate and promising new clinical data for anti-CD19 and anti-CD33 conjugates are additional advancements. Enrichment of antibody-drug conjugates with newly developed potent cytotoxic molecules and linkers are also in the pipeline for various tumor targets. However, the complexity of antibody-drug conjugate components, conjugation methods, and off-target toxicities still pose challenges for the strategic design of antibody-drug conjugates to achieve their fullest therapeutic potential. This review will discuss the emergence of clinical antibody-drug conjugates, current trends in optimization strategies, and recent study results for antibody-drug conjugates that have incorporated the latest optimization strategies. Future challenges and perspectives toward making antibody-drug conjugates more amendable for broader disease indications are also discussed.

• 한국군사과학기술학회지
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• 제18권1호
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• pp.66-83
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• 2015

Global Positioning System(hereafter; GPS) is recently an essential element in the various navigation and weapon delivery systems of military aircraft. However, GPS is vulnerable to the jamming threats since its signal power is very weak. Therefore, ROK defense has been concerning how to resolve this issue and how to integrate these systems needed, and is trying to acquire the proper anti-jamming GPS system. This study is to provide several schemes against the jamming threats effectively. We propose the several processes to analyze the required capability and demonstrate the result's of modeling and simulations(hereafter; M&S) for this integration of military aircraft, and the mathematical programming model for system optimization of military aircraft anti-jamming GPS system on the basis analysis of M&S results which could be considered available budget and the project characteristic. These schemes will be helpful on proper acquisition of these systems and. We are looking forward to contributing to the integration of anti-jamming GPS system of ROK military aircraft.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 춘계학술대회논문집
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• pp.120-123
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• 2005

A dynamic system identification technique based on the topology optimization method is developed. The specific problem in consideration is the damage location identification of a plate structure using the Frequency Response Function (FRF) of a damaged structure. In this work, the identification problem is formulated as a topology optimization problem. The importance of using anti-resonance information in addition to using resonance information is addressed. Though a simple problem was considered here, the possibility of using the topology optimization for damage identification is investigated lot the first time.

• 한국축산식품학회지
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• 제34권6호
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• pp.836-843
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• 2014

Obesity, a condition in which an abnormally large amount of fat is stored in adipose tissue, causing an increase in body weight, has become a major public health concern worldwide. The purpose of this study was to optimize the process for fermented milk for the production of a functional product with an anti-obesity effect by using Lactobacillus plantarum Q180 isolated from human feces. We used a 3-factor, 3-level central composite design (CCD) combined with the response surface methodology (RSM). Concentration of skim milk powder (%, $X_1$), incubation temperature ($^{\circ}C$, $X_2$), and incubation time (h, $X_3$) were used as the independent factors, whereas pH (pH, $Y_1$), anti-lipase activity (%, $Y_2$) and anti-adipogenetic activity (%, $Y_3$) were used as the dependent factors. The optimal conditions of fermented milk for the highest anti-lipase and anti-adipogenetic activity with pH 4.4 were the 9.5% of skim milk powder, $37^{\circ}C$ of incubation temperature, 28 h of incubation time. In the fermentation condition, the predicted values of pH, anti-lipase activity and anti-adipogenetic activity were 4.47, 55.55, and 20.48%, respectively. However, the actual values of pH, anti-lipase activity and anti-adipogenetic activity were 4.50, 52.86, and 19.25%, respectively. These results demonstrate that 9.5% of skim milk powder and incubation at $37^{\circ}C$ for 28 h were the optimum conditions for producing functional fermented milk with an anti-obesity effect.

• 한국강구조학회 논문집
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• 제25권4호
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• pp.441-449
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• 2013

손상을 입은 구조물은 고유 특성 값이 변한다. 본 연구는 건전상태의 고유 특성 값과 손상상태의 특성 값 차이를 사용하여 손상 탐지 하는 것을 목적으로 한다. 두 대비되는 모델간의 특성 차이를 극대화 시키는 조건을 찾는 역 최적화 기법이 사용되었다. 본 논문은 손상탐지 알고리즘 구축의 전 단계로 건전상태와 손상상태의 트러스 구조물 변형에너지의 차이를 극대화 할 수 있는 하중조건을 찾는 알고리즘을 개발하였다. 트러스 구조물에 대한 예제는 제안 기법의 정확성과 효과를 입증한다.

• 한국수산과학회지
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• 제54권3호
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• pp.271-279
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• 2021

Ultrasound-assisted extraction (UAE) conditions, including extraction time, extraction temperature, and ethanol concentration, were optimized to increase the total flavonoid content (TFC), tyrosinase inhibitory activity (TIA), and collagenase inhibitory activity (CIA) of Spirulina platensis through central composite design (CCD). For the optimization of the three dependent variables, a quadratic regression model was derived from 17 experimental sets for the simultaneous maximization of TFC, TIA, and CIA. The predicted optimal UAE conditions were 44.0 min of extraction time, 82.8℃ of extraction temperature, and 96.0% of ethanol concentration. Under these conditions, 0.93 mg QE/g DM of TFC, 81.9% of CIA, and 92.1% of TIA were predicted. The CCD-based UAE optimization enabled an increase in TFC, CIA, and TIA, thereby confirming that the S. platensis extract can be used in the development of a cosmetic material with skin whitening and anti-wrinkle effects.