• Title/Summary/Keyword: anaphylaxis

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Adverse Drug Reaction of Chinese Herbal Injection: Focusing on the Anaphylaxis Reaction (중약주사제의 약물유해반응: 아나필락시스 반응을 중심으로)

  • Jeung, Chang-woon;Jeon, Sun-woo;Jo, Hee-Geun
    • Journal of Korean Medicine Rehabilitation
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    • v.30 no.4
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    • pp.133-142
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    • 2020
  • Objectives Studies on Chinese herbal injections are increasing. But, its safety are still not well reported. We have reviewed the literature related to the safety of Chinese herbal injection, especially those related to anaphylaxis. Methods The PubMed database was used to select the literatures related to anaphylaxis in China and to study the quality control and safety of Chinese herbal injection. Results Chinese herbal injection is a major traditional medical treatment in China, but it is the cause of adverse drug reactions including anaphylaxis. In order to solve this problem, various proposals have been made to identify the pharmacological and chemical causes of major side effects and to use them safely clinically. In addition, various researches have been conducted from preclinical to postmarketing surveillance to secure the safety of Chinese herbal injection. Based on this, it was found that various efforts are needed to secure the safety of bee sting needles. Conclusion In order to secure the safety of chinese herbal injections, it is necessary to identify the main mechanism of action and the pharmacological components contributing to it, and to develop a standardized formulation based on this. In addition, institutional pharmacovigilance is required.

Anaphylactic reaction after local lidocaine infiltration for retraction of retained teeth

  • Kim, Hyerim;Lee, Jung-Man;Seo, Kwang-Suk;Kwon, Seok Min;Row, Hyung Sang
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.19 no.3
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    • pp.175-180
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    • 2019
  • Although allergic reactions are not rare complications in drug use, anaphylaxis or anaphylactoid reactions to some widely used drugs can embarrass clinicians because anaphylaxis is not easily diagnosed at the time of the event and treatment is unfamiliar to many. Lidocaine is a very popular drug in dental procedures and anaphylactoid reaction to it has been rarely reported. Clinicians who use lidocaine daily should, however, be aware of the possibility of anaphylaxis after its use. Once it occurs, anaphylaxis can be fatal, but if it is quickly diagnosed or suspected, treatment is simpler than most clinicians believe. An 86-year-old woman experienced an anaphylactic reaction 30 min after local infiltration of lidocaine for retraction of retained teeth. The dentist called an anesthesiologist for assistance. Fortunately, an anaphylactic reaction was quickly suspected and after subsequent rapid treatment with the administration of fluid and drug therapy, the patient recovered completely.

Hypersensitivity Reaction to Perioperative Drug Mistaken for Local Anesthetic Systemic Toxicity in a Patient under Brachial Plexus Block

  • Jun, Jee Young;Kim, Youn Jin;Kim, Jong Hak;Han, Jong In
    • Kosin Medical Journal
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    • v.33 no.3
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    • pp.468-476
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    • 2018
  • Perioperative anaphylaxis, although rare, is a severe, life-threatening unexpected systemic hypersensitivity reaction. Simultaneous administration of various drugs during anesthesia, the difficulty of communicate with patients in sedation and anesthesia, and coverage of the patient with surgical drapes are considered to be factors that impede early recognition of anaphylactic reactions. It is very important to perform an intradermal skin test because antibiotics are the most common cause of perioperative anaphylaxis. We report a case of negative-intradermal skin test antibiotic anaphylaxis mistaken for local aesthetic systemic toxicity without increase of serum tryptase for confirmative diagnostic biomaker during surgery under brachial plexus block. It is not possible to exclude the danger of anaphylaxis completely, even if it is negative-intradermal skin test and normal tryptase level. Therefore, anesthesiologists should be closely monitored and treated early for antibiotics related hypersensitive reaction, like other medicines during anesthesia.

기니픽과 토끼에서 PDT-Hepa의 항원성 시험

  • 강경선;이영순
    • Environmental Mutagens and Carcinogens
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    • v.11 no.2
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    • pp.141-147
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    • 1991
  • 기니픽과 New Zealand White Rabbit에서 PDT-Hepa에 대한 항원성 시험을 실시하였다. 1) Active Systemic Anaphylaxis (ASA), 2) Passive Systemic Anaphylaxis (PSA), 3) Passive Custaneous Anaphylaxis (PCA) 시험을 실시한 결과 ASA, PSA 실험에서 anaphylaxis와 관련된 어떠한 특이적인 임상증상도 나타나지 않아 PDT-Hepa는 기니픽과 토끼에서 항원성이 없는 것으로 보인다. 또한 PCA 실험에서 청색반점이 관찰되지 않은 것으로 보아 PDT-Hepa specific IgE는 생성되지 않는 것으로 판단된다.

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Inhibitory Effect of Lycopus lucidus on Mast Cell-Mediated Immediate-Type Allergic Reactions (택란의 비만세포 매개 즉시형 알레르기 반응의 억제 효과)

  • 김숙현;김대근;임종필;채병숙;신태용
    • YAKHAK HOEJI
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    • v.46 no.6
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    • pp.405-410
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    • 2002
  • The effect of aqueous extract of Lycopus lucidus Turcz. (Labiatae)(LLAE) on mast cell-mediated immediate-type allergic reactions was investigated. LLAE (0.01 to 1 mg/g) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80. LLAE (0.001 to 1 mg/g) also dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. When LLAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. LLAE (0.001 to 1 mg/mι) dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when LLAE (1 mg/mι) was added, significantly was increased, compared with that of normal control. These results provide evidences that LLAE may be beneficial in the treatment of allergic diseases.

ANTIGENICITY TEST OF COPTIS RHIZOME AND CROTON TIGLIUM L. EXTRACTS(CP-2) IN GUINEA PIG AND RABBITS

  • Kang, Kyung-Sun;Cho, Jae-Jin;Kim, Hyung-Ook;Lee, Yong-Soon;Lim, Yoon-Kyu
    • Toxicological Research
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    • v.8 no.1
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    • pp.139-143
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    • 1992
  • Antigenicity tests-ASA(Active Systemic Anaphylaxis), PSA(Passive Systemic Anaphylaxis), PCA(Passive Cutaneous Anaphylaxis)-of CP-2(Green cross Co). were performed according to the established regulations of National Institute of Safety Research. The results were as follows. 1. No specic clinical signs related anaphylaxis were observed, therefore, it was considered that CP-2 had not antigenicity in guinea pigs and rabbits. 2. No blue spots were observed on the back of guinea pig in the PCA test` CP-2 related IgE was not produced.

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Inhibitory Effect of Isodon japonicus Hara on Mast Cell-Mediated Immediate-Type Allergic Reactions (비만세포 매개 즉시형 알레르기 반응에 대한 연명초의 억제 효과)

  • Kim, Sung-Hwa;Kim, Dae-Keun;Chae, Byeong-Suk;Shin, Tae-Yong
    • Korean Journal of Pharmacognosy
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    • v.34 no.2 s.133
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    • pp.132-137
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    • 2003
  • The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated local anaphylaxis. When IJAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. IJAE dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when IJAE was added, significantly was increased, compared with that of normal control. These results indicate that IJAE will beneficial in the treatment of immediate-type allergic reaction.

Suppression of Immediate Hypersensitivity by Methyleugenol (메틸유제놀에 의한 즉시형 과민 반응의 억제)

  • Kim, Chang-Young;Shin, Tae-Yong;Kim, Hyung-Min
    • YAKHAK HOEJI
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    • v.41 no.2
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    • pp.268-272
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    • 1997
  • We studied the action of methyleugenol on immediate hypersensitivity. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol al so inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. These results suggest that the inhibitory effect of methyleugenol on anaphylaxis induced by compound 48/80 or anti-DNP IgE is due to, in part at least, the membrane stabilization of mast cells.

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Antigenicity Study on IDC7181, a Quaternary Ammoniopropenyl Cephalosporin Possessing Two Vinyl Groups (Cephalosporin계 항생제 IDC7181에 대한 항원성시험)

  • 신지순;장호송;최은경;권운;채희열;조영민;김윤배;강종구
    • Toxicological Research
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    • v.19 no.4
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    • pp.321-324
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    • 2003
  • Antigenic potential of a novel cephalosporin, IDC7181 was examined a active systemic anaphylaxis (ASA) and passive cutaneous anaphylaxis (PCA) test, in guinea pig and mouse-rat models, respectively. In ASA test, IDC7181 induced the signs of restlessness in a few animals immunized with a high dose (100 mg/kg) of IDC7181 alone or in combination with Freund's complete adjuvant (FCA). In PCA test, only one of ten sera from the animals immunized with a high dose (100 mg/kg) of IDC7181 in the absence or presence of FCA showed positive reaction. The positive reaction, induced by IDC7181, which may be due to $\beta$-lactam ring, in ASA and PCA tests were negligible in comparison with those of traditional cephalosporins. Taken together, it is suggested that IDC7181 do not cause immunological problems in clinical dosage.

Antiallergic Activity of Menthae Herba (박하의 항알레르기 활성)

  • Kim, Dae-Keun;Shin, Tae-Yong
    • Korean Journal of Pharmacognosy
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    • v.29 no.3
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    • pp.248-253
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    • 1998
  • Antiallergic activity of the aqueous extract of Menthae herba (MHAE) was investigated in mice and rats. MHAE inhibited systemic anaphylaxis induced by compound 48/80 in mice. Especially, MHAE inhibited compound 48/80 induced systemic anaphylaxis 100% with a dose of 500 mg/kg body weight. MHAE significantly inhibited serum histamine levels induced by compound 48/80. MHAE inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Our studies provide evidence that MHAE will be beneficial in the treatment of anaphylaxis.

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