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Inhibitory Effect of Isodon japonicus Hara on Mast Cell-Mediated Immediate-Type Allergic Reactions  

Kim, Sung-Hwa (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Chae, Byeong-Suk (College of Science and Engineering, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.2, 2003 , pp. 132-137 More about this Journal
Abstract
The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated local anaphylaxis. When IJAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. IJAE dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when IJAE was added, significantly was increased, compared with that of normal control. These results indicate that IJAE will beneficial in the treatment of immediate-type allergic reaction.
Keywords
Isodon japonicus; Anaphylaxis; Compound 48/80; Anti-dinitrophenyl (DNP) IgE; cAMP; Histamine; Mast cells;
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