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Inhibitory Effect of Lycopus lucidus on Mast Cell-Mediated Immediate-Type Allergic Reactions  

김숙현 (우석대학교 약학대학)
김대근 (우석대학교 약학대학)
임종필 (우석대학교 약학대학)
채병숙 (우석대학교 이공대학)
신태용 (우석대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.46, no.6, 2002 , pp. 405-410 More about this Journal
Abstract
The effect of aqueous extract of Lycopus lucidus Turcz. (Labiatae)(LLAE) on mast cell-mediated immediate-type allergic reactions was investigated. LLAE (0.01 to 1 mg/g) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80. LLAE (0.001 to 1 mg/g) also dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. When LLAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. LLAE (0.001 to 1 mg/mι) dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when LLAE (1 mg/mι) was added, significantly was increased, compared with that of normal control. These results provide evidences that LLAE may be beneficial in the treatment of allergic diseases.
Keywords
Lycopus lucidus; anaphylaxis; compound 48/80; anti-dinitrophenyl (DNP) IgE; cAMP; histamine; mast cells;
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