• 치위생과학회지
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• 제17권5호
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• pp.433-438
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• 2017

Relative to its incidence, oral cancer has serious negative social effects. The exact causes of oral cancer have not been clarified, but many studies have implicated smoking and drinking. However, the fundamental mechanism of oral cancer causation has yet to be elucidated. Lysophosphatidic acid (LPA) augments epithelial mesenchymal transition (EMT) and development of various cancer cells. However, a detailed mechanistic explanation for LPA-induced EMT and the effects of EMT-promoting conditions on oral squamous cell carcinoma development remain elusive. In the present study, a quantitative reverse transcription polymerase chain reaction was used to analyze TWIST1, Slug, E-cadherin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) transcript expression. Immunoblotting was used to analyze TWIST1, Slug, E-cadherin, and GAPDH protein expression. siRNAs were used to silence TWIST1 and Slug transcript expression. A matrigel-coated in vitro invasion insert was used to analyze oral cancer cell invasion. The results of the present study show that the expression levels of TWIST1 and Slug, which are EMT factors, were increased by LPA treatment in YD-10B oral squamous cell carcinoma. Conversely, E-cadherin expression was significantly reduced. In addition, transfection of the cells with TWIST1 and Slug siRNA strongly inhibited LPA-induced oral cancer cell invasion. The present study shows that TWIST1 and Slug mediate LPA-induced oral cancer cell EMT and invasiveness. The present study confirmed the mechanism by which LPA promotes oral cancer cell development, with TWIST1 and Slug providing novel biomarkers and promising therapeutic targets for oral cancer cell development.

• 한국경영과학회지
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• 제17권3호
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• pp.13-26
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• 1992

Set-up reduction is an important aspect of the Japanese Just-In-Time (JIT) and Zero Inventory (ZI) concepts. In this paper, we first analyze the effects of set-up cost reduction on tatal inventory, average lot size and forecast horizon in the dynamic lot size model. We also examine the various effects of set-up cost reduction in the EOQ model and explain why many Japanese firms try to cut set-up cost and/or set-up time greatly.

• Journal of Information Technology Applications and Management
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• 제14권2호
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• pp.97-115
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• 2007

The present paper investigates the technological and conceptional characteristics of peering and transit in internet interconnection. Especially, the market with two ISP competing for customers is modeled and the outcome with peering is compared with transit. This paper also analyze the congestion effects on retail price and network capacity. When there is congestion effects occurring from network sharing, the retail price is increased and the fixed fee is decreased with the degree of congestion. Finally, the optimal access charge assuring the socially optimal retail price and network capacity is derived.

• 한국농공학회:학술대회논문집
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• 한국농공학회 1999년도 Proceedings of the 1999 Annual Conference The Korean Society of Agricutural Engineers
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• pp.162-168
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• 1999

This study was performed to analyze dealinization effects on gypsum treatments in reclaimed tidelands and to obtain the basci data for developing prediction techniques f desalinization to be applicable in the begining of tideland reclamation. In this study , the reclamation experiments with 4 treatments were conducted through the leachig method, using the samples of silt soil and silt loam soil collected in 5 units of tideland reclamation projects. The electrical conductivity , exchangeable sodium percentage and hydraulic conductivity were analyzed in order to investigate the effects of desalinizatino for reclaiming the tidelands with high salt concentration.

• Communications for Statistical Applications and Methods
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• 제24권1호
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• pp.81-96
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• 2017

Cumulative logit random effects models are typically used to analyze longitudinal ordinal data. The random effects covariance matrix is used in the models to demonstrate both subject-specific and time variations. The covariance matrix may also be homogeneous; however, the structure of the covariance matrix is assumed to be homoscedastic and restricted because the matrix is high-dimensional and should be positive definite. To satisfy these restrictions two Cholesky decomposition methods were proposed in linear (mixed) models for the random effects precision matrix and the random effects covariance matrix, respectively: modified Cholesky and moving average Cholesky decompositions. In this paper, we use these two methods to model the random effects precision matrix and the random effects covariance matrix in cumulative logit random effects models for longitudinal ordinal data. The methods are illustrated by a lung cancer data set.

• 한국초등수학교육학회지
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• 제12권1호
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• pp.27-46
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• 2008

본 연구에서는 초등학교 6-가 단계 수학 교과에 사이버가정학습을 적용한 후, 수학 학업성취도와 수학적 성향에 미치는 효과를 분석함으로써 학생들의 전반적인 수학 학습에 대한 학업성취도와 수학적 성향을 향상시킬 수 있는 방안을 모색하고자 하는데 그 목적이 있다.

• ETRI Journal
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• 제25권1호
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• pp.34-40
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• 2003

This paper considers a TMN-based management system for the management of public ATM switching networks using a four-level hierarchical structure consisting of one network management system, several element management systems, and several agent-ATM switch pairs. Using Jackson's queuing model, we analyze the effects of one TMN command on the performance of the component ATM switch in processing local calls. The TMN command considered is the permanent virtual call connection. We analyze four performance measures of ATM switches- utilization, mean queue length and mean waiting time for the processor directly interfacing with the subscriber lines and trunks, and the call setup delay of the ATM switch- and compare the results with those from Jackson's queuing model.

• International Journal of Advanced Culture Technology
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• 제5권4호
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• pp.63-70
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• 2017

The purpose of the study is to analyze the effects of customer satisfaction verses eco-friendly agricultural products (ingredients) awareness factors in luxury hotel Chinese restaurants on hotel image and customer loyalty (repurchase intention). To analyze what kind of effects of customer satisfaction verses eco-friendly agricultural products (ingredients) awareness factors in Chinese restaurants have on hotel image and behavior intention (loyalty), the study identified eco-friendly ingredients awareness factors. The study aims to suggest implications on service strategies and marketing strategies in luxury hotel Chinese restaurants based on the influence of customer satisfaction on hotel image and behavior intention (loyalty) using the identified factors.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.51-56
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• 1998

In this paper, we analyze the effects of scaling factors on the performance of a fuzzy logic controller(FLC). The quantitative relation between input and output variables of FLC is obtained by using a qualsi-linear fuzzy model, and an approximate transfer function of FLC is dervied from the comparison of it with the conventional PID controller. Then we analyze in detail the effects of scaling factor using this approximate transfer function and root locus method. Also we suggest an on-line tuning method for scaling factors which employs an sample performance function and a variable reference for tuning index.

• 한국조리학회지
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• 제13권1호
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• pp.166-178
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• 2007

A review of literature relating to the research topic and a survey method have been implemented in order to analyze effects of service orientation. For data analysis, a reliability analysis was performed to test the reliability of the construct and a series of an exploratory factor analysis was used for the validity test. The findings of the study were as follows: Classified into sex, service leadership factor and service skill factor showed meaningful difference between groups. Classified with age, service training factor, service leadership factor, service standardization factor, service technology factor, and service compensation factor showed meaningful difference between groups. Classified with scholarship, service compensation factor showed meaningful difference. Classified into working year, employees' discretion factor showed meaningful difference. Classified into work department, service training factor and employees' right factor showed meaningful difference. In addition, classified into monthly average incomes, employees' discretion factor showed meaningful difference.