• Molecules and Cells
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• v.42 no.3
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• pp.237-244
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• 2019

Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted from two different types of datasets. First, resistance signatures were extracted from transcriptomic profiles of cancer cells or patient samples and their resistance-induced counterparts for >30 cancer drugs. Second, drug resistance group signatures were also extracted from two large-scale drug sensitivity datasets representing ~1,000 cancer cell lines. All the datasets are available for download, and are conveniently accessible based on drug class and cancer type, along with analytic features such as clustering analysis, multidimensional scaling, and pathway analysis. CDRgator allows meta-analysis of independent resistance models for more comprehensive understanding of drug-resistance mechanisms that is difficult to accomplish with individual datasets alone (database URL: http://cdrgator.ewha.ac.kr).

• Tribology and Lubricants
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• v.22 no.6
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• pp.307-313
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• 2006

In this paper, a theoretical analysis is carried out to study the effect of viscosity variation with pressure in multiply grooved moving hydraulic spool valves. Analytical expressions for pressure distribution in the clearance and leakage flowrate are obtained solving one-dimensional Reynolds. For constant viscosity, an analytical expression for lateral force is also presented. The results showed that variation of viscosity with pressure affect highly on pressure distribution, leakage flowrate and lateral forces in hydraulic spool valves. Therefore additional intensive studies, including numerical analysis for two-dimensional Reynolds, should be required to investigate detailed lubrication characteristics of spool valves for high pressure.

• Bulletin of the Korean Chemical Society
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• v.33 no.3
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• pp.1020-1028
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• 2012

This work compares various models for geminate reversible diffusion influenced reactions. The commonly utilized contact reactivity model (an extension of the Collins-Kimball radiation boundary condition) is augmented here by a volume reactivity model, which extends the celebrated Feynman-Kac equation for irreversible depletion within a reaction sphere. We obtain the exact analytic solution in Laplace space for an initially bound pair, which can dissociate, diffuse or undergo "sticky" recombination. We show that the same expression for the binding probability holds also for "mixed" reaction products. Two different derivations are pursued, yielding seemingly different expressions, which nevertheless coincide numerically. These binding probabilities and their Laplace transforms are compared graphically with those from the contact reactivity model and a previously suggested coarse grained approximation. Mathematically, all these Laplace transforms conform to a single generic equation, in which different reactionless Green's functions, g(s), are incorporated. In most of parameter space the sensitivity to g(s) is not large, so that the binding probabilities for the volume and contact reactivity models are rather similar.

• Journal of the Korean Chemical Society
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• v.51 no.3
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• pp.227-231
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• 2007

We improve Wilehemski-Fixmann theory for intrachain reaction dynamics of a polymer chain by taking into account excluded volume effects between reactive groups in the polymerchain. An approximate analytic expression for the intra-chain reaction dynamics is obtained for Gaussian chain model and compared to Brownian dynamics simulation results. The results of the present theory are in a better agreement to Brownian dynamics simulation results than those calculated by previously reported theories.

• Bulletin of the Korean Chemical Society
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• v.24 no.8
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• pp.1069-1074
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• 2003

A theoretical description and experimental demonstration of homodyne-detected two-color transient grating (2-C TG) signal are presented. By treating the coupled bath degrees of freedom as a collection of harmonic oscillators and using a short-time expansion method, approximated nonlinear response functions were obtained. An analytic expression for the two-color transient grating signal was obtained by carrying out relevant Gaussian integrals. The initial rising and decaying parts of the 2-C TG signal is shown to be critically dependent on the ultrafast inertial component of the solvation correlation function. The experimental results confirm the predictions of the theoretical model.

• ETRI Journal
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• v.30 no.3
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• pp.355-364
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• 2008

Multiple-input multiple-output (MIMO) systems can provide significant increments in capacity; however, the capacity of MIMO systems degrades severely when spatial correlation among multipath channels is present. This paper demonstrates that the influence of shadowing on the channel capacity is more substantial than that of multipath fading; therefore, the shadowing effect is actually the dominant impairment. To overcome the composite fading effects, we propose combining macroscopic selection diversity (MSD) schemes with MIMO technology. To analyze the system performance, the capacity outage expression of MIMO-based MSD (MSD-MIMO) systems using a characteristic function is applied. The analytic results show that there are significant improvements when MSD schemes are applied, even for the two-base-station diversity case. It is also observed that the effect of spatial correlation due to multipath fading is almost negligible when multiple base stations cooperatively participate in the mobile communication topology.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.7
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• pp.1314-1321
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• 1992

In analyzing the plastic flow of axisymmetric tube extrusion a new method of formulation using the stream function approach and upper-bound theorem is proposed which permits the prediction of plastically deformed zone in analytic expression as well as metal flow. It is shown that the formulation proposed in this work covers the solid extrusion and tube extrusion in axisymmetric case. The effect of some process parameters such as area reduction, the ratio of radii(inner radius to outer radius) and friction factor on extrusion pressure, deformation zone and plastic flow through stream-lined dies has been studied. The presented theoretical analysis can be effectively used for the prediction of deformation zone and plastic flow.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.57.2-57.2
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• 2011

In this study, the effects of shear flows around a 2-dimensional airfoil, S809 on its aerodynamic characteristics were analyzed by CFD simulations. Various parameters including reference inflow velocity, shear rate, angle of attack, and cord length of the airfoil were examined. From the simulation results, several important characteristics were found. Shear rate in a flow makes some changes in the lift coefficient depending on its sign and magnitude but angle of attack does not have a distinguishable influence. Cord length and reference inflow also cause proportional and inversely proportional changes in lift coefficient, respectively. We adopted an analytic expression for the lift coefficient from the thin airfoil theory and proposed a modified form applicable to the traditional load analysis procedure based on the blade element momentum theory. Some preliminary results applied to an well known load simulation software, FAST, are presented.

• Advances in environmental research
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• v.7 no.1
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• pp.29-37
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• 2018

A simple mathematical model for predicting fixed bed adsorption dynamics is described. The model is characterized by a linear adsorption isotherm and a linear driving force expression for mass transfer. Its analytic solution can be approximated with an algebraic equation in closed form which is easily evaluated by spreadsheet computation. To demonstrate one application of the fixed bed model, a previously published adsorption system is used as a case study in this work. The adsorption system examined here describes chromium breakthrough in a fixed bed adsorber packed with imidazole functionalized adsorbent particles and is characterized by a nonlinear adsorption isotherm. However, the equilibrium behavior of the fixed bed adsorber is in essence governed by a linear adsorption isotherm due to the use of a low influent chromium concentration. It is shown that chromium breakthrough is predicted reasonably well by the fixed bed model. The model's parameters can be easily extracted from independent batch experiments. The proposed modeling approach is very simple and rapid, and only Excel is used for computation.

• Communications of the Korean Mathematical Society
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• v.12 no.2
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• pp.479-490
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• 1997

We consider long nonlinear waves in the two-layer flow of an inviscid and incompressible fluid bounded above by a free surface and below by a rigid boundary. The flow is forced by a bump on the bottom. The derivation of the forced KdV equation fails when the density ratio h and the depth ratio $\rho$ yields a condition $1 + h\rho = (2-h)((1-h)^2 + 4\rho h)^{1/2}$. To overcome this difficulty we derive a forced modified KdV equation by a refined asymptotic method. Numerical solutions are given and hydraulic fall solution of a two layer fluid is expressed analytically in the case that derivation of the forced KdV (FKdV) equation fails.