• Archives of Pharmacal Research
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• v.15 no.3
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• pp.251-255
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• 1992

A number of 4-hydroxy-2H (or alkyl)-N-(3-aralkyl-2-thio-1-hydantoinyl)-1, 2-benzothiazine3-carboxamide 1, 1-dioxides were synthesized through the reaction of 4-hydroxy-2H (or alkyl)1, 2-benzothiazine-3-carboxylic methyl ester 1, 1-dioxide and 1-amino-2-thio-3-aralkyl-4-imidazolones in xylene. The compounds synthesized were screened for antinflammatory effect on carrageenin-induced edema in rat and for analgesic effect on acetic acid-induced Writhing syndrome in mice. Most compounds were inhibots of carrageenin-induced rat foot edema and some showed significant antinflammatory activity comparable to that of indomethacin and significant analgesic activity comparable to that of indomethacin and aspirin.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.3 no.1
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• pp.17-24
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• 1990

In order to investigate the effects of Chungylsodokeum on Analgesic, Anti-inflammatory activity were administered. The results were summarized as follows : 1. The Analgesic effect of acetic acid showed inhibitory effect more than Chungyulsodokeum extract 3mg/kg. 2. The Analgesic effect of Hot Plate showed inhibitory effect more than Chungyulsodokeum 100mg/kg. 3. The Anti-inflammatory effect of Acetic acid showed inhibitory effect at Chungyulsodokeum extract 30, 100mg/kg.

• Korean Journal of Pharmacognosy
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• v.22 no.4
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• pp.240-245
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• 1991

This study was attempted to examine the acute toxicity and the effect of Sopunghwalhul-Tang water extract(SHTE) on analgesic action in mice, anti- inflammatory action in rats and blood pressure in rabbits. The results were as follows; SHTE showed 10% mortality at 2,000mg/kg(p.o.), had significant analgesic activity in the pain caused by 0.7% acetic acid and was shown to have significant anti-inflammatory activity in the edema-induced by 5% acetic acid at 450mg/kg. SHTE given into a ear vein of rabbits produced a dose-related vasodepressur responses. SHTE-induced hypotension was significantly inhibited by pretreatment with atropine, but was not affected by chlorisondamine, phentolamine, propranolol, and dephenhydramine.

• Korean Journal of Pharmacognosy
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• v.27 no.3
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• pp.184-189
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• 1996

Ohyaksungisan, combined preparation of crude drugs, has been used for hemiplegia, arthralgia and paralysis in traditional Korean medicine. The anti-inflammatory activity of the aqueous extract from Ohyaksungisan(OSSE) was investigated on acetic acid-induced edema and adjuvant arthritis in rats. Acute toxicity and analgesic action in mice were also examined. Its anti-inflammatory activity on 5% acetic acid-induced edema and adjuvant arthritis was observed with oral administration. The acute toxicity showed 10% mortality at 2400 mg/kg (p.o), but was not showed at 1200 mg/kg (i.p). OSSE was showed to have significant analgesic action (P<0.05) at 150 mg/kg and this action was strengthened at 300, 600 mg/kg. The anti-inflammatory effect was showed significant preventive effect on the hind paw edema from 90 min. and the adjuvant arthritis, when orally administered for 19 days. showed significant inhibitory effect on the hind paw edema from the 5th day.

• Advances in Traditional Medicine
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• v.7 no.4
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• pp.444-446
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• 2007

Ethanolic extract of Aphanamixis polystachya bark was used to investigate its analgesic activity by acetic acid induced writhing in mice. The bark extract exhibited statistically significant and dose dependent analgesic activity in mice. The bark extract at the doses of 250 and 500 mg/kg body weight showed 40.69% and 62.07% writhing inhibition respectively in mice whereas diclofenac-Na produced 75.17% writhing inhibition as a positive control.

• Korean Journal of Pharmacognosy
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• v.15 no.4
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• pp.194-198
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• 1984

Analgesic activity of the 'Ssangkum-tang' (water extract) were studied. Analgesic activities were determined by the acetic acid method, hot plate method and Randall-Sellito method. The water fraction showed a significant inhibitory effect at the dose of 1.25g/kg, 2.5g/kg and 5.0g/kg.

• Archives of Pharmacal Research
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• v.11 no.1
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• pp.41-44
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• 1988

Several 4-cyano-1-benzofuranyl-1-butanone derivatives were synthesized and screened for potential antiinflammatory and analgesic activities. The effect of structural variation of these molecules on biological activities was systematically examined. Among these compounds $V_a,\;V_c\;and\;VI_e$ were found to demonstrate a significant antiinflammatory effect. Compounds $VI_e,\;V_a,\;I_d,\;I_band\;VII_f$ were also significantly effective as analgesic ones.

• Advances in Traditional Medicine
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• v.6 no.4
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• pp.349-354
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• 2006

In the present study, three Malaysian Channa spp. fish Channa striatus, Channa micropeltes and Channa lucius were assessed for their analgesic activity. Distilled water and mixture of chloroform: methanol were used for extraction. The analgesic or antinociceptive activity was investigated by abdominal writhing and hot plate test. The water extract of Channa striatus and the chloroform: methanol extract Channa lucius produced potent antinociceptive effect when assessed with the abdominal writhing test. The activity was compared to morphine where the activity of the extracts was less potent than the opioid. In the hote plate test, water extract of Channa striatus revealed significant activity and chloroform:methanol extract of Channa micropeltes had moderate activity. However, these activities were statistically lower than morphine. Collectively, this study also showed that Channa striatus extract was more potent analgesic agent when compared to the other closely related snakehead Channa micropeltes and Channa lucius.

• Journal of the Korean Chemical Society
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• v.57 no.6
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• pp.755-760
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• 2013

The present study is synthesis of derivatives of N'-(4-amino-5-sulfanyl-4H-1,2,4-triazole-3-yl)-2-(1H-benzimidazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted by disc diffusion method. Compound $2MB_1$, $2MB_3$, $2MB_5$ inhibit the appreciable microbial growth while rest of the compound possess the moderate activities. Anti-inflammatory activity tested by reduces local edema induced in the rat paw by injection of phlogestic agent. Compound $2MB_1$, $2MB_8$, $2MB_5$, $2MB_3$ and $2MB_6$ exhibit satisfying anti-inflammatory activity while analgesic activity conducted by acetic acid induced writhing effect in mice while compound $2MB_1$, $2MB_4$ and $2MB_7$ having the good analgesic activity. The chemical structures of all newly synthesized compounds were confirmed by their IR, $^1H$ NMR and mass spectral data.

• Korean Journal of Pharmacognosy
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• v.27 no.3
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• pp.274-281
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• 1996

Ulmus parvifolia has been used as a traditional folk medicine to treat the carbuncle in deep skin. In this study, the effect of water extract of root bark of Ulmus parvifolia (WUP) on the carbuncle, pain, inflammation and hypersensitivity was evaluated in animal models. The administration of WUP significantly decreased the size of Staphylococcus aureus ($10^8$ cells/mouse)-induced carbuncle, and also exhibited analgesic activity in the HAc-induced writhing syndrome at doses of 50-500 mg/kg. It also showed significant anti-inflammatory activity in the carageenin- and complete Freund's adjuvant-induced inflammation. In the histamine-induced anaphylaxis, it decreased the percent of mortality by protecting mice treated with Bordetella pertussis. In the immune responses in the mice sensitized and challenged with sheep red blood cells, the Arthus reaction determined by swelling of foot pad at 4 h after challenge, HA titer, HY titer and PFC which can be used to evaluate the humoral immune response were significantly suppressed by oral administration of WUP at doses of 100 and 200mg/kg. The cellular immune responses in the same mice such as delayed type hypersensitivity determined by swelling of foot pad at 24 h after challenge and RFC were also significantly suppressed in the same manner.