Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Analgesic activity of three Channa spp. fish extracts

  • Solihah, MH (Department of Biomedical Science, Faculty of Medicine and Health Sciences) ;
  • Israf, DA (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Laboratory of Natural Resources, Institute of Bioscience) ;
  • Zuraini, A (Department of Biomedical Science, Faculty of Medicine and Health Sciences) ;
  • Arifah, AK (Department of Pathology and Microbiology, Faculty of Veterinary Medicine) ;
  • Zakaria, MS (Laboratory of Marine Sciences, Institute of Bioscience, University Putra Malaysia) ;
  • Zakaria, ZA (Universiti Industri Selangor) ;
  • Sulaiman, MR (Department of Biomedical Science, Faculty of Medicine and Health Sciences) ;
  • Jais, AM Mat (Department of Biomedical Science, Faculty of Medicine and Health Sciences) ;
  • Somchit, N (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Laboratory of Natural Resources, Institute of Bioscience)
  • Published : 2006.12.31
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Abstract

In the present study, three Malaysian Channa spp. fish Channa striatus, Channa micropeltes and Channa lucius were assessed for their analgesic activity. Distilled water and mixture of chloroform: methanol were used for extraction. The analgesic or antinociceptive activity was investigated by abdominal writhing and hot plate test. The water extract of Channa striatus and the chloroform: methanol extract Channa lucius produced potent antinociceptive effect when assessed with the abdominal writhing test. The activity was compared to morphine where the activity of the extracts was less potent than the opioid. In the hote plate test, water extract of Channa striatus revealed significant activity and chloroform:methanol extract of Channa micropeltes had moderate activity. However, these activities were statistically lower than morphine. Collectively, this study also showed that Channa striatus extract was more potent analgesic agent when compared to the other closely related snakehead Channa micropeltes and Channa lucius.

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References

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