Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Reactions of Some Cinnamoyl Benzofuran Derivatives with Activated Nitrites and their Biological Activity

  • El-Diwani, H.I. (Natural Products Department, National Research Centre) ;
  • Nakkady, S.S. (Natural Products Department, National Research Centre) ;
  • El-Shabrawy, O. (Pharmacology Department, National Research Centre) ;
  • Gohar, A-K.M.N. (Chemistry Department, Faculty of Science, Minia University) ;
  • Hishmat, O.H. (Natural Products Department, National Research Centre)
  • Published : 1988.03.01
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Abstract

Several 4-cyano-1-benzofuranyl-1-butanone derivatives were synthesized and screened for potential antiinflammatory and analgesic activities. The effect of structural variation of these molecules on biological activities was systematically examined. Among these compounds $V_a,\;V_c\;and\;VI_e$ were found to demonstrate a significant antiinflammatory effect. Compounds $VI_e,\;V_a,\;I_d,\;I_band\;VII_f$ were also significantly effective as analgesic ones.

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