• Title/Summary/Keyword: alternative models

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Suggestion of Risk Assessment Models for Cardiovascular Disease in the Workplace

  • Choi, Eui Rak;Jeong, Byung Yong
    • Journal of the Ergonomics Society of Korea
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    • v.33 no.4
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    • pp.289-297
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    • 2014
  • Objective: The purpose of this study is to identify the incidence risk of cardiovascular disease (CVD) in the workplace, and to suggest the prediction models for level of CVD incidence risk. Background: CVD can be caused by various factors related to personal habits such as diet and exercise, or genetics. However it can also be caused and aggravated by work, making the elimination of such risk factors at work crucial disease (KOSHA, 2013). Method: The distribution of CVD risk assessment levels of 162 workers was compared with the acquired medical examination data to discuss the necessity of assigning additional risk factors. Two alternative risk assessment models were given to enhance the accuracy of the evaluation; adjusting risk scores given in the KOSHA GUIDE H-1-2013 (alternative 1) and building a matrix of KOSHA GUIDE H-1-2013 and risk assessment results based on work condition levels (alternative 2). To verify the suggested models, medical examination results of 12 workers approved of convalescence were referred to. Results: The second alternative showed more relevance between the results and workers approved of convalescence in predicting the risk group when applied to actual heath examination data from the approved workers. The power of description of the new method for determining the risk of CVD incidence, 83.3%, is higher than that of KOSHA GUIDE H-1-2013, 25%. Conclusion: Results of this study imply that more approved workers had been from unmanaged normal groups than managed risk groups, raising the importance of CVD management. Application: The new prediction model considering working time and shift work developed in this study is expected to be a fundamental data for risk analysis and management of CVD in the workplace.

Alternatives to In Vivo Draize Rabbit Eye and Skin Irritation Tests with a Focus on 3D Reconstructed Human Cornea-Like Epithelium and Epidermis Models

  • Lee, Miri;Hwang, Jee-Hyun;Lim, Kyung-Min
    • Toxicological Research
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    • v.33 no.3
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    • pp.191-203
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    • 2017
  • Human eyes and skin are frequently exposed to chemicals accidentally or on purpose due to their external location. Therefore, chemicals are required to undergo the evaluation of the ocular and dermal irritancy for their safe handling and use before release into the market. Draize rabbit eye and skin irritation test developed in 1944, has been a gold standard test which was enlisted as OECD TG 404 and OECD TG 405 but it has been criticized with respect to animal welfare due to invasive and cruel procedure. To replace it, diverse alternatives have been developed: (i) For Draize eye irritation test, organotypic assay, in vitro cytotoxicity-based method, in chemico tests, in silico prediction model, and 3D reconstructed human cornealike epithelium (RhCE); (ii) For Draize skin irritation test, in vitro cytotoxicity-based cell model, and 3D reconstructed human epidermis models (RhE). Of these, RhCE and RhE models are getting spotlight as a promising alternative with a wide applicability domain covering cosmetics and personal care products. In this review, we overviewed the current alternatives to Draize test with a focus on 3D human epithelium models to provide an insight into advancing and widening their utility.

Mouse Models of Atopic Dermatitis for Drug Discovery from Medicinal Plants (아토피 피부염 치료제 개발에 활용할 수 있는 마우스 모델에 대한 고찰)

  • Yun, Young-Gab;Hwang, Joo-Min;Kim, Hyung-Rul;Jang, Seon-Il
    • Herbal Formula Science
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    • v.15 no.1
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    • pp.145-161
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    • 2007
  • Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.

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Alternative Derivation of Continuous-Time Model for Current-Mode Control (전류모드제어를 위한 연속시간모델의 새로운 유도 방법)

  • 정동열;홍성수;최병조;안현식;사공석진
    • The Transactions of the Korean Institute of Power Electronics
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    • v.8 no.2
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    • pp.137-142
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    • 2003
  • Two existing continuous-time models for the current-mode control have presented noticeable differences in their small-signal predictions. As an attempt to clarify the origin of these disparities, this paper presents an alternative way of deriving a continuous-time model for the current-model control. The results of this paper would provide insights to comprehend the dissimilarity in the modeling method and final results of the earlier models of current-mode control models.

Analysis of the Causal Relationships Among the Factors that Influence the Use of Mobile Phone Services (국내 이동전화 서비스 이용에 영향을 미치는 요인에 관한 연구)

  • Suh, Bo-Mil;Wee, Kyeong-Woo;Yoo, Jin-Soo
    • Journal of Information Technology Services
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    • v.6 no.1
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    • pp.47-63
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    • 2007
  • A lot of researchers have been interested in the factors influencing the use of mobile phone services. Most of the previous studies, however, verified only the research models developed by the authors. They did not consider which model agrees better with the real situation. This study presents six alternative models based on various previous studies, and compares the data fitness of the models. A Web survey of mobile phone users collected 2,217 cases. Statistical analyses, using SEM (Structural Equation Modeling), show that the fitness of the simplest alternative model is better than that of any other model. The simplest model has no causal relationship among exogenous factors, and proposes that all of exogenous factors have direct impacts on the customer satisfaction. In addition, the analyses say that corporate and brand image and additional service are more important than the other exogenous factors such as communication quality.

Design of Emergency Spillway Using Hydraulic and Numerical Model - ImHa Multipurpose Dam (수리모형실험과 수치모의를 이용한 비상여수로 설계-임하댐)

  • Jeon, Tae-Myoung;Kim, Hyung-Il;Park, Hyung-Seop;Baek, Un-Il
    • Proceedings of the Korea Water Resources Association Conference
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    • 2006.05a
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    • pp.1726-1731
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    • 2006
  • Hydraulic and numerical models were applied to design the emergency spillway of ImHa multipurpose Dam. For the numerical model, FLOW-3D was used to evaluate the three-dimensional flow in the spillway. The results of hydraulic model were compared with those of the numerical model which were separated into four zones such as approaching zone, weir zone, transition & tunnel chute zone, and dissipator zone. Moreover, for optimum design of the spillway, the hydraulic and numerical models were performed for the basic plan. Solving the problems of the basic plan, the optimized alternative design was proposed. The numerical models for various conditions of the spillway were performed, which is not always feasible in the hydraulic models. Verified by using the hydraulic models, the optimum alternative design was proposed.

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A Simulation Approach for Testing Non-hierarchical Log-linear Models

  • Park, Hyun-Jip;Hong, Chong-Sun
    • Communications for Statistical Applications and Methods
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    • v.6 no.2
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    • pp.357-366
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    • 1999
  • Let us assume that two different log-linear models are selected by various model selection methods. When these are non-hierarchical it is not easy to choose one of these models. In this paper the well-known Cox's statistic is applied to compare these non-hierarchical log-linear models. Since it is impossible to obtain the analytic solution about the problem we proposed a alternative method by extending Pesaran and pesaran's (1993) simulation approach. We find that the values of proposed test statistic and the estimates are very much stable with some empirical results.

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A Study on Adoption/Diffusion Models for New Product (신제품 수용$\cdot$확산모형에 관한 연구)

  • 김용준;박영근
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.10 no.16
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    • pp.149-158
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    • 1987
  • The Adoption/Diffusion of Innovations(New Product), a topic of study and research that has frown rapidly in the past few decades, deals with how a new product is adopted in a society. It is of high importance to marketing organizations because New Products must be brought out continuously in order to service. The purpose of this paper is to examine the Adoption/Diffusion Models for New product which will help to analyze the Adoption/Diffusion process of Adopters. There are a number of models that, with varying degrees of success, have been used to predict market acceptance of new product. In this paper, following types of new product Adoption/Diffusion Models was suggested. (1) Adoption Models : The Alternative Models of Adoption. The Rogers Model of the Innovation Decision Process. (2) Diffusion Models : First Purchase Models(Basic Models, Extension of the Basic Models), Repeat Purchase Models

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GENERALIZED RELAXED PROXIMAL POINT ALGORITHMS INVOLVING RELATIVE MAXIMAL ACCRETIVE MODELS WITH APPLICATIONS IN BANACH SPACES

  • Verma, Ram U.
    • Communications of the Korean Mathematical Society
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    • v.25 no.2
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    • pp.313-325
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    • 2010
  • General models for the relaxed proximal point algorithm using the notion of relative maximal accretiveness (RMA) are developed, and then the convergence analysis for these models in the context of solving a general class of nonlinear inclusion problems differs significantly than that of Rockafellar (1976), where the local Lipschitz continuity at zero is adopted instead. Moreover, our approach not only generalizes convergence results to real Banach space settings, but also provides a suitable alternative to other problems arising from other related fields.