• 한국환경보건학회지
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• 제39권1호
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• pp.90-98
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• 2013

Objectives: Many studies have shown that air pollution and temperature have adverse effects on mortality and morbidity. But the interactive effect between air pollution and temperature on mortality has been rarely investigated. This study aims to explore whether temperature modifies the associations between ambient particulate matter less than $10{\mu}m$ in diameter ($PM_{10}$) and mortality in Seoul, Korea. Methods: The time-series analysis examined the effect of the interaction between $PM_{10}$ and temperature on mortality from 1999 to 2010 in Seoul. In order to examine the interactive effect between $PM_{10}$ and temperature on mortality, we fitted a response surface model controlling the time-trends and meteorological variables. The effects of $PM_{10}$ were stratified by temperature stratum to quantitatively estimate the $PM_{10}$-health outcome associations. Results: When temperature was low (below the threshold temperature), the percentage increases per $10{\mu}g/m^3$ increase of $PM_{10}$ increased 0.38% (95% Confidence Interval[CI]: 0.09~0.68%) and 0.31% (95% CI: - 0.07~0.68%) of mortality in the all age group and ${\geq}65$ year age group, respectively. When temperature was high (above the threshold temperature), the percentage increases per $10{\mu}g/m^3$ increase of $PM_{10}$ increased 1.09% (95% CI: 0.47~1.72%) and 1.35% (95% CI: 0.65~2.06%) for mortality in the all age group and ${\geq}65$ year age group, respectively. Conclusion: The results of this study showed strong modification by temperature in the association between $PM_{10}$ and mortality. We recommend that public health strategies to minimize adverse health impact of heat and $PM_{10}$ should be considered in control and prevention measures for air pollution and weather-related health impacts.

• 대한한방내과학회지
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• 제42권4호
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• pp.488-509
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• 2021

Purpose: Functional dyspepsia (FD) is a chronic syndrome accompanied by repetitive digestive symptoms that appear in the upper gastrointestinal tract and are not caused by specific diseases. Psychological symptoms like anxiety, depression, insomnia, and somatization are frequently observed in FD. The purpose of this study was to review the effect of herbal medicine on the psychological symptoms that accompany FD. Methods: Database search (PubMed, EMBASE, KISS, Kmbase, KoreanMed, NDSL, OASIS, CNKI) was performed on February 24, 2021; a total of 1825 studies were searched. After the screening, 22 studies were included. Results: The studies were assessed by Cochrane RoB 2 and sorted into a table according to psychological symptoms. Meta-analysis was performed to estimate the effect of herbal medicine. Twenty of the twenty-two studies reported that herbal medicine was significantly more effective than the control group. Only three of the studies did not have a high risk of bias. Conclusion: Herbal medicine was significantly effective with or without Western medicine and had fewer adverse effects. Severe adverse effect was not reported. Psychological symptoms in FD affect onset and duration of FD, and some FD patients want to be treated for their anxiety before other symptoms. Reliable information about treatment for the psychological symptoms of FD is lacking. We reviewed the effect of herbal medicine treatment in this study, the results of which could be selected for primary or secondary treatment for FD.

• Journal of Ginseng Research
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• 제43권4호
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• pp.676-683
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• 2019

Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause "fireness" (上火 in Chinese) because of its "dryness" (燥性 in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome. Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale. Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups. Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of "fireness" related to KRG.

• 서비스연구
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• 제12권3호
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• pp.26-44
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• 2022

업무 중 경험하게 되는 직무스트레스는 성과 향상 등 조직에 긍정적인 영향을 미치는 반면, 적절히 관리되지 않으면 소화기 질환 등 다양한 신체 질병을 유발하고 우울증, 신경 질환 등 정신 질환을 일으키기도 한다. 특히 환자의 건강과 밀접히 관련된 일을 하는 의료기관 종사자는 타 직업군 근로자에 비해 직무스트레스의 정도가 높기 때문에 그 위험성이 더욱 크다. 직무스트레스가 오랫동안 지속되면 정서적 소진과 우울을 유발하게 되는데 이는 개인과 조직에 상당한 악영향을 미치기 때문에 반드시 올바른 관리를 통해 스트레스를 감소시켜야 한다. 이에 본 연구에서는 의료기관 종사자의 직무스트레스, 정서적 소진과 우울의 관계에서 정서적 소진의 매개효과를 알아보고자 자가 보고식 설문 조사법을 이용하여 서술적 조사 연구를 실시하였다. 총 298부의 유효 설문지를 통계분석 자료로 이용하였으며, 수집된 자료는 코딩 과정을 거쳐 IBM SPSS statistics version 25 및 AMOS 20.0 프로그램을 이용하여 분석하였다. 분석 결과, 의료기관 종사자의 직무스트레스가 정서적 소진과 우울에 일부 유의한 정(+)의 영향을 미치는 것으로 나타났으며 의료기관 종사자의 정서적 소진이 우울에 일부 유의한 정(+)의 영향을 미치는 것으로 나타났다. 본 연구를 통해 의료기관 종사자의 직무스트레스와 정서적 소진, 우울 간에 유의한 관련성이 있다는 사실을 알 수 있었으며, 직무스트레스와 우울의 관계에서 정서적 소진이 매개변수로서 작용한다는 것을 알 수 있었다. 의료기관 종사자의 직무스트레스는 근로자의 정신건강과 신체 건강을 위협하고 의료서비스의 질적 저하를 유발하는 등 조직적 측면의 악영향 등을 일으킨다는 점을 미루어 볼 때 의료기관 종사자의 직무스트레스를 해소하고 적절히 관리할 수 있도록 조직적 측면에서의 노력이 필요할 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제16권2호
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• pp.204-210
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• 2003

To see the effect of Beragfat T-300, a by pass fat, on the production and composition of milk, four primiparous crossbred cows in their early lactation were used in a $4{\times}4$ Latin Square Design. Each period was of 30 days including 15 days of adjustment period. The diets were formulated to contain 0, 2.5, 3.5 and 4.5% of Bergafat and were isonitrogenous and isoenergetic. The intake of DM, OM, CP, NDF, ADF, Cellulose and ADL were not affected, however, the EE intake was increased by the supplementation of Bergafat in the diet of cows. The digestibilities of NDF and EE remained unaffected, whereas the digestibilites of DM, OM and CP were reduced. Milk yield remained unaltered, while 4%FCM yield increased as a result of adding Bergafat in the daily ration. Bergafat upto 4.5% of the diet DM can be added in the diet of crossbred cows without any adverse effect on the DM intake and digestibilities of DM and NDF. Furthermore, Bergafat does not cause any butter fat depression in the milk of cows.

• 한국정보시스템학회지:정보시스템연구
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• 제24권2호
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• pp.53-72
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• 2015

Purpose The purpose of this study was to investigate the factors affecting the users' stress and using reluctant intention to use social network service(SNS). This study especially focused on stress of SNSs' user. Because SNS has led to negative effects such as invasion of privacy, addiction and social overload recently. In addition, adverse effects of SNS had caused SNSs' user to feel stress and fatigue. Design/methodology/approach This study developed hypotheses to empirically examine the factors that affect SNS users' stress and using reluctant intention. In order to verify research hypotheses, this study collected data from 362 users who currently use the SNS in Korea. Further, we used the smartPLS analysis. Findings The results of this study are as follows; First, reputation perception, unwanted relation burden, privacy concern, information overload and interaction overload had a significant positive effect on SNS users' stress. But international influence had no significant positive effect on SNS users' stress. Second, SNS users' stress had a significant positive effect on using reluctant intention. The results of this study provides theoretical foundations on the research for dark side of SNS and implies that SNS providers are in need of exerting an effort to minimize the negative aspects.

• 대한화학회지
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• 제29권5호
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• pp.533-538
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• 1985

Spermine에 의하여 誘發되는 凝縮 DNA 構造의 安定化에 있어서 hydrophobic interaction의 重要性을 試驗하기 위하여 spermine-DNA 複合體의 異例的 吸光度-溫度 樣相에 미치는 urea의 效果를 調査하였다. 그 結果 異例的 吸光度-溫度 樣相의 downward peak(trough) 領域에 이르는 相變移에 對한 cooperativity, enthalpy, midpoint의 값들이 Tm 領域의 값들 보다 urea에 敏感한 影響을 받았으며, urea의 濃度 增加에 따라 downward peak가 점차 사라졌다. 이 data는 異例的 吸光度-溫度 樣相을 構成하는 downward peak가 spermine에 의하여 誘發되는 hydrophobic interaction에 의한 凝縮된 tertiary structure의 形成을 나타내고 있다고 불 수 있다.

• Ocean Systems Engineering
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• 제5권4호
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• pp.261-277
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• 2015

Internal solitary waves occur due to density stratification and are nonlinear in nature. These waves have been observed in many parts of the world including the South China Sea, Andaman Sea and Sulu Sea. Their effect on floating systems has been an emerging field of interest and recent offshore developments in the South China Sea where several offshore oil and gas discoveries are located have confirmed adverse effects including large platform motions and riser system damage. A valid numerical model conforming to the physics of internal waves is implemented in this paper and the effect on a spar platform is studied. The physics of internal waves is modeled by the Korteweg-de Vries (KdV) equation, which has a general solution involving Jacobian elliptical functions. The effects of vertical density stratification are captured by solving the Taylor Goldstein equation. Fully coupled time domain analyses are conducted to estimate the effect of internal waves on a typical truss spar, which is configured to South China Sea development requirements and environmental conditions. The hull, moorings and risers are considered as an integrated system and the platform global motions are analyzed. The study could be useful for future guidance and development of offshore systems in the South China Sea and other areas where the internal wave phenomenon is prominent.

• Journal of Nutrition and Health
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• 제29권5호
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• pp.528-532
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• 1996

The purpose of this study was to analyse copper intake and effect ofZn(30mg ZnSO4/d) supplementation on plasma copper level of Korean adults. Daily Cu intakes were studied in ninety subjects aging 20-20 years. Among them twenty four subjects participated in 6 weeks Zn supplementation study. The men consumed 1.47($\pm$0.64)mg of Cu and the women consumed 0.98($\pm$0.43)mg of Cu daily. the most abundant sources of Cu was meat, fish, egg and soybean group, the second was cereal and grain group and the third was vegetable group. These three groups supplied about 90% of copper in the subjects. The plasma copper level of the subjects was not changed much until two weeks of Zn supplementation. However, after two weeks of Zn supplementation plasma copper level was reduced continuously during the experiment. There was no significant difference in plasma Cu level between control and supplement group of the men, while the supplemented women showed significantly lower plasma Cu level than control group at week 4(p<0.01) and week 6(p<0.05). Although plasma Cu level of the subjects was slightly changed, its concentration in plasma was still in normal range in all groups and no one showed clinical Cu deficiency. Therefore the Zn supplementation of RDA level doesn't seem to cause any adverse effect on Cu status.

• 한국지구과학회지
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• 제39권4호
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• pp.317-326
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• 2018

Effect of the nonuniform grid on the two-dimensional transport equation was investigated in terms of theoretical analysis and finite difference method (FDM). The nonuniform grid having a typical structure of the numerical weather forecast model was incorporated in the vertical direction, while the uniform grid was used in the zonal direction. The staggered and non-staggered grid were placed in the vertical and zonal direction, respectively. Time stepping was performed with the third-order Runge Kutta scheme. An error analysis of the spatial discretization on the nonuniform grid was carried out, which indicated that the combined effect of the nonuniform grid and advection velocity produced either numerical diffusion or numerical adverse-diffusion. An analytic function is used for the quantitative evaluation of the errors associated with the discretized transport equation. Numerical experiments with the non-uniformity of vertical grid were found to support the analysis.