• 우울조울병
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• 제16권3호
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• pp.140-151
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• 2018

Objectives : The purpose of this study was to examine effects of adjunctive aripiprazole versus bupropion, on depressive symptoms of female depression. Methods : Sixty six female patients with major depressive disorders were enrolled from a six-week, randomized prospective open-label multi-center study. Participants were randomized to receive aripiprazole (2.5-10 mg/day) or bupropion (150-300 mg/day). Montgomery Asberg Depression Rating Scale, 17-item Hamilton Depression Rating scale (HAM-D17), Iowa Fatigue Scale, Drug-Induced Extrapyramidal Symptoms Scale, Psychotropic-Related Sexual Dysfunction Questionnaire scores, and Clinical Global Impression-Severity (CGI-S) were obtained at baseline and after one, two, four, and six weeks. Changes on individual items of HAM-D17 were assessed as well as on composite scales (anxiety, insomnia and drive), and on four core subscales that capture core depression symptoms. Results : Overall, both treatments improved depressive symptoms, without causing serious adverse events. There were significant differences in the HAM-D17 total score (p=0.046) and CGI-S (p=0.004), between aripiprazole and bupropion augmentation, favoring aripiprazole over bupropion. Aripiprazole revealed significantly greater effect size in depressed mood (p=0.006), retardation (p=0.005), anxiety psychic (p=0.032), and general somatic symptom (p=0.01). Conclusion : While both treatments were effective, results of this study suggested that aripiprazole may be preferable, in treating general and core symptoms of female depression.

• 한국가금학회지
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• 제46권1호
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• pp.11-15
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• 2019

본 연구는 홍국분말 함량(0%, 1%, 2% 및 3%)에 따른 닭다리살 소시지를 제조함에 있어 닭다리살 소시지(대조구)는 1.2% NPS(Nitrite Picking Salt)를 사용하였고, 홍국분말 1%, 2%, 3% 닭다리살 소시지는 1.2% 정제염을 첨가하여 홍국분말 첨가에 따른 적색도 발현효과와 이화학적 특성을 조사하였다. 홍국분말 첨가량에 따른 가열 전 후 pH는 홍국분말 첨가량이 증가할수록 감소하는 경향을 보였으며, 3% 홍국분말을 첨가한 닭다리살 소시지의 pH가 가장 낮게 나타나는 경향을 보였다(P<0.05). 닭다리살 소시지의 가열 전과 후의 명도와 황색도는 홍국첨가량이 증가함에 따라 감소하는 경향을 보였으며(P<0.05), 적색도는 홍국분말의 첨가량이 증가함에 따라 유의적으로 증가하는 경향을 보였다(P<0.05). 닭다리살 소시지의 가열 수율은 홍국분말의 첨가량이 증가함에 따라 증가하는 경향을 보였으나, 유의적인 차이는 나타내지 않았다. 닭다리살 소시지의 경도는 홍국분말 첨가량이 증가할수록 증가하는 추세를 보였고, 3% 첨가 처리구가 가장 높은 값을 나타내었다(P<0.05). 탄력성과 응집성은 3% 홍국분말을 첨가한 닭다리살 소시지에서 가장 낮은 값을 보였다. 이러한 결과를 바탕으로 홍국분말 1%를 첨가한 닭다리살 소시지의 품질특성이 가장 우수한 것으로 나타났으나, 소비자의 기호도에 맞는 육가공품을 생산하기 위해서는 관능적 특성에 대한 연구가 추가적으로 이루어져야 할 것으로 사료된다.

• Toxicological Research
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• 제35권3호
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• pp.225-232
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• 2019

Thymus vulgaris L. is widely used as an ingredient in cooking and in herbal medicine. However, there is little information about its toxicity. The present study was performed to evaluate the acute and repeated 28-day oral dose toxicity of thyme essential oil in rats. For the acute toxicity test, two groups of three rats were used. The rats received a single dose of essential oil: 300 or 2,000 mg/kg of body weight (bw). The rats were observed individually during the first four hours, and then daily until day 14. For the toxicity test with repeated doses, four groups of 10 rats were used. Doses of 100, 250, and 500 mg/kg/day were tested for 28 days. At the end of the experiment, blood was collected and the animals were sacrificed. Histopathological examination showed that in the lungs of rats given the 2,000 mg/kg bw dose, polymorph nuclear infiltrates, hemosiderin macrophages, and interstitial space thickening were present. In the repeated dose study, all rats survived the 28-day treatment period and apparently showed no signs of toxicity. The hematological and biochemical parameters were not altered. The histopathological study of the organs showed severe changes in the lung, with the dose of 500 mg/kg/day; in the other organs, no alterations were observed or the changes were slight. The body weight was only altered in male rats given the 500 mg/kg dose. The relative weight of the organs did not show any significant changes. Our studies revealed that the essential oil of Thymus vulgaris has moderate oral toxicity according to the results of the acute test, whereas the results of the 28-day oral toxicity test suggest that the no-observed-adverse effect level (NOAEL) is greater than 250 mg/kg/day.

• 정보화정책
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• 제26권3호
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• pp.3-35
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• 2019

4차 산업혁명시대에 지능정보기술의 발전에 따라 인공지능의 다양한 역할이 주목을 받고 있다. 구글의 알파고를 계기로 인공지능은 더 이상 공상의 기술이 아닌 실존하는 기술이라는 점에서 사회전역에 파급효과를 가져올 것으로 예상되고 있다. 이에 따라 본 연구에서는 공공부문에서 인공지능을 활용한 정책결정의 가능성과 쟁점에 대한 탐색적 논의를 진행하였다. 이에 따른 연구목적은 세 가지 측면으로 구분되며, 첫째, 공공부문에서 인공지능이 정책결정까지 이어질 수 있는지에 대한 검토이다. 둘째, 인공지능의 정책결정과정이 기존 정책결정과의 어떠한 차이를 가지는가이다. 셋째, 인공지능이 정책결정에 도입될 경우에 나오게 될 쟁점을 다루었다. 이러한 인공지능에 의한 정책결정이 기존의 정채결정과 구별되는 점은 많은 정보와 대안에 기반한 합리적 의사결정, 투명성 및 신뢰성의 제고, 정책이슈에 대한 객관적인 시각, 신속한 의사결정 등이다. 하지만 인공지능의 정책의사결정시 야기되는 쟁점 역시 존재 한다. 첫째는 인공지능의 우월성, 둘째 윤리성 논란, 셋째 책임성, 넷째 기존 민주주의의 변화, 다섯째 공공부문 인력의 대체 논쟁, 여섯째 인공지능에 필요한 데이터 활용의 문제점 등이다. 공공부문 정책의사결정에서 인공지능의 도입은 향후 실현될 것이기 때문에, 사회적 충격을 최소화하기 위해 그에 따른 순기능과 역기능에 대한 융합적인 접근이 필요하다.

• Korean Journal of Acupuncture
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• 제36권2호
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• pp.127-138
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• 2019

Objectives : This study was carried out in order to toxicity and safety of Drosera Rotundifolia L. pharmacopuncture in BALB/c mice. Methods : In order to investigate toxicity and safety of Drosera Rotundifolia L. pharmacopuncture, BALB/c mice were chosen in these studies and injected to ST36. In 50% Lethal Dose (LD 50) study, mice were divided into 8 groups. Doses of pharmacopuncture at 300, 600, 1,200, 2,400, 3,600, 4,800, 6,000, 7,200 mg/kg were given to the each group. we observed mortality and toxic signs for 7 days after injection. In single-dose toxicity, mice were divided into 4 groups. Doses of pharmacopuncture, 300, 600, 1,200 mg/kg, were administered to the experimental group. And a dose of normal saline, 0.2 ml was administered to the control group. We observed mortality and toxic signs for 14 days after injection. In repeated-dose toxicity for 4 weeks, mice were divided in 4 groups. Doses of pharmacopuncture, 150, 300, 600 mg/kg, were administered to the experimental group. And a dose of normal saline, 0.2 ml, was administered to the control group. We observed mortality, toxic signs, body weight, hematological values et al. Results : The LD 50 of Drosera Rotundifolia L. pharmacopuncture was 4,800 mg/kg. In single-dose toxicity, no deaths, no toxic signs occurred in any of groups. In repeated-dose toxicity for 4 weeks, no deaths, no toxic signs occurred in any of groups. Conclusions : No Observed Adverse Effect Level (NOAEL) of Drosera Rotundifolia L. pharmacopuncture injection for 4 weeks was more than 600 mg/kg.

• 교육시설 논문지
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• 제25권5호
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• pp.3-12
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• 2018

The purpose of this study is to examine the degree of appropriateness of using design quality indicators for the educational building, and complements for design quality indicators. For doing this, each items of the Korean educational building design indicator was validated by teachers, school staff and an education officer. First, School Personnel and Teachers considered indicators for the classroom designed for general subjects as being valid. However, in terms of indicators for the outside space, they thought of them as not being valid. In particular, it seemed that school staff would have a passive attitude toward the open of the school facility for the local society. It is judged that there happens an adverse effect caused by the open of the school facility for the local society in the educational environment of the school. Second, Education Office Supervisors thought that eco-friendly indicators, LED lighting, an outer wall, and widows and doors had a high validity. On the contrary, he viewed the validity of a rainwater retention basin as being low, which was likely because he rarely had expertise on the construction. When it comes to the indicator of technology capability, ultrahigh-speed information network was seen as being valid, and the indicator of economic feasibility had high validity on maintenance and durability. Third, compared to groups of Teachers and School Personnel, the group of education officers presented high validity of indicators. Validity of indicators might be differently showed because different items on indicators were measured. However, it is speculated that Education Office Supervisors mostly acknowledged the validity of indicators. Fourth, a majority of Teachers, School staff, and Education Office Supervisors were favor of the system of the evaluation accreditation for school facilities since it played a guide role in improving the quality of school. In order to settle the system of the evaluation accreditation for school facilities, it is most important that institutions in the local society which are publicly reliable should participate in the phase of designing the system of the evaluation accreditation for school facilities. In sum, overall respondents agreed with the system of the evaluation accreditation for school facilities but were aware that reliable organizations in public would need to take part in planning the system of the evaluation accreditation for school facilities from the beginning.

• Toxicological Research
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• 제35권2호
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• pp.103-117
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• 2019

The mixture of 5-chloro-2-methylisothiazol-3(2H)-one (CMIT) and 2-methylisothiazol-3(2H)-one (MIT), CMIT/MIT, is a preservative in cosmetics. CMIT/MIT is a highly effective preservative; however, it is also a commonly known skin sensitizer. Therefore, in the present study, a risk assessment for safety management of CMIT/MIT was conducted on products containing 0.0015% of CMIT/MIT, which is the maximum MIT level allowed in current products. The no observed adverse effect level (NOAEL) for CMIT/MIT was 2.8 mg/kg bw/day obtained from a two-generation reproductive toxicity test, and the skin sensitization toxicity standard value for CMIT/MIT, or the no expected sensitization induction level (NESIL), was $1.25{\mu}g/cm^2/day$ in humans. According to a calculation of body exposure to cosmetics use, the systemic exposure dosage (SED) was calculated as 0.00423 mg/kg bw/day when leave-on and rinse-off products were considered. Additionally, the consumer exposure level (CEL) amounted to $0.77512{\mu}g/cm^2/day$ for all representative cosmetics and $0.00584{\mu}g/cm^2/day$ for rinse-off products only. As a result, the non-cancer margin of safety (MOS) was calculated as 633, and CMIT/MIT was determined to be safe when all representative cosmetics were evaluated. In addition, the skin sensitization acceptable exposure level (AEL)/CEL was calculated as 0.00538 for all representative cosmetics and 2.14225 for rinse-off products; thus, CMIT/MIT was considered a skin sensitizer when all representative cosmetics were evaluated. Current regulations indicate that CMIT/MIT can only be used at concentrations 0.0015% or less and is prohibited from use in other cosmetics products. According to the results of this risk assessment, the CMIT/MIT regulatory values currently used in cosmetics are evaluated as appropriate.

• 산업식품공학
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• 제21권1호
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• pp.93-98
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• 2017

박력분에 대한 양배추 분말 대체량을 0-8%로 달리하여 쿠키를 제조한 후 물리 화학적 품질특성, 산화방지 활성 및 소비자 기호도를 조사하였다. 양배추 분말 첨가량에 따른 쿠키 반죽 밀도의 유의적인 차이는 나타나지 않았으나(p>0.05), 반죽의 pH와 수분함량은 각각 유의적으로 감소 또는 증가하였다(p<0.05). 쿠키의 퍼짐성과 경도는 양배추 분말 첨가량이 증가할수록 유의적으로 증가한 반면, 손실률은 유의적으로 감소하는 경향을 보였다(p<0.05). 한편 명도($L^*$), 황색도($b^*$) 모두 양배추 분말의 첨가량이 증가함에 따라 유의적으로 감소하였으나(p<0.05), 적색도($a^*$)는 유의적으로 증가하였다(p<0.05). 산화방지 활성을 나타내는 DPPH에 대한 전자공여능 및 ABTS에 대한 라디칼 소거능은 유의적인 차이를 보이며 증가하였고(p<0.05), 두 지표간에 매우 높은 상관관계를 보였다. 소비자 검사 결과, 2% 첨가군은 모든 항목에서 대조군과 대등한 평점을 받았고, 특히 색, 부드러운 정도, 전체적인 기호도에서 유의적으로 가장 높은 평점을 받았다(p<0.05). 한편 양배추 분말 첨가량이 4%를 초과하면 부드러운 정도를 제외한 모든 평가항목에서 기호도가 급격히 감소하는 것으로 나타났다. 따라서 양배추 분말의 생리적 활성과 쿠키의 관능적 품질을 고려한 최적의 첨가농도는 2%가 가장 적절한 것으로 판단된다.

• Journal of Animal Science and Technology
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• 제63권5호
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• pp.1034-1063
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• 2021

The experiment was designed as a 3 × 3 × 2 factorial arrangement of treatments, including (i) pomegranate peel (zero, 4%, and 8 percent), (ii) oxidized soybean oil (zero, 2%, and 4 percent), and (iii) alpha-tocopherol (zero and 200 mg/kg). Supplementation of 8% pomegranate peel in diets significantly decreased the growth performance of broiler chickens. The supplementation of 4% oxidized oil in diets significantly reduced body weight gain and Feed intake whole experimental period (p < 0.05). The results showed that supplementation of 4% pomegranate peel in the diet was associated with low aspartate transaminase (AST), alanine transaminase, and malondialdehyde (MDA). However, 4% pomegranate peel increased the total antioxidant capacity (TAC) and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. The supplemental 4% oxidized oil increased the serum AST, alanine aminotransferase (ALT), and MDA concentrations. TAC, SOD, and Catalase (CAT) activities were affected by 4% oxidized oil and alpha-tocopherol. The use of oxidized oil and vitamin E decreased MDA concentration. The serum glucose and globulin concentrations were significantly lower in the 8% pomegranate peel. The results showed that supplementation with 4% pomegranate peel in diets reduced serum low-density lipoprotein (LDL). The inclusion of 4% oxidized oil in diets reduced serum glucose and increased the blood lipid concentration such as triglyceride, cholesterol and LDL. Vitamin E supplementation reduced the serum cholesterol and LDL concentrations. The use of 8% pomegranate peel reduced red blood cell (RBC), hemoglobin, and packed cell value (PCV). The results indicated that supplementation with 8% pomegranate peel and 4% oxidized oil in diets decreased the immunoglobulin concentration in broilers. In addition, it was found that the inclusion of 4% pomegranate peel in diets resulted in higher IgG, IgM and total immunoglobulin. Pomegranate peel supplementation significantly decreased meat MDA concentration. Supplementation of 4% oxidized oil increased MDA of meat (p < 0.05). Vitamin E supplementation (200 mg/kg) significantly decreased MDA of meat (p < 0.05). Consequently, the results of this experiment showed that supplementation with 4% pomegranate peel had beneficial effects on broiler chickens. It was also found that feeding 2% oxidized oil in diets had no adverse effect on broilers.

• 한국환경복원기술학회지
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• 제22권5호
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• pp.1-12
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• 2019

It is important to measure the height of trees as an essential element for assessing the forest health in urban areas. Therefore, an automated method that can measure the height of individual tree as a three-dimensional forest information is needed in an extensive and dense forest. Since airborne LiDAR dataset is easy to analyze the tree height(z-coordinate) of forests, studies on individual tree height measurement could be performed as an assessment forest health. Especially in urban forests, that adversely affected by habitat fragmentation and isolation. So this study was analyzed to measure the height of individual trees for assessing the urban forests health, Furthermore to identify environmental factors that affect forest growth. The survey was conducted in the Mt. Bongseo located in Seobuk-gu. Cheonan-si(Middle Chungcheong Province). We segment the individual trees on coniferous by automatic method using the airborne LiDAR dataset of the two periods (year of 2016 and 2017) and to find out individual tree growth. Segmentation of individual trees was performed by using the watershed algorithm and the local maximum, and the tree growth was determined by the difference of the tree height according to the two periods. After we clarify the relationship between the environmental factors affecting the tree growth. The tree growth of Mt. Bongseo was about 20cm for a year, and it was analyzed to be lower than 23.9cm/year of the growth of the dominant species, Pinus rigida. This may have an adverse effect on the growth of isolated urban forests. It also determined different trees growth according to age, diameter and density class in the stock map, effective soil depth and drainage grade in the soil map. There was a statistically significant positive correlation between the distance to the road and the solar radiation as an environmental factor affecting the tree growth. Since there is less correlation, it is necessary to determine other influencing factors affecting tree growth in urban forests besides anthropogenic influences. This study is the first data for the analysis of segmentation and the growth of the individual tree, and it can be used as a scientific data of the urban forest health assessment and management.