• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.147-153
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• 2021

Collagen hydrolysate (CH) is known to prevent skin aging by stimulating skin dermal fibroblasts to promote synthesis of extracellular matrix such as collagen and elastin. Recently, among the various factors that cause skin aging, advanced glycation end products (AGEs) have received particular attention. However, the effect of CH on AGE accumulation has not been studied. Since CH could affect AGE accumulation by promoting production of skin structural proteins, clinical trial was performed using low molecule collagen peptide (LMCP), which were CH containing 25% tripeptide and 4% Gly-Pro-Hyp. Skin autofluorescence (SAF) values were measured using an AGE reader to evaluate accumulation of AGE in skin. As a result of applying 0.5% and 1.0% LMCP solutions to the subject's forearm for 8 weeks, the SAF value at the test site significantly decreased compared to the control site. Additionally, in vitro test was performed using CCD-986sk to evaluate the promotion of collagen synthesis in skin fibroblasts by LMCP. As a result, 800 ㎍/mL of LMCP significantly increased synthesis of human pro-collagen Iα1 (COL1A1) in CCD-986sk. Through this study, we have confirmed that tropical LMCP applications can promote collagen synthesis to help anti-glycation effects, suggesting that LMCP has potential as an anti-aging cosmetic material.

• Journal of Home Health Care Nursing
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• v.20 no.2
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• pp.133-140
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• 2013

Purpose: This study examined the demographic and lifestyle differences between women with osteopenia and those with normal bone mineral density (BMD) to identify risk factors for osteopenia. Method: Participants comprised 381 women age 40-64 years. Data were collected using surveys, BMD measures, and anthropometric parameters. Results: Prevalence of osteopenia was 29.1%; significant differences in age group, job, age at menarche, age at menopause, and body mass index were found between women with osteopenia and those with normal BMD. Logistic regression analysis indicated that advanced age, unemployment, lower body mass index, and lack of exercise in women were significantly associated with osteopenia. Conclusion: This study suggests the need for strategies to improve bone health and continuous cohort studies to identify risk factors.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.103.2-103.2
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• 2011

We measure the degree of polarization of the lunar regolith to map the distributions of the age and the particle size. We use a 12cm refracting telescope with a 2k-square pixel color CCD (R band) and a polarization filter. The angular resolution obtained is 3.02 km/pixel. Our goal is to obtain a map of the lunar particle size distribution on the lunar regolith and then that of the age distribution. Polarization of the light scattered by lunar surface contains information on their mean particle size. The mean particle size of the lunar surface has been decreased by continued micro-meteoroid impact over a long period. One can estimate the age of the lunar surface if the mean particle size is known. Particle sizes can be measured through observations of polarization because the mean particle size is related to the maximum polarization and albedo. The age and the particle size of the lunar regolith can give vital information for the future lunar exploration.

• Journal of Ginseng Research
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• v.39 no.2
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• pp.116-124
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• 2015

Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such as Alzheimer's disease (AD). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-${\kappa}B$). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantly reduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutase activity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE and NF-${\kappa}B$. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments and regulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairment and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the RAGE/NF-${\kappa}B$ pathway. Our results provided the experimental basis for applying PG in preventing and treating AD.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.762-766
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• 2002

This paper proposes a method or estimating lifetime distribution for products under two-dimensional warranty in which age and usage are used simultaneously to determine the eligibility of a warranty claim. For such a case, existing methods reduce the two-dimensional time stale to a single stale assuming that the two variables have a functional relationship. This assumption is, however, not appropriate since the functional relationship is unknown in practice. In this paper, the field age and usage data are modeled with a bivariate lifetime distribution. Method of obtaining maximum likelihood estimators is outlined, their asymptotic properties are studied and specific formulas for a bivariate Weibull distribution are obtained. The proposed model is compared with the existing one which assumes a lineal relationship between the two variables Simulation studios are performed to investigate the effect of the degree of dependency between the two variables.

• Clinical and Experimental Pediatrics
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• v.54 no.11
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• pp.429-435
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• 2011

Although Korean population has been growing steadily during the past four decades, the nation is rapidly becoming an aging society because of its declining birth rate combined with an increasing life expectancy. In addition, Korea has one of the lowest fertility rates in the world due to fewer married couples, advanced maternal age, and falling birth rate. The prevalence of low birth weight infants and multiple births has been increased compared with the decrease in the birth rate. Moreover, the number of congenital anomalies is expected to increase due to the advanced maternal age. In addition, the number of interracial children is expected to increase due to the rise in the number of international marriages. However, the maternal education level is high, single-mother birth rate is low, and the gender imbalance has lessened. The number of overweight babies has been decreased, as more pregnant women are receiving adequate prenatal care. Compared to the Asian average birth weight, the average birth weight is the highest in Asia. Moreover, the rate of low birth weight infants is low, and infant mortality is similarly low across Asia. Using birth data from Statistics Korea and studies of birth outcomes in Korea and abroad, this study aimed to assess the changes in maternal and infant characteristics associated with birth outcomes during the past four decades and identify necessary information infrastructures to study countermeasures the decrease in birth rate and increase in low birth weight infants in Korea.

• Journal of Families and Better Life
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• v.26 no.5
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• pp.15-25
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• 2008

By population graying, elderly residing problem is risen by social problem. Specially, because residing is occupying many parts in psychological sentimentalize stability of elderly senescence, it is misgovernment that suitable countermeasure is pressing hereupon with governmental interest so that elderly age may can inhabit to suitable residing space. The purposes of this research used content analysis method about elderly residing support policy laying stress on data of elderly residing support policy connection literature, virtue research etc.. and research result is as following ; First, as elderly residing connection equipment is permitted by common people subject operation in government burden gradually in van abroad including our country, supply of elderly equipment is spreading. Second, support about elderly dependent is introducing house priority supply system to financial favors benefit and income tax exemption, aged parents supporter being increasing. Third, through reconstruction and so on of house, real elderly's ashes are developing by support policy. Also, is administering elderly residing support policy by total service that can support elderly aging in place.

• Journal of the Korean Society of Costume
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• v.22
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• pp.61-70
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• 1994

the purpose of study is to grasp the actual state of the textiles of Kojosun, Booyeo and Kogooryeo, by examining and studying about the excavated article of the textile of the Booyeo Age which was being gamered in the Research Institute of Study of antiquities of Civilization of gilimsung without being analyzed and examined after being excavated at September in 1990 and 1993, the textile of Kojosun Age wich was excavated and examined at East and North Gilimsung in China and the textile excavated and examined at the Kogooryeo grave at jiban China. 1. The kinds of textiles of Booye Age are warp kum plin weave silk plain weave bang gong Sa, and drawn and dyed textile, It is deemed that the real state of keum, Jeung and Hwi in the old literature of Sam guk Ji was grasped. 2. It emerges that more detailed wool than the wool fabric of China area of the same age was manufactured as the textile of Kojosun Age. hemp cloth corresponds to 12 Seung, in converting into fabric width of 50cm. 3. Keum was examined and reported as the textile of Kogooryeo Age and the real state of Woonkeum of Kogooryeo Age was grasped through "Wang ja moon keum" of Keumjang of mural of South and North I room of the grave that the same keum was excavated. The real state of dyed textile of hemp was grasped as the red hemp cloth was examined. Moreover the real state of development of advanced technique to weave with machine appeared by the grasp of inclination of loom with reed of Kogooryeo.Kogooryeo.

• Women's Health Nursing
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• v.19 no.4
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• pp.230-241
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• 2013

Purpose: This study was done to confirm prenatal health management and educational needs for pregnant women with advanced maternal age (AMA) and pregnant women under 35 years of age. Methods: This study was a descriptive research in which self-report questionnaires were used. Participants were 279 pregnant women (83 AMA and 196 less than 35). Results: Only 32.5% of AMA women had received prenatal education and 51.8% reported wanting internet education. AMA women, compared to the under 35 women, had higher levels of self-awareness of health problems and possibility of health problems but lower levels of alcohol experience before pregnancy. For prenatal health management, scores were low for prenatal exercise, prenatal education and nutrition. For prenatal health management education, AMA women reported high levels of need for education on health problems. Conclusion: The results indicate that prenatal health management education must be given considering differences in age-related requirements by emphasizing health care and obstetric complications during pregnancy for AMA women and anemia and information on substance use during pregnancy for women under 35. Reliable internet-based education programs need to be developed using available information and communication technology for the increasing number of employed pregnant women.

• Clinical Endoscopy
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• v.56 no.2
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• pp.155-163
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• 2023

Malignant hilar biliary obstruction (MHO), an aggressive perihilar biliary obstruction caused by cholangiocarcinoma, gallbladder cancer, or other metastatic malignancies, has a poor prognosis. Surgical resection is the only curative treatment for biliary malignancies. However, the majority of patients with MHO cannot undergo surgery on presentation because of an advanced inoperable state or a poor performance state due to old age or comorbid diseases. Therefore, palliative biliary drainage is mandatory to improve symptomatic jaundice and the quality of life. Among the drainage methods, endoscopic biliary drainage is the current standard for palliation of unresectable advanced MHO. In addition, combined with endoscopic drainage, additional local ablation therapies, such as photodynamic therapy or radiofrequency ablation (RFA), have been introduced to prolong stent patency and survival. Currently, RFA is commonly used as palliative therapy, even for advanced MHO. This literature review summarizes recent studies on RFA for advanced MHO.