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http://dx.doi.org/10.15230/SCSK.2021.47.2.147

The Effect of Low Molecule Collagen Peptide on Skin Anti-glycation and Collagen Synthesis as a Skin Aging Therapy  

Kim, Hong Seok (Human Co., Ltd. Skin Research Institute)
Hong, Won Kyu (Human Co., Ltd. Skin Research Institute)
Lee, Mun Hoe (Health Food Research and Development, NEWTREE Co., Ltd.)
Kim, Hyeong Min (Health Food Research and Development, NEWTREE Co., Ltd.)
Chung, Hee Chul (Health Food Research and Development, NEWTREE Co., Ltd.)
Lee, Jin Hee (Health Food Research and Development, NEWTREE Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.47, no.2, 2021 , pp. 147-153 More about this Journal
Abstract
Collagen hydrolysate (CH) is known to prevent skin aging by stimulating skin dermal fibroblasts to promote synthesis of extracellular matrix such as collagen and elastin. Recently, among the various factors that cause skin aging, advanced glycation end products (AGEs) have received particular attention. However, the effect of CH on AGE accumulation has not been studied. Since CH could affect AGE accumulation by promoting production of skin structural proteins, clinical trial was performed using low molecule collagen peptide (LMCP), which were CH containing 25% tripeptide and 4% Gly-Pro-Hyp. Skin autofluorescence (SAF) values were measured using an AGE reader to evaluate accumulation of AGE in skin. As a result of applying 0.5% and 1.0% LMCP solutions to the subject's forearm for 8 weeks, the SAF value at the test site significantly decreased compared to the control site. Additionally, in vitro test was performed using CCD-986sk to evaluate the promotion of collagen synthesis in skin fibroblasts by LMCP. As a result, 800 ㎍/mL of LMCP significantly increased synthesis of human pro-collagen Iα1 (COL1A1) in CCD-986sk. Through this study, we have confirmed that tropical LMCP applications can promote collagen synthesis to help anti-glycation effects, suggesting that LMCP has potential as an anti-aging cosmetic material.
Keywords
collagen hydrolysates (CH); low molecule collagen peptide (LMCP); anti-aging; advanced glycation end-products (AGEs); skin autofluorescence (SAF);
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1 N. Verzijl, J. DeGroot, S. R. Thorpe, R. A. Bank, J. N. Shaw, T. J. Lyons, J. W. Bijlsma, F. P. Lafeber, J. W. Baynes, and J. M. TeKoppele, Effect of collagen turnover on the accumulation of advanced glycation end products, J. Biol. Chem., 275(50), 39027 (2000).   DOI
2 H. Corstjens, D. Dicanio, N. Muizzuddin, A. Neven, R. Sparacio, L. Declercq, and D. Maes, Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects, Exp. Gerontol., 43(7), 663 (2008).   DOI
3 A. Sanchez, M. Blanco, B. Correa, R. I. Perez-Martin, and C. G. Sotelo, Effect of fish collagen hydrolysates on type I collagen mRNA levels of human dermal fibroblast culture, Mar Drugs, 16(5), 144 (2018).   DOI
4 P. Gkogkolou and M. Bohm, Advanced glycation end products: key players in skin aging?, Dermatoendocrinol., 4(3), 259 (2012).   DOI
5 Y. Shigemura, K. Iwai, F. Morimatsu, T. Iwamoto, T. Mori, C. Oda, T. Taira, E. Y. Park, Y. Nakamura, and K. Sato, Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin, J. Agric. Food Chem., 57(2), 444 (2009).   DOI
6 M. Peppa, H. Brem, P. Ehrlich, J. G. Zhang, W. Cai, Z. Li, A. Croitoru, S. Thung, and H. Vlassara, Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice, Diabetes, 52(11), 2805 (2003).   DOI
7 T. Goldberg, W. Cai, M. Peppa, V. Dardaine, B. S. Baliga, J. Uribarri, and H. Vlassara, Advanced glycoxidation end products in commonly consumed foods, J. Am. Diet Assoc., 104(8), 1287 (2004).   DOI
8 H. Ohara, H. Matsumoto, K. Ito, K. Iwai, and K. Sato, Comparison of quantity and structures of hydroxyprolinecontaining peptides in human blood after oral ingestion of gelatin hydrolysates from different sources, J. Agric. Food Chem., 55(4), 1532 (2007).   DOI
9 H. Ohshima, M. Oyobikawa, A. Tada, T. Maeda, H. Takiwaki, M. Itoh, and H. Kanto, Melanin and facial skin fluorescence as markers of yellowish discoloration with aging, Skin Res Technol., 15(4), 496 (2009).   DOI
10 D. U. Kim, H. C. Chung, J. Choi, Y. Sakai, and B. Y. Lee, Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: a randomized, double-blind, placebo-controlled study, Nutrients, 10(7), 826 (2018).   DOI
11 A. Leon-Lopez, A. Morales-Penaloza, V. M. MartinezJuarez, A. Vargas-Torres, D. I. Zeugolis, and G. AguirreAlvarez, Hydrolyzed collagen-sources and applications, Molecules, 24(22), 4031 (2019).   DOI
12 S. Sibilla, M. Godfrey, S. Brewer, A. Budh-Raja, and L. Genovese, An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: scientific background and clinical studies, The Open Nutraceuticals Journal, 8, 29 (2015).   DOI
13 Q. Zhang, J. M. Ames, R. D. Smith, J. W. Baynes, and T. O. Metz, A perspective on the Maillard reaction and the analysis of protein, J. Proteome Res., 8(2), 754 (2009).   DOI
14 M. Narda, L. Peno-Mazzarino, J. Krutmann, C. Trullas, and C. Granger, Novel facial cream containing carnosine inhibits formation of advanced glycation, Skin Pharmacol. Physiol., 31(6), 324 (2018).   DOI
15 C. Y. Liu, Q. F. Huang, Y. B. Cheng, Q. H. Guo, Q. Chen, Y. Li, and J. G. Wang, A comparative study on skin and plasma advanced glycation end products and their associations with arterial stiffness, Pulse (Basel), 4(4), 208 (2016).   DOI
16 A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, Advanced glycation end products sparking the development of diabetic vascular injury, Circulation, 114(6), 597 (2006).   DOI
17 R. P. Dearlove, P. Greenspan, D. K. Hartle, R. B. Swanson, and J. L. Hargrove, Inhibition of protein glycation by extracts of culinary herbs and spices, J. Med. Food, 11(2), 275 (2008).   DOI
18 H. Ohara, S. Ichikawa, H. Matsumoto, M. Akiyama, N. Fujimoto, T. Kobayashi, and S. Tajima, Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts, J. Dermatol., 37(4), 330 (2010).   DOI
19 S. A. Chen, H. M. Chen, Y. D. Yao, C. F. Hung, C. S. Tu, and Y. J. Liang, Topical treatment with antioxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products, Eur. J. Pharm. Sci., 47(5), 875 (2012).   DOI