• 대한의생명과학회지
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• 제13권2호
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• pp.91-97
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• 2007

Obesity is defined as increased mass of adipose tissue, conferring a higher risk of cardiovascular and metabolic disorders such as diabetes, hyperlipidemia, and coronary heart disease. To get a better understanding of the role of a male sex hormone testosterone on obesity, we thus measured the effects of testosterone on white adipose tissue (WAT) mass, adipocyte histology and hepatic lipid accumulation in male castrated (CAST) C57BL/6J mice. Compared to male CAST control mice, testosterone-treated mice had the decreased WAT mass and the increased the number of adipocytes. Especially, histological data showed that the adipocyte size was reduced in a dose-dependent manner and was most effective at dose 150 $\mu$g per mouse for testosterone. In addition, the administration of testosterone resulted in the inhibition of hepatic lipid accumulation compared with control mice. Our results suggest that testosterone regulates adipocytes development and hepatic lipid metabolism, resulting in the prevention of obesity in male CAST mice.

• Journal of Community Nutrition
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• 제8권2호
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• pp.69-75
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• 2006

Adipose tissue has now been recognized as a rich source of metabolically active molecules that include leptin and angiotensinogen (AGT), the precursor of angiotensin II (Ang II). Both of which have been implicated in the pathogenesis of metabolic alteration and hypertension associated with obesity. In this study, we examined the relationship between body mass index (BMI), adipocyte size, leptin, Ang II secretion and mRNA expression in human adipose tissue obtained from female subjects. Leptin and Ang II were analyzed using specific radioimmunoassay kits following a 48hour tissue culture. Leptin and Ang II secretion varied from 1.4 - 72.1ng/g and 0.8 - 57.3pg/g of tissue respectively. These large individual variations limit significant correlation between BMI, leptin and Ang II secretion. Ang II secretion was significantly higher in the obese than the non-obese (p < 0.05) and positively correlated with BMI. However, no difference in leptin secretion between the obese and the non-obese was observed and leptin secretion showed negative correlation with BMI. No difference in leptin and AGT mRNA expression in adipose tissue between the obese and the non-obese was observed. Although several limitations of this study, we found increased Ang II secretion in obese patients compared with non-obese patients, and positive correlation between AGT and BMI. Observed difference in AGT expression between the obese and the non-obese in this study might be of importance in relation with obesity related hypertension. (J Community Nutrition 8(2): 69-75, 2006)

• 한국응용과학기술학회지
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• 제37권3호
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• pp.385-397
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• 2020

본 연구는 수영운동이 백색지방조직의 혈관신생을 조절함으로써 비만을 개선하는지를 조사하였다. 고지방식이를 섭취한 암컷 쥐는 모의 수술 군(Sham), 난소절제 수술 군(OVX) 및 수영운동을 실시한 난소절제 군(OVX + Swim)으로 나뉘었다. Sham에 비해 OVX는 몸무게, 지방조직무게 및 지방세포의 크기가 증가 되었다. 그러나 OVX + Swim의 이러한 요소들(: 몸무게, 지방조직무게 및 지방세포의 크기)은 OVX에 비해 감소 되었다. Sham에 비해 OVX는 백색지방조직에서 혈관신생 촉진인자와 MMPs의 유전자 발현이 증가하였고, 혈관신생 억제인자들의 유전자 발현은 감소하였다. 그러나 OVX + Swim은 OVX에 비해 백색지방조직에서 혈관신생 촉진인자와 MMPs의 유전자 발현이 감소하였고, 혈관신생 억제인자들의 유전자 발현은 증가하였다. 이러한 연구결과들은 고지방식이를 섭취한 난소절제 암컷 쥐에서 수영운동이 백색지방조직의 혈관신생을 억제함으로써 비만을 개선한다는 것을 제시하였다.

• Molecules and Cells
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• 제40권11호
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• pp.855-863
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• 2017

Adipose tissue plays a central role in regulating dynamic cross-talk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects undergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with $TNF-{\alpha}$ in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.

• Journal of Chest Surgery
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• 제23권3호
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• pp.561-565
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• 1990

We experienced thymolipoma which is a rare benign mediastinal tumor, an admixture of atrophic thymic tissue and matured adipose tissue. The patient was, 13 years old boy, admitted due to anterior mediastinal mass on routine chest X-ray and complained of mild exertional dyspnea. The physical examination revealed percussion dullness, decreased breathing sound at right anterior hemithorax. The chest PA and lateral views showed both paracardiac mass density and obliteration of retrosternal clear space. The chest CT Scan showed tubular structure containing of thymic tissue and enhanced fatty tissue, suggested thymolipoma. Operation was performed under the impression of thymolipoma. Through median sternotomy, the huge mass was resected. Grossly, the mass was yellowish fatty colored, measured 15X12X10cm, weighed 600gm. Light microscopic examination showed that thymic tissue containing of Hassal`s corpuscles were surrounded by matured adipose tissue, as the characteristic finding of thymolipoma. The postoperative course was uneventful.

• 대한통합의학회지
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• 제8권1호
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• pp.125-135
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• 2020

Purpose : Obesity indices are major predictive markers for coronary artery stenosis, but there are few studies about the relationship between obesity indices and coronary artery stenosis in the Korean population. Therefore, we analyzed the association between obesity indices and coronary artery stenosis among health-screen examinees. Methods : This study included 99 males and females who visited a health-examination center. The obesity indices included body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT), visceral adipose tissue/subcutaneous adipose tissue ratio (V/S ratio). All subjects had their degree of coronary artery stenosis measured using coronary computed tomography angiography (CCTA). A multiple logistic regression test was conducted to analyze the association between obesity indices and coronary artery stenosis. Results : This study was taken by multiple logistic regression test adjusted by age, sex, smoking status, frequency of alcohol drinking/week and frequency of exercise/week. The adjusted odds ratio for the presence of coronary artery stenosis for subjects with abdominal obesity (abdominal obesity defined as a waist circumference ≥ 90 cm in males; ≥ 85 cm in females) was 6.263 (95 % confidence interval (CI) 1.974-19.869), for subjects with visceral obesity by visceral adipose tissue (visceral obesity defined as a visceral adipose tissue ≥ 100) was 11.430 (95 % CI 3.044-42.928). Conclusion : In this study of adults, WC and VAT were independent predictors of coronary artery stenosis. These results suggest that WC and VAT may be useful markers of coronary artery stenosis.

• 재활복지공학회논문지
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• 제11권3호
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• pp.239-245
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• 2017

본 연구는 비만 청소년기 남성을 대상으로 복부지방면적과 피하지방두께, 신체둘레, 신체구성, 혈중 지질 간의 상관관계를 분석하였으며 주요 결과는 다음과 같다. 첫째, 복부지방면적과 피하지방두께 간의 관련성과 관련하여 전체지방면적과 피하지방면적은 피하지방두께를 구성하는 대부분의 변인과 관련성이 있었으며 특히 견갑골 아래 피부두께는 전체지방면적을 포한한 피하지방면적과 관련성이 높은 것으로 나타났다. 반면 피하지방 두께 변인들 중 가슴 부위 피하지방두께는 내장지방면적을 예측할 수 있는 유일한 변수로 조사되었다. 둘째, 신체둘레 및 신체구성 변수는 내장지방면적과는 상관관계가 없었으나 전체 및 피하지방면적과 관련성이 높은 것으로 나타났다. 신체둘레와 전체 및 피하지방면적과의 관련성에 있어서 허리둘레는 엉덩이 둘레 및 허리와 엉덩이 둘레를 더한 값보다 상관계수가 높게 나타났다. 또한 전체 및 피하지방면적의 예측에 있어서 체지방량은 체지방율 및 근육량 보다 관련성이 높은 것으로 나타났다. 셋째, 혈중 중성지방과 수축기 혈압은 각각 내장지방면적 및 피하지방면적을 예측할 수 있는 유일한 변수로 조사되었다.

• 한국정보통신학회논문지
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• 제17권12호
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• pp.2995-3000
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• 2013

본 연구는 고지방식이를 섭취한 정소절제수술을 한 수컷 마우스에서 백색지방증가의 개선에 대한 testosterone의 영향과 그것에 대한 분자생물학적 조절기전을 규명하였다. Testosterone이 처리된 정소절제수술 마우스(CAST+T)는 정소절제수술 마우스 (CAST)에 비해 지방조직무게, 지방세포크기 및 $C/EBP{\alpha}$와 지방세포 표지유전자의 mRNA 발현이 감소되었다. 본 연구결과는 testosterone이 $C/EBP{\alpha}$와 $C/EBP{\alpha}$에 의해 조절되는 지방세포 표지 유전자들의 발현을 억제시킴으로써 지방세포 조절기전이 억제되고 지방조직의 무게가 감소된다는 것을 시사하고 있다. 따라서 본 연구는 성선기능저하증 남성의 비만조절에 대한 testosterone therapy의 유익한 분자생물학적 정보를 제공할 것이다.

• 운동영양학회지
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• 제13권1호
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• pp.9-14
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• 2009

The effects of a hypocaloric diet with or without strength training on body fat distribution and serum lipid concentrations in obese elderly women were investigated. Twenty-six healthy women (age 66±4.6 yr; body mass index 32.3±2.9 kg/m²) were randomly assigned to 3 groups: control (C; n=8), hypocaloric diet (DO; n=9) or hypocaloric diet with strength training (DST; n=9). Subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and inter and intra muscular adipose tissue (IMAT) were measured using magnetic resonance imaging. Serum lipid concentrations including total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and triglycerides (TG) were measured. No significant changes occurred in body weight and percent body fat in the C group over the 16-week period. The DO and DST groups lost similar amounts of weight and fat after 16 weeks. SAT and VAT decreased after weight loss in the DO and DST groups but not in the C group. IMAT was significantly reduced in the DO and DST groups, whereas in the C group IMAT increased. The loss in IMAT mass was similar in the DO and DST groups. TC and LDLC decreased in the DO and DST groups but not in the C group. There were no differences between the DO and DST groups in decrease in TC and LDLC. HDLC decreased in the DO group but not in the C and DST groups. TG tended to decrease in the DST group. In conclusion, body fat distribution including SAT, VAT, and IMAT and serum lipid concentratons were modulated by weight loss resulting from the hypocaloric diet with or without strength training in obese elderly women. Strength training did not enhance the improvement in body fat distribution and serum TC and LDLC concentrations by the hypocaloric diet.

• 대한방사선기술학회지:방사선기술과학
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• 제41권4호
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• pp.305-312
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• 2018

The incidence of cardiovascular disease increases rapidly after 40's. The thickness of the epicardial adipose tissue was measured to analyze the risk factors affecting the thickness change. We present the cut off value for the epicardial adipose tissue thickness for high impacted variables. For the study, 547 patients underwent echocardiography, epicardial adipose tissue thickness, body mass index, abdominal subcutaneous fat thickness and diabetes mellitus were used as analytical variables. As a result, multiple regression analysis of age group showed that diabetes mellitus was highly influential in all age group, so we could predict the cut off value for the epicardial adipose tissue thickness for diabetes mellitus. As a result of ROC curve analysis, cut off value of 7.44 mm was obtained with sensitivity of 79.6% and specificity of 60.6% for diab etes variab le. Logistic regression analysis b ased on this value showed that the risk for diab etes increased 6 times with each increase in the thickness of the epicardial adipose tissue. Among the various obesity indexes, epicardial adipose tissue is used as an important index especially to prevent the risk of cardiovascular disease. Therefore, we suggest that the use of echocardiography as a routine screening method for the prevention of cardiovascular disease and metabolic syndrome, which is rapidly increasing in patients over 40's age, will enable more effective monitoring. Radiation is the emission or transmission of energy in the form of waves or particles through space or through a material medium.