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http://dx.doi.org/10.12925/jkocs.2020.37.3.385

Effect of swimming exercise on anti-angiogenesis of white adipose tissue in high-fat diet-fed female ovariectomized mice  

Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.3, 2020 , pp. 385-397 More about this Journal
Abstract
This study investigated whether swimming exercises improves obesity through regulation of angiogenesis in white adipose tissue. Female mice with high-fat diets were divided into sham-operated group (Sham), ovariectomized group (OVX), and swim-trained ovariectomized group (OVX + Swim). Compared to the Sham, OVX increased body weight, adipose tissue mass and size of adipocyte. However, these factors (: such as body weight, adipose tissue mass and size of adipocyte) of OVX + Swim decreased compared with OVX. Compared with the Sham, OVX increased the mRNA expression of angiogenic activator and MMPs and decreased the mRNA expression of angiogenic inhibitors in white adipose tissue. But OVX + Swim decreased the mRNA expression of angiogenic activator and MMPs and increased the mRNA expression of angiogenic inhibitors in white adipose tissue, compared with the OVX. Theses results suggested that swimming exercises the angiogenesis in white adipose tissue, resulting to improve obesity in high-fat diet-fed female OVX mice.
Keywords
Swimming exercises; White adipose tissue; Angiogenesis; Obesity; High-fat diet;
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1 V. F. Motta, M. B. Aguila, C. A. Mandarim-DE-Lacerda, "High-intensity interval training (swimming) significantly improves the adverse metabolism and comorbidities in diet-induced obese mice", The Journal of Sports Medicine and Physical Fitness, Vol.56, No.5 pp. 655-663, (2016).
2 S. Jeong, "Anti-obesity Effects of Genistein in Female Ovariectomy-induced Obese Mice", Journal of Oil and Applied Science, Vol.34, No.3 pp. 427-435, (2017).   DOI
3 M. Klagsbrun, M. A. Moses, "Molecular angiogenesis", Chemistry and Biology, Vol.6, No.8 pp. R217-R224, (1999).   DOI
4 N. Ferrara, K. Carver-Moore, H, Chen, M. Dowd, L. Lu, K. S. O'Shea, L. Powell-Braxton, K. J. Hillan, M. W. Moore, "Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene", Nature, Vol.380, No.6573 pp. 439-442, (1996).   DOI
5 F. Shalaby, J. Rossant, T. P. Yamaguchi, M. Gertsenstein, X. F. Wu, M. L. Breitman, A. C. Schuh, "Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice", Nature, Vol.376, No.6535 pp. 62-66, (1995).   DOI
6 G. H. Fong, J. Rossant, M. Gertsenstein, M. L. Breitman, "Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium", Nature, Vol.376, No.6535 pp. 66-70, (1995).   DOI
7 J. Li, X. Yu, W. Pan, R. H. Unger, "Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity", American Journal of Physiology. Endocrinology and Metabolism, Vol.282, No.6 pp. E1334-E1341, (2002).   DOI
8 C. Duggan, D. Tapsoba Jde, C. Y. Wang, A. McTiernan, "Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial", Cancer Research, Vol.76, No.14 pp. 4226-4235, (2016).   DOI
9 J. S. Kim, B. Y. Park, E. K. Park, H. S. Lee, J. C. Hahm, K. H. Bae, M. Y. Kim. "Screening of anti-angiogenic activity from plant extracts", Korean Journal of Pharmacognosy, Vol.37, No.4 pp. 253-257, (2006).
10 H. Lee, D. Park, M. Yoon, "Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice", Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association. Vol.53, pp. 402-408, (2013).   DOI
11 J. Lawler, "Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth", Journal of Cellular and Molecular Medicine, Vol.6, No.1 pp. 1-12, (2002).   DOI
12 J. Lawler, M. Detmar, "Tumor progression: the effects of thrombospondin-1 and -2", The International Journal of Biochemistry & Cell Biology, Vol.36, No.6 pp. 1038-1045, (2004).   DOI
13 D. E. Gomez, D. F. Alonso, H. Yoshiji, U. P. Thorgeirsson, "Tissue inhibitors of metalloproteinases: structure, regulation and biological functions", European Journal of Cell Biology, Vol.74, No.2 pp. 111-122, (1997).
14 M. A. Moses, "The regulation of neovascularization of matrix metalloproteinases and their inhibitors", Stem Cells, Vol.15, No.3 pp. 180-189, (1997).   DOI
15 M. D. Johnson, H. R. Kim, L. Chesler, G. Tsao-Wu, N. Bouck, P. J. Polverini, "Inhibition of angiogenesis by tissue inhibitor of metalloproteinase", Journal of Cellular Physiology, Vol.160, No.1 pp. 194-202, (1994).   DOI
16 B. Y. Park, H. Lee, S. Woo, M. Yoon, J. Kim, Y. Hong, H. S. Lee, E. K. Park, J. C. Hahm, J. W. Kim, S. S. Shin, M. Y. Kim, M. Yoon, "Reduction of Adipose Tissue Mass by the Angiogenesis Inhibitor ALS-L1023 from Melissa officinalis", Public Library of Science One, Vol.10, No.11 pp. e0141612, (2015).
17 L. R. Simkin-Silverman, R. R. Wing, "Weight Gain during Menopause. Is It Inevitable or Can It Be Prevented?", Postgraduate Medicine, Vol.108, No.3 pp. 47-56, (2000).   DOI
18 J. Oh, H. Lee, D. Park, J. Ahn, S. S. Shin, M. Yoon, "Ginseng and Its Active Components Ginsenosides Inhibit Adipogenesis in 3T3-L1 Cells by Regulating MMP-2 and MMP-9", Evidence-based Complementary and Alternative Medicine : eCAM. Vol.2012, Article ID 265023, (2012).
19 A. Bouloumie, C. Sengenes, G. Portolan, J. Galitzky, M. Lafontan, "Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation', Diabetes, Vol.50, No.9 pp. 2080-2086, (2001).   DOI
20 D. L. Crandall, G. J. Hausman, J. G. Kral, "A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives", Microcirculation, Vol.4, No.2 pp. 211-232, (1997).   DOI
21 M. Abbey, A. Owen, M. Suzakawa, P. Roach, P. J. Nestel, "Effects of Menopause and Hormone Replacement Therapy on Plasma Lipids, Lipoproteins and LDL-receptor Activity", Maturitas, Vol.33, No.3 pp. 259-269, (1999).   DOI
22 S. Corvera, O. Gealekman, "Adipose tissue angiogenesis: impact on obesity and type-2 diabetes", Biochimica et Biophysica Acta, Vol.1842, No.3 pp. 463-472, (2014).   DOI
23 R. 1. Pasquali, F. Casimirri, A. M. Labate, O. Tortelli, G. Pascal, B. Anconetani, M. R. Gatto, R. Flamia, M. Capelli, L. Barbara, "Body Weight, Fat Distribution and the Menopausal Status in Women. The VMH Collaborative Group", International Journal of Obesity and Related Metabolic Disorders, Vol.18, No.9 pp. 614-621, (1994).
24 P. Carmeliet, R. K. jain, "Angiogenesis in cancer and other diseases", Nature, Vol.407, No.6801 pp. 249-257, (2000).   DOI
25 A. Bouloumie, K. Lolmede, C. Sengenes, J. Galitzky, M. Lafontan, "Angiogenesis in adipose tissue", Annales d'endocrinologie, Vol.63, No.2 pp. 91-95, (2002).
26 V. Christiaens, H. R. Lijnen, "Angiogenesis and development of adipose tissue", Molecular and Cellular Endocrinology, Vol.318, No.1-2 pp. 2-9, (2010).   DOI
27 M. A. Rupnick, D. Panigrahy, C. Y. Zhang, S. M. Dallabrida, B. B. Lowell, R. Langer, M. J. Folkman, "Adipose tissue mass can be regulated through the vasculature", Proceedings of the National Academy of Sciences of the United States of America, Vol.99, No.16 pp. 10730-10735, (2002).   DOI
28 D. L. Crandall, G. J. Hausman, J. G. Kral, "A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives", Microcirculation, Vol.4, No.2 pp. 211-232, (1997).   DOI
29 K. Sun, C. M. Kusminski, P. E. Scherer, "Adipose tissue remodeling and obesity", The Journal of Clinical Investigation, Vol.121, No.6 pp. 2094-2101, (2011).   DOI
30 E. Brakenhielm, R. Cao, B. Gao, B. Angelin, B. Cannon, P. Parini, Y. Cao, "Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice", Circulation Research, Vol.94, No.12 pp. 1579-1588, (2004).   DOI
31 Han DB, Payne WA, Mauer EB, Focus on Health (7th ed.), pp.151-157, Mcgraw-Hill Higher Education, (2005).
32 L. B. Andersen, J. Haraldsdottir, "Coronary Heart Disease Risk Factors, Physical Activity, and Fitness in Young Danes", Medicine and Science in Sports and Exercise, Vol.27, No.2 pp. 158-163, (1995).
33 E. A. Richter, N. B. Ruderman, "AMPK and the Biochemistry of Exercise: Implications for Human Health and Disease", The Biochemical Journal, Vol.418, No.2 pp. 261-275, (2009).   DOI
34 S. Jeong, "The Effect of Swimming plus Hypolipidemic Agent on Obesity", Journal of the Korean Applied Science and Technology, Vol.36, No.1 pp. 34-46, (2019).   DOI
35 S. Jeong, "The study of mechanism on the regulation of obesity and health promotion by swimming in postmenopausal women", Koren Public Health Research, Vol.37, No.2 pp. 17-30, (2011).