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http://dx.doi.org/10.6109/jkiice.2013.17.12.2995

Effects of Testosterone on Adipose Tissue Metabolism  

Jeong, Sunhyo (Department of Science Management, Mokwon University)
Publication Information
Journal of the Korea Institute of Information and Communication Engineering / v.17, no.12, 2013 , pp. 2995-3000 More about this Journal
Abstract
We investigated the effects of testosterone on the improvement of white adipose tissue explant and its molecular mechanism in adipose tissue of high fat diet-fed male castrated (CAST) mice. The CAST mice treated with testosterone had lower adipose tissue weights, the average size of adipocytes and mRNA levels of $C/EBP{\alpha}$ as well as adipocyte marker genes than the vehicle-treated CAST mice. These results suggest that testosterone prevent the expression of $C/EBP{\alpha}$ and $C/EBP{\alpha}$-mediated adipocyte marker genes, resulting in decreased adipose tissue mass and adipocyte metabolism in male CAST mice. Moreover, this study give a valuable molecular and biological knowledge on testosterone therapy in obese hypogonadal men.
Keywords
testosterone; $C/EBP{\alpha}$; male CAST mice; adipose tissue mass;
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