• Asian-Australasian Journal of Animal Sciences
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• 제22권3호
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• pp.336-342
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• 2009

Avian embryos at high altitude are independent of maternal protection against hypoxia, which is contrary to mammals. It is well known that chronic hypoxic exposure at key points can significantly impact on avian development. Tibetan Chicken, a Chinese indigenous breed, living in Tibetan areas with an altitude of 2.2 to 4.1 thousand meters, has an adaptive mechanism to hypoxia. In the present study, fertilized eggs of Tibetan Chicken were incubated under 13% and 21% oxygen concentration. Two lowland chicken breeds, Shouguang Chicken, an indigenous chicken breed in Shandong Province of China, and Dwarf Recessive White Chicken, an imported breed in Beijing, were used as control groups. The embryo mass and some organs such as brain, heart, liver, stomach and eye weight in the three species were measured at Hamburger-Hamilton stage 39, 41, 43 and 45 under hypoxic and normal conditions. The results showed that in hypoxia Tibetan Chicken significantly differed from the two lowland chicken breeds in embryo mass at Hamburger-Hamilton stage 41, 43 and 45 (p<0.01). In particular, Dwarf Recessive White Chicken and Shouguang Chicken showed retarded growth in hypoxic incubation (p<0.01), whereas Tibetan Chicken showed no significant difference between hypoxic and normal conditions (p>0.05). In addition, heart and the other organs showed different susceptibility to hypoxia at the studied stages. In conclusion, chronic hypoxia induced a change in the embryo development of the three different species and Tibetan Chicken showed adaptation to hypoxia. Of note, the embryo developmental physiology of Tibetan Chicken in response to hypoxia will shed light on the process of physiological acclimation or evolutionary adaptation as well as the study of clinical disease.

• 한국콘텐츠학회논문지
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• 제12권2호
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• pp.163-172
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• 2012

영웅은 TV드라마의 오랜 소재이다. TV드라마 속에서의 역사적 영웅은 대중의 욕망에 대한 대리자이자 그것의 집약체로서 기능하는데, 특정 시기 드라마가 형상화 해내는 영웅의 모습과 그것을 환영하는 시청자간의 소통은 당대 대중의식을 가름할 수 있는 장치가 되기도 한다. 본 연구는 오늘날 각종 문화 영역에서 환영받고 있는 일본의 역사적 영웅 '요시쓰네'를 주인공으로 한 드라마를 영웅의 서사연구, 스토리 분석에 있어서 중요한 위치를 차지하고 있는 조셉 캠벨의 17가지 영웅 서사 단계를 토대로 분석하여 원형과 변용을 알아보았다. 드라마는 캠벨의 17단계 중 11가지 단계를 적용하고, 2가지단계의 생략과 4가지단계의 변형을 보여주며, 대중문화 콘텐츠로 재탄생하기 위해서는 일정한 선택과 변형이 필요하다는 것을 알 수 있었다.

• 지역사회간호학회지
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• 제16권3호
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• pp.249-259
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• 2005

Purpose: The purpose of this study was to understand the coping process that family caregivers experience during the process of care, to grasp coping behaviors used to solve problems and, finally, to develop a substantive theory by analyzing the coping process. Method: The methodology of collecting and analyzing data used in this study followed the ground theory of Strauss and Corbin(1998). Data were collected through in-depth interviews with open-ended and descriptive questions about the subjects' coping experiences, which were audio-taped and transcribed. The survey was conducted between February 2000 and February 2001. The subjects of this study were 17 women. Result: The result of the study is as follows. The coping process of family caregivers while taking care of the demented elderly was found to have six stages: problem recognition: undertaking care: struggling: mental control: burden mediation; and acceptance. These stages proceed with reciprocal action and in cycle. Conclusion: The result of this study is helpful for developing effective and individual nursing strategies suitable for each coping stage. It is necessary to develop an assessment tool that can judge caregivers' coping stage based on the result of this study. Moreover, we need continuous study to practice nursing mediation and to analyze the change about nursing effect and family members' adaptation.

• 대한한의진단학회지
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• 제22권1호
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• pp.33-44
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• 2018

Objectives This study aimed to perform a cross-cultural translation of 5 kinds of pattern identification questionnaires from Korean to English: questionnaires for seven emotions, fatigue and malaise, phlegm, food retention, and blood stasis. Methods We followed the strict guideline on the cross-cultural translation of healthcare evaluation tool. Total five stages of study were conducted. First, translations of two individual translators. Second, synthesizing of the two results. Third, two back translations from synthesized version to Korean. Fourth, expert committee reviewed with the original version, synthesized version, back translated versions to make a pre-final version. Last, with the pre-final version, 5 Americans evaluated face validity of the pre-final version. We made a final version after the above-mentioned 5 stages. Result and conclusion International versions of the 5 kinds of pattern identification questionnaires were completed. We can expect this versions are widly used for clinical usage and following academical researches.

• BMB Reports
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• 제41권7호
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• pp.529-536
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• 2008

Cinnamate-4-hydroxylase (C4H) is a key enzyme in the phenylpropanoid pathway, which is responsible for synthesizing a variety of secondary metabolites that participate in development and adaptation. In this study, we isolated a full-length cDNA of the C4H gene from the Korean black raspberry (Rubus sp.) and found that this gene existed as a single gene. By comparing the deduced amino acid sequence of Rubus sp. C4H with other sequences reported previously we determined that this sequence was highly conserved among widely divergent plant species. In addition, quantitative real time PCR studies indicated that the C4H gene had a differential expression pattern during fruit development, where gene expression was first detected in green fruit and was then remarkably reduced in yellow fruit, followed by an increase in red and black fruit. To investigate the two peaks in expression observed during fruit development and ripening, we measured the flavonoid content. The content of the major flavanol of Korean black raspberry fruits was determined to be highest at the beginning of fruit development, followed by a gradually decrease according to the developmental stages. In contrast, the content of anthocyanins during the progress of ripening was dramatically increased. Our results suggest that the C4H gene in Korean black raspberry plays a role during color development at the late stages of fruit ripening, whereas the expression of C4H gene during the early stages may be related to the accumulation of flavanols.

• 대한간호학회지
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• 제36권1호
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• pp.25-36
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• 2006

Purpose: The purpose of the study was to identify the adaptation process to problem based learning(PBL) among nursing students who have experienced PBL classes for two years. Method: Data was collected from 11 nursing students with in-depth interviews and direct observation of their PBL experiences by a researcher who has been a facilitator for PBL class for 3years. Immediately after the interviews all of them were transcribed. It was analyzed by the Ground theory of Corbin and Strauss. Results: A derived core category was 'Acquiring PBL'. 4 stages of the acquiring process were derived and written in time sequence: chaos, confusion, beginning insight, and achievement stage. Conclusion: The results will not only expand understanding of the students for the facilitator and school which has adopted PBL but also provide information to develop an orientation program for PBL. Further research on the facilitator's role experiences is recommended.

• 대한간호학회지
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• 제37권4호
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• pp.501-509
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• 2007

Purpose: The purpose of this study was to identify job stress experienced by head nurses of general hospitals. Methods: Data was collected from 10 head nurses with in-depth interviews about their actual experiences. The main questions were when, why, and from whom they get stress in the work field; how they are affected by the stressful situation; and how they cope with this stress. All the interviews were recorded and transcribed. The collected data was analyzed using a consistent comparative data analysis method. Results: Job stress of head nurse was formed by 3 axis; causes, reactions, and coping strategies in complicated situational context such as human relationship, culture of hospital, individual characteristics, social support. Conclusion: The results of this study yields very useful information for nursing mangers to identify, by stages, the demands of the head nurses in their role adaptation process. The findings of this study contributes to developing programs and supportive policies that palliates the head nurses' job stress.

• 대한의용생체공학회:의공학회지
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• 제15권3호
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• pp.355-364
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• 1994

The most important requirement for the controller of a prosthetic arm is that it has a high fidelity discriminator where the motion control may be performed open loop using EMG signals as a control source. Therefore, it is very effective method to reduce the influence of misclassification of classifier for the total system performance. This paper presents the new function discrimination method which combines MLP classifier and frizzy filter by stages for the requirement. The major advantage of MLP is a consistent learning capability for the easy adaptation to environments. The fuzzy filter uses all informations of MLP outputs and prior EMG activity informations which increase as the experience increases. That property is superior to one which uses maximum output of MLP in view of information amounts and quality. Simulation result shows that proposed method is superior to the probabilistic model, MLP model and the combined model of both in the respect of discrimination quaity.

• Biomolecules & Therapeutics
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• 제26권1호
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• pp.69-80
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• 2018

Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects: generating additional energy, providing more anabolic molecules for biosynthesis, and rebalancing cellular redox states in cancer cells. Metabolic pathways are considered the pipelines to supply metabolic cofactors of epigenetic modifiers. In this regard, cancer metabolism, whereby cellular metabolite levels are greatly altered compared to normal levels, is closely associated with cancer epigenetics, which is implicated in many stages of tumorigenesis. In this review, we provide an overview of cancer metabolism and its involvement in epigenetic modifications and suggest that the metabolic adaptation leading to epigenetic changes in cancer cells is an important non-genetic factor for tumor progression, which cooperates with genetic causes. Understanding the interaction of metabolic reprogramming with epigenetics in cancers may help to develop novel or highly improved therapeutic strategies that target cancer metabolism.

• 가정과삶의질연구
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• 제25권1호
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• pp.183-207
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• 2007

The purpose of this study was to improve the understanding of the essential experience of Separated Families in South and North Korea in a socio-cultural context and to explore their post-separation adjustment process from the perspective of the families. Major findings in this study are summarized as follows. First, 'han' was the central phenomenon that the participants experienced following their separation. Second, the core issue in the process of post-separation adjustment was 'accepting the separation and rearrangement of reality for reunion', and over time the participants went through four stages in their adjustment process: the stage of being overwhelmed, the stage of conflict, the stage of awareness, and the stage of acceptance. Third, the main factors affecting the participants' adjustment were supportive systems, available resources(individual variables) and interaction with other separated families. fourth, four types were observed in the typology of adjustment and reunion of the participants.