• Molecules and Cells
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• v.28 no.5
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• pp.441-446
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• 2009

During epididymal transit, mammalian sperm acquire selected proteins secreted by the epididymis. We previously showed that a disintegrin and metalloprotease (ADAM) 7 is expressed specifically in the epididymis and transferred to the sperm surface during epididymal transit. Here, we show that mouse ADAM7 secreted to the epididymal lumen is associated with membranous vesicles known as epididymosomes. Furthermore, we found that ADAM7 can be transferred directly from epididymal vesicles to sperm and that it is an integral plasma membrane protein in sperm. Thus, our study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.

• International Journal of Internet, Broadcasting and Communication
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• v.11 no.4
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• pp.31-36
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• 2019

Unsupervised neural networks have not caught enough attention until Generative Adversarial Network (GAN) was proposed. By using both the generator and discriminator networks, GAN can extract the main characteristic of the original dataset and produce new data with similarlatent statistics. However, researchers understand fully that training GAN is not easy because of its unstable condition. The discriminator usually performs too good when helping the generator to learn statistics of the training datasets. Thus, the generated data is not compelling. Various research have focused on how to improve the stability and classification accuracy of GAN. However, few studies delve into how to improve the training efficiency and to save training time. In this paper, we propose a novel optimizer, named FAST-ADAM, which integrates the Lookahead to ADAM optimizer to train the generator of a semi-supervised generative adversarial network (SSGAN). We experiment to assess the feasibility and performance of our optimizer using Canadian Institute For Advanced Research - 10 (CIFAR-10) benchmark dataset. From the experiment results, we show that FAST-ADAM can help the generator to reach convergence faster than the original ADAM while maintaining comparable training accuracy results.

• The Journal of the Korea Contents Association
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• v.16 no.10
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• pp.608-616
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• 2016

The Smith-Watrman (SW) algorithm is a local alignment algorithm which is one of important operations in DNA sequence analysis. The SW algorithm finds the optimal local alignment with respect to the scoring system being used, but it has a problem to demand long execution time. To solve the problem of SW, some methods to perform SW in distributed and parallel manner have been proposed. The ADAM which is a distributed and parallel processing framework for DNA sequence has parallel SW. However, the parallel SW of the ADAM does not consider that the SW is a dynamic programming method, so the parallel SW of the ADAM has the limit of its performance. In this paper, we propose a method to enhance the parallel SW of ADAM. The proposed parallel SW (PSW) is performed in two phases. In the first phase, the PSW splits a DNA sequence into the number of partitions and assigns them to multiple nodes. Then, the original Smith-Waterman algorithm is performed in parallel at each node. In the second phase, the PSW estimates the portion of data sequence that should be recalculated, and the recalculation is performed on the portions in parallel at each node. In the experiment, we compare the proposed PSW to the parallel SW of the ADAM to show the superiority of the PSW.

• Journal of Korea Water Resources Association
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• v.56 no.1
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• pp.63-74
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• 2023

High-reliability prediction of dam inflow is necessary for efficient dam operation. Recently, studies were conducted to predict the inflow of dams using Multi Layer Perceptron (MLP). Existing studies used the Gradient Descent (GD)-based optimizer as the optimizer among MLP operators to find the optimal correlation between data. However, the GD-based optimizers have disadvantages in that the prediction performance is deteriorated due to the possibility of convergence to the local optimal value and the absence of storage space. This study improved the shortcomings of the GD-based optimizer by developing Adaptive moments combined with Improved Harmony Search (AdamIHS), which combines Adaptive moments among GD-based optimizers and Improved Harmony Search (IHS). In order to evaluate the learning and prediction performance of MLP using AdamIHS, Daecheong Dam inflow was learned and predicted and compared with the learning and prediction performance of MLP using GD-based optimizer. Comparing the learning results, the Mean Squared Error (MSE) of MLP, which is 5 hidden layers using AdamIHS, was the lowest at 11,577. Comparing the prediction results, the average MSE of MLP, which is one hidden layer using AdamIHS, was the lowest at 413,262. Using AdamIHS developed in this study, it will be possible to show improved prediction performance in various fields.

• Atmosphere
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• v.17 no.1
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• pp.87-99
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• 2007

Simulation results of Asian Dust Aerosol Model (ADAM) for the period of April 7-9, 2006 were analyzed, comparing with observed PM10 data. ADAM simulated around ten times lower than on-site PM10 concentration in the source regions: Zhurihe, Tongliao, Yushe, Dalian and Huimin. As the result of this low concentration, transported amounts of Asian Dust were under-estimated as well. In order to quantify a forecasting accuracy, Bias and RMSE were calculated. Even though remarkably negative Biases and high RMSEs were observed, ADAM simulation had followed well up the time of dust outbreak and a transported path. However, the emission process to generate dust from source regions requires a great enhancement. The PM10 concentration at the surface reached up to $2,300{\mu}gm^{-3}$ at Baeknyoungdo and Seoul (Mt. Gwanak), up to $1,750{\mu}gm^{-3}$ at KGAWO about 18:00 LST in April 8, respectively; however, ADAM did not simulate the same result on its second peak. It is considered that traveling Asian dust might have been lagged over the Korean peninsula by the blocking of surface high pressure. Moreover, the current RDAPS's 30 km grid resolution (which ADAM adopts as the meteorological input data) might not adequately represent small-scale atmospheric motions below planetary boundary layer.

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.371-380
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• 2013

Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity of doxorubicin (DOX). A Disintegrin And Metalloproteinase (ADAMs) are transmembrane ectoproteases to regulate cell-cell and cell-matrix interactions, but role in cardiac disease is unclear. The aim of this study was to determine whether DOX activates peroxynitrite and ADAM 10 and thus ADAM and matrix metalloproteinase (MMP) induce cardiac remodeling in DOX-induced cardiomyopathy. Adult male Sprague-Dawley rats were subjected to cardiomyopathy by DOX (6 times of 2.5 mg/kg DOX over 2-weeks), and were randomized as four groups. Then followed by 3, 5, 7, and 14 days after cessation of DOX injection. DOX-injected animals significantly decreased left ventricular fractional shortening compared with control by M-mode echocardiography. The expressions of cardiac nitrotyrosine by immunohistochemistry were significant increased, and persisted for 2 weeks following the last injection. The expression of eNOS was increased by 1.9 times (p<0.05), and iNOS was marked increased in DOX-heart compared with control (p<0.001). Compared to control rats, cardiac ADAM10- and MMP 9- protein expressions increased by 20 times, and active/total MMP 9 proteolytic activity showed increase tendency at day 14 after cessation of DOX injection (n=10, each group). DOX-treated $H_9C_2$ cell showed increased ADAM10 protein expression with dose-dependency (p<0.01) and morphometric changes showed the increase of ventricular interstitial, nonvascular collagen deposition. These data suggest that activation of cardiac peroxynitrite with increased iNOS expression and ADAM 10-dependent MMP 9 expression may be a molecular mechanism that contributes to left ventricular remodeling in DOXinduced cardiomyopathy.

• Molecules and Cells
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• v.24 no.1
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• pp.139-147
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• 2007

Although transforming growth factors (TGFs) are implicated in the process of endochondral ossification, which is initiated by the differentiation of mesenchymal cells into chondrocytes, it is not clear how $TGF-{\beta}3$ regulates the chondrogenic differentiation of limb bud mesenchymal cells. Here, differential display polymerase chain reaction (DD-PCR) screening and RT-PCR analysis revealed that transcripts of A Disintegrin And Metalloprotease 10 (ADAM 10) decreased during the chondro-inhibitory action of $TGF-{\beta}3$ on cultured chick leg bud mesenchymal cells. Electroporation of ADAM 10 morpholino antisense oligonucleotides inhibited the ectodomain shedding of delta-1, and cell proliferation and subsequent precartilage condensation, in a manner similar to that caused by $TGF-{\beta}3$. The suppression of mesenchymal cell proliferation induced by $TGF-{\beta}3$ and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA. Collectively, these data indicate that, in cultured chick leg bud mesenchyme cells, $TGF-{\beta}3$ downregulates ADAM 10 and inhibits cell proliferation and subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, and that this results in the activation of Notch signaling.

• BMB Reports
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• v.46 no.3
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• pp.139-150
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• 2013

The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.9
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• pp.1977-1982
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• 2012

Social network service user or smart phone user is very convenient, because there are supported to various social network services such as Facebook, Twitter, Flickr, Naver blog, Daum blog, and so on. This Is very good because they store multimedia datas that user wants to cyber space if they want it conveniently. But, if social network user increases, space of cloud storage increases sharply, and when social network service used user dies then they have big problems such as they did not know in existing. Typically, problems of notice, dissemination, storage, and inheritance for digital asset can happen representatively. Now, If successor send relation information of he and his dead user that is family to social network service provider then service provider checks it. And successor may can use, save and only backup are possible after confirm of family relation truth. Therefore, We wish to propose ADAM that successor may can inherit digital assets easily, conveniently, and safely in this paper. If someone use ADAM, successor submits information about dead and own family relation in the third certification party. And ADAM can be inherited freely and conveniently about digital assets as general assets passing through right inheritance process.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.59-59
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• 2003