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http://dx.doi.org/10.5483/BMBRep.2013.46.3.176

ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis  

Przemyslaw, Leszczynski (Department of Genetics, Wroclaw Medical University)
Boguslaw, Hendrich Andrzej (Department of Biology and Medical Parasitology, Wroclaw Medical University)
Elzbieta, Szmida (Department of Genetics, Wroclaw Medical University)
Malgorzata, Sasiadek Maria (Department of Genetics, Wroclaw Medical University)
Publication Information
BMB Reports / v.46, no.3, 2013 , pp. 139-150 More about this Journal
Abstract
The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
Keywords
ADAM; ADAMTS; Apoptosis; Cell proliferation; Colorectal cancer;
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