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http://dx.doi.org/10.1007/s10059-009-0140-x

ADAM7 Is Associated with Epididymosomes and Integrated into Sperm Plasma Membrane  

Oh, Jeong Su (Department of Life Science, Gwangju Institute of Science and Technology)
Han, Cecil (Department of Life Science, Gwangju Institute of Science and Technology)
Cho, Chunghee (Department of Life Science, Gwangju Institute of Science and Technology)
Publication Information
Molecules and Cells / v.28, no.5, 2009 , pp. 441-446 More about this Journal
Abstract
During epididymal transit, mammalian sperm acquire selected proteins secreted by the epididymis. We previously showed that a disintegrin and metalloprotease (ADAM) 7 is expressed specifically in the epididymis and transferred to the sperm surface during epididymal transit. Here, we show that mouse ADAM7 secreted to the epididymal lumen is associated with membranous vesicles known as epididymosomes. Furthermore, we found that ADAM7 can be transferred directly from epididymal vesicles to sperm and that it is an integral plasma membrane protein in sperm. Thus, our study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
Keywords
disintegrin; epididymis; epididymosomes; fertilization; metalloprotease; sperm;
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Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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