• Proceedings of the Korean Institute of Industrial Safety Conference
• /
• 1997.11a
• /
• pp.191-202
• /
• 1997

점점 과학의 고도화가 이루어지면서 산업 현장에서 사용하는 장비나 플랜트의 대형화, 복잡화가 이루어지고 있다. 이에 이러한 시스템들의 정량적 위험성 평가가 요구하기 시작했고, 이를 계산하기 위해서 ETA, FTA, CCA등 여러 가지 방법들이 사용되고 있다. 그 중에서도 가장 보편적으로 많이 사용하는 방법으로 FTA(Fault Tree Analysis)를 손꼽을 수 있다. 관찰하는 시스템이 커지는 경우 FTA를 수행하기 위해서는 복잡한 계산 과정을 거치면서 많은 항의 계산을 하게 된다. 이러한 계산시간을 줄이기 위해서 많은 노력들이 있었으며 이중 하나는 FT를 graph(acyclic nonliner graph)로 변형시킨 후 graph이론을 사용하여 신뢰도를 계산하는 것이다. (중략)

• Journal of the Korean Society of Safety
• /
• v.13 no.2
• /
• pp.136-144
• /
• 1998

FTA is the most commonly used method among quantitative safety assessment. In case that the observing system become larger, a lot of terms should be calculated to accomplish FTA through complicated process. Many methods have been tried to reduce time, one of tries is How to calculate the reliability using graph theory after changing W to graph. This paper suggests an algorithm that can calculate more rapidly reliability and outset of system expressed by non-linear graph as like as FTA or CCA.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1993.04a
• /
• pp.41-41
• /
• 1993

현재 유일하게 AIDS 치료제로 허가된 AZT를 비롯하여 항 virus 효과를 나타내는 약물의 대부분은 구조적으로 Nucleoside계에 속하는 화합물로서 수많은 약리학적 연구 및 합성 화학적 연구가 이루어져 왔다. 특히 합성 화학적 측면에서 이들 화합물의 합성은 크게 두 가지로 나누어지는데 그것은 Sugar 부위의 변형을 통한 방법과 염기 부위의 변형을 통한 방법에 의해 새로운 항 바이러스제를 개발하는 것이다. 최근의 연구 동향에 있어서 주목할 만한 변화의 하나는 Sugar 부위의 구조적 변형을 시도하는데 있어서 종래의 5원환 형태에서 환이개열된 형태의 Acyclic Nucleoside에 대한 연구가 이루어져 좋은 효과를 거두고 있다는 사실이다. Acyclovir, Ganciclovir 등의 개발이 그것이다. 본 연구에서는 이와 같은 Acyclic Nucleoside계의 새로운 항 virus제를 합성하여 그 생리 활성을 검색하고자 한다.

• Proceedings of the IEEK Conference
• /
• 2000.07b
• /
• pp.623-626
• /
• 2000

The purpose of this paper is to find an efficient solution for multiple constant multiplication (MCM) problem. Since the circuit structure can be represented as a directed acyclic graph, evolutionary computing is considered as an effective tool for optimization of circuit synthesis. In this paper, we propose a stack type operator as a chromosome element to synthesize a directed acyclic graph efficiently. This type of chromosome can represent a graph structure with a set of simple symbols and so we can employ the similar method to a conventional GA.

• Bulletin of the Korean Chemical Society
• /
• v.18 no.12
• /
• pp.1256-1260
• /
• 1997

A series of acyclic polyethers bearing amide end-groups and lipophilic alkyl chains (3-5) were successfully synthesized with quantitative yields. Based upon the transport experiment in a bulk liquid membrane (BLM) system and solvent extraction, a very high selectivity of Pb2+ over other transition metal cations was observed. Measurement of thermodynamic parameters for complexation in methanol at 25 ℃ gave a strong evidence for excellent selective complexation for lead ion over other transition metal ions.

• Kyungpook Mathematical Journal
• /
• v.15 no.2
• /
• pp.141-145
• /
• 1975

• Journal of Pharmacopuncture
• /
• v.20 no.2
• /
• pp.119-126
• /
• 2017

Objectives: Semecarpus anacardium Linn. is a plant well-known for its antimicrobial, antidiabetic and anti-arthritic properties in the Ayurvedic and Siddha system of medicine. This has prompted the screening of this plant for antibacterial activity. The main aims of this study were to isolate compounds from the plant's seeds and to evaluate their antibacterial effects on clinical bacterial test strains. Methods: The n-butanolic concentrate of the seed extract was subjected to thin layer chromatography (TLC) and repeated silica gel column chromatography followed by elution with various solvents. The compound was identified based on observed spectral (IR, $^1H$ NMR, $^{13}C$ NMR and high-resolution mass spectrometry) data. The well diffusion method was employed to evaluate the antibacterial activities of the isolated acyclic isoprenoid compound (final concentration: $5-15{\mu}g/mL$) on four test bacterial strains, namely, Staphylococcus aureus (MTCC 96), Bacillus cereus (MTCC 430), Escherichia coli (MTCC 1689) and Acinetobacter baumannii (MTCC 9829). Results: Extensive spectroscopic studies showed the structure of the isolated compound to be an acyclic isoprenoid ($C_{21}H_{32}O$). Moreover, the isoprenoid showed a remarkable inhibition of bacterial growth at a concentration of $15{\mu}g/mL$ compared to the two other doses tested (5 and $10{\mu}g/mL$) and to tetracycline, a commercially available antibiotic that was used as a reference drug. Conclusion: The isolation of an antimicrobial compound from Semecarpus anacardium seeds validates the use of this plant in the treatment of infections. The isolated compound found to be active in this study could be useful for the development of new antimicrobial drugs.

• Journal of Embryo Transfer
• /
• v.33 no.4
• /
• pp.305-311
• /
• 2018

Gonadotropin releasing hormone (GnRH) centrally plays a role in control of the hypothalamic-pituitary-gonadal axis-related hormone secretions in the reproductive neuroendocrine system. In addition, hormone receptors like luteinizing hormone receptor (LHR) are important element for hormones to take effect in target organ. However, ageing-dependent changes in terms of the distribution of GnRH neurons in the brain and LHR expression in the acyclic ovary have not been fully understood yet. Therefore, we comparatively investigated those ageing-dependent changes using young (1-5 months), middle (11-14 months) and old (21-27 months) aged female mice. Whereas a number of GnRH positive fibers and neurons with monopolar or bipolar morphology were abundantly observed in the brain of the young and middle aged mice, a few GnRH positive neurons with multiple dendrites were observed in the old aged mice. In addition, acyclic ovary without repeated development and degeneration of the follicles was shown in the old aged mice than others. LHR expression was localized in theca cells, granulosa cell, corpora lutea and atretic follicle in the ovaries from young and middle aged mice, in contrast, old aged mice had few positive LHR expression on the follicles due to acyclic ovary. However, the whole protein level of LHR was higher in the ovary of old aged mice than others. These results are expected to be used as an important basis on the relationship between GnRH and LHR in old aged animals as well as in further research for reproduction failure.

• ETRI Journal
• /
• v.39 no.4
• /
• pp.592-604
• /
• 2017

Intrusion detection is very important for network situation awareness. While a few methods have been proposed to detect network intrusion, they cannot directly and effectively utilize semi-quantitative information consisting of expert knowledge and quantitative data. Hence, this paper proposes a new detection model based on a directed acyclic graph (DAG) and a belief rule base (BRB). In the proposed model, called DAG-BRB, the DAG is employed to construct a multi-layered BRB model that can avoid explosion of combinations of rule number because of a large number of types of intrusion. To obtain the optimal parameters of the DAG-BRB model, an improved constraint covariance matrix adaption evolution strategy (CMA-ES) is developed that can effectively solve the constraint problem in the BRB. A case study was used to test the efficiency of the proposed DAG-BRB. The results showed that compared with other detection models, the DAG-BRB model has a higher detection rate and can be used in real networks.

• Journal of Korea Society of Industrial Information Systems
• /
• v.9 no.2
• /
• pp.9-16
• /
• 2004

Recently, lattice conditional independence models(LCIMs) have been introduced for the analysis of non-monotone missing data patterns and of non-nested dependent regression models. This approach has been successfully applied to solve various problems in data pattern analysis, however, it suffers from computational burden to search LCIMs. In order to cope with this drawback, we propose a new scheme for finding LCIMs based on the essential graph. Also, we show that the class of LCIMs coincides with the class of all transitive acyclic directed graph(TADG) models which are Markov equivalent to a specific acyclic directed graph(ADG) models.