• 과학교육연구지
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• 제36권2호
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• pp.216-234
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• 2012

이 연구에서는 초등학교 5학년 영재학급 학생 14명을 대상으로, 과제의 개방도와 학생들의 인지수준에 따라 TS 활동에서 나타나는 언어적 상호작용이 어떤 특징을 보이는지 알아보았다. 연구 결과, 학생들은 과제의 개방도가 낮은 안내형 TS 활동보다는 개방도가 높은 개방형 TS 활동에서 훨씬 많은 언어적 상호작용을 보였고, 상위 수준의 상호작용도 안내형 활동보다는 개방형 활동에서 많았는데, 이런 결과는 언어적 상호작용의 거의 모든 하위 범주에서 나타났다. 또한, 안내형 과제를 수행하는 과정에서는 행동참여를 지시하거나 자기만족을 나타내는 언어사용 빈도가 높은 반면에, 개방형 과제를 수행하는 과정에서는 행동참여를 권유하거나 불만을 나타내는 빈도가 높았다. 학생들의 인지 수준에 따른 언어적 상호작용의 특징을 보면, 인지수준이 높을수록 상호작용의 빈도가 높고, 다양한 유형의 언어적 상호작용이 이루어지며, 상위수준의 상호작용이 많은 것으로 나타났다. 그러나 학생들의 인지 수준과 과제의 개방도는 학생들의 언어적 상호작용에 복합적으로 영향을 주는 것으로 나타났다. 즉, 인지 수준이 높은 학생일지라도 안내형 활동에서는 상호작용의 수준이 높지 않았으며, 개방도가 높은 활동이라도 인지 수준이 낮은 학생들은 참여도가 낮고 상호작용의 수준도 높지 않았다. 이는 개방가 높은 과제가 학생들의 사고를 자극하여 상위 수준의 상호작용을 이끌어낼 수 있지만, 그 효과는 학생들의 인지 수준에 따른 한계가 있음을 의미한다. 따라서 과제 활동에서 인지 수준이 낮은 학생들의 사고를 자극하고 참여도를 높이기 위한 과제 개방도의 조절과 교수 전략의 개발이 중요한 추후 과제라 생각된다.

• Journal of Hospice and Palliative Care
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• 제14권3호
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• pp.163-171
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• 2011

목적: 본 연구는 호스피스 자원봉사참여의 동기 및 결과에 대한 모형을 검증하여 자원봉사 참여활성화에 기여하고자 시도되었다. 방법: 조사는 2007년 한국호스피스협회 추계학술대회에 참석하는 자원봉사자 200명과 5개 호스피스 기관의 자원봉사자 132명을 대상으로 진행되었다. 결과: 연구결과를 요약하면 자원봉사참여도를 내생변수로 실존적 안녕감 ${\rightarrow}$ 자원봉사참여도의 경로가 유의하였으며, 자원봉사지속성을 내생변수로 가치동기 ${\rightarrow}$ 자원봉사지속성, 자원봉사참여도 ${\rightarrow}$ 자원봉사지속성, 자원봉사만족도 ${\rightarrow}$ 자원봉사지속성의 경로가 유의하였다. 또한 자원봉사만족도를 내생변수로 실존적 안녕감 ${\rightarrow}$ 자원봉사만족도, 사회동기 ${\rightarrow}$ 자원봉사만족도, 이해동기 ${\rightarrow}$ 자원봉사만족도, 가치동기 ${\rightarrow}$ 자원봉사만족도의 경로가 통계적으로 유의하였다. 간접효과의 경우 자원봉사지속성을 내생변수로 실존적안녕감 ${\rightarrow}$ 자원봉사 참여정도 ${\rightarrow}$ 자원봉사지속성, 실존적안녕감 ${\rightarrow}$ 자원봉사만족도 ${\rightarrow}$ 자원봉사지속성, 사회동기 ${\rightarrow}$ 자원봉사만족도 ${\rightarrow}$ 자원봉사지속성, 이해동기 ${\rightarrow}$ 자원봉사만족도 ${\rightarrow}$ 자원봉사지속성의 경로가 통계적으로 유의한 것으로 나타났다. 결론: 이러한 결과를 바탕으로 호스피스 자원봉사자 들의 실존적 안녕감 증진을 위한 프로그램 개발, 이타적 가치추구 유도교육, 지적성장 격려, 친밀한 관계의 경험에 기초한 자원봉사활동, 지속적 봉사활동 유도에 대한 제언을 제시하였다.

• 근관절건강학회지
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• 제6권1호
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• pp.100-135
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• 1999

Typical symptoms of rheumatic disease affect overall daily living and cause severe stress. Individuals afflicted with rheumatic disease have many illness-related stresses. Pain was the predominantly perceived stress followed by limitation in mobility, difficulties in carrying out activities of daily living. helplessness, dependency on others, threat to self-esteem, interference in social activity, interference in family relationships. difficulties performing at work, and discomfort of the treatment. Patients with chronic arthritis are subjected to long periods of continuous stress, which may require the management by the health care provider. In these cases, the purpose of the nursing is helping to promote health through supporting patient's coping. Therefore, for the nursing intervention to be effective, it is critical to build a theoretical framework that describes stress-coping for chronic arthritis. Thus, the purpose of this dissertation is to present a theoretical framework which describes the stress-coping processes and to empirically test pathos of this framework for the people with chronic arthritis. The foundation upon which this framework is built in the Erickson, Tomlin, and Swain(1983) theory of Modeling and role-Modeling. The subjects were 275 patients with rheumatoid arthritis or osteoarthritis who visited the outpatient clinic. A hypothetical model of stress-coping was tested by covariance structure analysis with PC-LISREL 8.12 program. As a result, the overall fit was good(Chi-square=94.49, P=0.00, RMR=0.067, GFI=0.95, AGFI=0.91, NNFI=0.93, NFI=0.91) for the hypothetical model. The results of hypothesis testing were as follows : Basic need satisfaction had a statistically significant influence on illness-related experience, emotional stress and coping resources. Internal health locus of control had a statistically significant influence on coping resources. However, independent variables(basic need satisfaction, internal health locus of control, illness-related experience, emotional stress and coping resource) did not have significantly influence on coping. And then, the hypothetical model was modified by considering both the theoretical implication and statistical significance of the parameter estimates. The revised model had a better fit to the data(Chi-square=83.11(P=0.00), RMR=0.061, GFI=0.96, AGFI=0.92, NNFI=0.95, NFI=0.92). Hypothesis emerged from the revised model was tested. The results of hypothesis testing were as follows : Basic need satisfaction had a statistically significant influence on illness-related experience, emotional stress and coping resources. Internal health locus of control had a statistically significant influence on illness-related experience and coping resources. Internal health locus of control, illness-related experience, emotional stress and coping resources had a significantly influence on coping. According to the results of this dissertation, basic need satisfaction and internal health locus of control play a central role in appraisal of illness-related experience and coping resources. And illness related-experience, emotional stress, and coping resources affect on coping activities. In summary, nursing interventions to enhance basic need satisfaction and internal health locus of control will decrease illness related experience and emotional stress and increase coping resources. Increased coping resources will prompt coping activities.

• 근관절건강학회지
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• 제6권1호
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• pp.22-36
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• 1999

The purpose of the study was to identify disease characteristics and behavior pattern of treatment for patients with Fibromyalgia. This study was carried out between May to Aug. in 1998 through direct interview in Rheumatism clinic at H. University Hospital and subject in this study were 125 outpatients diagnosed with Fibromyalgia. Collected data were analyzed by descriptive statistics and t-test, ANOVA using SPSS Window program. The results of this study are as follows. 1. General Characteristics : All of the persons with Fibromyalgia were female who were mostly in their forties(37.5%). A third of them(38.4%) were graduated from high school. The greatest part of them(54.4%) were christians but little part of them(16.8%) were employed 2. Disease Characteristics : They have struggled with Fibromyalgia for 10 years on an average. About half of them(56.9%) suffered from Fibromyalgia only but the others had another diseases which were in greatest part occupied by Osteoarthritis. The number of tender point which is a feature of Fibromyalgia differed according to measuring criteria. Yunus criteria. however, was proved to be the most proper measuring criteria than any other method as it showed high correlations between symptoms and physical activities. The most serious symptoms that complained the patients among subjective symptoms are pain, sleep disorder, and fatigue in sequence, and activities most hard to do among physical activities are washing by hand, scrubbing by hand, and shopping in sequence. 3. Behavior Pattern of Treatment : The largest part of them(42.4%) had received medical treatment after they were determined to have the disease and most of them were taking medicine as prescribed by physician(88.8%) or other medicines(16.8%), Of them, two thirds stated that the medicine they took were effective. Around a third of them took exercises mostly composed of swimming. The medical institution they visited in the past were orthopedic surgical department, Oriental hospital, physical therapy department in sequence and, in a slight percent(11.4%), psychiatric department. 4. Relations between Disease Characteristics and Behavior pattern of Treatment : It shows that number of tender point and level of symptom are significantly different according to duration of disease and medical intervention. As a results, it can be suggest that persons with Fibromyalgia need to take exercises and medicine continually regardless of medical treatment as it is a chronic disease whose symptoms are hardly mitigated.

• 한국해양환경ㆍ에너지학회지
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• 제17권4호
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• pp.297-305
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• 2014

본 연구에서는 2013년 11월 21일부터 30일까지 9일간 이어도 종합해양과학기지에 선박자동식별장치(AIS)를 설치하여 관할해역과 한 중 잠정조치수역의 항행 선박 및 어업활동을 모니터링하기 위해 선박정보를 수집하였다. 수집된 AIS 원시자료는 자체적으로 개발된 프로그램을 이용해 선박의 고유정보(해상이동업무식별번호, IMO 번호, 호출 부호, 선명 등)와 위치정보(위치, 속력, 침로 등)를 추출하고, 국적과 선종 정보만을 이용해 선박을 분류하였다. 선박의 국적 정보는 해상식별부호(MID)로 파악되는데, 소형선박에서 많이 탑재하고 있고 기능이 보다 간소화된 소출력의 Class B AIS는 국제해사기구(IMO)의 탑재 요건을 따르고 있지 않아 국적을 알 수 없는 선박이 다수 존재함을 확인하였다. 국적 정보를 가지고 있는 선박 중에서는 중국선박과 한국선박이 많았으며, 선종정보를 가지고 있는 선박 중에서는 화물선, 어선 순으로 많았다. 또한 국적을 알 수 없는 선박의 특성을 파악하기 위해 이어도해양과학기지 주변의 항행빈도수가 높은 중국선박과 한국선박의 항적과 비교하였으며, 이를 통해 국적미상 선박이 중국선박의 항행경로와 높은 유사성을 보이는 것을 확인하였다. 따라서 이 해역에서 중국어선은 선단의 형태로 자주 출몰하는 것으로 판단된다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2001년도 제2회 생물정보학 국제심포지엄
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• pp.129-137
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• 2001

We used cDNA microarrays to assess gene expression profiles in 60 human cancer used in a drug discovery screen by the National Cancer Institute. Using these data, we linked bioinformatics and chemoinformatics by correlating gene expression and drug activity pattens in the NCI60 lines. Clustering the cell lines on the basis of gene expression yielded relationships very different from those obtained by clustering the cell lines on the basis of their response to drugs. Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance. This is the first study to intergrate large databases on gene expression and molecular pharmacology.

• 동의생리병리학회지
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• 제18권4호
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• pp.1055-1060
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• 2004

Apoptosis is the ability of cells to self-destruct by the activation of an intrinsic cellular suicide program when the cells are no longer needed or when they are seriously damaged. Morphologically, apoptosis is characterized by the appearance of membrane blebbing, cell shrinkage, chromatin condensation, DNA cleavage, and the fragmentation of the cell membrane-bound apoptotic bodies. Siegesbeckia glabrescens Makino (Siegesbeckiae Herba, SG) has been widely used as treatments for arthritis, and fever, as well as detoxification properties. The present studies were undertaken to evaluate if SG has an anti-apoptotic property. Cell viability was measured by XTT and tryphan blue stain. Morphological characteristic of human aortic smooth muscle cells(HASMC) were visualized with a phase-contrast microscope. SG significantly reduced HASMC, but not human umbilical vein endothelial cell(HUVEC), viability in a dose-dependent manner. Confluent untreated cells at 24hrs showed normal morphology, flat with a uniform polygonal shape. SG-treated cells (0.5㎎/㎖) at 24hrs showed apoptotic morphology. Cells became irregular with elongated lamellipodia, and exhibited condensed chromatin in nuclei with occasional endoucleation. There was an increase in the number of apoptotic cells rounding-up and being detached from the substrate. TUNEL staining of SG-treated cells showed dark-brown stains in nuclei and cytosol. Caspases are central components of the machinery responsible for apoptosis and are generally divided into two categories; the initiator caspases, which include caspases-2,-8,-9, and -10, and the effector caspases, which include caspases-3,-6, and -7. SG decreased anti-caspase-3 protein expression, which means activation of caspases-3 activity. It has been reported that there is a link between NO formation and apoptosis. NO production was accelerated by SG treatment in HASMC. L-NNA, NOS inhibitor, inhibited SG-induced apoptosis. These results, therefore, indicated that both caspases-3 and NO production are involved in apoptosis in smooth muscle cells. According to these results, SG may have a potential effect in the treatment of hypertensive atherosclerosis.

• Biomolecules & Therapeutics
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• 제24권4호
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• pp.410-417
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• 2016

Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside (Rham2) are mono-, di-, and tri-glycosylated forms of quercetin, respectively. In a previous study, we showed that quercetin can enhance ${\alpha}7$ nicotinic acetylcholine receptor (${\alpha}7$ nAChR)-mediated ion currents. However, the role of the carbohydrates attached to quercetin in the regulation of ${\alpha}7$ nAChR channel activity has not been determined. In the present study, we investigated the effects of quercetin glycosides on the acetylcholine induced peak inward current ($I_{ACh}$) in Xenopus oocytes expressing the ${\alpha}7$ nAChR. $I_{ACh}$ was measured with a two-electrode voltage clamp technique. In oocytes injected with ${\alpha}7$ nAChR copy RNA, quercetin enhanced $I_{ACh}$, whereas quercetin glycosides inhibited $I_{ACh}$. Quercetin glycosides mediated an inhibition of $I_{ACh}$, which increased when they were pre-applied and the inhibitory effects were concentration dependent. The order of $I_{ACh}$ inhibition by quercetin glycosides was Rutin${\geq}$Rham1>Rham2. Quercetin glycosides-mediated $I_{ACh}$ enhancement was not affected by ACh concentration and appeared voltage-independent. Furthermore, quercetin-mediated $I_{ACh}$ inhibition can be attenuated when quercetin is co-applied with Rham1 and Rutin, indicating that quercetin glycosides could interfere with quercetin-mediated ${\alpha}7$ nAChR regulation and that the number of carbohydrates in the quercetin glycoside plays a key role in the interruption of quercetin action. These results show that quercetin and quercetin glycosides regulate the ${\alpha}7$ nAChR in a differential manner.

• 여성건강간호학회지
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• 제2권1호
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• pp.138-157
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• 1996

Recently, there has been increase perception of health promotion with development of the economic state and science. Individual's responsibility and psychosocial factors have impacted on the individual's lifestyle. Health promotion can be maintained or improved through changes of lifestyle of individuals. Also, there has been supported results of health behavior health has been focused on menopausal symptom and reproductive organ. Until recently, little research has been available on the health or health care of midlife women. The purpose of this study was to explain relationship between health promoting lifestyle and hardiness, gender role characteristics. A total of 254 items of data were obtained from randomly selected subjects. The data collected from the interviews were analyzed using SPSS, yielding frequency, mean. t-test, ANOVA, Pearson Correlation, Stepwise multiple regression. The result of this study are as follows : 1) For the health promoting lifestyle, the mean score was 116.3, the highest score was nutrition(3.30) and interpersonal support(2.86), the lowest score was exercise(1.68). The highest subscale for the hardiness was committment(2.44). Also for the gender role characteristics was higher than median score(37.8). 2) There was a statistically difference the demographic variables. A total health promotion lifestyle was predicted by income and marriage satisfaction, hardiness was predicted by education, income, marriage satisfaction, support person and gender role characteristics was predicted by education. 3) With regard to the relationship among health promoting lifestyle, hardiness, gender role characteristics, the correlation coefficient between health promoting lifestyle and hardiness was r=-.48, p<.001. Also there were significant correlation between health promoting lifestyle and gender role characteristics(r=.22, p<.01), hardiness and gender role characteristics(r=-.39, p<.001). 4) A stepwise multiple regression analysis was done on the total health promoting lifestyle score using the demographic variables, hardiness subscale and gender role characteristics for independent variables. A total of 25% of the variance was explained inthe total health promoting lifestyle by the control, challenge and marriage satisfaction. In conclusion, hardiness and gender role characteristics were engaged in health promoting activity in midlife women. This study also provides new information about the health practices that midlife women report they practice. Therefore, nursing intervention to increase women's health have to be planed program that consider on the basis the results of this study.

• 한국과학교육학회지
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• 제30권8호
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• pp.1084-1096
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• 2010

본 연구에서는 초등학교 초임교사의 과학수업에 대한 초등 교사들의 수업비평을 분석하여 교사들이 나타내는 수업비평의 관점과 특징을 알아보는 것을 목적으로 하였다. 연구대상인 수업비평자들은 저경력과 고경력 초등교사를 포함하여 모두 6명이다. 비평의 대상이 된 수업은 초등학교 5학년 1학기 7단원 '식물의 잎이 하는 일'중 두 차시의 실험수업이다. 본 연구의 분석 결과, 교사들은 18개의 코드 중 다음 3가지 코드인 동기유발, 학생 중심의 탐구, 결과정리를 주요 관점으로 비평하고 있었다. 표준적인 체크리스트와 같은 요소별 비평을 하고 있으며, 부분상황적, 맥락적 특징을 드러내는 비평을 하고 있었다. 또한 저경력 교사들은 초임교사의 과학수업에 많은 공감을 나타냈으며, 자신의 초임시절 수업경험을 성찰하며 수업비평을 나타낸다. 그에 비해 고경력의 교사들은 자기 성찰, 상황해석이나 이해보다는 수업전반을 평가하려는 평가자의 입장이 우세하였다. 초등학교 과학수업에 대한 교사들의 수업비평 관점을 조사한 본 연구의 결과는 교사들의 과학수업에 대한 전문성 발달 프로그램 설정 및 교사교육을 위한 기초자료로 활용될 수 있을 것이다.