Proceedings of the Korean Society for Bioinformatics Conference (한국생물정보학회:학술대회논문집)

Korean Society for Bioinformatics (한국생명정보학회)
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A gene expression database for the molecular pharmacology of cancer

  • Scherf, Uwe (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)/Gene Logic Inc.) ;
  • Ross, Douglas-T. (Department of Biochemistry, Stanford University School of Medicine) ;
  • Waltham, Mark (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Smith, Lawrence-H. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Lee, Jae-K. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Tanbe, Lorraine (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Kohn, Kurt-W. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Reinhold, William-C. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Mayers, Timothy-G. (Information Technology Branch, Develomental Therapeutics program(DTP), Division Cancer Treatment and Diagnosis(DCTD)) ;
  • Andrews, Darren-T. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Scudiero, Dominic-A. (SAIC-NCI-Frederick Cancer Research and Development Center) ;
  • Eisen, Michael-B. (Department of Genetics, Stanford University School of Medicine) ;
  • Sausville, Edward-A. (Office of the Associate Director, DTP, DCTD, NCI, NIH) ;
  • Pommier, Yves (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH)) ;
  • Botstein, David (Department of Genetics, Stanford University School of Medicine) ;
  • Brown, Patrick-O. (Department of Biochemistry, Stanford University School of Medicine/Howard Hughes Medical Institute, Stanford University school of medicine) ;
  • Weinstein, John-N. (Laboratory of Molecular Pharmacology, Division of Basic Science National Cancer Institute(NCI), National Institutes of Health(NIH))
  • Published : 2001.08.01
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Abstract

We used cDNA microarrays to assess gene expression profiles in 60 human cancer used in a drug discovery screen by the National Cancer Institute. Using these data, we linked bioinformatics and chemoinformatics by correlating gene expression and drug activity pattens in the NCI60 lines. Clustering the cell lines on the basis of gene expression yielded relationships very different from those obtained by clustering the cell lines on the basis of their response to drugs. Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance. This is the first study to intergrate large databases on gene expression and molecular pharmacology.

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