• 분석과 대안
• /
• 제6권1호
• /
• pp.259-282
• /
• 2022

本文关注到与过去不同的新常态下 '新东北现象' 的复合特征,着重阐述最近 '新东北现象' 里的主要三个现象-经济现象, 人口现象, 财政现象。2014年以来东北地区经济增速减缓虽成大问题,同其间东北有关人口状况与财政支出结构变动也很突出。总之, 2014年以后在东北地区, 经济增长衰退, 人口减少与人才流失加剧, 老龄化提速, 财政收支缺口增加与社会保障支出激增, 这些现象都同时发生, 互相影响着产生恶性循环, 新常态下的 '新东北现象' 之难点就在这复合实质。那么, 新常态下的 '新东北现象' 之如此复合特征与难点给全中国何含意? 本文提出两点。第一, 基于近来中国一些有关状况变化趋势来看, 东北可以被视为中国的一个缩影, 新常态下的 '新东北现象' 不限于东北地区, 不久将来很可能扩散到中国其他区域, 会成为全中国现象。第二, 新常态下的 '新东北现象' 出现, 对于改革开发以来实行的西部大开发战略, 中部崛起战略, 东北振兴战略等一系列区域大开发战略的根本性效果, 要求深刻的反思且重新构想。这些区域发展战略, 虽有所成就, 中西部地区, 尤其是西部, 还仍然相对很落后, 中国区域差距一向没有缩小。振兴东北战略实行已有了20来年, 新常态下的 '新东北现象' 出现也显示长期以来困扰东北经济的深层次问题始终没有得到解决。近来习进平格外强调 '共同富裕', '新东北现象' 也成为本届中央政府最急切解决的问题之一, 如果成功了, 既能为重新构思和调整区域发展战略提出有效方向, 又能为对应未来中国经济社会变动成为一个重要标志。

• 생명과학회지
• /
• 제33권1호
• /
• pp.50-55
• /
• 2023

본 연구는 Rosa davurica Pall. 잎 추출물의 염증 억제 효과 및 그 조절 기전을 알아보기 위해 수행되었다. Rosa davurica Pall. 잎 추출물의 항염 평가는 LPS로 자극한 Raw 264.7 대식세포에서 생성되는 NO와 iNOS 분석을 통해 확인하였다. Rosa davurica Pall. 추출물의 처리는 농도의존적으로 LPS에 의한 NO 생성과 iNOS 단백질의 발현을 유의미하게 억제하였고 500 ㎍/ml의 고농도에서는 세포 독성을 나타내었다. Rosa davurica Pall. 추출물은 LPS에 의해 인산화된 IκB 발현을 억제하였고 LPS에 의해 활성화된 NF-κB의 인산화를 약화시킴으로써 NF-κB의 활성화를 억제하였다. 또한, NF-κB signaling 특이 저해제인 PDTC와 Rosa davurica Pall. 추출물의 동시 처리는 각각 처리군에 비해 NO 생성과 iNOS 단백질 발현을 더욱 억제하였다. 이상의 결과는 Rosa davurica Pall. 추출물이 NF-κB signaling 조절에 의해 NO 생성을 억제함으로써 LPS에 의한 대식세포 염증 반응을 제어하고 있음을 제시해 주고 있다.

• Smart Structures and Systems
• /
• 제31권4호
• /
• pp.421-436
• /
• 2023

This paper presents a vibration displacement measurement and damage identification method for a space truss structure from its vibration videos. Features from Accelerated Segment Test (FAST) algorithm is combined with adaptive threshold strategy to detect the feature points of high quality within the Region of Interest (ROI), around each node of the truss structure. Then these points are tracked by Kanade-Lucas-Tomasi (KLT) algorithm along the video frame sequences to obtain the vibration displacement time histories. For some cases with the image plane not parallel to the truss structural plane, the scale factors cannot be applied directly. Therefore, these videos are processed with homography transformation. After scale factor adaptation, tracking results are expressed in physical units and compared with ground truth data. The main operational frequencies and the corresponding mode shapes are identified by using Subspace Stochastic Identification (SSI) from the obtained vibration displacement responses and compared with ground truth data. Structural damages are quantified by elemental stiffness reductions. A Bayesian inference-based objective function is constructed based on natural frequencies to identify the damage by model updating. The Success-History based Adaptive Differential Evolution with Linear Population Size Reduction (L-SHADE) is applied to minimise the objective function by tuning the damage parameter of each element. The locations and severities of damage in each case are then identified. The accuracy and effectiveness are verified by comparison of the identified results with the ground truth data.

• 대한통합의학회지
• /
• 제11권3호
• /
• pp.59-67
• /
• 2023

Purpose : Epithelial-to-mesenchymal transition (EMT) is recognized as an important cellular response in metastatic proceduresand characterized by loss of cellular polarity as well as gain of mesenchymal features, which enables migration and invasion. Hepatocellular carcinoma (HCC) is one of the most common primary carcinomas in the liver and exhibits a poor prognosis due to frequent extrahepatic metastasis. Taraxacum officinale has been used for a long time in oriental medicine because of its various pharmacological activitiessuch as anti-rheumatic, anti-inflammatory, antioxidative, and anticarcinogenic activities. In this study, the anti-metastatic activity of T. officinale water extract (TOWE) and ethanol extract (TOEE) was investigated through the regulation of EMT in the Huh7 cells. Methods : The effects of TOWE and TOEE on migratory and invasive activities were investigated by wound healing and in vitro invasion assays. Western blot analysis was also applied to analyze protein expression levels associated with EMT and their upstream transcription factors in Huh7 cells. Results : TOWE and TOEE treatment potently inhibited migration and invasion of Huh7 cells compared to the untreated group. Both extracts treatment inhibited protein expression levels of N-cadherin, matrix metalloproteinase (MMP)-9, and vimentin while E-cadherin was significantly accelerated. In addition, the activated status of transcription factors, Snail, nuclear factor (NF)-κ B, and zinc finger E-box binding homeobox (ZEB)1 was also inhibited with statistical significance. In comparison to both extracts, TOEE more potently attenuated migration, invasion, and EMT markers as well as their transcription factors in Huh7 cells than TOWE, which means that TOEE might possess more functional phytochemicals than TOWE. Conclusion : Consequently, TOWE and TOEEattenuated metastatic activity of hepatocellular carcinoma through the regulation of EMT markers and their transcription factors in Huh7 cells, which means that T. officinale might be a promising strategy for a chemopreventive agent against HCC metastasis.

• Nuclear Engineering and Technology
• /
• 제19권2호
• /
• pp.115-121
• /
• 1987

SNU 1.5MV 직렬형 반데그라프 가속기의 고전압 안정화 계통을 설치하여 그 동작 특성을 파악하고 최적화하였다. 이온빔 수송계통의 최적 운전 조건을 단계적인 실험을 통하여 결정하였으며 적절한 운전 조건하에 표적함에서 350nA의 가속된 양성자빔을 얻었다. 고전압을 안정화하지 않았을 때의 고전압 변동은 이온빔을 가속하지 않을 때와 가속할 때 각각 $\Delta$V/V=5.2$\times$$10^{-3}$, 7.2$\times$$10^{-3}$이었으며 그 변동 주파수는 3Hz 이하였다. 터미날 전압 247.3kV에서 고전압 안정화 계통의 최적 운전을 통하여 터미날 전압의 변동은 $\Delta$V/V=2.45$\times$$10^{-4}$ 으로 줄었고 에너지 안정도는 $\Delta$E/E=2.44$\times$$10^{-4}$ 으로 유지되었으며 이 때의 안정화 계수는 29.4였다.

• Molecules and Cells
• /
• 제46권4호
• /
• pp.245-255
• /
• 2023

This study aimed to exploring the pathophysiological mechanism of 7α,25-dihydroxycholesterol (7α,25-DHC) in osteoarthritis (OA) pathogenesis. 7α,25-DHC accelerated the proteoglycan loss in ex vivo organ-cultured articular cartilage explant. It was mediated by the decreasing extracellular matrix major components, including aggrecan and type II collagen, and the increasing expression and activation of degenerative enzymes, including matrix metalloproteinase (MMP)-3 and -13, in chondrocytes cultured with 7α,25-DHC. Furthermore, 7α,25-DHC promoted caspase-dependent chondrocyte death via extrinsic and intrinsic pathways of apoptosis. Moreover, 7α,25-DHC upregulated the expression of inflammatory factors, including inducible nitric oxide synthase, cyclooxygenase-2, nitric oxide, and prostaglandin E₂, via the production of reactive oxygen species via increase of oxidative stress in chondrocytes. In addition, 7α,25-DHC upregulated the expression of autophagy biomarkers, including beclin-1 and microtubule-associated protein 1A/1B-light chain 3 via the modulation of p53-Akt-mTOR axis in chondrocytes. The expression of CYP7B1, caspase-3, and beclin-1 was elevated in the degenerative articular cartilage of mouse knee joint with OA. Taken together, our findings suggest that 7α,25-DHC is a pathophysiological risk factor of OA pathogenesis that is mediated a chondrocyte death via oxiapoptophagy, which is a mixed mode of apoptosis, oxidative stress, and autophagy.

• Korean Journal of Radiology
• /
• 제21권1호
• /
• pp.77-87
• /
• 2020

Objective: To assess the feasibility of simultaneous multislice-accelerated diffusion-weighted imaging (SMS-DWI) of the rectum in comparison with conventional DWI (C-DWI) in rectal cancer patients. Materials and Methods: This study included 65 patients with initially-diagnosed rectal cancer. All patients underwent C-DWI and SMS-DWI with acceleration factors of 2 and 3 (SMS2-DWI and SMS3-DWI, respectively) using a 3T scanner. Acquisition times of the three DWI sequences were measured. Image quality in the three DWI sequences was reviewed by two independent radiologists using a 4-point Likert scale and subsequently compared using the Friedman test. Apparent diffusion coefficient (ADC) values for rectal cancer and the normal rectal wall were compared among the three sequences using repeated measures analysis of variance. Results: Acquisition times using C-DWI, SMS2-DWI, and SMS3-DWI were 173 seconds, 107 seconds, (38.2% shorter than C-DWI), and 77 seconds (55.5% shorter than C-DWI), respectively. For all image quality parameters other than distortion (margin sharpness, artifact, lesion conspicuity, and overall image quality), C-DWI and SMS2-DWI yielded better results than did SMS3-DWI (Ps < 0.001), with no significant differences observed between C-DWI and SMS2-DWI (Ps ≥ 0.054). ADC values of rectal cancer (p = 0.943) and normal rectal wall (p = 0.360) were not significantly different among C-DWI, SMS2-DWI, and SMS3-DWI. Conclusion: SMS-DWI using an acceleration factor of 2 is feasible for rectal MRI resulting in substantial reductions in acquisition time while maintaining diagnostic image quality and similar ADC values to those of C-DWI.

• Journal of Chest Surgery
• /
• 제24권9호
• /
• pp.843-852
• /
• 1991

We prospectively studied postoperative cardiac arrhythmia after open heart surgery to analyze the types and incidence of cardiac arrhythmia and to predict preoperative risk factors. And also we evaluated the effectiveness of atrial and ventricular epicardial electrodes which were placed during operation Between March 1990 and August 1990, We had operated on in 211 patients and we studied 201 consecutive patients excluding 10 patients. The study group included 99 males and 102 female patients, ages 1 month to 75 years[Mean$\pm$SD=28.0$\pm$21.7 years]. Postoperatively, all patients were regularly seen by the cardiac surgeon and cardiologist, They had continuous electrocardiographic monitoring for the first 3 days, initially in the intensive care unit and were checked routine electrocardiography on the postoperative 7 days, The postoperative cardiac arrhythmia were analyzed and possible associations of this arrhythmia with various pre, intra, and postoperative factors were studied by univariate and multivariate discriminant analysis, The overall incidence of postoperative cardiac arrhythmia except relative sinus bradycardia was 36.8%;[74/201], The incidence of postoperative cardiac arrhythmia in acyanotic congenital heart disease: 19.4%, cyanotic congenital heart disease: 20.8%, cardiac arrhythmia surgery: 33.3%, acquired valvular heart disease: 60.9% and coronary artery occlusive disease: 38.9%. Both univariate and multivariate studies indicated the pre operative symptom duration[p = 0013], the duration of medication[p=0.003], presence of preoperative arrhythmia[p<0.001] and pre-operative left atrial dimension in echocardiography to be the factor promoting postoperative cardiac arrhythmia. Multivariate discriminant analysis showed that the presence of preoperative cardiac arrhythmia, bypass time and the duration of preoperative symptom duration conveyed considerable risk factor on post-operative arrhythmia. The atrial wire electrodes were used diagnostically in 36 and were used therapeutically in 89 among 201 patients. Atrial pacing were used to treat relative sinus bradycardia, accelerated junctional tachycardia or premature atrial or ventricular contractions in 51 patients. Atrioventricular sequential pacing were used in 16 patients and ventricular pacing were used in 20 patients. Hemodynamics were evaluated in 2 patients of relative sinus bradycardia before and after atrial pacing. The atrial pacing increased the amount of cardiac output to 15% more. Because of their great utility in the diagnosis and treatment of arrhythmias, we conclude that routine placement of atrial and ventricular electrodes at the time of operation is indicated regardless of the nature of the open-heart procedure.

• The Korean Journal of Physiology and Pharmacology
• /
• 제20권3호
• /
• pp.305-314
• /
• 2016

Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating inflammation and fibrosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 ($10{\mu}mol/L$) treatment as experimental models. Addition of NecroX-5 significantly increased decorin (Dcn) expression levels in HR-treated hearts. In contrast, expression of transforming growth factor beta 1 ($TGF{\beta}1$) and Smad2 phosphorylation (pSmad2) was strongly attenuated in NecroX-5-treated hearts. In addition, significantly increased production of tumor necrosis factor alpha ($TNF{\alpha}$), $TGF{\beta}1$, and pSmad2, and markedly decreased Dcn expression levels, were observed in LPS-stimulated H9C2 cells. Interestingly, NecroX-5 supplementation effectively attenuated the increased expression levels of $TNF{\alpha}$, $TGF{\beta}1$, and pSmad2, as well as the decreased expression of Dcn. Thus, our data demonstrate potential antiinflammatory and anti-fibrotic effects of NecroX-5 against cardiac HR injuries via modulation of the $TNF{\alpha}/Dcn/TGF{\beta}1/Smad2$ pathway.

• 기술혁신학회지
• /
• 제18권3호
• /
• pp.468-491
• /
• 2015

본 연구의 목적은 공공 기술이전 활성화를 위해서 연구개발 단계에서 선행적으로 도입할 연구개발 관리관점과 전략을 제시하는 것이다. 기술이전 사업화 영향요인은 기술공급자 관점에서 기술미활용 영향요인, 기술수요자 관점에서 기술이전 영향요인과 기업의 사업화 영향요인 등으로 구성하였고, 영향요인을 도출하기 위해서 21세기 프론티어사업단 기술자료를 활용하였다. 기술 미활용에 대한 주요 영향변수는 추가 기술개발, 수요기업의 발굴, 대량생산 기술의 확보와 신뢰성 검증 등으로 나타났고, 기술이전 영향변수는 기술의 우수성(혁신성)과 새로운 시장창출로 나타났다. 기업의 사업화 성공요인은 추가기술 개발과 개량, 연구개발 인력의 우수성과 CEO역량 등으로 도출하였다. 연구개발 기술이전 성과를 개선하기 위해서는 연구개발단계부터 기술이전 사업화 목표를 분명히 하고, 향후 라이선스 관점에서 상용화 가능한 원천형 핵심기술을 창출하여야 한다. 또한 연구개발조직의 성과관리가 정량적 성과보다는 글로벌 기술경쟁력, 상용화 파급효과 등으로 평가된다면, 기술이전 사업화 흐름이 가속화될 수 있을 것이다.