Purpose : This study examined how of nursing students affects their academic self-efficacy and communication ability on self-leadership. Methods : The subjects of this study included 269 nursing students enrolled in a college located in City B, South Korea during a period between June and July 2021. The collected data were analyzed using SPSS/WIN 22.0 program to compute frequency, percentage, mean and standard deviation and conduct t-test, ANOVA, Scheffe's test, Pearson Correlation Coefficient, and multiple regression analysis. Results : The nursing students had average academic self-efficacy of 3.10±.42, communication ability of 3.78±.53, and self-leadership of 3.16±.44. Among the self-leadership sub-factors, self-reward was the highest with 3.94±.74 points. The academic self-efficacy of the subjects demonstrated a significant difference according to happiness index (F=8.83, p<.001) and health (F=3.38, p=.035). The communication ability showed a significant difference depending on year of study (F=5.62, p<.001), happiness index (F=5.95, p<.001), and experience of clinical training (t=-3.57, p<.001). The self-leadership demonstrated a significant difference according to year of study (F=4.28, p=.006), satisfaction with major (F=7.37, p<.001), happiness index (F=3.68, p=.013), and experience of clinical training (t=-3.41, p<.001). A positive correlation was observed between the subject's academic self-efficacy and communication ability (r=.40, p<.001), as well as the academic self-efficacy and self-leadership (r=.45, p<.001). The communication ability (𝛽=.36, p<.001) was proven to be the strongest influential factor on the self-leadership, followed by academic self-efficacy (𝛽=.28, p<.001), satisfaction with major (𝛽=.13, p=.011), and experience of clinical training (𝛽=.13, p=.013). Conclusion : This study results imply that repeated studies that investigate the nursing students' academic self-efficacy, communication ability, and self-leadership are required. Furthermore, efforts should be made to develop programs aimed at enhancing nursing students' academic self-efficacy, communication ability, and self-leadership.