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무치증과 저한성 외배엽 이형성증 보고 (Case Report of Hypohidrotic Ectodermal Dysplasia with Anotondia)

  • 박계라;이경은;서봉직
    • Journal of Oral Medicine and Pain
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    • 제31권2호
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    • pp.121-126
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    • 2006
  • 저한성 외배엽 이형성증은 감모증, 치아의 수 또는 형태이상과 땀샘의 이상이 특징으로 나타나는 질환이다. 이중 치아 이상은 유치열, 영구치열 모두 영향을 받을 수 있으며 완전 무치증, 부분무치증이 특징이며 치아의 형태는 원추형으로 비정상적으로 나타난다. 이에 저자는 완전무치증을 가진 저한성 외배엽 이형성증 경험하였기에 이에 대한 증례보고와 함께 문헌고찰을 하고자 한다.

방사선의 발생독성 검색을 위한 단기 최기형성 시험법의 확립 (Establishment of Short-Term Teratogenicity Study for Detecting Developmental Toxicity Induced by Gamma Radiation)

  • 김종춘;김성호;신동호;신진영;김세라;이해준;박승춘;조성기;이윤실
    • Toxicological Research
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    • 제20권2호
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    • pp.117-122
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    • 2004
  • The present study was carried out to establish a short-term teratogenicity study for detecting developmental toxic potential induced by gamma radiation in ICR mice. Pregnant mice were exposed at dose levels of 0, 0.5, 1, 2, or 4 Gy on gestational day 8.5. All dams were subjected to caesarean section on gestational day 10.5 and their embryos were examined for growth, differentiation, and morphological abnormalities. An increase in the number of resorption was found at 4 Gy in a dose-dependent manner. Dose-dependent decreases in the developmental score of yolk sac circulation and olfactory system at above 1 Gy, in the number of somite pairs and developmental score of allantois, optic system, and maxillary process at above 2 Gy, and in the all growth and developmental parameters examined at 4 Gy were found. Various types of morphological abnormalities were seen at dose levels of 0.5 Gy or greater. Characteristic malformations induced by gamma radiation were abnormal axial rotation, hematoma, craniofacial hypoplasia, open neuropore, shortened prosencephalon, kinked somites, irregular somites, swelling, hydropericardium, absent branchial bar, and absent limb bud. Morphological alterations such as hematoma, craniofacial hypoplasia, open neuropore, and kinked somites were noted even in the lowest dose (0.5 Gy). These results indicated that the short-term teratogenicity study established in this study can be a useful tool for not only detecting the developmental toxic potential induced by gamma radiation, but also screening radio-protective agents in ICR mice.

The role of visual and verbal information on the functionality of shapewear in female consumers' online purchase decisions

  • Shin, Eonyou;Zhang, Ling;Hwang, Chanmi;Baytar, Fatma
    • 복식문화연구
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    • 제27권6호
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    • pp.539-552
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    • 2019
  • The purpose of the current study was to examine the role of information on shapewear's functionality in consumers' purchase decisions in an online shopping context. Through two steps of stimulus development process, four mock websites were developed to conduct a main study. In the main study, a 2 (visual information: absent vs. present images of the shapewear's functionality) x 2 (verbal information: absent vs. present descriptions of the shapewear's functionality) between-subject factorial design was employed to examine the impact of visual and verbal information regarding the functionality of shapewear on the consumer decision-making process (i.e., attitudes and purchase intentions). The results showed that verbal information about how shapewear reduces the size of specific body parts (i.e., waist, abdomen, hips, and thighs) were effective in increasing perceived attractiveness in an online context, which increased attitudes and purchase intentions. In addition, attitudes toward the shapewear mediated the effects of expected physical attractiveness on purchase intentions. The results of this study provided empirical support for the importance of expected physical attractiveness in consumers' online purchase decision on shapewear and useful managerial implications for enhancing the effectiveness of online shapewear presentations by including descriptions of the functionality of shapewear in decreasing the size of body parts.

Roles of ginsenosides in inflammasome activation

  • Yi, Young-Su
    • Journal of Ginseng Research
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    • 제43권2호
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    • pp.172-178
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    • 2019
  • Inflammation is an innate immune response that protects the body from pathogens, toxins, and other dangers and is initiated by recognizing pathogen-associated molecular patterns or danger-associated molecular patterns by pattern-recognition receptors expressing on or in immune cells. Intracellular pattern-recognition receptors, including nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2, and cysteine aspartate-specific protease (caspase)-4/5/11 recognize various pathogen-associated molecular patterns and danger-associated molecular patterns and assemble protein complexes called "inflammasomes." These complexes induce inflammatory responses by activating a downstream effector, caspase-1, leading to gasdermin D-mediated pyroptosis and the secretion of proinflammatory cytokines, such as interleukin $(IL)-1{\beta}$ and IL-18. Ginsenosides are natural steroid glycosides and triterpene saponins found exclusively in the plant genus Panax. Various ginsenosides have been identified, and their abilities to regulate inflammatory responses have been evaluated. These studies have suggested a link between ginsenosides and inflammasome activation in inflammatory responses. Some types of ginsenosides, including Rh1, Rg3, Rb1, compound K, chikusetsu saponin IVa, Rg5, and Rg1, have been clearly demonstrated to inhibit inflammatory responses by suppressing the activation of various inflammasomes, including the NLRP3, NLRP1, and absent in melanoma 2 inflammasomes. Ginsenosides have also been shown to inhibit caspase-1 and to decrease the expression of $IL-1{\beta}$ and IL-18. Given this body of evidence, the functional relationship between ginsenosides and inflammasome activation provides new insight into the understanding of the molecular mechanisms of ginsenoside-mediated antiinflammatory actions. This relationship also has applications regarding the development of antiinflammatory remedies by ginsenoside-mediated targeting of inflammasomes, which could be used to prevent and treat inflammatory diseases.

한국산 색가오리과(Dasyatidae) 어류 1미기록종, Hemitrygon izuensis (Nishida and Nakaya, 1988) (First reliable record of a stingray, Hemitrygon izuensis (Nishida and Nakaya, 1988) (Chondrichthyes: Dasyatidae) from Korea)

  • 장서하;김진구
    • 수산해양기술연구
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    • 제57권3호
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    • pp.205-213
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    • 2021
  • Two specimens of Hemitrygon izuensis (395.8-471.5 mm in disc width), belonging to the family Dasyatidae (Myliobatiformes), were collected from the waters off north-eastern Jeju-do Island in June 2016 and Pohang in August 2019. This species was characterized by having no spots on dorsal side of disc, white ventral tail fold and short preorbital snout length (15.6-18.3% of disc width). This species is similar to H. akajei and H. sinensis reported in Korea, but differs in small denticles on mid-line of dorsal surface of disc (absent in H. izuensis vs. present in H. akajei and H. sinensis), the length of ventral tail fold (28.1-31.0% in H. izuensis vs. 48.0-48.6% in H. akajei vs. 45.0% in H. sinensis), color of ventral tail fold (white in H. izuensis vs. black in H. akajei and H. sinensis) and small tubercles on the posterior part of tail (absent in H. izuensis vs. present in H. akajei and H. sinensis). We suggest a Korean name for H. izuensis as "I-ju-gal-saeg-ga-o-li" following Kim et al. (2019).

신문사 근로자들의 스트레스와 건강상태에 관한 연구 (A Study on the Stress and the Health Status of Newspaper Employees)

  • 김진희
    • 한국직업건강간호학회지
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    • 제10권1호
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    • pp.41-54
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    • 2001
  • This study was designed to assess the relationship between occupational stress and health status in a study group of 197 workers employed in four newspaper publishing companies, using a self-adminstrative questionnaire. The types of occupation of them were reporters(79), clerical workers(54), and engineers (64). The studies on workers' health have been focused mainly on the physical, chemical, and biological diseases in our country. Therefore, the study of mental health, especially of occupational stress, is to be carried out. I consider stress as a factor having an effect on the health status of the newspaper employees, who have been well known to have high stress due to time pressures. I expect that this research will be helpful not only for understanding of health status by occupation, but also for making clear the issues that have been raised continuously from the previous researches. The results of this study are as follows; 1. The mean values of stress by occupation were statistically significant; the reporters had the highest stress symptom scores, and the engineers had the lowest levels of stress. The mean values of stress symptoms were higher in the workers who had long working hours. 2. The health status by occupation showed significant differences in gastrointestinal systems and in depression. The clerical workers were healthier than the engineers in gastrointestinal systems, and the reporters were more depressed than the engineers in depression. 3. The health status by the general characteristics, there was a statistical significance as for a gender, marital status, and absenteeism in the gastrointestinal systems. The men, the married, and the workers who had not been absent were more healthy. Only absenteeism had an effect on the problems in optical-dermal systems and in oro-fecal systems. Gender, marital status, absenteeism, and working hours were related with health status : the men. the married, the workers who had not been absent, and the workers who had longer working hours were more healthy. In mental stability, gender had a significant effect : the men were more healthy than the women. In general condition, the men, the older, the married, and the workers who had not been absent were more healthy. 4. Stress level had an effect on the health status in the respiratory systems, optical-dermal systems, oro-fecal system, depression, mental stability, general condition, and health condition. The workers who perceived more stress had more problems in their health status. 5. In the results of the multiple regression analyses, age in the respiratory systems, absenteeism in the optical-dermal systems, occupation and absenteeism in the gastrointestinal systems and in the oro-fecal systems, gender in depression and in mental stability, gender, age, absenteeism, and working hours in the general condition, absenteeism in the health condition had an effect on the health status of the workers.

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시추공경과 공내검층기가 분산곡선에 미치는 영향에 대한 비교 연구 (A comparative study of borehole size and tool effect on dispersion curves)

  • 조유준;김종만;김영화
    • 지구물리와물리탐사
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    • 제12권1호
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    • pp.154-162
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    • 2009
  • 단극 및 쌍극 음원을 이용하여 S파속도 결정에 큰 영향을 미치는 분산특성을 연구하였다. 이를 위하여 동일한 물성을 가지면서 공경을 달리하는 3종류의 시추공모형(${\Phi}520\;mm$. ${\Phi}150\;mm$and ${\Phi}76\;mm$)을 중심으로 이른 분산곡선을 구하고 공경과 공내검층기 존재 유무에 따른 분산 특성의 변화를 비교 분석하였다. 분산곡선의 형태는 단극음원에서 시추공 내의 공내검층기 유무에 크게 영향을 받지 않고 비슷하게 나타난 반면에 쌍극음원에서는 공내검층기 유무가 큰 차이를 보였다. 반면에 절단주파수에서는 쌍극음원에 비하여 단극음원에서 공내검층기 유무에 따른 차이가 크며 특히 소구경 시추공에서 큰 차이를 보여 단극음원을 이용한 토목시추공 음파검층에서 주파수 선택이 매우 중요한 변수가 될 수 있음을 보였다. 수치모델링결과, 절단주파수와 시추공경과의 관계는 기존에 알려진 일반적인 반비례 관계보다는 지수함수적으로 감소하는 관계임을 확인하였으며, 분산모드의 종류나 공내검층기 유무에 상관없이 각 환경에 있어서의 절단주파수 값을 지수함수로 표시할 수 있었다. 특정 시추공 환경에서의 분산곡선 및 분산특성들은 과거 연구결과들로부터 비교적 잘 알려져 있지만 분산곡선의 직접 비교에 의하여 분산특성에 미치는 시추공경과 공내측정기 영향을 보다 구체적으로 밝힐 수 있었다.

선천성 거대결장 및 특발성 거대결장에서 카할 세포의 역할 (The Role of Interstitial Cells of Cajal in Congenital Megacolons and Idiopathic Megacolons)

  • 유수영;고용택;한애리;정순희;엄민섭;김일호
    • Advances in pediatric surgery
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    • 제8권2호
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    • pp.113-118
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    • 2002
  • The etiology of several motility disorders, including persistent megacolon after definitive surgery for Hirschsprung's disease, meconium ileus which is not associated with cystic fibrosis and idiopathic megacolon, is still unclear. Interstitial cells of Cajal (ICC) are thought to modulate gut motility as gastrointestinal pace maker cells. The aim of this study was to evaluate the role of ICC in the bowel walls of the patients (n=15) who had variable motility disorders. The ICC were identified by immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. The ICC were immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. Whereas ICC were evenly distributed in the ganglionic bowels of G2, they were not seen or scarecely distributed in the ganglionic bowels of G3. Two patients (G4) who suffered from idiopathic megacolon showed absence or decrease of ICC in spite of presence of ganglion cells in their colons. Four neonates (G5) who underwent ileostomy because of meconium obstruction showed absent or markedly decreased ICC in the the colon at the time of ileostomy and the distribution of ICC was changed to a normal pattern at the time of ileostomy closure between 39-104 days of age and their bowel motility were restored after that. The results suggest that lack of ICC caused reduce motility in the ganglionic colons and it may be responsible for the development of various motility disorders. Delayed maturity of ICC may also playa role in the meconium obstruction of neinates.

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배스가 국내 호소에 서식하는 붕어 개체군에 미치는 영향 (Impact of Largemouth Bass (Micropterus salmoides) on the Population of Korean Native Fish, Crucian Carp (Carassius auratus))

  • 이진웅;김정희;박상현;최기룡;이혜진;윤주덕;장민호
    • 환경생물
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    • 제31권4호
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    • pp.370-375
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    • 2013
  • 수생태계에서 외래종의 문제는 국내뿐만 아니라 국제적으로도 많은 문제를 야기하고 있다. 배스의 경우 높은 포식압으로 수생태계 내에서 상당한 교란 요인으로 작용하고 있으며, 환경부에서 위해종으로 선정되어 관리 받고 있다. 본 연구에서는 위해종인 배스가 국내토착종인 붕어의 개체군에 미치는 영향을 파악하였다. 조사는 총 7지역의 저수지에서 시행하였으며, 배스의 유무에 따라 붕어의 길이분포와 길이무게 상관관계를 분석하였다. 연구결과 배스가 서식하는 지역의 붕어 개체군은 1년생 이하 치어의 비율이 전반적으로 높지 않았고 오히려 2년생 이상의 큰 개체의 비율이 높게 나타났다. 반면 배스가 서식하지 않는 호소의 붕어 개체군은 1년생 이하의 비율이 높게 나타나 일반적인 성장 패턴을 보였다. 또한 배스의 직접적인 먹이가 되는 1년생 이하의(160 mm 이하) 붕어개체를 대상으로 길이-무게 상관관계 분석 결과 배스가 서식하지 않는 호소에서 매개변수 b값이 2.909, 배스가 서식하는 호소에서는 매개변수 b값이 3.100로 나타나 배스가 존재하는 환경에서 붕어의 무게가 상대적으로 더 빠르게 증가하는 것을 확인할 수 있었다. 따라서 배스의 포식에 직접적으로 영향을 받는 호소내 개체군이 생존을 위해 상대적으로 빠른 성장 전략을 사용한 것으로 사료되었으며, 이와 같은 현상은 붕어뿐만 아니라 국내 토착하는 다른종에서도 유사하게 확인될 것으로 판단된다.

First Record of the Antrorse Spined Gurnard Pterygotrigla multiocellata (Triglidae, Scorpaeniformes) from Korea

  • Kim, Joon Sang;Song, Choon Bok
    • Fisheries and Aquatic Sciences
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    • 제18권3호
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    • pp.283-286
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    • 2015
  • This is the first report of Pterygotrigla multiocellata from the family Triglidae, collected in Korea. The specimen (314 mm in standard length) was caught in a gill net in the coastal waters of Jeju Island on 11 February 2010. This species is characterized by the following morphological traits: head large and triangular, bony plates absent along the base of the second dorsal fin, antrorse rostral spine long, and cleithral spine long. We suggest a new Korean name, "Gin-ppul-mit-seong-dae" for P. multiocellata.