• Herbal Formula Science
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• v.10 no.1
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• pp.41-55
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• 2002

There are total 403 prescriptions containing Radix Scutellariae in Donguibogam and among them, 106 prescriptions treat Radix Scutellariae as a principal medicine. This report describes the study on therapeutic range, symptom, pathology and composition of 106 Radix Scutellariae-main blended Prescriptions from Donguibogam. The frequency and percentage of Radix Scutellariae-main blended prescriptions for the therapeutic range are as follows; cold symptom-complex is the most frequent(11 prescriptions, 10.37%) and gynecology is second(10 prescriptions, 9.43%). The symptoms that Radix Scutellariae-main blended prescriptions are made out for are 70 prescriptions of 28 therapeutic ranges, for example, minor Eum physical appearance, fire of triple burners jaundice, etc. The main pathologies that Radix Scutellariae-main blended prescriptions are being affected by cold, fire triple burners, dampness and heat, wind and heat, heat of heart and lung, heat of liver, heat of spleen, etc. Through the research into the composition of Radix Scutellariae-main blended prescriptions, the kind of medicines and certain rules of compounding medicines centering on Radix Scutellariae are deduced as follows: The main combinations of herbal medicines are Radix Scutellariae and Fructus Gardeniae, Radix Scutellariae and Rhizona Rhei, and Radix Scutellariae, Rhizona coptidis and Fructus Gardeniae. The main combinations of prescriptions are Yihwanghwan(Radix Scutellariae, Rhizoma Cotidis, Radix Glycyrrhizae), Boanbaekchulsan(Radix Scutellariae. Rhizoma Atractylodis macrocephalae), Sambohwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendrj), Samhwangwon(Radix Scutellariae, Rhizoma Cotidis, Rhizoma Rhei), Hwangryeonhaedoktang(Radix Scutellariae, Cortex Phellodendri, Rhizoma Cotidis. Fructus Gardeniae), Daegumhwahwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendri. Rhizoma Rhei). Sanyeolumja(Radix Scutellariae. Rhizoma Cotidis. Radix Osterici koreani. Radix Ledebouriellae), etc.

• The Korean Journal of Food And Nutrition
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• v.34 no.6
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• pp.662-668
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• 2021

Aster koraiensis Nakai (A. koraiensis) which has been used as a food and medicinal plant in the past, is valuable as functional food material. Therefore, the aim of this study was to determine the antioxidant properties and major phenolics of A. koraiensis extracts with different ethanol concentrations (0, 50, 70, and 100% aqueous ethanol solution). When ethanol concentration in the extraction solvent was increased, extraction yield decreased; 34.2, 23.2, 21.0, and 5.5% in 0, 50, 70, and 100% ethanolic extracts, respectively. Total phenolics content and antioxidant activities of extracts were increased in an ethanol concentration-dependant manner. The major phenolics in the extracts were chlorogenic acid (21.264~58.666 mg/g), isochlorogenic acid A (10.432~145.353 mg/g), and isochlorogenic acid C(0.239~13.148 mg/g), and these phenolic contents were higher in 70 and 100% ethanolic extracts than other extracts. Significant correlations were observed between ethanol concentration of extraction solvent, antioxidant properties, and major phenolics. These results indicated that the optimal ethanol concentration for extraction was 70%.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.3
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• pp.75-86
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• 2022

Objectives The purpose of the study is to review the trend of clinical trials conducted in China with oral herbal medicine treatment on childhood primary hyperhidrosis. Methods We searched the randomized controlled trials (RCTs) with oral herbal medicine treatment on childhood primary hyperhidrosis from the China National Knowledge Infrastructure (CNKI). The demographic data, duration of illness, intervention, treatment period, outcome and composition of herbal medicine were analyzed for this study. Results A total of five RCTs were selected and analyzed. The effectiveness of the oral administration of herbal medicines on childhood primary hyperhidrosis was found to be significant. In one study, there was no statistical difference between the treatment group and the control group when curative effect was evaluated two weeks after the intervention; however, the treatment group showed a statistically higher curative effect than the control group at one and two months after intervention, and also one month after the intervention was terminated. Conclusions Oral herbal medicine has been shown to be an effective treatment for childhood primary hyperhidrosis, and it takes at least one month for the administered oral herbal medicines to take effect. However, further well-designed large-scale randomized controlled trials are needed to confirm the efficacy and safety of oral herbal medicines in childhood primary hyperhidrosis.

• Herbal Formula Science
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• v.23 no.2
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• pp.209-224
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• 2015

Objective : The main purpose of this study is to find a reasonable solutions for utilization of herbal formulas based on the medical classics. Methods : We used official Ten 'Selected Korean Medical Classics(SKMC)'. For input of formulas from SKMC, we had to select proper editions of them. After consultations with experts of 'The Korean Medicine Society for the Herbal Formula Study' and 'Korean Society of Medical History', we chose the proper editions of SKMC, and according to those books, we built formulas database using microsoft office excel sheets, respectively. Results : After whole input procedures, we requested several experts to inspect the results and also, to correct errors in them. Input categories were name of formula, name of classic, classification, original source, composition herb, weight, unit of weight, weight conversion index, converted weight, basic formula, indications, reason for modification, preparing method, taking method and contraindications. Final number of whole formulas in DB was 32,882. Conclusions : We used SKMC and built database using excel program. Through this procedure, we can provide a developmental ways to make a foundation for herbal formulas from the medical classics, so that we can make herbal formulas be standardized or industrialized more efficiently.

• Journal of Ecology and Environment
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• v.33 no.2
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• pp.141-147
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• 2010

This study compared the antimicrobial activity and chemical composition of two plants used as "Injin" (Korean herbal medicine), namely, Injinho (Artemisia capillaris Thunberg) and Haninjin (Artemisia iwayomogi Kitamura). The ethyl acetate and ether fractions of crude methanol extracts from A. capillaris and A. iwayomogi were tested against three grampositive bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus), two gram-negative bacteria (Escherichia coli, Pseudomonas fluorescens), and a yeast (Saccharomyceus cerevisiae). The antimicrobial activity of the ethyl acetate and ether fraction of both plants was strong, but that of A. iwayomogi extracts was higher than that of A. capillaris extract for the microbes tested. The minimum inhibitory concentration of the ether and ethyl acetate fraction of A. iwayomogi was highest for P. fluorescens and lowest for S. aureus and E. coli. We analyzed the chemical composition of the ethyl acetate fraction of A. capillaris and A. iwayomogi using gas chromatography-mass spectrometry. The main components of A. capillaris and A. iwayomogi were escoparone (86.82%) and scopoletin (20.47%), respectively.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.11-37
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• 2014

Objectives : The purpose of this study was to analyze and identify the problems of the changes in regulations that are relevant to approval, notification, and review of herbal medicinal preparations and crude drug preparations. Methods : I collected the regulations of approval, notification, and review of medicinal products mostly from official gazettes, analyzed enactment and amendments regarding herbal medicinal preparations and crude drug preparations, and studied it from the view point of Korean medicine field. Results : Regulations in regards to approval, notification, and review of herbal medicinal preparations and crude drug preparations were first established in 1978. Herbal drugs started to be categorized as crude drug preparations in 1981 and the regulatory outlines were completed in 1999. From 2008 to 2012, the regulatory standards that let crude drug preparations be new drugs from natural products were established. Through those procedures, the followings became crude drug preparations: 1) wholly new prescriptions that are not recorded in Korean Medical Classics, 2) prescriptions that are recorded in Korean Medical classics but prepared with new standard, composition and efficacy, 3) prescriptions that are recorded in Korean Medical classics but prepared with new formulation, and 4) herbal drugs. In case of herbal medicinal preparations, however, only regulations that are related to 1) drugs prepared with new compositions that are not recorded in Korean Medical Classics, 2) drugs with same prescription and same formulation, and 3) drugs with new formulation were arranged. Conclusions : Actual circumstances on crude drug-oriented regulations regarding approval, notification and review and future forms of prescription and drug administration in Korean Medical Institutions can be expected due to expansion in range of herbal medicinal preparations and shrink in that of on-site preparations. Reasonable improvement in efficient usage of modernized herbal medicinal preparations in Korean medical institutions and prospective cooperation from related pharmaceutical industry are needed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.4
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• pp.114-125
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• 2020

Objectives : The aim of this study is to review the topical anesthetic effect of herbal medicine. Methods : Using domestic database(OASIS, RISS) and foreign database(Pubmed, Embase, Cochrane library, CNKI), clinical studies about efficacy of herbal medicine as topical anesthetics were searched. Only randomized controlled trials(RCT) were selected and analyzed. Results : Total 647 studies were searched. After screening process, 5 articles were selected. 2 were from Chinese database and 3 were from English database. Articles were about clinical use of herbal medicine as topical anesthetics and compare their efficacy with conventional topical anesthetics. Out of 5 articles, 4 articles used pain rating scales recorded by subjects as outcome measurement. All studies showed lower pain score in herbal medicine using groups. 4 studies showed that there was no statistically significant difference in pain score between herbal medicine using group and conventional topical anesthetics using group. Conclusions : The results suggest that topical anesthetics using herbal medicine is as effective as or maybe even more effective than conventional topical anesthetics. However, experimental design and composition of intervention were all different, which provides inaccuracy when comparing the experimental results. Also, sample sizes were small and the number of RCTs were insufficient to identify full list of herbs that have potentials to be used topical anesthetics. Further studies need to be conducted to find out potentials of herbal medicine as topical anesthetics.

• Radioisotope journal
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• v.21 no.4
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• pp.38-45
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• 2006

A new herbal composition. HemoHIM, was developed using irradiated animal models and was successfully applied as an immune-improving agent. In a view that the protection and recovery of immune, hematopoietic and self-renewal tissues are essential for radioprotective agents, HemoHIM was developed based on a novel combination of three edible herbs (Angelica Radix, Cnidii Rhizoma. Paeonin Radix) that meet all those requirements. HemoHIM significantly protected the immune and hematopoietic system and enhanced their recovery in y-irradiated mice. For the application of HemoHIM as a health functional food and a supplementary agent for the cancer patients, the efficacy of HemoHIM to improve the immune functions was further evaluated in immune-depressed animals and humans. Animal studies demonstrated that HemoHIM significantly improved the immune functions in cyclophosphamide-treated mice, aged mice, and dexamethasone-treated mice. In human studies, HemoHIM enhanced the immune activity and cytokine secretion in sub-healthy volunteers, and alleviated the severe leukocyre depression in cancer patients during radiation and chemotherapy. Based on these results, HemoHIM was approved by Korea FDA as a material of health functional food for immune function improvement and will be commercially available soon. This case of HemoHIM research and development suggested that irradiated animals can be good models for biological degenerations such as immune depression, self-renewal tissue damage, and aging for the development of biological modulators.

• The Journal of Korean Medical History
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• v.35 no.2
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• pp.19-34
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• 2022

Objectives : The purpose of this study was to compare the prescriptions used for insomnia in Uihagimmun and Donguibogam. Methods : In Uihagimmun, 17 prescriptions were selected. If there was a change in the medicinal material, the altered herbal medicine was indicated along with the prescription name. In Donguibogam, 14 prescriptions were selected. Each prescription was analyzed by dividing it into prescription composition, and herbal medicine. Medications constituting a prescription were classified according to the classification of Korean herbal medicines and arranged based on their frequency of appearance. Result : The causes of insomnia were classified mainly as exhaustion in Uihagimmun and as exhaustion, stress, low energy, aging and discomfort in Donguibogam. In Uihagimmun, numerous medicines were used to relieve fever, and in Donguibogam, the use of stabilizers increased. More warm medicines were used in Donguibogam than in Uihagimmun, and the taste trend was similar in each. Conclusions : The types of causes of insomnia increased more in Donguibogam than Uihagimmun. Accordingly, the two books showed differences in drug classification and properties of a medicine. However, in terms of taste and action of medicinal herbs, they showed similar patterns, and there was only a difference in the order of frequency.

• The Journal of Korean Medical History
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• v.33 no.2
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• pp.89-104
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• 2020

The purpose of this research is to build a database structure that can be useful for evidence-based medical practices by constructing the knowledge related to oriental medicine in the classical literature knowledge in a form that can utilize new forms of information technology. As a method, "database" is used as a keyword to search published studies in the field of oriental medicine, research is conducted on classic literature knowledge, and studies describing the contents of the data structure are found and analyzed. In conclusion, the original text DB for the preservation of the original texts and the presentation of the supporting texts should include 'Contents Text', 'Tree Structure', 'Herbal Structure', 'Medicine Manufacture', and 'Disease Structure' tables. In order to search, calculate, and automatically extract expressions written in the original text of the old literature, the tool DB should include 'Unit List', 'Capacity Notation List', 'CUI', 'LUI', and 'SUI' tables. In addition, In order to manage integrated knowledge such as herbal, medicine, acupuncture, disease, and literature, and to implement a search function such as comparison of similarity of control composition, the knowledge DB must contain 'dose-controlled medicine name', 'dose-controlled medicine composition', 'relational knowledge', 'knowledge structure', and 'computational knowledge' tables.