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http://dx.doi.org/10.7778/jpkm.2022.36.3.75

Review of Recent Clinical Research for Oral Herbal Medicine Treatment on Primary Hyperhidrosis in Children - Focused on Chinese Randomized Controlled Trials -  

Choil, Il Shin (Department of Korean Pediatrics, Pusan National University Korean Medicine Hospital)
Kim, Ki Bong (Department of Korean Pediatrics, Pusan National University Korean Medicine Hospital)
Cheon, Jin Hong (Department of Korean Pediatrics, Pusan National University Korean Medicine Hospital)
Publication Information
The Journal of Pediatrics of Korean Medicine / v.36, no.3, 2022 , pp. 75-86 More about this Journal
Abstract
Objectives The purpose of the study is to review the trend of clinical trials conducted in China with oral herbal medicine treatment on childhood primary hyperhidrosis. Methods We searched the randomized controlled trials (RCTs) with oral herbal medicine treatment on childhood primary hyperhidrosis from the China National Knowledge Infrastructure (CNKI). The demographic data, duration of illness, intervention, treatment period, outcome and composition of herbal medicine were analyzed for this study. Results A total of five RCTs were selected and analyzed. The effectiveness of the oral administration of herbal medicines on childhood primary hyperhidrosis was found to be significant. In one study, there was no statistical difference between the treatment group and the control group when curative effect was evaluated two weeks after the intervention; however, the treatment group showed a statistically higher curative effect than the control group at one and two months after intervention, and also one month after the intervention was terminated. Conclusions Oral herbal medicine has been shown to be an effective treatment for childhood primary hyperhidrosis, and it takes at least one month for the administered oral herbal medicines to take effect. However, further well-designed large-scale randomized controlled trials are needed to confirm the efficacy and safety of oral herbal medicines in childhood primary hyperhidrosis.
Keywords
Childhood primary hyperhidrosis; Randomized controlled trials; Oral herbal medicine; Review;
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1 Ballet JS. Diagnosis and treatment of primary focal hyperhidrosis in children and adolescents. Semin Cutan Med Surg. 2010;29(2):121-6.   DOI
2 Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016;308(10):743-9.   DOI
3 Bahar R, Zhou P, Liu Y, Huang YS, Philips A, Lee TK, Su MW, Yang S, Kalia S, Zhang XJ, Zhou YW. The prevalence of anxiety and depression in patients with or without hyperhidrosis. JAAD. 2016;75(6):1126-33.   DOI
4 Kisielnicka A, Szczerkowska-Dobosz A, Purzycka-Bohdan D, Nowicki RJ. Hyperhidrosis: disease aetiology, classification and management in the light of modern treatment modalities. Postepy Dermatol Alergol. 2022;39(2):251-7.   DOI
5 I Hoorens, K Ongenae. Primary focal hyperhidrosis: current treatment options and a step-by-step approach. J Eur Acad Dermatol Venereol. 2012;26(1):1-8.
6 Wecher T, Feldman SR, Taylor SL. The treatment of primary focal hyperhidrosis. Skin Therapy Lett. 2019;24(1):1-7.
7 Jung HJ, Jung SG, Lee HG. Dong-Eui pulmonary internal medicine. 5th ed. Seoul: Han-munhwasa. 2002:242-53.
8 Wang LQ, Hai RQ. Effect of Xingpi Yanger granules combined with Chinese herbal paste in night sweating children differentiated as type of heat accumulation in spleen and stomach. J Clin Med in Pract. 2020;24(6):69-71.
9 Ye SW. Observation of the treatment efficacy of Astragalus Root granules for children with hyperhidrosis. J Pediatr Pharmacy. 2009;15(2):28-9.
10 Li J. The clinical effect of Sanjia Fumai decoction in the treatment of children with hyperhidrosis of qiyin deficiency. Clin Res and Pract. 2016;1(27):122-3.
11 Jeong AR, Lee JY, Chang GT, Lee SH, Lee JH, Baek JH, Lee HR, Ku EJ, Kim JH, Min SY, Kim BNR, Yu SA, Kwon JH, Kim KB, Cheon JH, Jeong HS, Seong HG, Jeong MJ, Park EJ. Pediatrics of Korean medicine. 3rd ed. Seoul: Ui Sung Dang Publishing Co. 2020:945-9.
12 Rural Development Administration. Development of rice-derived gamma-oryzanol and its complexes used for medicinalfood sources as immune system controling agents and its utilization {Internet}. Rural Development Administration; 2019 {cited 2022 July 30}. Available from: https://atis.rda.go.kr/rdais/rsrchReportInfo/rsrchReportInfoList.vw
13 Park MS, Kim YM. Pathologic study on representative prescriptions in Wenbingtiaobian and their coverage of diseases. J Physiol & Pathol Korean Med. 2018;32(1):1-12.   DOI
14 Park JM, Choi SW, Chae JW. A case report of hands and feet hyperhidrosis. J Pediatr Korean Med. 2013;27(4):68-76.   DOI
15 Yun KR. A study on the mechanism of spontaneous sweating and night sweating - focusing on discussions in classical medical texts. JKMC. 2020:33(3):111-33.
16 Tong Y, Zou J, Ni LQ, Liang SH, Cao BY, Chen HJ. The effect of four kinds of traditional Chinese herbal compound on the experimental acute stress behaviors and the hypothalamus-pituitary-adrenal gland axis. Zhongguo Zhong Yao Za Zhi. 2005;30(23):1863-6.
17 Hong SH, Park SE. A case report on a patient with night sweats treated with an external Korean medical treatment. J Int Korean Med. 2020;41(6):1282-8.   DOI
18 Li X. Clinical curative research of Yulong decoction on the treatment of children hyperhidrosis (lung deficiency and disharmony of ying and wei syndrome). [Master]. Nanjing University of Chinese Medicine, Nanjing. China. 2015. 42p.
19 The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology. Textbook of Korean medicine dermatology. 6th ed. Seoul: Koreauihak. 2015:543-54.
20 Kong Fy. Study on the effect of Sanjia Fumai decoction on syndrome score and curative effect of hyperhidrosis of children with hyperhidrosis due to qi-yin deficiency. Chin J Mod Drug Appl. 2020;14(20):209-11.
21 Gu YS. Correct understanding of medicine. 4th ed. Ewha Womans University Press. 2001:179.
22 Johannes KK, Dorthe G, Carl S, Anette B. In hyperhidrosis quality of life is even worse than in acne, eczema, or psoriasis. A comparison of Skindex-16 and Dermatology Life Quality Index (DLQI). Int J Dermatol. 2020;59(11):e392-3.
23 National Korean Medicine University Herbology Joint Textbook Comilation Committee. Bonchohak. 3rd ed. Seoul: Young Lim Publishing Co. 2014:553-4.
24 Kim KI, Lee HB, Choi KH, Jung SK, Jung HJ. A case series report on 11 patients of primary palmar/plantar hyperhidrosis in children and adolescents treated with hospitalization program of a hyperhidrosis clinic. Korean J Orient Int Med. 2012;33(3):327-37.
25 Gel bard CM, Epstein H, Herbert A. Primary pediatric hyperhidrosis: a review of current treatment options. Pediatric Dermatology. 208;25(6):591-8.
26 Hoorens I, Ongenae K. Primary focal hyperhidrosis: current treatmet options and a step-by-step approach. J Eur Acad Dermatol Venereol. 2012;26:1-8.   DOI
27 Elham G, Seyed MH, Hamid RM, Khosro KK, Saeed TM, Alireza AB, Seyedeh MM. Intra tester reliability of sympathetic skin responses in subjects with primary palmar hyperhidrosis. J Bodyw Mov Ther. 2020;24(4):57-62.
28 Lee DY, Hwang JJ. Hyperhidrosis and its treatment. J Korean Med Assoc. 2005 ;48(8):757-63.   DOI
29 Lee SH, Baek JH. A review of Korean medicine treatment for hyperhidrosis. J Pediatr Korean Med. 2019;33(3):42-55.
30 Remington C, Ruth J, Hebert AA. Primary hyperhidrosis in children: A review of therapeutics. Pediatr Dermatol. 2021;;38(3):561-7.   DOI
31 Lear W, Kessler E, Solish N, Glaser DA. An epidemiological study of hyperhidrosis. Dermatol Surg. 2007;33:69-75.
32 Kim KI, Lee HB, Choi KH, Jung SK, Jung HJ. A case series report on 11 patients of primary palmar/plantar hyperhidrosis in children and adolescents treated with hospitalization program of a hyperhidrosis clinic. Korean J Orient Int Med. 2012;33(3):327-37.