• The Korean Journal of Physiology and Pharmacology
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• 제19권2호
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• pp.119-124
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• 2015

The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or $H_2O_2$, results in genomic instability in non-tumorigenic human lung epithelial L132 cells. To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined. Exposure to 0.5 Gy IR or 0.05 mM $H_2O_2$ for 9 h resulted in the highest levels of aneuploidy; however, no cells were observed in the subG1 phase, which indicated the absence of apoptotic cell death. Exposure to an ELF-MF alone (1 mT or 2 mT) did not affect the percentages of G2/M-arrested cells, aneuploid cells, or the populations of cells in the subG1 phase. Moreover, when cells were exposed to a 1 mT or 2 mT ELF-MF in combination with IR (0.5 Gy) or $H_2O_2$ (0.05 mM), the ELF-MF did not further increase the percentages of G2/M-arrested cells or aneuploid cells. These results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when administered in combination with different stressors.

• BMB Reports
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• 제44권2호
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• pp.140-145
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• 2011

Impaired responsiveness of platelets to epinephrine (epi) and other catecholamines (CA) has been reported in approximately 20% of the healthy Korean and Japanese populations. In the present study, platelet aggregation induced by epi was potentiated by RO 31-8220 (RO) or G$\ddot{o}$ 6983 (G$\ddot{o}$). Phosphorylated Akt (p-Akt) was very low in epi-stimulated PRP from CA-hypo- responders (CA-HY), whereas it was detected in those from CA-good responders (CA-GR). RO and G$\ddot{o}$ increased p-Akt, one of the major downstream effectors of phosphoinositol-3 kinase (PI3K), in epi-stimulated PRP from both groups. Wortmannin, a PI3K inhibitor, attenuated the RO or G$\ddot{o}$-induced potentiation of p-Akt in epi-stimulated PRP, suggesting positive effects for RO and G$\ddot{o}$ on PI3K. $TXA_2$ formation was increased by the addition of either RO or G$\ddot{o}$ in epi-stimulated platelets. The present data also suggest that impaired Akt phosphorylation may be responsible for epinephrine hypo-responsiveness of platelets.

• Parasites, Hosts and Diseases
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• 제46권2호
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• pp.87-90
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• 2008

Gynaecotyla squatarolae (Digenea: Microphallidae) adult flukes were recovered from experimental chicks at day 4-6 post-infection and their tegumental ultrastructure was observed with a scanning electron microscopy. They were pyriform in shape, and their anterior halves were concaved ventrally. The whole body surface was covered with tegumental spines, which were wide and 16-17 digitated between oral and ventral suckers. The density of spines and number of digits decreased posteriorly. The oral sucker was subterminal and the excretory pore was at the posterior end of the worm. Two ventral suckers were similar in appearance and protruded near midline of the worm. The genital atrium was dextral to the small ventral sucker. The dorsal surface was covered with tegumental spines, but the spines were sparser than on the ventral surface. On the middle portion of the dorsal surface, a small opening presumed to be the Laurer's canal was seen. From these findings, it has been confirmed that the adult G. squatarolae has unique characteristics in the surface ultrastructure.

• 화약ㆍ발파
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• 제30권1호
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• pp.37-51
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• 2012

본 시공사례는 "성남~여주 복선전철 제${\bigcirc}$공구 노반건설공사"로서 터널의 노선을 따라 진동 및 소음으로 인한 피해영향권내에 주요 보안물건이 위치하고 있다. 설계단계에서 이러한 피해영향을 고려하여 기계식 암파쇄 굴착공법이 적용되어 있으나, 합리적인 공사기간 단축을 위한 대안 터널굴착공법이 요구되어 당 현장의 발파진동 허용기준(우사:0.09cm/sec, 주택 0.2cm/sec)을 준수하면서 시공성 및 경제성을 높일 수 있는 전자발파공법이 검토되었다. 이에, 최근 활성화 되고 있는 터널용 전자발파시스템(eDev)을 활용한 현장 시험시공을 통한 환경영향평가를 실시한 결과, 발파공해에 대한 안정적인 관리가 가능한 것으로 판단되었으며, 이를 기초로 한 시공결과 근접 보안물건에 대한 피해영향 없이 높은 굴진효율성을 보였다.

• 콘크리트학회논문집
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• 제21권4호
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• pp.419-429
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• 2009

이 논문에서는 긴장력 도입을 위한 강선의 용접절단순서가 강선의 변형률과 콘크리트 응력에 미치는 영향 을 실험과 유한요소해석을 통해 고찰하였다. 실험에서는 각각 다른 3개의 용접절단순서에 따른 강선과 횡방향 보강 철 근의 변형률 변화를 계측하였다. 해석에서는 실험과 동일한 조건에 대한 유한요소해석을 수행하였으며, 그 결과를 실험 결과와 비교·고찰하였다. 연구 결과, 강선의 변형률과 횡방향 보강근의 변형률이 긴장재의 절단순서에 따라 다른 결과 를 나타내는 것을 확인하였다. 또한 이 결과는 해석을 통하여도 검증되었다. 따라서 프리스트레스 구조물의 시공시 구 조특성에 따라 적절한 절단순서의 조절이 고려되어야 한다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.851-854
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• 2008

순환골재의 사용은 매립을 줄이고 고갈되어 가는 천연골재의 대체자원으로 사용할 수 있어 친환경적인 방법이다. 그러나 기존연구에서는 낮은 품질의 순환골재를 사용하거나 작은 크기의 부재만을 연구하였다. 본 연구에서는 순환굵은골재의 치환율(0, 30, 60, 100%)과 전단보강근에 따른 철근콘크리트 보의 전단거동을 파악하기 위하여 총 6개의 보를 실험하였다. 실험결과 순환골재를 사용한 실험체는 전단보강근의 사용 유무에 관계없이 천연골재를 사용한 실험체와 대등한 전단강도를 나타내었다. 또한 본 연구와 기존 연구의 실험값을 전단경간비, 압축강도, 단면크기, 유효깊이에 따른 전단강도특성을 비교한 결과 순환골재 콘크리트는 천연골재 콘크리트와 유사한 전단강도특성을 나타내었다. 순환골재를 사용한 구조물의 순환골재를 사용한 구조물의 적용성을 검토하기 위하여 현행 KCI2007 규준식 및 Zsutty의 전단강도 계산 값을 실험결과와 비교한 결과 현행규준식은 전단강도를 안전측으로 평가하고 있어 순환골재를 사용한 실험체에도 적용 가능 할 수있는 것으로 판단된다.

• 대한수의학회지
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• 제39권5호
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• pp.896-907
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• 1999

The morphometrical characteristics such as external measurements and mandible size assessment in mice and rats have to be highly heritable and sufficiently variable between strains in order to calculate a strain specific profiles. The coat color of Korean wild rats were observed and morphometric analysis of external measurements were carried out on Korean wild rats compared to laboratory strains in order to clarify the genetic characteristics of Korean wild rats and to establish background data as a domestication of Korean wild rats for new laboratory strain. Korean wild rats were captured from Chunchon and Hoengsong. 4 inbred and 1 outbred strains of rats were used in this study for the comparison of genetic characteristic of Korean wild rats. Total body length, head length, tail length, hind foot length and ear length were measured and then statistical analysis were carried out by discrimiant analysis. The coat color of Korean wild rat showed golden white in ventral portion and dark agouti in dorsal portion. Korean wild rats could be distinguished from the other laboratory strains distinctly by morphogenetical analysis. There was significant variations among Korean wild rat compared to those of the other laboratory strains of rat. This study may provide that Korean wild rats have a unique genetic characterization compared to those of other inbred strains of rats based on morphogenetical characteristics by external measurements.

• 아동학회지
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• 제34권2호
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• pp.1-25
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• 2013

The purpose of this study was to examine the relationship among infants' nonverbal communication, maternal verbal behaviors and the infants' acquisition of vocabulary. The subjects were 93 pairs of 10 to 18 months old infants and their mothers residing in the Seoul and GyeongGi-Do area. The results were as follows : (1) In terms of the infants' nonverbal communicative means, it appeared that the group of 16~18 month olds utilized more gesture and vocalization. As regards the infants' nonverbal communicative functions in terms of social behavior and joint attention, the group of 16~18 month olds was found to perform more of the behaviors from this category than the other groups. There was a significant difference in the maternal verbal behavior among the different age groups. (2) Among the infants' nonverbal communicative means, gesture and vocalization, there appeared to be a significant relationship between vocalization and the infants' acquisition of vocabulary. In addition, there was an important relationship between the high usage of infants' nonverbal communicative functions with behavior regulation and the high usage of joint attention and the successful acquisition of vocabulary among infants. (3) Social play, which is a maternal verbal behavior categorized as one of the strategies for getting infants' attention, was significantly related to the acquisition of infants' vocabulary. (4) When mothers used more imitating sounds and mimetic words, requests for information, descriptions, conventional social expressions, and imitation to enhance responsiveness, infants were found to have acquired a larger vocabulary.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권4호
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• pp.245-254
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• 2018

Background: When performing dental treatment under general anesthesia in adult patients who have difficulty cooperating due to intellectual disabilities, anesthesia induction may be difficult as well. In particular, patients who refuse to come into the dental office or sit in the dental chair may have to be forced to do so. However, for adult patients with a large physique, physical restraint may be difficult, while oral sedatives as premedication may be helpful. Here, a retrospective analysis was performed to investigate the effect of oral sedatives. Methods: A hospital-based medical information database was searched for patients who were prescribed oral midazolam or triazolam between January 2009 and December 2017. Pre-anesthesia evaluation, anesthesia, and anesthesia recovery records of all patients were analyzed, and information on disability type, reason for prescribing oral sedatives, prescribed medication and dose, cooperation level during anesthesia induction, anesthesia duration, length of recovery room stay, and complications was retrieved. Results: A total of 97 patients were identified, of whom 50 and 47 received midazolam and triazolam, respectively. The major types of disability were intellectual disabilities, autism, Down syndrome, blindness, cerebral palsy, and epilepsy. Analyses of changes in cooperation levels after drug administration showed that anesthesia induction without physical restraint was possible in 56.0% of patients in the midazolam group and in 46.8% of patients in the triazolam group (P = 0.312). Conclusions: With administration of oral midazolam or triazolam, general anesthesia induction without any physical restraint was possible in approximately 50% of patients, with no difference between the drugs.

• 대한기계학회논문집A
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• 제24권9호
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• pp.2183-2190
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• 2000

A thermal aging is observed in a primary reactor cooling system(RCS) made of a casting stainless steel when the RCS is exposed for long period at the reactor operating temperature, 290~3300C An investigation of effects of thermal aging on a low cycle fatigue characteristics included a stress variations caused by a reactor operation and trip, is required. The purpose of the present investigation is to find an effect of a thermal aging of the CF8M on a low cycle fatigue life. The specimen of CF8M are prepared by an artificially accelerated aging technique holding 300 and 1800hr at 4300C respectively. The low cycle fatigue tests for the virgin and two aged specimens are performed at the room temperature for various strain amplitudes($\varepsilon$ta), 0.3, 0.5, 0.8, 1.0, 1.2 and 1.5% strain. Through the experiment, it is found that the fatigue life is rapidly reduced with an creasing of the aging time. The experimental fatigue life estimation formulas between the virgin and two aged specimen are obtained and are proposed to a analysis purpose.