• The Korean Journal of Food And Nutrition
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• v.36 no.6
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• pp.436-444
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• 2023

To produce an intestinal immunomodulatory beverage containing Centella asiatica extract (CAE), three types of CAE-added beverage prototypes were prepared, and their immunomodulatory activities and marker compounds were analyzed. As a result of the cytotoxicity assessment, all the beverages did not show significant toxicity compared to the control group. Next, the immunomodulatory activities of the beverage prototype were evaluated using the inflammatory model of IL-1β-induced intestinal epithelial cell line. All the samples significantly reduced the production of IL-6, IL-8, and MCP-1 in a CAE concentration-dependent manner. In addition, CAE-added beverages inhibited NO, IL-6, and IL-12 production in LPS-induced RAW 264.7 cells. When the major triterpenoids, as marker compounds for the production of CAE-added beverages, were analyzed by HPLC-DAD, only asiaticoside was detected beyond the limit of quantification, while madecassoside, madecassic acid, and asiatic acid were not detected. The amounts of asiaticoside in CAE-added beverage prototypes were confirmed in No. 1 (19.39 ㎍/mL), 2 (19.25 ㎍/mL), and 3 (19.98 ㎍/mL). In conclusion, the results of this study suggested that CAE-added beverage prototypes induced immunomodulatory effects in the intestinal inflammatory cell line models and asiaticoside could be used as a marker compound for CAE-added beverage production.

• Herbal Formula Science
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• v.9 no.1
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• pp.165-206
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• 2001

After this study, I report the following result from it 1. 'Qiao zhang' is the symptoms that the abdomen is distension and fullness, but face, eye, four limb is not dropsial swelling. It corresponds to the Gu zhang(?脹), Zhang man(脹滿), Jiju(積聚), Dan fu zhang(單腹脹), Zhong man(重滿) of the Oriental Medicine. 2. The cause and overeating and, and malfunction pathology of the 'Qiao zhang' were accumulation of water cause of overeating and, overdrinking, the hurt of feeling, overwork, infection of blood sucker and malfunction of liver, spleen and kidney for jandice and Jiji(積聚) 3. The treatment of the 'Qiao zhang' was reinforcing middle-energizer and replenishing Qi and allevating water retention because middle-energizer were much weak. 4. The prescription of the 'Qiao zhang' that Zhang man fen xiao wan(中滿分消散) were 16 times the most. Zhang man fen xiao tang(中滿分消湯), Guang man kui jian tang(廣茂潰堅湯), ren shen gui pi tang(人蔘芎歸湯), Yu yu liang wan(禹餘糧丸), mun xiang sun qi tang(木香順氣散) were next. 5. The single herb of the prescription of the 'Qiao zhang' that were Auckrandiae Radix(木香), Citri Pericarpium(陳皮) for rephenshing qi drug, Atractylodis Macrocephalae Phieoma(白朮), Ginseng Radix(人蔘), Magnoliae Cortex(厚朴) for regurating qi drug, Pinelliae Rhzoma(半夏) for dischanging phlegm drug.

• Aerospace Engineering and Technology
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• v.4 no.2
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• pp.163-170
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• 2005

According to the KSLV program of KARI, it is planed to develop various launch vehicle and satellite 10 years hereafter. Large-scale test facilities, such as ReTF and PTA-II, are needed to fulfill this launch vehicle/satellite development project. The authors intend to arrange and describe various indexes that are needed in test facility design, construction and operation process. This technical paper is describing model analysis of damage prediction of accident in KSLV Integrated Propulsion System Test Facility based on propellant storage quantity and layout. In addition, the result can be used to produce safer design of test facility.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.151-154
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• 2005

A study was conducted to investigate safe testing on propulsion system, especially concentrated on effects of contaminants accumulation and transfer in LOX system. Several methods for system operation decreasing accidents caused by oxidizer leakage and contaminants accumulation was investigated. These methods can be applied to LOX system and other propellants system in liquid propellants propulsion system.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• v.y2005m4
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• pp.23-26
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• 2005

The method of decreasing the ecological risk for the LRE(Liquid Rocket Engine) test is developed, working on the cryogenic oxidizer and the high-boiling fuel(Kerosene). This Method is based on the study that contains a technical solution method and an accident occurrence range for decreasing of accident probability and damage. This paper contains schematic on the all risk circumstance bring to accident, block-diagram for an accident growth process in case of the propellant leakage, evaluation method of safety distance from test stand to residential area. It will be used to alternative method for the risk reduction of complex technical systems.

• Journal of the Korean Society of Food Culture
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• v.30 no.6
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• pp.797-803
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• 2015

Atopic dermatitis (AD) is usually caused by foods such as wheat, egg, milk, and peanuts, leading to common health problems in early childhood with complications like urtication. The aim of this study was to evaluate ethanol extracts of rice and rice snacks concentrated until the ethanol was completely eliminated and hot-air dried. In vitro analyses were carried out using murine macrophage RAW 264.7 cells. We measured cytotoxicity, nitric oxide (NO) production, and inflammatory cytokine level. The NO level of the cells exposed to lipopolysaccharide (LPS) was significantly reduced by rice and rice snack extracts. $TNF-{\alpha}$ level decreased in contrast to the LPS group, although a significant difference was not observed. On the other hand, IL-6 significantly decreased in both rice and rice snack extracts in a dose-dependent manner. The results of the present study suggest that rice and rice snack decreased NO and inflammatory cytokine levels. Therefore, rice could be useful as a raw material for relieving child atopic dermatitis caused by snacks made from wheat.

• Korean Journal of Pharmacognosy
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• v.43 no.1
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• pp.27-31
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• 2012

This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-${\beta}$ (TGF-${\beta}$). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was $1{\mu}g/mL$ and $50{\mu}g/mL$, respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.

• Journal of the Optical Society of Korea
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• v.17 no.2
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• pp.200-204
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• 2013

We propose a cell structure for the fast switching of liquid crystals by the fringe field. By forming protrusion between patterned electrodes, we can obtain enhancement of response time. The protrusion reduces the effective cell gap, with which a fast response time can be realized. There is little decrease in the transmittance because the protrusion is located between patterned electrodes. We confirmed that the total response time can be decreased by 33% with little loss of the transmittance by optimizing the shape of the protrusion structure.

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.426-426
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• 2005

• Parasites, Hosts and Diseases
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• v.44 no.4 s.140
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• pp.313-320
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• 2006

In an effort to characterize, on the molecular scale, the Acanthamoeba initially isolated from the cornea of an amoebic keratitis patient associated with overnight-wear orthokeratology lens in Korea, we conducted mitochondrial DNA restriction fragment length polymorphism, 18S rDNA sequencing, and drug sensitivity analyses on the isolate (KA/PE1). The patient was treated with polyhexamethylene biguanide, chlorhexidine and oral itraconazole, which resulted in resolution of the patient's ocular inflammation. The majority of the molecular characteristics of the KA/PE1 were determined to be identical, or quite similar, to those of A. castellanii Ma strain, which had been isolated also from amoebic keratitis. The risk of Acanthamoeba keratitis as a potential complication of overnight orthokeratology is briefly discussed.