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Inhibitory Effect of Cirsium japonicum Root or Flower Extract on Hepatic Stellate Cells Activation  

Kim, Sang-Jun (Jeonju Biomaterials Institute)
Kim, Seon-Young (Jeonju Biomaterials Institute)
Kim, Ji-Ae (Jeonju Biomaterials Institute)
Park, In-Sun (Jeonju Biomaterials Institute)
Yu, Kang-Yeol (Jeonju Biomaterials Institute)
Chung, Chang-Ho (Jeonju Biomaterials Institute)
Shim, Jae-Suk (Imsil Herbal Medicine Association)
Jang, Seon-Il (College of Alternative Medicine,Jeonju University)
Jeong, Seung-Il (Jeonju Biomaterials Institute)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.1, 2012 , pp. 27-31 More about this Journal
Abstract
This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-${\beta}$ (TGF-${\beta}$). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was $1{\mu}g/mL$ and $50{\mu}g/mL$, respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.
Keywords
Cirsium japonicum; Hepatic stellate cells; LX-2 cells; Liver fibrosis; Silymarin;
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