• International Journal of Stem Cells
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• v.17 no.2
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• pp.130-140
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• 2024

Cardiac organoids have emerged as invaluable tools for assessing the impact of diverse substances on heart function. This report introduces guidelines for general requirements for manufacturing cardiac organoids and conducting cardiac organoid-based assays, encompassing protocols, analytical methodologies, and ethical considerations. In the quest to employ recently developed three-dimensional cardiac organoid models as substitutes for animal testing, it becomes imperative to establish robust criteria for evaluating organoid quality and conducting toxicity assessments. This guideline addresses this need, catering to regulatory requirements, and describes common standards for organoid quality and toxicity assessment methodologies, commensurate with current technological capabilities. While acknowledging the dynamic nature of technological progress and the potential for future comparative studies, this guideline serves as a foundational framework. It offers a comprehensive approach to standardized cardiac organoid testing, ensuring scientific rigor, reproducibility, and ethical integrity in investigations of cardiotoxicity, particularly through the utilization of human pluripotent stem cell-derived cardiac organoids.

• Archives of Plastic Surgery
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• v.45 no.1
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• pp.14-22
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• 2018

Background Liposuction has become one of the most frequently performed procedures in the field of aesthetic surgery. Fat embolism syndrome after liposuction can easily be overlooked or underestimated; however, occasionally, fulminating fat embolism syndrome can develop and lead to a critical situation within 2-3 days after lipoplasty. Changes over time in the amount of circulating fat particles and the histology of major organs have not yet been studied. Methods This study was conducted using 18 male Sprague-Dawley rats aged 12 weeks and weighing 500-628 g (average, 562 g). Fifteen rats were used as the experimental group and 3 as the control group. Under general anesthesia, tumescent-technique liposuction was performed at the lateral flank areas and abdomen for 1 hour. Blood, lung, and brain tissue specimens were obtained at 1 hour, 1 day, and 2 days after the liposuction procedure. Results The average number of fat particles in the blood samples was 25,960/dL at 1 hour, 111,100/dL at 24 hours, and 21,780/dL at 48 hours. The differences between study groups were statistically significant. Both intravascular and extravascular fat particles with inflammation were seen in all 15 rats, as were inflammatory cell infiltration, hemorrhage, and consolidation with shrinkage of the lung alveoli. Conclusions These results imply that there is a strong possibility of fat embolism syndrome after liposuction in real clinical practice, and the first 24-48 hours after the operation were found to be the most important period for preventing pulmonary embolism and progression to fulminating fat embolism syndrome.

• The Journal of Internal Korean Medicine
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• v.40 no.4
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• pp.612-628
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• 2019

Objective: The aim of this review was to investigate clinical studies on Korean medical treatments for dysmenorrhea. Method: Using the keywords "dysmenorrhea," "Korean medical treatment," "acupuncture," and "herbal medicine," searches were conducted using domestic databases, including the National Discovery for Science Leaders (NDSL), the Research Information Sharing Service(RISS), and the Oriental Medicine Advanced Searching Integrated System (OASIS). The keywords were combined in various ways, instead of being searched individually. Papers that did not cover clinical studies or were not matched with the subject, absent of the abstract and text, were excluded. Results: Using the above searching method, 20 studies were found. Of these, 15 were in the form of case reports and five were in the form of randomized controlled trials. Acupuncture, herb medicine, pharmacopuncture, moxibustion, and cupping were used as treatments for dysmenorrhea. All of these studies reported that the Korean medical treatment was effective. Conclusion: According to the results, Korean medical treatments can provide an effective treatment for dysmenorrhea. However, more clinical studies on dysmenorrhea should be conducted for further clinical applications.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.56 no.3
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• pp.293-299
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• 2023

Acne vulgaris is often associated with acne-related bacteria such as Cutibacterium acnes. In this study, we investigated the antibacterial effects of the methanol extract of the algae Ecklonia cava and its solvent-soluble extract against C. acnes. Among five solvent fractions, the ethyl acetate (EtOAc) fraction exhibited the strongest antibacterial activity against C. acnes. Furthermore, the EtOAc-soluble extract exhibited the highest total phenolic contents among the five solvent fractions tested. The EtOAc subfraction 07 (Fr. 07) extract showed the highest antibacterial effect against C. acnes and isolated C. acnes along with minimum inhibitory concentration (MIC) ranging from 32 to 64 ㎍/mL. Additionally, MICs of antibiotics against antibiotic-resistant C. acnes strains were substantially reduced when antibiotics were combined with Fr. 07, suggesting that Fr. 07 restore the antibacterial activity of the antibiotics. The fractional inhibitory concentration indices clearly revealed an additive synergistic effect of Fr. 07 with antibiotics. The results of the present study suggest a potential role for E. cava in the control of infections related to acne vulgaris.

• East Asian mathematical journal
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• v.31 no.4
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• pp.459-481
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• 2015

In this study, we investigated whether the theorem is established even if we replace a 'square' element in the Euclidean proof of the Pythagorean theorem with different figures. At this time, we used different figures as equilateral, isosceles triangle, (mutant) a right triangle, a rectangle, a parallelogram, and any similar figures. Pythagorean theorem implies a relationship between the three sides of a right triangle. However, the procedure of Euclidean proof is discussed in relation between the areas of the square, which each edge is the length of each side of a right triangle. In this study, according to the attached figures, we found that the Pythagorean theorem appears in the following three cases, that is, the relationship between the sides, the relationship between the areas, and one case that do not appear in the previous two cases directly. In addition, we recognized the efficiency of Euclidean proof attached the square. This proving activity requires a mathematical process, and a generalization of this process is a good material that can experience the diversity and rigor at the same time.

• Korean Journal of Environmental Biology
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• v.35 no.1
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• pp.1-5
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• 2017

A native species to the European ocean, the tunicate Ciona intestinalis now appears worldwide, from sub-Arctic to tropical regions. C. intestinalis generally occurs as an opportunistic fouling organism on artificial substrates in harbors or aquaculture. This study focused on estimating the early growth pattern of C. intestinalis under various temperature conditions. Adults were collected from the Guryungpo harbour in November 2016, and their artificially inseminated eggs were used for the study. The growth of the C. intestinalis was investigated at 8 constant temperatures, ranging from $12^{\circ}C$ to $26^{\circ}C$, at 30 psu. Results indicate that the growth of C. intestinalis increased with increasing temperature. The growth was sluggish at $12^{\circ}C$, and decreased at $26^{\circ}C$. The optimal temperature for growth of C. intestinalis was therefore estimated to be between $20^{\circ}C$ and $24^{\circ}C$.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.2
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• pp.134-138
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• 2011

Fault detection for dynamic loading conditions of rotational machineries was considered from the contactless, non-destructive infrared thermographic method, rather than the traditional diagnosis method. In this paper, by applying a rotating deep-grooved ball bearing, passive thermographic experiment was performed as an alternative way proceeding the traditional fault monitoring. In addition, the thermographic experiments were compared with the vibration spectrum analysis to evaluate the efficiency of the proposed method. Based on the results, it was concluded the temperature characteristics of the ball bearing under dynamic loading conditions were analyzed thoroughly.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.07b
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• pp.1151-1154
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• 2003

Ultraviolet rays, OH H O radical and $O_3$ produced by the streamer discharge in water are widely used to deactivate microorganisms and remove organic contaminants in water and the dominant factor of these decomposition is the oxidized reaction of hydrogen peroxide and dissolved $O_3$ in water. In this paper, the barrier discharge was used to create plasma in a gas, liquid and solid medium and the electrode with the reactor combined barrier with packed type(BPR) was made as noncontact way against water so that the effect of water characteristic change by the erosion of electrodes exposing in water should be minimized. The active radical and $O_3$ gas generated in plasma region were reacted into the water as electrode so that at the same time a dissolved $O_3$ and hydrogen peroxide were formed in water and The change of pH and conductivity were measured.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.428-431
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• 2008

Korea Aerospace Research Institute(KARI) is achieving the Korea Space Launch Vehicle(KSLV) program according to National Space Technology Development Program. KSLV-I will be composed to liquid propellant(first stage) and solid propellant(second stage) propulsion system. The propulsion system of KSLV-I second stage is solid kick motor with high expansion ratio and its starting altitude is 300km high. In order to verify the performance of upper stage propulsion system designed to operate in the upper atmosphere, test facility which can simulate high altitude is needed. High Altitude Simulation Test Facility is composed to Thrust Measurement System, Control & Measurement system, Diffuser, SKID for cooling water supply to diffuser, CCTV, fire protection system and so on. This paper introduces TMS adapted to High Altitude Simulation Test for KSLV-I Kick Motor Development and results of hot firing test for its performance verification.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.469-472
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• 2005

이 논문은 게임물리엔진에서 게임세계의 물리적인 요소를 통하여 게임에 존재하는 캐릭터들에게 인공지능을 부여하기 위한 연구에 관해서 다룬다. 게임속에서의 물리적인 상황을 자동인식하기 위해서 신경망을 이용하였다. 게임속에서의 인공지능의 적용은 게임의 속도저하를 가져오게 되는데 이 논문에서는 그러한 단점을 보완하기 위하여 물리엔진에서 캐릭터의 움직임을 계산하는 수치적분 메서드들에 대한 각 물리상황에 따른 최적의 성능을 분석하여 각각의 물리 상황마다 다른 수치 적분 메서드를 적용하는 내부 구조를 취하였다. 수치적분 메서드에 대한 각각의 성능 분석은 세가지의 물리적 상황을 구분하여 그에 기반하여 실험되었다. 인공지능 캐릭터에 대한 실험은 신경망의 토폴로지에 대한 변화와 학습 횟수에 대한 변화 및 은닉층에 대한 변화로 신경망에서의 최적의 성능에 대한 평가를 실시하였다.